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Displaying record number 61308

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HXB2 Location	Gag(453-466) p2p7p1p6(90-103) DNA(2146..2187)	Gag Epitope Map
Author Location	Gag
Epitope	PEPTAPPAESFGFG	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(B*35)
Immunogen	in vitro stimulation or selection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ, Other
Keywords	binding affinity

Notes

• Ex vivo-expanded HIV-specific T cells and antigen presenting cells from seronegative donors were identified against specific Gag or Nef epitopes with the goal of using them in allogenic hematopoietic stem cell transplantation. This is the first domonstration of ex vivo-primed and expanded HIV-specific T cells releasing IFNγ in response to mapped epitopes, with enhanced ability to suppress HIV replication in vitro.
• This is the first domonstration of ex vivo-primed and expanded HIV-specific T cells releasing IFNγ in response to epitope , and with enhanced ability to suppress HIV replication in vitro.
• Gag epitope PEPTAPPAESFGFG was found to elicit CTL immune response in a seronegative donor.

References

Patel2016 Shabnum Patel, Sharon Lam, Conrad Russell Cruz, Kaylor Wright, Christina Cochran, Richard F. Ambinder, and Catherine M. Bollard. Functionally Active HIV-Specific T Cells that Target Gag and Nef Can Be Expanded from Virus-Naive Donors and Target a Range of Viral Epitopes: Implications for a Cure Strategy after Allogeneic Hematopoietic Stem Cell Transplantation. Biol. Blood Marrow Transplant., 22(3):536-541, Mar 2016. PubMed ID: 26721209. Show all entries for this paper.