HIV molecular immunology database
Found 16 matching records:
Download this epitope record as JSON.
HXB2 Location | Gag(124-132) p17(124-132) DNA(1159..1185) |
Gag Epitope Map |
---|---|---|
Author Location | Gag(124-132) | |
Epitope |
NSSKVSQNY
|
Epitope Alignment
|
Show epitope variants | ||
Subtype | A, D | |
Species (MHC/HLA) | human(A*01:01) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | 1932: A*01:01, B*37:01, B*81:01, C*06:02, C*18:01; 2297: A*01:01, A*30:01, B*08:01, B*57:03, C*07:04, C*18:01; ML2261: A*01:01, A*03:01, B*27:26, B*49:01, C*02:02, C*07:01; 2178: A*01:01, A*29:02, B*81:01, C*07:04, C*08:04; 1589: A*01:01, A*30:02, B*58:02, C*06:02, C*06:06; 2646: A*01:01, A*29:02, B*45:01, B*57:01, C*06:02, C*07:01; 893: A*01:01, A*24:02, B*15:17, B*35:02, C*04:01, C*17:01 | |
Country | Kenya | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Other, Tetramer binding | |
Keywords | subtype comparisons, HIV exposed persistently seronegative (HEPS), assay or method development, novel epitope |
Luo2012 Ma Luo, Christina A. Daniuk, Tamsir O. Diallo, Rupert E. Capina, Joshua Kimani, Charles Wachihi, Makubo Kimani, Thomas Bielawny, Trevor Peterson, Mark G. R. Mendoza, Sandra Kiazyk, T. Blake Ball, and Francis A. Plummer. For Protection from HIV-1 Infection, More Might Not Be Better: A Systematic Analysis of HIV Gag Epitopes of Two Alleles Associated with Different Outcomes of HIV-1 Infection. J. Virol., 86(2):1166-1180, Jan 2012. PubMed ID: 22072744. Show all entries for this paper.
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HXB2 Location | Gag(124-132) p17(124-132) DNA(1159..1185) |
Gag Epitope Map |
---|---|---|
Author Location | p17 | |
Epitope |
NSSKVSQNY
|
Epitope Alignment
|
Epitope Name | Gag-NY9; p17-NY9 | |
Subtype | B | |
Species (MHC/HLA) | human(B*35) | |
Immunogen | HIV-1 infection | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | HAART, ART |
Sabbaj2003 Steffanie Sabbaj, Anju Bansal, G. Douglas Ritter, Christopher Perkins, Bradley H. Edwards, Ethan Gough, Jianming Tang, James J. Szinger, Bette Korber, Craig M. Wilson, Richard A. Kaslow, Mark J. Mulligan, and Paul A. Goepfert. Cross-Reactive CD8+ T Cell Epitopes Identified in US Adolescent Minorities. J. Acquir. Immune Defic. Syndr., 33(4):426-438, 1 Aug 2003. PubMed ID: 12869831. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(124-132) p17(124-132) DNA(1159..1185) |
Gag Epitope Map |
---|---|---|
Author Location | p17(124-132) | |
Epitope |
NSSKVSQNY
|
Epitope Alignment
|
Species (MHC/HLA) | human(B*35) | |
Immunogen | HIV-1 infection | |
Country | Spain | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Proliferation | |
Keywords | HAART, ART, supervised treatment interruptions (STI) |
Plana2004 Montserrat Plana, Felipe Garcia, Annette Oxenius, Gabriel M. Ortiz, Anna Lopez, Anna Cruceta, Gabriel Mestre, Emilio Fumero, Catherine Fagard, Maria Antonia Sambeat, Ferran Segura, José M. Miró, Mireia Arnedo, L. Lopalcos, Tomas Pumarola, Bernard Hirschel, Rodney E. Phillips, Douglas F. Nixon, Teresa Gallart, and Jose M. Gatell. Relevance of HIV-1-Specific CD4+ Helper T-Cell Responses During Structured Treatment Interruptions in Patients With CD4+ T-Cell Nadir Above 400/mm3. J. Acquir. Immune Defic. Syndr., 36(3):791-799, 1 Jul 2004. PubMed ID: 15213562. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(124-132) p17(124-132) DNA(1159..1185) |
Gag Epitope Map |
---|---|---|
Author Location | p17(124-132) | |
Epitope |
NSSKVSQNY
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(B*35) | |
Immunogen | HIV-1 infection | |
Country | Canada | |
Experimental methods | Other | |
Keywords | characterizing CD8+ T cells, elite controllers |
Peretz2011 Yoav Peretz, Olivia Marra, Réjean Thomas, Danielle Legault, Pierre Côté, Mohamed-Rachid Boulassel, Danielle Rouleau, Jean-Pierre Routy, Rafick-Pierre Sékaly, Christos M Tsoukas, Cécile Tremblay, and Nicole F. Bernard. Relative Contribution of HIV-Specific Functional Lymphocyte Subsets Restricted by Protective and Non-Protective HLA Alleles. Viral Immunol, 24(3):189-198, Jun 2011. PubMed ID: 21668360. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(124-132) p17(124-132) DNA(1159..1185) |
Gag Epitope Map |
---|---|---|
Author Location | p17(124-132 LAI) | |
Epitope |
NSSKVSQNY
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(B35) | |
Immunogen | in vitro stimulation or selection | |
Experimental methods | ||
Keywords |
Lalvani1997 A. Lalvani, T. Dong, G. Ogg, A. A. Patham, H. Newell, A. V. Hill, A. J. McMichael, and S. Rowland-Jones. Optimization of a Peptide-Based Protocol Employing IL-7 for In Vitro Restimulation of Human Cytotoxic T Lymphocyte Precursors. J. Immunol. Methods, 210:65-77, 1997. PubMed ID: 9502585. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(124-132) p17(124-132) DNA(1159..1185) |
Gag Epitope Map |
---|---|---|
Author Location | p17 | |
Epitope |
NSSKVSQNY
|
Epitope Alignment
|
Species (MHC/HLA) | human(B35) | |
Immunogen | ||
Experimental methods | ||
Keywords | HIV exposed persistently seronegative (HEPS), HIV-2 |
RowlandJones1995 S. L. Rowland-Jones, J. Sutton, K. Ariyoshi, T. Dong, F. Gotch, S. McAdam, D. Whitby, S. Sabally, A. Gallimore, T. Corrah, M. Takiguchi, T. Schultz, A. McMichael, and H. Whittle. HIV-Specific Cytotoxic T Cells in HIV-Exposed but Uninfected Gambian Women. Nat. Med., 1:59-64, 1995. Four HIV-1 and -2 cross-reactive epitopes that are presented to CTL from HIV-infected Gambians by HLA-35 were identified. These peptides could elicit HIV-specific CTLs from 3 of 6 repeatedly exposed but seronegative sex workers who carry the HLA-B35 allele. Most CTL derived from HIV-2 positive donors also recognized the HIV-2 peptide and the analogous HIV-1 peptide. PubMed ID: 7584954. Show all entries for this paper.
Rowland-Jones1999 S. L. Rowland-Jones, T. Dong, L. Dorrell, G. Ogg, P. Hansasuta, P. Krausa, J. Kimani, S. Sabally, K. Ariyoshi, J. Oyugi, K. S. MacDonald, J. Bwayo, H. Whittle, F. A. Plummer, and A. J. McMichael. Broadly Cross-Reactive HIV-Specific Cytotoxic T Lymphocytes in Highly-Exposed Persistently Seronegative Donors. Immunol. Lett., 66:9-14, 1999. PubMed ID: 10203028. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(124-132) p17(124-132) DNA(1159..1185) |
Gag Epitope Map |
---|---|---|
Author Location | p17 | |
Epitope |
NSSKVSQNY
|
Epitope Alignment
|
Species (MHC/HLA) | human(B35) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | HAART, ART |
Seth2001 A. Seth, J. Markee, A. Hoering, A. Sevin, D. E. Sabath, J. E. Schmitz, M. J. Kuroda, M. A. Lifton, M. S. Hirsch, A. C. Collier, N. L. Letvin, and M. J. McElrath. Alterations in T cell phenotype and human immunodeficiency virus type 1-specific cytotoxicity after potent antiretroviral therapy. J. Infect. Dis., 183(5):722-9, 1 Mar 2001. PubMed ID: 11181148. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(124-132) p17(124-132) DNA(1159..1185) |
Gag Epitope Map |
---|---|---|
Author Location | p17(124-132 SF2) | |
Epitope |
NSSKVSQNY
|
Epitope Alignment
|
Species (MHC/HLA) | human(B35) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | HAART, ART, acute/early infection |
Altfeld2001b M. Altfeld, E. S. Rosenberg, R. Shankarappa, J. S. Mukherjee, F. M. Hecht, R. L. Eldridge, M. M. Addo, S. H. Poon, M. N. Phillips, G. K. Robbins, P. E. Sax, S. Boswell, J. O. Kahn, C. Brander, P. J. Goulder, J. A. Levy, J. I. Mullins, and B. D. Walker. Cellular immune responses and viral diversity in individuals treated during acute and early HIV-1 infection. J. Exp. Med., 193(2):169-80, 15 Jan 2001. URL: http://www.jem.org/cgi/content/full/193/2/169. PubMed ID: 11148221. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(124-132) p17(124-132) DNA(1159..1185) |
Gag Epitope Map |
---|---|---|
Author Location | ||
Epitope |
NSSKVSQNY
|
Epitope Alignment
|
Species (MHC/HLA) | human(B35) | |
Immunogen | HIV-1 infection, vaccine | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | vaccine-induced immune responses, characterizing CD8+ T cells |
Vaccine type | canarypox, canarypox prime with recombinant protein boost |
---|---|
Vaccine strain | B clade BRU, B clade LAI, B clade MN, multiple epitope immunogen |
Vaccine component | Gag, gp120, gp41, Nef, Pol, Protease |
Horton2006 Helen Horton, Ian Frank, Ruth Baydo, Emilie Jalbert, Justin Penn, Sean Wilson, John P. McNevin, Matthew D. McSweyn, Deborah Lee, Yunda Huang, Stephen C. De Rosa, and M. Juliana McElrath. Preservation of T Cell Proliferation Restricted by Protective HLA Alleles Is Critical for Immune Control of HIV-1 Infection. J. Immunol., 177(10):7406-7415, 15 Nov 2006. PubMed ID: 17082660. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(124-132) p17(124-132) DNA(1159..1185) |
Gag Epitope Map |
---|---|---|
Author Location | p17(124-132 LAI) | |
Epitope |
NSSKVSQNY
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(B35) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | review |
McMichael1994 A. J. McMichael and B. D. Walker. Cytotoxic T Lymphocytes Epitopes: Implications for HIV Vaccine. AIDS, 8S:S155-S173, 1994. Comprehensive review summarizing CTL epitopes that have known HLA type and are fine mapped to indicate epitope boundaries. Anchor residues are indicated when known for different HLA restricted epitopes. Includes a summary of the published literature, as well as much work that was in press or submitted for publication. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(124-132) p17(124-132) DNA(1159..1185) |
Gag Epitope Map |
---|---|---|
Author Location | ||
Epitope |
NSSKVSQNY
|
Epitope Alignment
|
Species (MHC/HLA) | human(B35) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | dynamics, acute/early infection |
Wilson2000 J. D. Wilson, G. S. Ogg, R. L. Allen, C. Davis, S. Shaunak, J. Downie, W. Dyer, C. Workman, S. Sullivan, A. J. McMichael, and S. L. Rowland-Jones. Direct Visualization of HIV-1-Specific Cytotoxic T Lymphocytes During Primary Infection. AIDS, 14:225-233, 2000. PubMed ID: 10716497. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(124-132) p17(124-132) DNA(1159..1185) |
Gag Epitope Map |
---|---|---|
Author Location | p17(124-132) | |
Epitope |
NSSKVSQNY
|
Epitope Alignment
|
Species (MHC/HLA) | human(B35) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords |
Birk1998 M. Birk, A. Vahlne, A. Sonnerborg, and M. Sallberg. Nonsynonymous Mutations within the Human Immunodeficiency Virus Type 1 p17 Gene Are Clustered to Sequences Binding to the Host Human Leukocyte Antigen Class I Molecules. AIDS Res. Hum. Retroviruses, 14:241-248, 1998. PubMed ID: 9491914. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(124-132) p17(124-132) DNA(1159..1185) |
Gag Epitope Map |
---|---|---|
Author Location | p17(124-132 LAI) | |
Epitope |
NSSKVSQNY
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(B35) | |
Immunogen | HIV-1 or HIV-2 infection | |
Country | Gambia | |
Experimental methods | ||
Keywords | HIV exposed persistently seronegative (HEPS), HIV-2 |
RowlandJones1995 S. L. Rowland-Jones, J. Sutton, K. Ariyoshi, T. Dong, F. Gotch, S. McAdam, D. Whitby, S. Sabally, A. Gallimore, T. Corrah, M. Takiguchi, T. Schultz, A. McMichael, and H. Whittle. HIV-Specific Cytotoxic T Cells in HIV-Exposed but Uninfected Gambian Women. Nat. Med., 1:59-64, 1995. Four HIV-1 and -2 cross-reactive epitopes that are presented to CTL from HIV-infected Gambians by HLA-35 were identified. These peptides could elicit HIV-specific CTLs from 3 of 6 repeatedly exposed but seronegative sex workers who carry the HLA-B35 allele. Most CTL derived from HIV-2 positive donors also recognized the HIV-2 peptide and the analogous HIV-1 peptide. PubMed ID: 7584954. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(124-132) p17(124-132) DNA(1159..1185) |
Gag Epitope Map |
---|---|---|
Author Location | Gag(124-132) | |
Epitope |
NSSKVSQNY
|
Epitope Alignment
|
Epitope Name | NY9 | |
Subtype | B | |
Species (MHC/HLA) | human(B*35:01) | |
Immunogen | HIV-1 infection | |
Country | United Kingdom | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Cytokine production, Flow cytometric T-cell cytokine assay, HLA binding | |
Keywords | computational epitope prediction |
Westrop2009 Samantha J. Westrop, Nathali Grageda, and Nesrina Imami. Novel Approach to Recognition of Predicted HIV-1 Gag B3501-Restricted CD8 T-Cell Epitopes by HLA-B3501+ Patients: Confirmation by Quantitative ELISpot Analyses and Characterisation Using Multimers. J. Immunol. Methods, 341(1-2):76-85, 28 Feb 2009. PubMed ID: 19056394. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(124-132) p17(124-132) DNA(1159..1185) |
Gag Epitope Map |
---|---|---|
Author Location | p17(124-132 LAI) | |
Epitope |
NSSKVSQNY
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(B*35:01) | |
Immunogen | HIV-1 or HIV-2 infection | |
Experimental methods | ||
Keywords | optimal epitope, A-list |
Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(124-132) p17(124-132) DNA(1159..1185) |
Gag Epitope Map |
---|---|---|
Author Location | p17(124-132) | |
Epitope |
NSSKVSQNY
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human | |
Immunogen | engineered | |
Experimental methods | Other, Relative replication capacity assay | |
Keywords | assay or method development, protective allele |
Du2017 Yushen Du, Tian-Hao Zhang, Lei Dai, Xiaojuan Zheng, Aleksandr M. Gorin, John Oishi, Ting-Ting Wu, Janice M. Yoshizawa, Xinmin Li, Otto O. Yang, Otoniel Martinez-Maza, Roger Detels, and Ren Sun. Effects of Mutations on Replicative Fitness and Major Histocompatibility Complex Class I Binding Affinity Are Among the Determinants Underlying Cytotoxic-T-Lymphocyte Escape of HIV-1 Gag Epitopes. mBio, 8(6), 28 Nov 2017. PubMed ID: 29184023. Show all entries for this paper.