HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 15 matching records:

Displaying record number 61945

HXB2 Location Gag(124-132)
p17(124-132)
DNA(1159..1185)
Gag Epitope Map
Author Location Gag(124-132)
Epitope NSSKVSQNY Epitope Alignment
NSSKVSQNY epitope logo
Show epitope variants
Subtype A, D
Species (MHC/HLA) human(A*0101)
Immunogen HIV-1 infection
Patient MHC/HLA 1932: A*0101, B*3701, B*8101, Cw*0602, Cw*1801; 2297: A*0101, A*3001, B*0801, B*5703, Cw*0704, Cw*1801; 2261: A*0101, A*4901, B*0202, B*2726, Cw*0202, Cw*0701; 2178: A*0101, A*2902, B*8101, Cw*0704, Cw*0804; 1589: A*0101, A*3002, B*5802, Cw*0602, Cw*0606; 2646: A*0101, A*2902, B*4501, B*5701, Cw*0602, Cw*0701; 893: A*0101, A*2402, B*1517, B*3502, Cw*0401, Cw*1701
Country Kenya
Experimental methods CD8 T-cell Elispot - IFNγ, Other, Tetramer binding
Keywords HIV exposed persistently seronegative (HEPS), assay or method development, novel epitope

Notes

References

Luo2012 Ma Luo, Christina A. Daniuk, Tamsir O. Diallo, Rupert E. Capina, Joshua Kimani, Charles Wachihi, Makubo Kimani, Thomas Bielawny, Trevor Peterson, Mark G. R. Mendoza, Sandra Kiazyk, T. Blake Ball, and Francis A. Plummer. For Protection from HIV-1 Infection, More Might Not Be Better: A Systematic Analysis of HIV Gag Epitopes of Two Alleles Associated with Different Outcomes of HIV-1 Infection. J. Virol., 86(2):1166-1180, Jan 2012. PubMed ID: 22072744. Show all entries for this paper.


Displaying record number 123

HXB2 Location Gag(124-132)
p17(124-132)
DNA(1159..1185)
Gag Epitope Map
Author Location  
Epitope NSSKVSQNY Epitope Alignment
NSSKVSQNY epitope logo
Species (MHC/HLA) human(B35)
Immunogen HIV-1 infection
Experimental methods  
Keywords dynamics, acute/early infection

Notes

References

Wilson2000 J. D. Wilson, G. S. Ogg, R. L. Allen, C. Davis, S. Shaunak, J. Downie, W. Dyer, C. Workman, S. Sullivan, A. J. McMichael, and S. L. Rowland-Jones. Direct Visualization of HIV-1-Specific Cytotoxic T Lymphocytes During Primary Infection. AIDS, 14:225-233, 2000. PubMed ID: 10716497. Show all entries for this paper.


Displaying record number 124

HXB2 Location Gag(124-132)
p17(124-132)
DNA(1159..1185)
Gag Epitope Map
Author Location p17(124-132)
Epitope NSSKVSQNY Epitope Alignment
NSSKVSQNY epitope logo
Species (MHC/HLA) human(B35)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Birk1998 M. Birk, A. Vahlne, A. Sonnerborg, and M. Sallberg. Nonsynonymous Mutations within the Human Immunodeficiency Virus Type 1 p17 Gene Are Clustered to Sequences Binding to the Host Human Leukocyte Antigen Class I Molecules. AIDS Res. Hum. Retroviruses, 14:241-248, 1998. PubMed ID: 9491914. Show all entries for this paper.


Displaying record number 125

HXB2 Location Gag(124-132)
p17(124-132)
DNA(1159..1185)
Gag Epitope Map
Author Location p17(124-132 LAI)
Epitope NSSKVSQNY Epitope Alignment
NSSKVSQNY epitope logo
Subtype B
Species (MHC/HLA) human(B35)
Immunogen HIV-1 or HIV-2 infection
Country Gambia
Experimental methods  
Keywords HIV exposed persistently seronegative (HEPS), HIV-2

Notes

References

RowlandJones1995 S. L. Rowland-Jones, J. Sutton, K. Ariyoshi, T. Dong, F. Gotch, S. McAdam, D. Whitby, S. Sabally, A. Gallimore, T. Corrah, M. Takiguchi, T. Schultz, A. McMichael, and H. Whittle. HIV-Specific Cytotoxic T Cells in HIV-Exposed but Uninfected Gambian Women. Nat. Med., 1:59-64, 1995. Four HIV-1 and -2 cross-reactive epitopes that are presented to CTL from HIV-infected Gambians by HLA-35 were identified. These peptides could elicit HIV-specific CTLs from 3 of 6 repeatedly exposed but seronegative sex workers who carry the HLA-B35 allele. Most CTL derived from HIV-2 positive donors also recognized the HIV-2 peptide and the analogous HIV-1 peptide. PubMed ID: 7584954. Show all entries for this paper.


Displaying record number 127

HXB2 Location Gag(124-132)
p17(124-132)
DNA(1159..1185)
Gag Epitope Map
Author Location p17(124-132 LAI)
Epitope NSSKVSQNY Epitope Alignment
NSSKVSQNY epitope logo
Subtype B
Species (MHC/HLA) human(B35)
Immunogen in vitro stimulation or selection
Experimental methods  
Keywords  

Notes

References

Lalvani1997 A. Lalvani, T. Dong, G. Ogg, A. A. Patham, H. Newell, A. V. Hill, A. J. McMichael, and S. Rowland-Jones. Optimization of a Peptide-Based Protocol Employing IL-7 for In Vitro Restimulation of Human Cytotoxic T Lymphocyte Precursors. J. Immunol. Methods, 210:65-77, 1997. PubMed ID: 9502585. Show all entries for this paper.


Displaying record number 128

HXB2 Location Gag(124-132)
p17(124-132)
DNA(1159..1185)
Gag Epitope Map
Author Location p17
Epitope NSSKVSQNY Epitope Alignment
NSSKVSQNY epitope logo
Species (MHC/HLA) human(B35)
Immunogen  
Experimental methods  
Keywords  

Notes

References

RowlandJones1995 S. L. Rowland-Jones, J. Sutton, K. Ariyoshi, T. Dong, F. Gotch, S. McAdam, D. Whitby, S. Sabally, A. Gallimore, T. Corrah, M. Takiguchi, T. Schultz, A. McMichael, and H. Whittle. HIV-Specific Cytotoxic T Cells in HIV-Exposed but Uninfected Gambian Women. Nat. Med., 1:59-64, 1995. Four HIV-1 and -2 cross-reactive epitopes that are presented to CTL from HIV-infected Gambians by HLA-35 were identified. These peptides could elicit HIV-specific CTLs from 3 of 6 repeatedly exposed but seronegative sex workers who carry the HLA-B35 allele. Most CTL derived from HIV-2 positive donors also recognized the HIV-2 peptide and the analogous HIV-1 peptide. PubMed ID: 7584954. Show all entries for this paper.

Rowland-Jones1999 S. L. Rowland-Jones, T. Dong, L. Dorrell, G. Ogg, P. Hansasuta, P. Krausa, J. Kimani, S. Sabally, K. Ariyoshi, J. Oyugi, K. S. MacDonald, J. Bwayo, H. Whittle, F. A. Plummer, and A. J. McMichael. Broadly Cross-Reactive HIV-Specific Cytotoxic T Lymphocytes in Highly-Exposed Persistently Seronegative Donors. Immunol. Lett., 66:9-14, 1999. PubMed ID: 10203028. Show all entries for this paper.


Displaying record number 122

HXB2 Location Gag(124-132)
p17(124-132)
DNA(1159..1185)
Gag Epitope Map
Author Location p17(124-132 LAI)
Epitope NSSKVSQNY Epitope Alignment
NSSKVSQNY epitope logo
Subtype B
Species (MHC/HLA) human(B35)
Immunogen HIV-1 infection
Experimental methods  
Keywords review

Notes

References

McMichael1994 A. J. McMichael and B. D. Walker. Cytotoxic T Lymphocytes Epitopes: Implications for HIV Vaccine. AIDS, 8S:S155-S173, 1994. Comprehensive review summarizing CTL epitopes that have known HLA type and are fine mapped to indicate epitope boundaries. Anchor residues are indicated when known for different HLA restricted epitopes. Includes a summary of the published literature, as well as much work that was in press or submitted for publication. Show all entries for this paper.


Displaying record number 1564

HXB2 Location Gag(124-132)
p17(124-132)
DNA(1159..1185)
Gag Epitope Map
Author Location p17(124-132 SF2)
Epitope NSSKVSQNY Epitope Alignment
NSSKVSQNY epitope logo
Species (MHC/HLA) human(B35)
Immunogen HIV-1 infection
Experimental methods  
Keywords HAART, ART, acute/early infection

Notes

References

Altfeld2001b M. Altfeld, E. S. Rosenberg, R. Shankarappa, J. S. Mukherjee, F. M. Hecht, R. L. Eldridge, M. M. Addo, S. H. Poon, M. N. Phillips, G. K. Robbins, P. E. Sax, S. Boswell, J. O. Kahn, C. Brander, P. J. Goulder, J. A. Levy, J. I. Mullins, and B. D. Walker. Cellular immune responses and viral diversity in individuals treated during acute and early HIV-1 infection. J. Exp. Med., 193(2):169-80, 15 Jan 2001. URL: http://www.jem.org/cgi/content/full/193/2/169. PubMed ID: 11148221. Show all entries for this paper.


Displaying record number 1487

HXB2 Location Gag(124-132)
p17(124-132)
DNA(1159..1185)
Gag Epitope Map
Author Location p17
Epitope NSSKVSQNY Epitope Alignment
NSSKVSQNY epitope logo
Species (MHC/HLA) human(B35)
Immunogen HIV-1 infection
Experimental methods  
Keywords HAART, ART

Notes

References

Seth2001 A. Seth, J. Markee, A. Hoering, A. Sevin, D. E. Sabath, J. E. Schmitz, M. J. Kuroda, M. A. Lifton, M. S. Hirsch, A. C. Collier, N. L. Letvin, and M. J. McElrath. Alterations in T cell phenotype and human immunodeficiency virus type 1-specific cytotoxicity after potent antiretroviral therapy. J. Infect. Dis., 183(5):722-9, 1 Mar 2001. PubMed ID: 11181148. Show all entries for this paper.


Displaying record number 54878

HXB2 Location Gag(124-132)
p17(124-132)
DNA(1159..1185)
Gag Epitope Map
Author Location  
Epitope NSSKVSQNY Epitope Alignment
NSSKVSQNY epitope logo
Species (MHC/HLA) human(B35)
Immunogen HIV-1 infection, vaccine
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords vaccine-induced immune responses, characterizing CD8+ T cells

Vaccine Details

Vaccine type canarypox, canarypox prime with recombinant protein boost
Vaccine strain B clade BRU, B clade LAI, B clade MN, multiple epitope immunogen
Vaccine component Gag, gp120, gp41, Nef, Pol, Protease

Notes

References

Horton2006 Helen Horton, Ian Frank, Ruth Baydo, Emilie Jalbert, Justin Penn, Sean Wilson, John P. McNevin, Matthew D. McSweyn, Deborah Lee, Yunda Huang, Stephen C. De Rosa, and M. Juliana McElrath. Preservation of T Cell Proliferation Restricted by Protective HLA Alleles Is Critical for Immune Control of HIV-1 Infection. J. Immunol., 177(10):7406-7415, 15 Nov 2006. PubMed ID: 17082660. Show all entries for this paper.


Displaying record number 53134

HXB2 Location Gag(124-132)
p17(124-132)
DNA(1159..1185)
Gag Epitope Map
Author Location p17(124-132)
Epitope NSSKVSQNY Epitope Alignment
NSSKVSQNY epitope logo
Species (MHC/HLA) human(B*35)
Immunogen HIV-1 infection
Country Spain
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Proliferation
Keywords HAART, ART, supervised treatment interruptions (STI)

Notes

References

Plana2004 Montserrat Plana, Felipe Garcia, Annette Oxenius, Gabriel M. Ortiz, Anna Lopez, Anna Cruceta, Gabriel Mestre, Emilio Fumero, Catherine Fagard, Maria Antonia Sambeat, Ferran Segura, José M. Miró, Mireia Arnedo, L. Lopalcos, Tomas Pumarola, Bernard Hirschel, Rodney E. Phillips, Douglas F. Nixon, Teresa Gallart, and Jose M. Gatell. Relevance of HIV-1-Specific CD4+ Helper T-Cell Responses During Structured Treatment Interruptions in Patients With CD4+ T-Cell Nadir Above 400/mm3. J. Acquir. Immune Defic. Syndr., 36(3):791-799, 1 Jul 2004. PubMed ID: 15213562. Show all entries for this paper.


Displaying record number 58531

HXB2 Location Gag(124-132)
p17(124-132)
DNA(1159..1185)
Gag Epitope Map
Author Location p17(124-132)
Epitope NSSKVSQNY Epitope Alignment
NSSKVSQNY epitope logo
Subtype B
Species (MHC/HLA) human(B*35)
Immunogen HIV-1 infection
Country Canada
Experimental methods Other
Keywords characterizing CD8+ T cells, elite controllers

Notes

References

Peretz2011 Yoav Peretz, Olivia Marra, Réjean Thomas, Danielle Legault, Pierre Côté, Mohamed-Rachid Boulassel, Danielle Rouleau, Jean-Pierre Routy, Rafick-Pierre Sékaly, Christos M Tsoukas, Cécile Tremblay, and Nicole F. Bernard. Relative Contribution of HIV-Specific Functional Lymphocyte Subsets Restricted by Protective and Non-Protective HLA Alleles. Viral Immunol, 24(3):189-198, Jun 2011. PubMed ID: 21668360. Show all entries for this paper.


Displaying record number 1997

HXB2 Location Gag(124-132)
p17(124-132)
DNA(1159..1185)
Gag Epitope Map
Author Location p17
Epitope NSSKVSQNY Epitope Alignment
NSSKVSQNY epitope logo
Epitope Name Gag-NY9; p17-NY9
Subtype B
Species (MHC/HLA) human(B*35)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords HAART, ART

Notes

References

Sabbaj2003 Steffanie Sabbaj, Anju Bansal, G. Douglas Ritter, Christopher Perkins, Bradley H. Edwards, Ethan Gough, Jianming Tang, James J. Szinger, Bette Korber, Craig M. Wilson, Richard A. Kaslow, Mark J. Mulligan, and Paul A. Goepfert. Cross-Reactive CD8+ T Cell Epitopes Identified in US Adolescent Minorities. J. Acquir. Immune Defic. Syndr., 33(4):426-438, 1 Aug 2003. PubMed ID: 12869831. Show all entries for this paper.


Displaying record number 126

HXB2 Location Gag(124-132)
p17(124-132)
DNA(1159..1185)
Gag Epitope Map
Author Location p17(124-132 LAI)
Epitope NSSKVSQNY Epitope Alignment
NSSKVSQNY epitope logo
Subtype B
Species (MHC/HLA) human(B*3501)
Immunogen HIV-1 or HIV-2 infection
Experimental methods  
Keywords optimal epitope

Notes

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 57480

HXB2 Location Gag(124-132)
p17(124-132)
DNA(1159..1185)
Gag Epitope Map
Author Location Gag(124-132)
Epitope NSSKVSQNY Epitope Alignment
NSSKVSQNY epitope logo
Epitope Name NY9
Subtype B
Species (MHC/HLA) human(B*3501)
Immunogen HIV-1 infection
Country United Kingdom
Experimental methods CD8 T-cell Elispot - IFNγ, Cytokine production, Flow cytometric T-cell cytokine assay, HLA binding
Keywords computational epitope prediction

Notes

References

Westrop2009 Samantha J. Westrop, Nathali Grageda, and Nesrina Imami. Novel Approach to Recognition of Predicted HIV-1 Gag B3501-Restricted CD8 T-Cell Epitopes by HLA-B3501+ Patients: Confirmation by Quantitative ELISpot Analyses and Characterisation Using Multimers. J. Immunol. Methods, 341(1-2):76-85, 28 Feb 2009. PubMed ID: 19056394. Show all entries for this paper.


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