HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 6 matching records:

Displaying record number 55663

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HXB2 Location Gag(254-262)
p24(122-130)
DNA(1549..1575)
Gag Epitope Map
Author Location Gag
Epitope NPVPVGNIY Epitope Alignment
NPVPVGNIY epitope logo
Subtype A, CRF02_AG
Species (MHC/HLA) human(B*35)
Immunogen HIV-1 or HIV-2 infection, HIV-2 infection
Country Gambia
Experimental methods CD8 T-cell Elispot - IFNγ, Other
Keywords subtype comparisons, variant cross-reactivity, HIV-2

Notes

References

Ondondo2008 Beatrice O. Ondondo, Sarah L. Rowland-Jones, Lucy Dorrell, Kevin Peterson, Matthew Cotten, Hilton Whittle, and Assan Jaye. Comprehensive Analysis of HIV Gag-Specific IFN-gamma Response in HIV-1- and HIV-2-Infected Asymptomatic Patients from a Clinical Cohort in The Gambia. Eur. J. Immunol., 38(12):3549-3560, Dec 2008. PubMed ID: 19016530. Show all entries for this paper.


Displaying record number 56346

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HXB2 Location Gag(254-262)
p24(122-130)
DNA(1549..1575)
Gag Epitope Map
Author Location Gag
Epitope NPVPVGNIY Epitope Alignment
NPVPVGNIY epitope logo
Subtype B, C
Species (MHC/HLA) human(B*35)
Immunogen HIV-1 infection
Country Canada, South Africa
Experimental methods  
Keywords escape

Notes

References

Carlson2008 Jonathan M. Carlson, Zabrina L. Brumme, Christine M. Rousseau, Chanson J. Brumme, Philippa Matthews, Carl Kadie, James I. Mullins, Bruce D. Walker, P. Richard Harrigan, Philip J. R. Goulder, and David Heckerman. Phylogenetic Dependency Networks: Inferring Patterns of CTL Escape and Codon Covariation in HIV-1 Gag. PLoS Comput Biol, 4(11):e1000225, Nov 2008. PubMed ID: 19023406. Show all entries for this paper.


Displaying record number 245

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HXB2 Location Gag(254-262)
p24(122-130)
DNA(1549..1575)
Gag Epitope Map
Author Location p24(245-253)
Epitope NPVPVGNIY Epitope Alignment
NPVPVGNIY epitope logo
Subtype HIV-2
Species (MHC/HLA) human(B*35:01)
Immunogen HIV-1 or HIV-2 infection
Country Gambia
Experimental methods  
Keywords HIV exposed persistently seronegative (HEPS), HIV-2

Notes

References

RowlandJones1995 S. L. Rowland-Jones, J. Sutton, K. Ariyoshi, T. Dong, F. Gotch, S. McAdam, D. Whitby, S. Sabally, A. Gallimore, T. Corrah, M. Takiguchi, T. Schultz, A. McMichael, and H. Whittle. HIV-Specific Cytotoxic T Cells in HIV-Exposed but Uninfected Gambian Women. Nat. Med., 1:59-64, 1995. Four HIV-1 and -2 cross-reactive epitopes that are presented to CTL from HIV-infected Gambians by HLA-35 were identified. These peptides could elicit HIV-specific CTLs from 3 of 6 repeatedly exposed but seronegative sex workers who carry the HLA-B35 allele. Most CTL derived from HIV-2 positive donors also recognized the HIV-2 peptide and the analogous HIV-1 peptide. PubMed ID: 7584954. Show all entries for this paper.


Displaying record number 59013

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HXB2 Location Gag(254-262)
p24(122-130)
DNA(1549..1575)
Gag Epitope Map
Author Location  
Epitope NPVPVGNIY Epitope Alignment
NPVPVGNIY epitope logo
Subtype HIV-2
Species (MHC/HLA) human(B*35:01)
Immunogen HIV-2 infection
Country Guinea-Bissau
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining, Tetramer binding
Keywords HIV-2

Notes

References

deSilva2013 Thushan I. de Silva, Yanchun Peng, Aleksandra Leligdowicz, Irfan Zaidi, Lucy Li, Harry Griffin, Marie-Eve Blais, Tim Vincent, Mavinga Saraiva, Louis-Marie Yindom, Carla van Tienen, Philippa Easterbrook, Assan Jaye, Hilton Whittle, Tao Dong, and Sarah L. Rowland-Jones. Correlates of T-Cell-Mediated Viral Control and Phenotype of CD8+ T Cells in HIV-2, a Naturally Contained Human Retroviral Infection. Blood, 121(21):4330-4339, 23 May 2013. PubMed ID: 23558015. Show all entries for this paper.


Displaying record number 61242

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HXB2 Location Gag(254-262)
p24(122-130)
DNA(1549..1575)
Gag Epitope Map
Author Location Gag(254-262)
Epitope NPVPVGNIY Epitope Alignment
NPVPVGNIY epitope logo
Epitope Name NY9
Species (MHC/HLA) human(B*35:01)
Immunogen HIV-2 infection
Experimental methods Other
Keywords review, immunodominance, TCR usage, variant cross-reactivity

Notes

References

Lissina2016 Anna Lissina, Lisa A. Chakrabarti, Masafumi Takiguchi, and Victor Appay. TCR Clonotypes: Molecular Determinants of T-Cell Efficacy against HIV. Curr. Opin. Virol., 16:77-85, Feb 2016. PubMed ID: 26874617. Show all entries for this paper.


Displaying record number 63098

Download this epitope record as JSON.

HXB2 Location Gag(254-262)
p24(122-130)
Gag Epitope Map
Author Location Gag(256-264)
Epitope NPVPVGNIY Epitope Alignment
NPVPVGNIY epitope logo
Show epitope variants
Species (MHC/HLA) human
Immunogen HIV-2 infection
Country Guinea-Bissau
Experimental methods CD8 T-cell Elispot - IFNγ, Other
Keywords autologous responses, HIV-2, HLA associated polymorphism

Notes

References

deSilva2018 Thushan I. de Silva, Aleksandra Leligdowicz, Jonathan Carlson, Miguel Garcia-Knight, Clayton Onyango, Nicholas Miller, Louis-Marie Yindom, Stephane Hue, Assan Jaye, Tao Dong, Matthew Cotten, and Sarah L. Rowland-Jones. HLA-associated polymorphisms in the HIV-2 capsid highlight key differences between HIV-1 and HIV-2 immune adaptation. AIDS, 32(6):709-714 doi, Mar 2018. PubMed ID: 29369160 Show all entries for this paper.


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