HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 28 matching records:

Displaying record number 60028

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HXB2 Location Pol(330-338)
RT(175-183)
DNA(3072..3098)
Pol Epitope Map
Author Location Pol(330-338)
Epitope NPDIVIYQY Epitope Alignment
NPDIVIYQY epitope logo
Epitope Name NQY9
Species (MHC/HLA) human(A*36)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope, chronic infection

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 60026

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HXB2 Location Pol(330-338)
RT(175-183)
DNA(3072..3098)
Pol Epitope Map
Author Location Pol(330-338)
Epitope NPDIVIYQY Epitope Alignment
NPDIVIYQY epitope logo
Epitope Name NQY9
Species (MHC/HLA) human(B*18)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope, chronic infection

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 60027

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HXB2 Location Pol(330-338)
RT(175-183)
DNA(3072..3098)
Pol Epitope Map
Author Location Pol(330-338)
Epitope NPDIVIYQY Epitope Alignment
NPDIVIYQY epitope logo
Epitope Name NQY9
Species (MHC/HLA) human(B*27)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope, chronic infection

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 57586

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HXB2 Location Pol(330-338)
RT(175-183)
DNA(3072..3098)
Pol Epitope Map
Author Location RT(175-183)
Epitope NPDIVIYQY Epitope Alignment
NPDIVIYQY epitope logo
Epitope Name NY9
Subtype B
Species (MHC/HLA) (B*35)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords acute/early infection

Notes

References

Dinges2010 Warren L. Dinges, Julia Richardt, David Friedrich, Emilie Jalbert, Yi Liu, Claire E. Stevens, Janine Maenza, Ann C. Collier, Daniel E. Geraghty, Jeremy Smith, Zoe Moodie, James I. Mullins, M. Juliana McElrath, and Helen Horton. Virus-Specific CD8+ T-Cell Responses Better Define HIV Disease Progression than HLA Genotype. J. Virol., 84(9):4461-4468, May 2010. PubMed ID: 20147397. Show all entries for this paper.


Displaying record number 56392

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HXB2 Location Pol(330-338)
RT(175-183)
DNA(3072..3098)
Pol Epitope Map
Author Location RT(175-183)
Epitope NPDIVIYQY Epitope Alignment
NPDIVIYQY epitope logo
Epitope Name NY9
Subtype B
Species (MHC/HLA) human(B*35)
Immunogen HIV-1 infection
Country Australia, Canada, Germany, United States
Experimental methods  
Keywords HLA associated polymorphism

Notes

References

Brumme2008 Zabrina L. Brumme, Chanson J. Brumme, Jonathan Carlson, Hendrik Streeck, Mina John, Quentin Eichbaum, Brian L Block, Brett Baker, Carl Kadie, Martin Markowitz, Heiko Jessen, Anthony D. Kelleher, Eric Rosenberg, John Kaldor, Yuko Yuki, Mary Carrington, Todd M. Allen, Simon Mallal, Marcus Altfeld, David Heckerman, and Bruce D. Walker. Marked Epitope- and Allele-Specific Differences in Rates of Mutation in Human Immunodeficiency Type 1 (HIV-1) Gag, Pol, and Nef Cytotoxic T-Lymphocyte Epitopes in Acute/Early HIV-1 Infection. J. Virol., 82(18):9216-9227, Sep 2008. PubMed ID: 18614631. Show all entries for this paper.


Displaying record number 1560

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HXB2 Location Pol(330-338)
RT(175-183)
DNA(3072..3098)
Pol Epitope Map
Author Location RT(175-183 SF2)
Epitope NPDIVIYQY Epitope Alignment
NPDIVIYQY epitope logo
Species (MHC/HLA) human(B35)
Immunogen HIV-1 infection
Experimental methods  
Keywords HAART, ART, acute/early infection

Notes

References

Altfeld2001b M. Altfeld, E. S. Rosenberg, R. Shankarappa, J. S. Mukherjee, F. M. Hecht, R. L. Eldridge, M. M. Addo, S. H. Poon, M. N. Phillips, G. K. Robbins, P. E. Sax, S. Boswell, J. O. Kahn, C. Brander, P. J. Goulder, J. A. Levy, J. I. Mullins, and B. D. Walker. Cellular immune responses and viral diversity in individuals treated during acute and early HIV-1 infection. J. Exp. Med., 193(2):169-80, 15 Jan 2001. URL: http://www.jem.org/cgi/content/full/193/2/169. PubMed ID: 11148221. Show all entries for this paper.


Displaying record number 52255

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HXB2 Location Pol(330-338)
RT(175-183)
DNA(3072..3098)
Pol Epitope Map
Author Location Pol
Epitope NPDIVIYQY Epitope Alignment
NPDIVIYQY epitope logo
Subtype B
Species (MHC/HLA) human(B35)
Immunogen HIV-1 infection
Patient MHC/HLA A11, A3, B35, B51
Experimental methods  
Keywords mother-to-infant transmission

Notes

References

Sabbaj2002a Steffanie Sabbaj, Bradley H. Edwards, Mrinal K. Ghosh, Katherine Semrau, Sanford Cheelo, Donald M. Thea, Louise Kuhn, G. Douglas Ritter, Mark J. Mulligan, Paul A. Goepfert, and Grace M. Aldrovandi. Human Immunodeficiency Virus-Specific CD8(+) T Cells in Human Breast Milk. J. Virol., 76(15):7365-7373, Aug 2002. PubMed ID: 12097549. Show all entries for this paper.


Displaying record number 54357

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HXB2 Location Pol(330-338)
RT(175-183)
DNA(3072..3098)
Pol Epitope Map
Author Location RT
Epitope NPDIVIYQY Epitope Alignment
NPDIVIYQY epitope logo
Epitope Name B35-NQY9(RT)
Species (MHC/HLA) human(B35)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, immunodominance, early-expressed proteins

Notes

References

Altfeld2006 Marcus Altfeld, Elizabeth T. Kalife, Ying Qi, Hendrik Streeck, Mathias Lichterfeld, Mary N. Johnston, Nicole Burgett, Martha E. Swartz, Amy Yang, Galit Alter, Xu G. Yu, Angela Meier, Juergen K. Rockstroh, Todd M. Allen, Heiko Jessen, Eric S. Rosenberg, Mary Carrington, and Bruce D. Walker. HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8+ T Cell Response against HIV-1. PLoS Med., 3(10):e403, Oct 2006. PubMed ID: 17076553. Show all entries for this paper.


Displaying record number 55040

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HXB2 Location Pol(330-338)
RT(175-183)
DNA(3072..3098)
Pol Epitope Map
Author Location  
Epitope NPDIVIYQY Epitope Alignment
NPDIVIYQY epitope logo
Species (MHC/HLA) human(B35)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, HLA binding
Keywords binding affinity, immunodominance, optimal epitope

Notes

References

Bihl2006 Florian Bihl, Nicole Frahm, Loriana Di Giammarino, John Sidney, Mina John, Karina Yusim, Tonia Woodberry, Kaori Sango, Hannah S. Hewitt, Leah Henry, Caitlyn H. Linde, John V. Chisholm, III, Tauheed M. Zaman, Eunice Pae, Simon Mallal, Bruce D Walker, Alessandro Sette, Bette T. Korber, David Heckerman, and Christian Brander. Impact of HLA-B Alleles, Epitope Binding Affinity, Functional Avidity, and Viral Coinfection on the Immunodominance of Virus-Specific CTL Responses. J. Immunol., 176(7):4094-4101, 1 Apr 2006. PubMed ID: 16547245. Show all entries for this paper.


Displaying record number 56016

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HXB2 Location Pol(330-338)
RT(175-183)
DNA(3072..3098)
Pol Epitope Map
Author Location RT
Epitope NPDIVIYQY Epitope Alignment
NPDIVIYQY epitope logo
Epitope Name NY9(RT)
Subtype B
Species (MHC/HLA) human(B35)
Immunogen HIV-1 infection
Country China
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords chronic infection

Notes

References

Zhai2008 Song Zhai, Yan Zhuang, Yang Song, Shu Li, Dedong Huang, Wenzhen Kang, Xinhong Li, Qi Liao, Yanhou Liu, Zhongfang Zhao, Yichen Lu, and Yongtao Sun. HIV-1-Specific Cytotoxic T Lymphocyte (CTL) Responses Against Immunodominant Optimal Epitopes Slow the Progression of AIDS in China. Curr. HIV Res., 6(4):335-350, Jun 2008. PubMed ID: 18691032. Show all entries for this paper.


Displaying record number 457

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HXB2 Location Pol(330-338)
RT(175-183)
DNA(3072..3098)
Pol Epitope Map
Author Location ( SF2)
Epitope NPDIVIYQY Epitope Alignment
NPDIVIYQY epitope logo
Show epitope variants
Species (MHC/HLA) human(B35)
Immunogen HIV-1 infection
Experimental methods  
Keywords binding affinity, rate of progression, escape

Notes

References

Kawana1999 A. Kawana, H. Tomiyama, M. Takiguchi, T. Shioda, T. Nakamura, and A. Iwamoto. Accumulation of Specific Amino Acid Substitutions in HLA-B35-Restricted Human Immunodeficiency Virus Type 1 Cytotoxic T Lymphocyte Epitopes. AIDS Res. Hum. Retroviruses, 15:1099-1107, 1999. PubMed ID: 10461830. Show all entries for this paper.


Displaying record number 459

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HXB2 Location Pol(330-338)
RT(175-183)
DNA(3072..3098)
Pol Epitope Map
Author Location RT(328-336 IIIB)
Epitope NPDIVIYQY Epitope Alignment
NPDIVIYQY epitope logo
Species (MHC/HLA) human(B35)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Menendez-Arias1998 L. Menendez-Arias, A. Mas, and E. Domingo. Cytotoxic T-Lymphocyte Responses to HIV-1 Reverse Transcriptase. Viral Immunol., 11:167-181, 1998. PubMed ID: 10189185. Show all entries for this paper.

Shiga1996 H. Shiga, T. Shioda, H. Tomiyama, Y. Takamiya, S. Oka, S. Kimura, Y. Yamaguchi, T. Gojoubori, H. G. Rammensee, K. Miwa, and M. Takiguchi. Identification of Multiple HIV-1 Cytotoxic T Cell Epitopes Presented by Human Leukocyte Antigen B35 Molecule. AIDS, 10:1075-1083, 1996. PubMed ID: 8874623. Show all entries for this paper.


Displaying record number 461

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HXB2 Location Pol(330-338)
RT(175-183)
DNA(3072..3098)
Pol Epitope Map
Author Location RT(328-336 IIIB)
Epitope NPDIVIYQY Epitope Alignment
NPDIVIYQY epitope logo
Show epitope variants
Species (MHC/HLA) human(B35)
Immunogen HIV-1 infection
Experimental methods  
Keywords review, escape

Notes

References

Menendez-Arias1998 L. Menendez-Arias, A. Mas, and E. Domingo. Cytotoxic T-Lymphocyte Responses to HIV-1 Reverse Transcriptase. Viral Immunol., 11:167-181, 1998. PubMed ID: 10189185. Show all entries for this paper.

Sipsas1997 N. V. Sipsas, S. A. Kalams, A. Trocha, S. He, W. A. Blattner, B. D. Walker, and R. P. Johnson. Identification of Type-Specific Cytotoxic T Lymphocyte Responses to Homologous Viral Proteins in Laboratory Workers Accidentally Infected with HIV-1. J. Clin. Invest., 99:752-762, 1997. To examine a situation where the autologous strain and the reference reagents would be the same, the CTL response of three lab workers accidentally infected with HIV IIIB was studied. Both group specific and type specific epitopes were targets for CTL clones. One subject had a broadening of CTL response over time, using a broad range of restricting HLA class I alleles. Characterization of the cytotoxic T lymphocyte (CTL) response against HIV-1 has been limited by the use of target cells expressing viral proteins from laboratory isolates of HIV-1. This approach has favored identification of group-specific CTL responses and precluded assessment of the extent of type-specific CTL responses directed against HIV-1. Using cells expressing viral proteins from the HIV-1 IIIB strain, we performed a detailed characterization of HIV-1-specific CTL response in three laboratory workers accidentally infected with HIV-1 IIIB. Eight of the epitopes identified were group specific, lying in relatively conserved regions of Gag, reverse transcriptase, and envelope. Three type-specific epitopes were identified, two of them in highly variable regions of envelope. In longitudinal studies in one subject, seven different epitopes and five different restricting HLA class I alleles were identified, with a progressive increase in the number of CTL epitopes recognized by this subject over time. Our data demonstrate that type-specific CTL responses make up a significant proportion of the host cellular immune response against HIV-1 and that a broadening of epitope specificity may occur. PubMed ID: 9045880. Show all entries for this paper.


Displaying record number 463

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HXB2 Location Pol(330-338)
RT(175-183)
DNA(3072..3098)
Pol Epitope Map
Author Location RT
Epitope NPDIVIYQY Epitope Alignment
NPDIVIYQY epitope logo
Show epitope variants
Species (MHC/HLA) human(B35)
Immunogen HIV-1 exposed seronegative
Experimental methods  
Keywords review, subtype comparisons, HIV exposed persistently seronegative (HEPS)

Notes

References

Menendez-Arias1998 L. Menendez-Arias, A. Mas, and E. Domingo. Cytotoxic T-Lymphocyte Responses to HIV-1 Reverse Transcriptase. Viral Immunol., 11:167-181, 1998. PubMed ID: 10189185. Show all entries for this paper.

RowlandJones1998b S. Rowland-Jones, T. Dong, P. Krausa, J. Sutton, H. Newell, K. Ariyoshi, F. Gotch, S. Sabally, T. Corrah, J. Kimani, K. MacDonald, F. Plummer, J. Ndinya-Achola, H. Whittle, and A. McMichael. The Role of Cytotoxic T Cells in HIV Infection. Dev. Biol. Stand., 92:209-214, 1998. In this paper CTL response to previously defined conserved epitopes was found in exposed but uninfected prostitutes in Nairobi. Subtypes A and D are circulating in this regions, and the reactive epitopes tended to be conserved. Similarly previous studies in the Gambia showed that exposed but uninfected prostitutes tended to have B35 presented CTL epitopes conserved between HIV-1 and HIV-2. It was suggested that what was special about B35 is simply that it presents epitopes found both in HIV-1 and HIV-2. PubMed ID: 9554277. Show all entries for this paper.


Displaying record number 464

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HXB2 Location Pol(330-338)
RT(175-183)
DNA(3072..3098)
Pol Epitope Map
Author Location Pol( subtype B)
Epitope NPDIVIYQY Epitope Alignment
NPDIVIYQY epitope logo
Show epitope variants
Subtype B
Species (MHC/HLA) human(B35)
Immunogen HIV-1 exposed seronegative
Experimental methods  
Keywords subtype comparisons

Notes

References

Rowland-Jones1998 S. L. Rowland-Jones, T. Dong, K. R. Fowke, J. Kimani, P. Krausa, H. Newell, T. Blanchard, K. Ariyoshi, J. Oyugi, E. Ngugi, J. Bwayo, K. S. MacDonald, A. J. McMichael, and F. A. Plummer. Cytotoxic T cell responses to multiple conserved HIV epitopes in HIV-resistant prostitutes in Nairobi. J. Clin. Invest., 102(9):1758-65, 1 Nov 1998. PubMed ID: 9802890. Show all entries for this paper.


Displaying record number 57924

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HXB2 Location Pol(330-338)
RT(175-183)
DNA(3072..3098)
Pol Epitope Map
Author Location Pol(330-338)
Epitope NPDIVIYQY Epitope Alignment
NPDIVIYQY epitope logo
Subtype B
Species (MHC/HLA) human(B35)
Immunogen HIV-1 infection
Patient MHC/HLA A*02:01, A*24:02, B*35:01, B*35:03, C*03:03, C*04:01
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords acute/early infection

Notes

References

Herbeck2011 Joshua T. Herbeck, Morgane Rolland, Yi Liu, Sherry McLaughlin, John McNevin, Hong Zhao, Kim Wong, Julia N. Stoddard, Dana Raugi, Stephanie Sorensen, Indira Genowati, Brian Birditt, Angela McKay, Kurt Diem, Brandon S. Maust, Wenjie Deng, Ann C. Collier, Joanne D. Stekler, M. Juliana McElrath, and James I. Mullins. Demographic Processes Affect HIV-1 Evolution in Primary Infection before the Onset of Selective Processes. J. Virol., 85(15):7523-7534, Aug 2011. PubMed ID: 21593162. Show all entries for this paper.


Displaying record number 57948

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HXB2 Location Pol(330-338)
RT(175-183)
DNA(3072..3098)
Pol Epitope Map
Author Location RT(175-183)
Epitope NPDIVIYQY Epitope Alignment
NPDIVIYQY epitope logo
Epitope Name NY9
Subtype A1, B, C
Species (MHC/HLA) human(B35)
Immunogen vaccine
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining
Keywords vaccine-induced immune responses

Vaccine Details

Vaccine type adenovirus
Vaccine strain B clade HXB2, A clade 92RW020, C clade 97ZA012
Vaccine component Env, Gag-Pol

Notes

References

Friedrich2011 David Friedrich, Emilie Jalbert, Warren L. Dinges, John Sidney, Alex Sette, Yunda Huang, M. Juliana McElrath, and Helen Horton. Vaccine-Induced HIV-Specific CD8+ T Cells Utilize Preferential HLA Alleles and Target-Specific Regions of HIV-1. J. Acquir. Immune Defic. Syndr., 58(3):248-252, 1 Nov 2011. PubMed ID: 21709567. Show all entries for this paper.


Displaying record number 52616

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HXB2 Location Pol(330-338)
RT(175-183)
DNA(3072..3098)
Pol Epitope Map
Author Location RT(175-183)
Epitope NPDIVIYQY Epitope Alignment
NPDIVIYQY epitope logo
Subtype B
Species (MHC/HLA) human(B*35:01)
Immunogen HIV-1 infection
Patient MHC/HLA A*23:01, B*15:03, B*35:01, Cw2, Cw7
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords binding affinity, acute/early infection, early-expressed proteins

Notes

References

Cao2003 Jianhong Cao, John McNevin, Sarah Holte, Lisa Fink, Lawrence Corey, and M. Juliana McElrath. Comprehensive Analysis of Human Immunodeficiency Virus Type 1 (HIV-1)-Specific Gamma Interferon-Secreting CD8+ T Cells in Primary HIV-1 Infection. J. Virol., 77(12):6867-6878, Jun 2003. PubMed ID: 12768006. Show all entries for this paper.


Displaying record number 61894

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HXB2 Location Pol(330-338)
RT(175-183)
DNA(3072..3098)
Pol Epitope Map
Author Location RT(330-338)
Epitope NPDIVIYQY Epitope Alignment
NPDIVIYQY epitope logo
Epitope Name NY9
Subtype B
Species (MHC/HLA) human(B*35:01)
Immunogen HIV-1 infection
Country Japan
Experimental methods CD8 T-cell Elispot - IFNγ, CTL suppression of replication, Intracellular cytokine staining, Tetramer binding
Keywords escape, HLA associated polymorphism

Notes

References

Murakoshi2018a Hayato Murakoshi, Madoka Koyanagi, Tomohiro Akahoshi, Takayuki Chikata, Nozomi Kuse, Hiroyuki Gatanaga, Sarah L. Rowland-Jones, Shinichi Oka, and Masafumi Takiguchi. Impact of a Single HLA-A*24:02-Associated Escape Mutation on the Detrimental Effect of HLA-B*35:01 in HIV-1 Control. EBioMedicine, 36:103-112, Oct 2018. PubMed ID: 30249546. Show all entries for this paper.


Displaying record number 460

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HXB2 Location Pol(330-338)
RT(175-183)
DNA(3072..3098)
Pol Epitope Map
Author Location RT(328-336 IIIB)
Epitope NPDIVIYQY Epitope Alignment
NPDIVIYQY epitope logo
Species (MHC/HLA) human(B*35:01)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Tomiyama1997 H. Tomiyama, K. Miwa, H. Shiga, Y. I. Moore, S. Oka, A. Iwamoto, Y. Kaneko, and M. Takiguchi. Evidence of Presentation of Multiple HIV-1 Cytotoxic T Lymphocyte Epitopes by HLA-B*3501 Molecules That Are Associated with the Accelerated Progression of AIDS. J. Immunol., 158:5026-5034, 1997. PubMed ID: 9144523. Show all entries for this paper.


Displaying record number 61554

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HXB2 Location Pol(330-338)
RT(175-183)
DNA(3072..3098)
Pol Epitope Map
Author Location RT(175-183)
Epitope NPDIVIYQY Epitope Alignment
NPDIVIYQY epitope logo
Show epitope variants
Epitope Name NY9
Subtype B
Species (MHC/HLA) human(B*35:01)
Immunogen HIV-1 infection
Patient MHC/HLA KI-833: B*35:01; KI-929: B*35:01; KI-980: B*35:01
Country Japan
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, Intracellular cytokine staining
Keywords subtype comparisons, variant cross-reactivity, mutation acquisition, drug resistance

Notes

References

Kuse2015 Nozomi Kuse, Mohammad Arif Rahman, Hayato Murakoshi, Giang Van Tran, Takayuki Chikata, Madoka Koyanagi, Kinh Van Nguyen, Hiroyuki Gatanaga, Shinichi Oka, and Masafumi Takiguchi. Different Effects of Nonnucleoside Reverse Transcriptase Inhibitor Resistance Mutations on Cytotoxic T Lymphocyte Recognition between HIV-1 Subtype B and Subtype A/E Infections. J. Virol., 89(14):7363-7372, Jul 2015. PubMed ID: 25972553. Show all entries for this paper.


Displaying record number 61869

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HXB2 Location Pol(330-338)
RT(175-183)
DNA(3072..3098)
Pol Epitope Map
Author Location  
Epitope NPDIVIYQY Epitope Alignment
NPDIVIYQY epitope logo
Epitope Name NY9
Subtype B
Species (MHC/HLA) human(B*35:01)
Immunogen HIV-1 infection, vaccine
Country Japan
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining, Other
Keywords vaccine-induced immune responses

Notes

References

Zou2019 Chengcheng Zou, Hayato Murakoshi, Nozomi Kuse, Tomohiro Akahoshi, Takayuki Chikata, Hiroyuki Gatanaga, Shinichi Oka, Tomáš Hanke, and Masafumi Takiguchi. Effective Suppression of HIV-1 Replication by Cytotoxic T Lymphocytes Specific for Pol Epitopes in Conserved Mosaic Vaccine Immunogens. J. Virol., 93(7), 1 Apr 2019. PubMed ID: 30674626. Show all entries for this paper.


Displaying record number 58658

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HXB2 Location Pol(330-338)
RT(175-183)
DNA(3072..3098)
Pol Epitope Map
Author Location Pol(330-338)
Epitope NPDIVIYQY Epitope Alignment
NPDIVIYQY epitope logo
Epitope Name RT NY9
Subtype B
Species (MHC/HLA) human(B*35:01)
Immunogen HIV-1 infection
Country Barbados, Botswana, Haiti, Japan, Mexico, South Africa, United Kingdom, United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords subtype comparisons

Notes

References

Matthews2012 Philippa C. Matthews, Madoka Koyanagi, Henrik N. Kløverpris, Mikkel Harndahl, Anette Stryhn, Tomohiro Akahoshi, Hiroyuki Gatanaga, Shinichi Oka, Claudia Juarez Molina, Humberto Valenzuela Ponce, Santiago Avila Rios, David Cole, Jonathan Carlson, Rebecca P. Payne, Anthony Ogwu, Alfred Bere, Thumbi Ndung'u, Kamini Gounder, Fabian Chen, Lynn Riddell, Graz Luzzi, Roger Shapiro, Christian Brander, Bruce Walker, Andrew K. Sewell, Gustavo Reyes Teran, David Heckerman, Eric Hunter, Søren Buus, Masafumi Takiguchi, and Philip J. R. Goulder. Differential Clade-Specific HLA-B*3501 Association with HIV-1 Disease Outcome Is Linked to Immunogenicity of a Single Gag Epitope. J. Virol., 86(23):12643-12654, Dec 2012. PubMed ID: 22973023. Show all entries for this paper.


Displaying record number 52066

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HXB2 Location Pol(330-338)
RT(175-183)
DNA(3072..3098)
Pol Epitope Map
Author Location RT(175-183 IIIB)
Epitope NPDIVIYQY Epitope Alignment
NPDIVIYQY epitope logo
Show epitope variants
Subtype B
Species (MHC/HLA) human(B*35:01)
Immunogen HIV-1 infection
Experimental methods  
Keywords epitope processing, escape

Notes

References

Moore2002b Corey B. Moore, Mina John, Ian R. James, Frank T. Christiansen, Campbell S. Witt, and Simon A. Mallal. Evidence of HIV-1 adaptation to HLA-restricted immune responses at a population level. Science, 296(5572):1439-1443, 24 May 2002. PubMed ID: 12029127. Show all entries for this paper.


Displaying record number 1338

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HXB2 Location Pol(330-338)
RT(175-183)
DNA(3072..3098)
Pol Epitope Map
Author Location Pol(330-338)
Epitope NPDIVIYQY Epitope Alignment
NPDIVIYQY epitope logo
Species (MHC/HLA) human(B*35:01)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Tomiyama2000a H. Tomiyama, S. Oka, G. S. Ogg, S. Ida, A. J. McMichael, and M. Takiguchi. Expansion of HIV-1-specific CD28- CD45RA- CD8+ T cells in chronically HIV-1-infected individuals. AIDS, 14(13):2049-51, 8 Sep 2000. PubMed ID: 10997412. Show all entries for this paper.


Displaying record number 60025

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HXB2 Location Pol(330-338)
RT(175-183)
DNA(3072..3098)
Pol Epitope Map
Author Location Pol(330-338)
Epitope NPDIVIYQY Epitope Alignment
NPDIVIYQY epitope logo
Epitope Name NQY9
Species (MHC/HLA) human(B*35:02, B*35:03, B*53:01)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope, chronic infection

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 58081

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HXB2 Location Pol(330-338)
RT(175-183)
DNA(3072..3098)
Pol Epitope Map
Author Location Pol
Epitope NPDIVIYQY Epitope Alignment
NPDIVIYQY epitope logo
Subtype B
Species (MHC/HLA) human
Immunogen vaccine
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords vaccine-induced immune responses

Vaccine Details

Vaccine type adenovirus type 5 (Ad5), DNA prime with Ad5 boost
Vaccine strain B clade IIIB, B clade JRFL, B clade CAM-1
Vaccine component Gag, Nef, Pol

Notes

References

Li2011a Fusheng Li, Adam C. Finnefrock, Sheri A. Dubey, Bette T. M. Korber, James Szinger, Suzanne Cole, M. Juliana McElrath, John W. Shiver, Danilo R. Casimiro, Lawrence Corey, and Steven G Self. Mapping HIV-1 Vaccine Induced T-Cell Responses: Bias Towards Less-Conserved Regions and Potential Impact on Vaccine Efficacy in the Step Study. PLoS One, 6(6):e20479, 2011. PubMed ID: 21695251. Show all entries for this paper.


Displaying record number 57316

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HXB2 Location Pol(330-338)
RT(175-183)
DNA(3072..3098)
Pol Epitope Map
Author Location RT
Epitope NPDIVIYQY Epitope Alignment
NPDIVIYQY epitope logo
Epitope Name NY9
Species (MHC/HLA) human
Immunogen HIV-1 infection
Country United States
Experimental methods Other
Keywords dendritic cells

Notes

References

Huang2009a Jinghe Huang, James J. Goedert, Eric J. Sundberg, Thai Duong Hong Cung, Patrick S. Burke, Maureen P. Martin, Liliana Preiss, Jeffrey Lifson, Mathias Lichterfeld, Mary Carrington, and Xu G. Yu. HLA-B*35-Px-Mediated Acceleration of HIV-1 Infection by Increased Inhibitory Immunoregulatory Impulses. J. Exp. Med., 206(13):2959-2966, 21 Dec 2009. PubMed ID: 20008523. Show all entries for this paper.


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