Search CTL/CD8+ T-Cell Epitope Database

Found 2 matching records:

Displaying record number 52856

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HXB2 Location	gp160(33-42) gp120(33-42) DNA(6321..6350)	gp160 Epitope Map
Author Location	Env
Epitope	NLWVTVYYGV	Epitope Alignment
Epitope Name	1256
Subtype	multiple
Species (MHC/HLA)	human(A2)
Immunogen	HIV-1 infection
Patient MHC/HLA	902991: A2, A30, B39
Country	United States
Experimental methods	T-cell Elispot
Keywords	binding affinity, computational epitope prediction, novel epitope

Notes

• Epitopes defined using sequence parsing and matching algorithm Conservatrix, and epitope prediction tool EpiMatrix, were shown to be conserved in a broad range of HIV-1 sequences derived from different parts of the world. 31 novel highly conserved HIV-1 epitopes were found, among which four were recognized as promiscuous epitopes and five as MHC supertypes.
• Estimated binding probability for NLWVTVYYGV: 84%

References

DeGroot2003 Anne S. De Groot, Bill Jesdale, William Martin, Caitlin Saint Aubin, Hakima Sbai, Andrew Bosma, Judy Lieberman, Gail Skowron, Fadi Mansourati, and Kenneth H. Mayer. Mapping Cross-Clade HIV-1 Vaccine Epitopes Using a Bioinformatics Approach. Vaccine, 21(27-30):4486-4504, 1 Oct 2003. PubMed ID: 14505932. Show all entries for this paper.

Displaying record number 55118

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HXB2 Location	gp160(33-42) gp120(33-42) DNA(6321..6350)	gp160 Epitope Map
Author Location	gp120(33-42)
Epitope	NLWVTVYYGV	Epitope Alignment
		Show epitope variants
Species (MHC/HLA)	human(A2)
Immunogen
Experimental methods
Keywords	subtype comparisons, viral fitness and reversion

Notes

• Determined the frequencies of known CD8+ and CD4+ Env epitope sequences among Brazilian HIV sequences of various subtypes.
• Present in 37/51 Brazilian HIV sequences; present in 100% of subtype C and F sequences.

References

Queiroz2007 Artur Trancoso Lopo de Queiroz, Luciane Amorim Santos, Domingos Ramon Moreau, Tulio de Oliveira, David I. Watkins, Bernardo Galvão-Castro, and Luiz Carlos Junior Alcantara. Identification and Characterization of Previously Described Epitopes in HIV-1 Subtypes B, C, F and BF in Brazil. Braz. J. Infect. Dis., 11(1):27-30, Feb 2007. PubMed ID: 17625722. Show all entries for this paper.