HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 6 matching records:

Displaying record number 58999

Download this epitope record as JSON.

HXB2 Location gp160(67-75)
gp120(67-75)
DNA(6423..6449)
gp160 Epitope Map
Author Location Env(67-)
Epitope NIWATHACV Epitope Alignment
NIWATHACV epitope logo
Epitope Name Env67
Subtype A
Species (MHC/HLA) human(A*02)
Immunogen HIV-1 infection, vaccine
Patient MHC/HLA P16: A*30:02, A*32:01, B*08:01, B*27:03
Country Guinea-Bissau
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords vaccine-induced immune responses, vaccine antigen design, therapeutic vaccine, chronic infection

Vaccine Details

Vaccine type peptide
Vaccine strain A clade
Adjuvant CAF01

Notes

References

Roman2013 Victor Raúl Gómez Román, Kristoffer Jarlov Jensen, Sanne Skov Jensen, Christian Leo-Hansen, Sanne Jespersen, David da Silva Té, Candida Medina Rodrigues, Christoph Mikkel Janitzek, Lasse Vinner, Terese Lea Katzenstein, Peter Andersen, Ingrid Kromann, Lars Vibe Andreasen, Ingrid Karlsson, and Anders Fomsgaard. Therapeutic Vaccination Using Cationic Liposome-Adjuvanted HIV Type 1 Peptides Representing HLA-Supertype-Restricted Subdominant T Cell Epitopes: Safety, Immunogenicity, and Feasibility in Guinea-Bissau. AIDS Res Hum Retroviruses, 29(11):1504-1512, Nov 2013. PubMed ID: 23634822. Show all entries for this paper.


Displaying record number 57141

Download this epitope record as JSON.

HXB2 Location gp160(67-75)
gp120(67-75)
DNA(6423..6449)
gp160 Epitope Map
Author Location Env
Epitope NIWATHACV Epitope Alignment
NIWATHACV epitope logo
Epitope Name Env67 V2I
Species (MHC/HLA) human(A*02:01)
Immunogen HIV-1 infection, vaccine
Country Denmark
Experimental methods Intracellular cytokine staining, Pentamer labeling
Keywords vaccine-induced immune responses, therapeutic vaccine

Vaccine Details

Vaccine type peptide
Vaccine strain multiple epitope immunogen
Vaccine component HIV-1, other

Notes

References

Kloverpris2009a Henrik Kloverpris, Ingrid Karlsson, Jesper Bonde, Mette Thorn, Lasse Vinner, Anders E. Pedersen, Julie L. Hentze, Betina S. Andresen, Inge M. Svane, Jan Gerstoft, Gitte Kronborg, and Anders Fomsgaard. Induction of Novel CD8+ T-Cell Responses during Chronic Untreated HIV-1 Infection by Immunization with Subdominant Cytotoxic T-Lymphocyte Epitopes. AIDS, 23(11):1329-1340, 17 Jul 2009. PubMed ID: 19528789. Show all entries for this paper.


Displaying record number 57147

Download this epitope record as JSON.

HXB2 Location gp160(67-75)
gp120(67-75)
DNA(6423..6449)
gp160 Epitope Map
Author Location Env
Epitope NIWATHACV Epitope Alignment
NIWATHACV epitope logo
Epitope Name Env67(2I)
Species (MHC/HLA) transgenic mouse(A*02:01)
Immunogen vaccine
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, Flow cytometric T-cell cytokine assay
Keywords immunodominance, dendritic cells

Vaccine Details

Vaccine strain multiple epitope immunogen
Vaccine component Env, Gag, Pol, Vif, Vpu

Notes

References

Kloverpris2009 Henrik N. Kloverpris, Ingrid Karlsson, Mette Thorn, Søren Buus, and Anders Fomsgaard. Immune Hierarchy among HIV-1 CD8+ T Cell Epitopes Delivered by Dendritic Cells Depends on MHC-I Binding Irrespective of Mode of Loading and Immunization in HLA-A*0201 Mice. APMIS, 117(11):849-585, Nov 2009. PubMed ID: 19845536. Show all entries for this paper.


Displaying record number 52677

Download this epitope record as JSON.

HXB2 Location gp160(67-75)
gp120(67-75)
DNA(6423..6449)
gp160 Epitope Map
Author Location Env(67-)
Epitope NIWATHACV Epitope Alignment
NIWATHACV epitope logo
Show epitope variants
Epitope Name Env67(2I)
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection, vaccine
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, Flow cytometric T-cell cytokine assay
Keywords binding affinity, subtype comparisons, computational epitope prediction

Vaccine Details

Vaccine type peptide
Vaccine component gp120
Adjuvant Incomplete Freund's Adjuvant (IFA)

Notes

References

Corbet2003 Sylvie Corbet, Henrik Vedel Nielsen, Lasse Vinner, Sanne Lauemoller, Dominic Therrien, Sheila Tang, Gitte Kronborg, Lars Mathiesen, Paul Chaplin, Søren Brunak, Søren Buus, and Anders Fomsgaard. Optimization and Immune Recognition of Multiple Novel Conserved HLA-A2, Human Immunodeficiency Virus Type 1-Specific CTL Epitopes. J. Gen. Virol., 84(Pt 9):2409-2421, Sep 2003. PubMed ID: 12917462. Show all entries for this paper.


Displaying record number 56066

Download this epitope record as JSON.

HXB2 Location gp160(67-75)
gp120(67-75)
DNA(6423..6449)
gp160 Epitope Map
Author Location Env(67-)
Epitope NIWATHACV Epitope Alignment
NIWATHACV epitope logo
Show epitope variants
Epitope Name Env67(2I)
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Country Denmark
Experimental methods Flow cytometric T-cell cytokine assay
Keywords rate of progression, escape, acute/early infection

Notes

References

Fomsgaard2008 Anders Fomsgaard, Lasse Vinner, Dominic Therrien, Louise B. Jørgensen, Claus Nielsen, Lars Mathiesen, Court Pedersen, and Sylvie Corbet. Full-Length Characterization of A1/D Intersubtype Recombinant Genomes from a Therapy-Induced HIV Type 1 Controller during Acute Infection and His Noncontrolling Partner. AIDS Res. Hum. Retroviruses, 24(3):463-472, Mar 2008. PubMed ID: 18373434. Show all entries for this paper.


Displaying record number 58411

Download this epitope record as JSON.

HXB2 Location gp160(67-75)
gp120(67-75)
DNA(6423..6449)
gp160 Epitope Map
Author Location Env
Epitope NIWATHACV Epitope Alignment
NIWATHACV epitope logo
Epitope Name Env067
Subtype B, CRF02_AG
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Country Cote D'Ivoire, Denmark, Ghana, Guinea-Bissau, Mali, Senegal
Experimental methods Intracellular cytokine staining, Pentamer labeling
Keywords vaccine antigen design

Notes

References

Corbet2003 Sylvie Corbet, Henrik Vedel Nielsen, Lasse Vinner, Sanne Lauemoller, Dominic Therrien, Sheila Tang, Gitte Kronborg, Lars Mathiesen, Paul Chaplin, Søren Brunak, Søren Buus, and Anders Fomsgaard. Optimization and Immune Recognition of Multiple Novel Conserved HLA-A2, Human Immunodeficiency Virus Type 1-Specific CTL Epitopes. J. Gen. Virol., 84(Pt 9):2409-2421, Sep 2003. PubMed ID: 12917462. Show all entries for this paper.

Kloverpris2009 Henrik N. Kloverpris, Ingrid Karlsson, Mette Thorn, Søren Buus, and Anders Fomsgaard. Immune Hierarchy among HIV-1 CD8+ T Cell Epitopes Delivered by Dendritic Cells Depends on MHC-I Binding Irrespective of Mode of Loading and Immunization in HLA-A*0201 Mice. APMIS, 117(11):849-585, Nov 2009. PubMed ID: 19845536. Show all entries for this paper.

Thorn2007 Mette Thorn, Sheila Tang, Dominic Therrien, Henrik Kløverpris, Lasse Vinner, Gitte Kronborg, Jan Gerstoft, Sylvie Corbet, and Anders Fomsgaard. Sequence Conservation of Subdominant HLA-A2-Binding CTL Epitopes in HIV-1 Clinical Isolates and CD8+ T-Lymphocyte Cross-Recognition May Explain the Immune Reaction in Infected Individuals. APMIS, 115(6):757-768, Jun 2007. PubMed ID: 17550385. Show all entries for this paper.

Vinner2011 Lasse Vinner, Birgitta Holmgren, Kristoffer J. Jensen, Joakim Esbjornsson, Marie Borggren, Julie L. Hentze, Ingrid Karlsson, Betina S. Andresen, Gregers J. Gram, Henrik Kloverpris, Peter Aaby, Zacarias José Da Silva, Eva-Maria Fenyö, and Anders Fomsgaard. Sequence Analysis of HIV-1 Isolates from Guinea-Bissau: Selection of Vaccine Epitopes Relevant in Both West African and European Countries. APMIS, 119(8):487-497, Aug 2011. PubMed ID: 21749448. Show all entries for this paper.


Questions or comments? Contact us at immuno@lanl.gov
 
Managed by Triad National Security, LLC for the U.S. Department of Energy’s National Nuclear Security Administration
Copyright © 2022 Triad National Security, LLC | Disclaimer/Privacy

Dept of Health & Human Services Los Alamos National Institutes of Health