HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 3 matching records:

Displaying record number 673

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HXB2 Location gp160(156-165)
gp120(156-165)
DNA(6690..6719)
gp160 Epitope Map
Author Location gp120(156-165)
Epitope NCSFNISTSI Epitope Alignment
NCSFNISTSI epitope logo
Species (MHC/HLA) human(C*08)
Immunogen HIV-1 infection
Experimental methods  
Keywords epitope processing

Notes

References

Ferris1999 R. L. Ferris, C. Hall, N. V. Sipsas, J. T. Safrit, A. Trocha, R. A. Koup, R. P. Johnson, and R. F. Siliciano. Processing of HIV-1 Envelope Glycoprotein for Class I-Restricted Recognition: Dependence on TAP1/2 and Mechanisms for Cytosolic Localization. J. Immunol., 162:1324-1332, 1999. PubMed ID: 9973386. Show all entries for this paper.


Displaying record number 672

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HXB2 Location gp160(156-165)
gp120(156-165)
DNA(6690..6719)
gp160 Epitope Map
Author Location gp120(156-165 IIIB)
Epitope NCSFNISTSI Epitope Alignment
NCSFNISTSI epitope logo
Show epitope variants
Species (MHC/HLA) human(Cw8)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Sipsas1997 N. V. Sipsas, S. A. Kalams, A. Trocha, S. He, W. A. Blattner, B. D. Walker, and R. P. Johnson. Identification of Type-Specific Cytotoxic T Lymphocyte Responses to Homologous Viral Proteins in Laboratory Workers Accidentally Infected with HIV-1. J. Clin. Invest., 99:752-762, 1997. To examine a situation where the autologous strain and the reference reagents would be the same, the CTL response of three lab workers accidentally infected with HIV IIIB was studied. Both group specific and type specific epitopes were targets for CTL clones. One subject had a broadening of CTL response over time, using a broad range of restricting HLA class I alleles. Characterization of the cytotoxic T lymphocyte (CTL) response against HIV-1 has been limited by the use of target cells expressing viral proteins from laboratory isolates of HIV-1. This approach has favored identification of group-specific CTL responses and precluded assessment of the extent of type-specific CTL responses directed against HIV-1. Using cells expressing viral proteins from the HIV-1 IIIB strain, we performed a detailed characterization of HIV-1-specific CTL response in three laboratory workers accidentally infected with HIV-1 IIIB. Eight of the epitopes identified were group specific, lying in relatively conserved regions of Gag, reverse transcriptase, and envelope. Three type-specific epitopes were identified, two of them in highly variable regions of envelope. In longitudinal studies in one subject, seven different epitopes and five different restricting HLA class I alleles were identified, with a progressive increase in the number of CTL epitopes recognized by this subject over time. Our data demonstrate that type-specific CTL responses make up a significant proportion of the host cellular immune response against HIV-1 and that a broadening of epitope specificity may occur. PubMed ID: 9045880. Show all entries for this paper.


Displaying record number 52213

Download this epitope record as JSON.

HXB2 Location gp160(156-165)
gp120(156-165)
DNA(6690..6719)
gp160 Epitope Map
Author Location Env(162-171 BH10, LAI)
Epitope NCSFNISTSI Epitope Alignment
NCSFNISTSI epitope logo
Species (MHC/HLA) human
Immunogen computer prediction
Experimental methods Other
Keywords computational epitope prediction, T-cell crossreactivity to human proteins

Notes

References

Maksiutov2002 A. Z. Maksiutov, A. G. Bachinskii, and S. I. Bazhan. [Searching for Local Similarities Between HIV-1 and Human Proteins. Application to Vaccines]. Mol Biol (Mosk), 36(3):447-459, May-Jun 2002. Article in Russian. PubMed ID: 12068630. Show all entries for this paper.


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