Search CTL/CD8+ T-Cell Epitope Database

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Displaying record number 348

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HXB2 Location	Gag(325-333) p24(193-201) DNA(1762..1788)	Gag Epitope Map
Author Location	p24(325-333)
Epitope	NANPDCKTI?	Epitope Alignment
Species (MHC/HLA)	human(B51)
Immunogen	HIV-1 infection
Experimental methods
Keywords	immunodominance

Notes

• Only 4/11 HLA-A2+ HIV+ individuals had CTL that reacted to SLYNTVATL, calling into question whether it is immunodominant.
• 95 optimally-defined peptides from this database were used to screen for INFγ responses to other epitopes.
• 3/11 of the HLA A2+ individuals were HLA B51 and two of these responded to this epitope as well as to other epitopes.

References

Betts2000 M. R. Betts, J. P. Casazza, B. A. Patterson, S. Waldrop, W. Trigona, T.-M Fu, F. Kern, L. J. Picker, and R. A. Koup. Putative Immunodominant Human Imunodeficiency Virus-Specific CD8+ T Cell Responses Cannot Be Predicted by Major Histocompatibility Complex Class I Haplotype. J. Virol., 74:9144-9151, 2000. PubMed ID: 10982361. Show all entries for this paper.