Search CTL/CD8+ T-Cell Epitope Database

Found 1 matching record:

Displaying record number 55730

Download this epitope record as JSON.

HXB2 Location	Gag(276-285) p24(144-153) DNA(1615..1644)	Gag Epitope Map
Author Location	Gag(276-285 SF2)
Epitope	`MYSPTSILDI`	Epitope Alignment
Epitope Name	MYS
Subtype	B
Species (MHC/HLA)	mouse(H-2^d)
Immunogen	vaccine
Experimental methods	CD8 T-cell Elispot - IFNγ, Chromium-release assay
Keywords	vaccine-induced immune responses

Vaccine Details

Vaccine type	protein
Vaccine strain	B clade SF2
Vaccine component	Gag, Tat
Adjuvant	Complete Freund's Adjuvant (CFA), Incomplete Freund's Adjuvant (IFA)

Notes

In order to increase the known number of epitopes in Gag protein so that they can be assayed for reactivity in vaccine studies, BALB/c mice were inoculated with Gag or Gag+Tat. OLPs were used to elicit T-cell immune responses from mouse splenocytes, tested for by cytotoxicity or ELISpot assays. 5 novel predicted optimal CTL epitopes, 2 novel predicted CD4 epitopes and 2 immune response eliciting peptides were found.
Predicted epitope MYSPTSILDI was found in reactive Peptide 69, IVRMYSPTSILDIRQ.

References

Cellini2008 Silvia Cellini, Cinzia Fortini, Eleonora Gallerani, Federica Destro, Egidio Brocca Cofano, Antonella Caputo, and Riccardo Gavioli. Identification of New HIV-1 Gag-Specific Cytotoxic T Lymphocyte Responses in BALB/c Mice. Virol. J., 5:81, 2008. PubMed ID: 18625037. Show all entries for this paper.