HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 9 matching records:

Displaying record number 53842

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HXB2 Location Gag(250-258)
p24(118-126)
DNA(1537..1563)
Gag Epitope Map
Author Location p24(118-126)
Epitope MTNNPPIPV Epitope Alignment
MTNNPPIPV epitope logo
Show epitope variants
Epitope Name MV9
Species (MHC/HLA) human(A*02)
Immunogen HIV-1 infection
Patient MHC/HLA P-1115: A*02, A*23, B*07, B*51, C*15; M-1004: A*23, A*31, B*07, B*49, C*07, C*15
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords responses in children, mother-to-infant transmission, escape, acute/early infection, viral fitness and reversion

Notes

References

Sanchez-Merino2005 Victor Sanchez-Merino, Siwei Nie, and Katherine Luzuriaga. HIV-1-Specific CD8+ T Cell Responses and Viral Evolution in Women and Infants. J. Immunol., 175(10):6976-6986, 15 Nov 2005. PubMed ID: 16272358. Show all entries for this paper.


Displaying record number 61284

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HXB2 Location Gag(250-258)
p24(118-126)
DNA(1537..1563)
Gag Epitope Map
Author Location p24(250-258 NL4-3)
Epitope MTNNPPIPV Epitope Alignment
MTNNPPIPV epitope logo
Epitope Name MV9
Subtype B
Species (MHC/HLA) human(A*02)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Other
Keywords epitope processing

Notes

References

Rucevic2016 Marijana Rucevic, Georgio Kourjian, Julie Boucau, Renata Blatnik, Wilfredo Garcia Bertran, Matthew J. Berberich, Bruce D. Walker, Angelika B. Riemer, and Sylvie Le Gall. Analysis of Major Histocompatibility Complex-Bound HIV Peptides Identified from Various Cell Types Reveals Common Nested Peptides and Novel T Cell Responses. J. Virol., 90(19):8605-8620, 1 Oct 2016. PubMed ID: 27440904. Show all entries for this paper.


Displaying record number 55268

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HXB2 Location Gag(250-258)
p24(118-126)
DNA(1537..1563)
Gag Epitope Map
Author Location p24(118-126)
Epitope MTNNPPIPV Epitope Alignment
MTNNPPIPV epitope logo
Subtype B
Species (MHC/HLA) human(A*02)
Immunogen HIV-1 infection
Country China
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining, Other
Keywords assay or method development, optimal epitope

Notes

References

Wang2007 Shaoyang Wang, Yongtao Sun, Song Zhai, Yan Zhuang, Shuguang Zhao, Whenzhen Kang, Xinhong Li, Dedong Huang, Xu G. Yu, Bruce D. Walker, and Marcus A. Altfeld. Identification of HLA-A11-Restricted HIV-1-Specific Cytotoxic T-Lymphocyte Epitopes in China. Curr. HIV Res., 5(1):119-128, Jan 2007. PubMed ID: 17266563. Show all entries for this paper.


Displaying record number 60651

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HXB2 Location Gag(250-258)
p24(118-126)
DNA(1537..1563)
Gag Epitope Map
Author Location p24(118-126)
Epitope MTNNPPIPV Epitope Alignment
MTNNPPIPV epitope logo
Epitope Name MV-9
Subtype B, C
Species (MHC/HLA) human(A*02)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Tenzer2014 Stefan Tenzer, Hayley Crawford, Phillip Pymm, Robert Gifford, Vattipally B. Sreenu, Mirjana Weimershaus, Tulio de Oliveira, Anne Burgevin, Jan Gerstoft, Nadja Akkad, Daniel Lunn, Lars Fugger, John Bell, Hansjörg Schild, Peter van Endert, and Astrid K. N. Iversen. HIV-1 Adaptation to Antigen Processing Results in Population-Level Immune Evasion and Affects Subtype Diversification. Cell Rep., 7(2):448-463, 24 Apr 2014. PubMed ID: 24726370. Show all entries for this paper.


Displaying record number 56191

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HXB2 Location Gag(250-258)
p24(118-126)
DNA(1537..1563)
Gag Epitope Map
Author Location Gag(271-)
Epitope MTNNPPIPV Epitope Alignment
MTNNPPIPV epitope logo
Species (MHC/HLA) human(A*02:01)
Immunogen vaccine
Country Botswana, United States
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay
Keywords vaccine antigen design

Vaccine Details

Vaccine type DNA, polyepitope
Vaccine strain multiple epitope immunogen

Notes

References

Gorse2008a Geoffrey J. Gorse, Lindsey R. Baden, Margaret Wecker, Mark J. Newman, Guido Ferrari, Kent J. Weinhold, Brian D. Livingston, Tonya L. Villafana, Hongli Li, Elizabeth Noonan, Nina D. Russell, and HIV Vaccine Trials Network. Safety and Immunogenicity of Cytotoxic T-Lymphocyte Poly-Epitope, DNA Plasmid (EP HIV-1090) Vaccine in Healthy, Human Immunodeficiency Virus Type 1 (HIV-1)-Uninfected Adults. Vaccine, 26(2):215-223, 10 Jan 2008. PubMed ID: 18055072. Show all entries for this paper.


Displaying record number 56532

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HXB2 Location Gag(250-258)
p24(118-126)
DNA(1537..1563)
Gag Epitope Map
Author Location Gag
Epitope MTNNPPIPV Epitope Alignment
MTNNPPIPV epitope logo
Epitope Name Gag271
Subtype B
Species (MHC/HLA) human(A2)
Immunogen vaccine
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords vaccine antigen design

Vaccine Details

Vaccine type DNA, polyepitope
Vaccine component other

Notes

References

Wilson2008 Cara C. Wilson, Mark J. Newman, Brian D. Livingston, Samantha MaWhinney, Jeri E. Forster, Jim Scott, Robert T. Schooley, and Constance A. Benson. Clinical Phase 1 Testing of the Safety and Immunogenicity of an Epitope-Based DNA Vaccine in Human Immunodeficiency Virus Type 1-Infected Subjects Receiving Highly Active Antiretroviral Therapy. Clin. Vaccine Immunol., 15(6):986-994, Jun 2008. PubMed ID: 18400976. Show all entries for this paper.


Displaying record number 58807

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HXB2 Location Gag(250-258)
p24(118-126)
DNA(1537..1563)
Gag Epitope Map
Author Location Gag
Epitope MTNNPPIPV Epitope Alignment
MTNNPPIPV epitope logo
Epitope Name Gag271
Subtype B, multiple
Species (MHC/HLA) human(A2, A3, B7)
Immunogen vaccine
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining
Keywords vaccine-induced immune responses

Vaccine Details

Vaccine type DNA, modified vaccinia Ankara (MVA)
Vaccine strain multiple epitope immunogen

Notes

References

Gorse2012 Geoffrey J. Gorse, Mark J. Newman, Allan deCamp, Christine Mhorag Hay, Stephen C. De Rosa, Elizabeth Noonan, Brian D. Livingston, Jonathan D. Fuchs, Spyros A. Kalams, Farah L. Cassis-Ghavami, and NIAID HIV Vaccine Trials Network. DNA and Modified Vaccinia Virus Ankara Vaccines Encoding Multiple Cytotoxic and Helper T-Lymphocyte Epitopes of Human Immunodeficiency Virus Type 1 (HIV-1) Are Safe but Weakly Immunogenic in HIV-1-Uninfected, Vaccinia Virus-Naive Adults. Clin. Vaccine Immunol., 19(5):649-658, May 2012. PubMed ID: 22398243. Show all entries for this paper.


Displaying record number 56512

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HXB2 Location Gag(250-258)
p24(118-126)
DNA(1537..1563)
Gag Epitope Map
Author Location Gag
Epitope MTNNPPIPV Epitope Alignment
MTNNPPIPV epitope logo
Epitope Name Gag271
Subtype B
Species (MHC/HLA) human, mouse(A2 supertype)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Other
Keywords binding affinity, supertype, vaccine-induced immune responses, HLA cross-presentation

Notes

References

Wilson2003 Cara C. Wilson, Denise McKinney, Michelle Anders, Samantha MaWhinney, Jeri Forster, Claire Crimi, Scott Southwood, Alessandro Sette, Robert Chesnut, Mark J Newman, and Brian D Livingston. Development of a DNA Vaccine Designed to Induce Cytotoxic T Lymphocyte Responses to Multiple Conserved Epitopes in HIV-1. J. Immunol., 171(10):5611-5623, 15 Nov 2003. PubMed ID: 14607970. Show all entries for this paper.


Displaying record number 1596

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HXB2 Location Gag(250-258)
p24(118-126)
DNA(1537..1563)
Gag Epitope Map
Author Location Gag(282-290)
Epitope MTNNPPIPV Epitope Alignment
MTNNPPIPV epitope logo
Species (MHC/HLA) human(A2 supertype)
Immunogen HIV-1 infection
Experimental methods  
Keywords supertype, rate of progression

Notes

References

Propato2001 A. Propato, E. Schiaffella, E. Vicenzi, V. Francavilla, L. Baloni, M. Paroli, L. Finocchi, N. Tanigaki, S. Ghezzi, R. Ferrara, R. Chesnut, B. Livingston, A. Sette, R. Paganelli, F. Aiuti, G. Poli, and V. Barnaba. Spreading of HIV-specific CD8+ T-cell repertoire in long-term nonprogressors and its role in the control of viral load and disease activity. Hum. Immunol., 62(6):561-76, Jun 2001. PubMed ID: 11390031. Show all entries for this paper.


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