HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 16 matching records:

Displaying record number 60021

HXB2 Location Gag(78-86)
p17(78-86)
DNA(1021..1047)
Gag Epitope Map
Author Location Gag(78-86)
Epitope LYNTVATLY Epitope Alignment
LYNTVATLY epitope logo
Epitope Name LY9
Species (MHC/HLA) human(A*02)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 56359

HXB2 Location Gag(78-86)
p17(78-86)
DNA(1021..1047)
Gag Epitope Map
Author Location p17(78-86)
Epitope LYNTVATLY Epitope Alignment
LYNTVATLY epitope logo
Epitope Name LY9
Subtype B
Species (MHC/HLA) human(A*29)
Immunogen HIV-1 infection
Country Australia, Canada, Germany, United States
Experimental methods  
Keywords HLA associated polymorphism

Notes

References

Brumme2008 Zabrina L. Brumme, Chanson J. Brumme, Jonathan Carlson, Hendrik Streeck, Mina John, Quentin Eichbaum, Brian L Block, Brett Baker, Carl Kadie, Martin Markowitz, Heiko Jessen, Anthony D. Kelleher, Eric Rosenberg, John Kaldor, Yuko Yuki, Mary Carrington, Todd M. Allen, Simon Mallal, Marcus Altfeld, David Heckerman, and Bruce D. Walker. Marked Epitope- and Allele-Specific Differences in Rates of Mutation in Human Immunodeficiency Type 1 (HIV-1) Gag, Pol, and Nef Cytotoxic T-Lymphocyte Epitopes in Acute/Early HIV-1 Infection. J. Virol., 82(18):9216-9227, Sep 2008. PubMed ID: 18614631. Show all entries for this paper.


Displaying record number 53920

HXB2 Location Gag(78-86)
p17(78-86)
DNA(1021..1047)
Gag Epitope Map
Author Location ( C consensus)
Epitope LYNTVATLY Epitope Alignment
LYNTVATLY epitope logo
Subtype C
Species (MHC/HLA) human(A*29)
Immunogen HIV-1 infection
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, optimal epitope

Notes

References

Kiepiela2007 Photini Kiepiela, Kholiswa Ngumbela, Christina Thobakgale, Dhanwanthie Ramduth, Isobella Honeyborne, Eshia Moodley, Shabashini Reddy, Chantal de Pierres, Zenele Mncube, Nompumelelo Mkhwanazi, Karen Bishop, Mary van der Stok, Kriebashnie Nair, Nasreen Khan, Hayley Crawford, Rebecca Payne, Alasdair Leslie, Julia Prado, Andrew Prendergast, John Frater, Noel McCarthy, Christian Brander, Gerald H. Learn, David Nickle, Christine Rousseau, Hoosen Coovadia, James I. Mullins, David Heckerman, Bruce D. Walker, and Philip Goulder. CD8+ T-Cell Responses to Different HIV Proteins Have Discordant Associations with Viral Load. Nat. Med., 13(1):46-53, Jan 2007. PubMed ID: 17173051. Show all entries for this paper.


Displaying record number 60019

HXB2 Location Gag(78-86)
p17(78-86)
DNA(1021..1047)
Gag Epitope Map
Author Location Gag(78-86)
Epitope LYNTVATLY Epitope Alignment
LYNTVATLY epitope logo
Epitope Name LY9
Species (MHC/HLA) human(A*29)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 57299

HXB2 Location Gag(78-86)
p17(78-86)
DNA(1021..1047)
Gag Epitope Map
Author Location p17(78-85)
Epitope LYNTVATLY Epitope Alignment
LYNTVATLY epitope logo
Epitope Name LY9
Subtype B
Species (MHC/HLA) (A*29, B*44)
Immunogen peptide-HLA interaction
Experimental methods CD8 T-cell Elispot - IFNγ, HLA binding, Other
Keywords epitope processing

Notes

References

Tenzer2009 Stefan Tenzer, Edmund Wee, Anne Burgevin, Guillaume Stewart-Jones, Lone Friis, Kasper Lamberth, Chih-hao Chang, Mikkel Harndahl, Mirjana Weimershaus, Jan Gerstoft, Nadja Akkad, Paul Klenerman, Lars Fugger, E. Yvonne Jones, Andrew J. McMichael, Søren Buus, Hansjörg Schild, Peter van Endert, and Astrid K. N. Iversen. Antigen Processing Influences HIV-Specific Cytotoxic T Lymphocyte Immunodominance. Nat. Immunol., 10(6):636-646, Jun 2009. PubMed ID: 19412183. Show all entries for this paper.


Displaying record number 53281

HXB2 Location Gag(78-86)
p17(78-86)
DNA(1021..1047)
Gag Epitope Map
Author Location ( C consensus)
Epitope LYNTVATLY Epitope Alignment
LYNTVATLY epitope logo
Subtype C
Species (MHC/HLA) human(A29)
Immunogen HIV-1 infection
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords characterizing CD8+ T cells

Notes

References

Kiepiela2004 Photini Kiepiela, Alasdair J. Leslie, Isobella Honeyborne, Danni Ramduth, Christina Thobakgale, Senica Chetty, Prinisha Rathnavalu, Corey Moore, Katja J. Pfafferott, Louise Hilton, Peter Zimbwa, Sarah Moore, Todd Allen, Christian Brander, Marylyn M. Addo, Marcus Altfeld, Ian James, Simon Mallal, Michael Bunce, Linda D. Barber, James Szinger, Cheryl Day, Paul Klenerman, James Mullins, Bette Korber, Hoosen M. Coovadia, Bruce D. Walker, and Philip J. R. Goulder. Dominant Influence of HLA-B in Mediating the Potential Co-Evolution of HIV and HLA. Nature, 432(7018):769-775, 9 Dec 2004. LA-UR 04-5920. PubMed ID: 15592417. Show all entries for this paper.


Displaying record number 55678

HXB2 Location Gag(78-86)
p17(78-86)
DNA(1021..1047)
Gag Epitope Map
Author Location Gag
Epitope LYNTVATLY Epitope Alignment
LYNTVATLY epitope logo
Subtype C
Species (MHC/HLA) human(A*2902)
Immunogen HIV-1 infection
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords variant cross-reactivity

Notes

References

Chopera2008 Denis R. Chopera, Zenda Woodman, Koleka Mlisana, Mandla Mlotshwa, Darren P. Martin, Cathal Seoighe, Florette Treurnicht, Debra Assis de Rosa, Winston Hide, Salim Abdool Karim, Clive M. Gray, Carolyn Williamson, and CAPRISA 002 Study Team. Transmission of HIV-1 CTL Escape Variants Provides HLA-Mismatched Recipients with a Survival Advantage. PLoS Pathog, 4(3):e1000033, Mar 2008. PubMed ID: 18369479. Show all entries for this paper.


Displaying record number 54117

HXB2 Location Gag(78-86)
p17(78-86)
DNA(1021..1047)
Gag Epitope Map
Author Location p17(78-86)
Epitope LYNTVATLY Epitope Alignment
LYNTVATLY epitope logo
Species (MHC/HLA) human(A*2902)
Immunogen  
Experimental methods  
Keywords optimal epitope

Notes

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 53057

HXB2 Location Gag(78-86)
p17(78-86)
DNA(1021..1047)
Gag Epitope Map
Author Location p17
Epitope LYNTVATLY Epitope Alignment
LYNTVATLY epitope logo
Epitope Name LY-9
Subtype C
Species (MHC/HLA) human(A*2902, B*4403)
Immunogen HIV-1 infection
Country South Africa
Experimental methods CD4 T-cell Elispot - IFNγ, CD8 T-cell Elispot - IFNγ, Chromium-release assay, Intracellular cytokine staining
Keywords subtype comparisons, epitope processing, immunodominance, HLA cross-presentation

Notes

References

Masemola2004a Agatha M. Masemola, Tumelo N. Mashishi, Greg Khoury, Helba Bredell, Maria Paximadis, Tiyani Mathebula, Debra Barkhan, Adrian Puren, Efthyia Vardas, Mark Colvin, Lynn Zijenah, David Katzenstein, Rosemary Musonda, Susan Allen, Newton Kumwenda, Taha Taha, Glenda Gray, James McIntyre, Salim Abdool Karim, Haynes W. Sheppard, and Clive M. Gray. Novel and Promiscuous CTL Epitopes in Conserved Regions of Gag Targeted by Individuals with Early Subtype C HIV Type 1 Infection from Southern Africa. J. Immunol., 173(7):4607-4617, 1 Oct 2004. PubMed ID: 15383595. Show all entries for this paper.


Displaying record number 58369

HXB2 Location Gag(78-86)
p17(78-86)
DNA(1021..1047)
Gag Epitope Map
Author Location p17
Epitope LYNTVATLY Epitope Alignment
LYNTVATLY epitope logo
Epitope Name A29 LY9
Subtype B, C
Species (MHC/HLA) human(A*2902, B*4403)
Immunogen HIV-1 infection, in vitro stimulation or selection, vaccine
Country South Africa, United States
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining, Tetramer binding
Keywords vaccine antigen design

Vaccine Details

Vaccine type adenovirus type 5 (Ad5)
Vaccine strain B clade, C clade
Vaccine component Gag

Notes

References

Ndhlovu2011 Zaza M. Ndhlovu, Alicja Piechocka-Trocha, Seanna Vine, Ashley McMullen, Kegakilwe C. Koofhethile, Phillip J. R. Goulder, Thumbi Ndung'u, Dan H. Barouch, and Bruce D. Walker. Mosaic HIV-1 Gag Antigens Can Be Processed and Presented to Human HIV-Specific CD8+ T Cells. J. Immunol., 186(12):6914-6924, 15 Jun 2011. PubMed ID: 21576505. Show all entries for this paper.


Displaying record number 60022

HXB2 Location Gag(78-86)
p17(78-86)
DNA(1021..1047)
Gag Epitope Map
Author Location Gag(78-86)
Epitope LYNTVATLY Epitope Alignment
LYNTVATLY epitope logo
Epitope Name LY9
Species (MHC/HLA) human(A*30)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 54128

HXB2 Location Gag(78-86)
p17(78-86)
DNA(1021..1047)
Gag Epitope Map
Author Location  
Epitope LYNTVATLY Epitope Alignment
LYNTVATLY epitope logo
Species (MHC/HLA) human(B*4403)
Immunogen  
Experimental methods  
Keywords optimal epitope

Notes

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 59110

HXB2 Location Gag(78-86)
p17(78-86)
DNA(1021..1047)
Gag Epitope Map
Author Location Gag(78-86)
Epitope LYNTVATLY Epitope Alignment
LYNTVATLY epitope logo
Epitope Name LY9
Subtype C
Species (MHC/HLA) human(B*81)
Immunogen HIV-1 infection
Patient MHC/HLA EC01: A*29, A*30, B*44, B*8101, Cw*07, Cw*18
Country United Kingdom, Zambia
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining, Other, Tetramer binding
Keywords kinetics

Notes

References

Smith2015 Nicola M. G. Smith, Petra Mlcochova, Sarah A. Watters, Marlene M. I. Aasa-Chapman, Neil Rabin, Sally Moore, Simon G. Edwards, Jeremy A. Garson, Paul R. Grant, R. Bridget Ferns, Angela Kashuba, Neema P. Mayor, Jennifer Schellekens, Steven G. E. Marsh, Andrew J. McMichael, Alan S. Perelson, Deenan Pillay, Nilu Goonetilleke, and Ravindra K. Gupta. Proof-of-Principle for Immune Control of Global HIV-1 Reactivation In Vivo. Clin. Infect. Dis., 61(1):120-128, 1 Jul 2015. PubMed ID: 25778749. Show all entries for this paper.


Displaying record number 60020

HXB2 Location Gag(78-86)
p17(78-86)
DNA(1021..1047)
Gag Epitope Map
Author Location Gag(78-86)
Epitope LYNTVATLY Epitope Alignment
LYNTVATLY epitope logo
Epitope Name LY9
Species (MHC/HLA) human(C*14)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 59405

HXB2 Location Gag(78-86)
p17(78-86)
DNA(1021..1047)
Gag Epitope Map
Author Location Gag
Epitope LYNTVATLY Epitope Alignment
LYNTVATLY epitope logo
Subtype B
Species (MHC/HLA) human
Immunogen HIV-1 infection
Patient MHC/HLA LTNP/EC-13: A*03, A*24, B*15, B*44, Cw*07, Cw*14
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, immunodominance

Notes

References

Migueles2015 Stephen A. Migueles, Daniel Mendoza, Matthew G. Zimmerman, Kelly M. Martins, Sushila A. Toulmin, Elizabeth P. Kelly, Bennett A. Peterson, Sarah A. Johnson, Eric Galson, Kate O. Poropatich, Andy Patamawenu, Hiromi Imamichi, Alexander Ober, Catherine A. Rehm, Sara Jones, Claire W. Hallahan, Dean A. Follmann, and Mark Connors. CD8+ T-Cell Cytotoxic Capacity Associated with Human Immunodeficiency Virus-1 Control Can Be Mediated through Various Epitopes and Human Leukocyte Antigen Types. EBioMedicine, 2(1):46-58, Jan 2015. PubMed ID: 26137533. Show all entries for this paper.


Displaying record number 58025

HXB2 Location Gag(78-86)
p17(78-86)
DNA(1021..1047)
Gag Epitope Map
Author Location Gag
Epitope LYNTVATLY Epitope Alignment
LYNTVATLY epitope logo
Subtype B
Species (MHC/HLA) human
Immunogen vaccine
Patient MHC/HLA A*0301, A*0301, B*3501, B*5101, Cw*0401, Cw*1402; A*0201, A*0206, B*5101, Cw*0401, Cw*1402
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords vaccine-induced immune responses

Vaccine Details

Vaccine type adenovirus type 5 (Ad5), DNA prime with Ad5 boost
Vaccine strain B clade IIIB, B clade JRFL, B clade CAM-1
Vaccine component Gag, Nef, Pol

Notes

References

Li2011a Fusheng Li, Adam C. Finnefrock, Sheri A. Dubey, Bette T. M. Korber, James Szinger, Suzanne Cole, M. Juliana McElrath, John W. Shiver, Danilo R. Casimiro, Lawrence Corey, and Steven G Self. Mapping HIV-1 Vaccine Induced T-Cell Responses: Bias Towards Less-Conserved Regions and Potential Impact on Vaccine Efficacy in the Step Study. PLoS One, 6(6):e20479, 2011. PubMed ID: 21695251. Show all entries for this paper.


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