HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 21 matching records:

Displaying record number 60012

HXB2 Location Pol(132-140)
Protease(76-84)
DNA(2478..2504)
Pol Epitope Map
Author Location Pol(132-140)
Epitope LVGPTPVNI Epitope Alignment
LVGPTPVNI epitope logo
Epitope Name LI9
Species (MHC/HLA) human(A*02)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 54568

HXB2 Location Pol(132-140)
Protease(76-84)
DNA(2478..2504)
Pol Epitope Map
Author Location Protease(76-84)
Epitope LVGPTPVNI Epitope Alignment
LVGPTPVNI epitope logo
Subtype B
Species (MHC/HLA) human(A*02)
Immunogen HIV-1 infection
Country United States
Experimental methods Intracellular cytokine staining, Other
Keywords rate of progression, escape, mutation acquisition

Notes

References

Karlsson2007 Annika C. Karlsson, Astrid K. N. Iversen, Joan M. Chapman, Tulio de Oliviera, Gerald Spotts, Andrew J. McMichael, Miles P. Davenport, Frederick M. Hecht, and Douglas F. Nixon. Sequential Broadening of CTL Responses in Early HIV-1 Infection Is Associated with Viral Escape. PLoS ONE, 2:e225, 2007. PubMed ID: 17311088. Show all entries for this paper.


Displaying record number 61318

HXB2 Location Pol(132-140)
Protease(76-84)
DNA(2478..2504)
Pol Epitope Map
Author Location  
Epitope LVGPTPVNI Epitope Alignment
LVGPTPVNI epitope logo
Show epitope variants
Subtype A, B, C, D
Species (MHC/HLA) humanized mouse(A*0201)
Immunogen vaccine
Experimental methods CD8 T-cell Elispot - IFNγ, HLA binding, Intracellular cytokine staining, Other
Keywords vaccine-induced immune responses, vaccine antigen design

Vaccine Details

Vaccine type modified vaccinia Ankara (MVA), adenovirus
Vaccine strain A clade, B clade, other, C clade

Notes

References

Abdul-Jawad2016 Sultan Abdul-Jawad, Beatrice Ondondo, Andy van Hateren, Andrew Gardner, Tim Elliott, Bette Korber, and Tomáš Hanke. Increased Valency of Conserved-Mosaic Vaccines Enhances the Breadth and Depth of Epitope Recognition. Mol. Ther., 24(2):375-384, Feb 2016. PubMed ID: 26581160. Show all entries for this paper.


Displaying record number 1306

HXB2 Location Pol(132-140)
Protease(76-84)
DNA(2478..2504)
Pol Epitope Map
Author Location Pol(163-)
Epitope LVGPTPVNI Epitope Alignment
LVGPTPVNI epitope logo
Epitope Name Pol-163
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Experimental methods  
Keywords binding affinity, supertype, computational epitope prediction, HLA cross-presentation

Notes

References

Altfeld2001 M. A. Altfeld, B. Livingston, N. Reshamwala, P. T. Nguyen, M. M. Addo, A. Shea, M. Newman, J. Fikes, J. Sidney, P. Wentworth, R. Chesnut, R. L. Eldridge, E. S. Rosenberg, G. K. Robbins, C. Brander, P. E. Sax, S. Boswell, T. Flynn, S. Buchbinder, P. J. Goulder, B. D. Walker, A. Sette, and S. A. Kalams. Identification of novel HLA-A2-restricted human immunodeficiency virus type 1-specific cytotoxic T-lymphocyte epitopes predicted by the HLA-A2 supertype peptide-binding motif. J. Virol., 75(3):1301-11, Feb 2001. URL: http://jvi.asm.org/cgi/content/full/75/3/1301. PubMed ID: 11152503. Show all entries for this paper.


Displaying record number 54083

HXB2 Location Pol(132-140)
Protease(76-84)
DNA(2478..2504)
Pol Epitope Map
Author Location Protease(76-84)
Epitope LVGPTPVNI Epitope Alignment
LVGPTPVNI epitope logo
Epitope Name LI9
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Experimental methods  
Keywords optimal epitope

Notes

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 54315

HXB2 Location Pol(132-140)
Protease(76-84)
DNA(2478..2504)
Pol Epitope Map
Author Location Protease(76-84)
Epitope LVGPTPVNI Epitope Alignment
LVGPTPVNI epitope logo
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, Cytokine production, HLA binding, Other
Keywords vaccine-induced immune responses, HLA cross-presentation, HLA associated polymorphism

Notes

References

Reche2006 Pedro A. Reche, Derin B. Keskin, Rebecca E. Hussey, Petronela Ancuta, Dana Gabuzda, and Ellis L. Reinherz. Elicitation from Virus-Naive Individuals of Cytotoxic T Lymphocytes Directed against Conserved HIV-1 Epitopes. Med. Immunol., 5:1, 2006. PubMed ID: 16674822. Show all entries for this paper.


Displaying record number 60970

HXB2 Location Pol(132-140)
Protease(76-84)
DNA(2478..2504)
Pol Epitope Map
Author Location Protease(76-84)
Epitope LVGPTPVNI Epitope Alignment
LVGPTPVNI epitope logo
Subtype B
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Patient MHC/HLA 53617: A*0201, A*0205, B*2705, B*4901, C*0202, C*0701
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords acute/early infection

Notes

References

Kunwar2013 Pratima Kunwar, Natalie Hawkins, Warren L. Dinges, Yi Liu, Erin E. Gabriel, David A. Swan, Claire E. Stevens, Janine Maenza, Ann C. Collier, James I. Mullins, Tomer Hertz, Xuesong Yu, and Helen Horton. Superior Control of HIV-1 Replication by CD8+ T Cells Targeting Conserved Epitopes: Implications for HIV Vaccine Design. PLoS One, 8(5):e64405, 2013. PubMed ID: 23741326. Show all entries for this paper.


Displaying record number 400

HXB2 Location Pol(132-140)
Protease(76-84)
DNA(2478..2504)
Pol Epitope Map
Author Location Protease(75-84 MN)
Epitope LVGPTPVNI Epitope Alignment
LVGPTPVNI epitope logo
Subtype B
Species (MHC/HLA) human(A*0201)
Immunogen in vitro stimulation or selection
Experimental methods Chromium-release assay, HLA binding, Other
Keywords binding affinity

Notes

References

Konya1997 J. Konya, G. Stuber, A. Bjorndal, E. M. Fenyo, and J. Dillner. Primary induction of human cytotoxic lymphocytes against a synthetic peptide of the human immunodeficiency virus type 1 protease. J. Gen. Virol., 78:2217-2224, 1997. PubMed ID: 9292009. Show all entries for this paper.


Displaying record number 53051

HXB2 Location Pol(132-140)
Protease(76-84)
DNA(2478..2504)
Pol Epitope Map
Author Location Protease(76-84)
Epitope LVGPTPVNI Epitope Alignment
LVGPTPVNI epitope logo
Show epitope variants
Subtype B
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Country Canada
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay
Keywords HAART, ART, escape, immunotherapy, variant cross-reactivity

Notes

References

Mason2004 Rosemarie D. Mason, M. Ian Bowmer, Constance M. Howley, Maureen Gallant, Jennifer C. E. Myers, and Michael D. Grant. Antiretroviral Drug Resistance Mutations Sustain or Enhance CTL Recognition of Common HIV-1 Pol Epitopes. J. Immunol., 172(11):7212-7219, 1 Jun 2004. PubMed ID: 15153547. Show all entries for this paper.


Displaying record number 54230

HXB2 Location Pol(132-140)
Protease(76-84)
DNA(2478..2504)
Pol Epitope Map
Author Location Protease
Epitope LVGPTPVNI Epitope Alignment
LVGPTPVNI epitope logo
Epitope Name A2-LI9(Pro)
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, immunodominance, early-expressed proteins

Notes

References

Altfeld2006 Marcus Altfeld, Elizabeth T. Kalife, Ying Qi, Hendrik Streeck, Mathias Lichterfeld, Mary N. Johnston, Nicole Burgett, Martha E. Swartz, Amy Yang, Galit Alter, Xu G. Yu, Angela Meier, Juergen K. Rockstroh, Todd M. Allen, Heiko Jessen, Eric S. Rosenberg, Mary Carrington, and Bruce D. Walker. HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8+ T Cell Response against HIV-1. PLoS Med., 3(10):e403, Oct 2006. PubMed ID: 17076553. Show all entries for this paper.


Displaying record number 52727

HXB2 Location Pol(132-140)
Protease(76-84)
DNA(2478..2504)
Pol Epitope Map
Author Location Protease(76-84 HXB2)
Epitope LVGPTPVNI Epitope Alignment
LVGPTPVNI epitope logo
Show epitope variants
Epitope Name PR82V
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Experimental methods Chromium-release assay, Intracellular cytokine staining
Keywords HAART, ART, escape

Notes

References

Karlsson2003 Annika C Karlsson, Steven G Deeks, Jason D Barbour, Brandon D Heiken, Sophie R Younger, Rebecca Hoh, Meghan Lane, Matti Sällberg, Gabriel M Ortiz, James F Demarest, Teri Liegler, Robert M Grant, Jeffrey N Martin, and Douglas F Nixon. Dual Pressure from Antiretroviral Therapy and Cell-Mediated Immune Response on the Human Immunodeficiency Virus Type 1 Protease Gene. J. Virol., 77(12):6743-6752, Jun 2003. PubMed ID: 12767994. Show all entries for this paper.


Displaying record number 55013

HXB2 Location Pol(132-140)
Protease(76-84)
DNA(2478..2504)
Pol Epitope Map
Author Location  
Epitope LVGPTPVNI Epitope Alignment
LVGPTPVNI epitope logo
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, HLA binding
Keywords binding affinity, immunodominance, optimal epitope

Notes

References

Bihl2006 Florian Bihl, Nicole Frahm, Loriana Di Giammarino, John Sidney, Mina John, Karina Yusim, Tonia Woodberry, Kaori Sango, Hannah S. Hewitt, Leah Henry, Caitlyn H. Linde, John V. Chisholm, III, Tauheed M. Zaman, Eunice Pae, Simon Mallal, Bruce D Walker, Alessandro Sette, Bette T. Korber, David Heckerman, and Christian Brander. Impact of HLA-B Alleles, Epitope Binding Affinity, Functional Avidity, and Viral Coinfection on the Immunodominance of Virus-Specific CTL Responses. J. Immunol., 176(7):4094-4101, 1 Apr 2006. PubMed ID: 16547245. Show all entries for this paper.


Displaying record number 53813

HXB2 Location Pol(132-140)
Protease(76-84)
DNA(2478..2504)
Pol Epitope Map
Author Location Protease(76-84)
Epitope LVGPTPVNI Epitope Alignment
LVGPTPVNI epitope logo
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Country Canada
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, Flow cytometric T-cell cytokine assay
Keywords variant cross-reactivity, characterizing CD8+ T cells

Notes

References

Mason2005 R. D. Mason, M. I. Bowmer, C. M. Howley, and M. D. Grant. Cross-Reactive Cytotoxic T Lymphocytes against Human Immunodeficiency Virus Type 1 Protease and Gamma Interferon-Inducible Protein 30. J. Virol., 79(9):5529-5536, May 2005. PubMed ID: 15827167. Show all entries for this paper.


Displaying record number 53578

HXB2 Location Pol(132-140)
Protease(76-84)
DNA(2478..2504)
Pol Epitope Map
Author Location Protease(76-84)
Epitope LVGPTPVNI Epitope Alignment
LVGPTPVNI epitope logo
Subtype B
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, HLA binding
Keywords acute/early infection, optimal epitope

Notes

References

Altfeld2005a Marcus Altfeld, Todd M. Allen, Elizabeth T. Kalife, Nicole Frahm, Marylyn M. Addo, Bianca R. Mothe, Almas Rathod, Laura L. Reyor, Jason Harlow, Xu G. Yu, Beth Perkins, Loren K. Robinson, John Sidney, Galit Alter, Mathias Lichterfeld, Alessandro Sette, Eric S. Rosenberg, Philip J. R. Goulder, Christian Brander, and Bruce D. Walker. The Majority of Currently Circulating Human Immunodeficiency Virus Type 1 Clade B Viruses Fail To Prime Cytotoxic T-Lymphocyte Responses against an Otherwise Immunodominant HLA-A2-Restricted Epitope: Implications for Vaccine Design. J. Virol., 79(8):5000-5005, Apr 2005. PubMed ID: 15795285. Show all entries for this paper.


Displaying record number 1601

HXB2 Location Pol(132-140)
Protease(76-84)
DNA(2478..2504)
Pol Epitope Map
Author Location Pol(156-164)
Epitope LVGPTPVNI Epitope Alignment
LVGPTPVNI epitope logo
Species (MHC/HLA) human(A2 supertype)
Immunogen HIV-1 infection
Experimental methods  
Keywords supertype, rate of progression

Notes

References

Propato2001 A. Propato, E. Schiaffella, E. Vicenzi, V. Francavilla, L. Baloni, M. Paroli, L. Finocchi, N. Tanigaki, S. Ghezzi, R. Ferrara, R. Chesnut, B. Livingston, A. Sette, R. Paganelli, F. Aiuti, G. Poli, and V. Barnaba. Spreading of HIV-specific CD8+ T-cell repertoire in long-term nonprogressors and its role in the control of viral load and disease activity. Hum. Immunol., 62(6):561-76, Jun 2001. PubMed ID: 11390031. Show all entries for this paper.


Displaying record number 60011

HXB2 Location Pol(132-140)
Protease(76-84)
DNA(2478..2504)
Pol Epitope Map
Author Location Pol(132-140)
Epitope LVGPTPVNI Epitope Alignment
LVGPTPVNI epitope logo
Epitope Name LI9
Species (MHC/HLA) human(B*40)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 59276

HXB2 Location Pol(132-140)
Protease(76-84)
DNA(2478..2504)
Pol Epitope Map
Author Location  
Epitope LVGPTPVNI Epitope Alignment
LVGPTPVNI epitope logo
Epitope Name peptide 42
Species (MHC/HLA) mouse(H-2Dd)
Immunogen vaccine
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining
Keywords vaccine-induced immune responses, optimal epitope, novel epitope

Vaccine Details

Vaccine type modified vaccinia Ankara (MVA), adenovirus
Vaccine component p17 Gag, p24 Gag

Notes

References

Ondondo2014 Beatrice Ondondo, Sultan Abdul-Jawad, Anne Bridgeman, and Tomáš Hanke. Characterization of T-Cell Responses to Conserved Regions of the HIV-1 Proteome in BALB/c Mice. Clin. Vaccine Immunol., 21(11):1565-1572, Nov 2014. PubMed ID: 25230940. Show all entries for this paper.


Displaying record number 59153

HXB2 Location Pol(132-140)
Protease(76-84)
DNA(2478..2504)
Pol Epitope Map
Author Location Pol(76-84)
Epitope LVGPTPVNI Epitope Alignment
LVGPTPVNI epitope logo
Epitope Name Pol-LI9
Subtype B
Species (MHC/HLA) mouse(H-2Dd)
Immunogen vaccine
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining, Tetramer binding
Keywords acute/early infection, TCR usage, characterizing CD8+ T cells

Vaccine Details

Vaccine type AIDSVAX B/E
Vaccine component Gag-Pol

Notes

References

Hill2014 Brenna J. Hill, Patricia A. Darrah, Zachary Ende, David R. Ambrozak, Kylie M. Quinn, Sam Darko, Emma Gostick, Linda Wooldridge, Hugo A. van den Berg, Vanessa Venturi, Martin Larsen, Miles P. Davenport, Robert A. Seder, David A. Price, and Daniel C. Douek. Epitope Specificity Delimits the Functional Capabilities of Vaccine-Induced CD8 T Cell Populations. J. Immunol., 193(11):5626-5636, 1 Dec 2014. PubMed ID: 25348625. Show all entries for this paper.


Displaying record number 58725

HXB2 Location Pol(132-140)
Protease(76-84)
DNA(2478..2504)
Pol Epitope Map
Author Location Pol
Epitope LVGPTPVNI Epitope Alignment
LVGPTPVNI epitope logo
Epitope Name L9I
Subtype B, C
Species (MHC/HLA) mouse
Immunogen vaccine
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining, Other
Keywords vaccine-induced immune responses, vaccine antigen design

Vaccine Details

Vaccine type attenuated poxvirus vector NYVAC
Vaccine strain B clade, C clade
Vaccine component Env, Gag-Pol, Nef

Notes

References

Bockl2012 Katharina Böckl, Jens Wild, Simon Bredl, Kathrin Kindsmüller, Josef Köstler, and Ralf Wagner. Altering an Artificial Gagpolnef Polyprotein and Mode of ENV Co-Administration Affects the Immunogenicity of a Clade C HIV DNA Vaccine. PLoS One, 7(4):e34723, 2012. PubMed ID: 22509350. Show all entries for this paper.


Displaying record number 55904

HXB2 Location Pol(132-140)
Protease(76-84)
DNA(2478..2504)
Pol Epitope Map
Author Location Protease
Epitope LVGPTPVNI Epitope Alignment
LVGPTPVNI epitope logo
Epitope Name LI9(Proteasee)
Subtype B
Species (MHC/HLA) human
Immunogen HIV-1 infection
Country China
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords  

Notes

References

Zhai2008 Song Zhai, Yan Zhuang, Yang Song, Shu Li, Dedong Huang, Wenzhen Kang, Xinhong Li, Qi Liao, Yanhou Liu, Zhongfang Zhao, Yichen Lu, and Yongtao Sun. HIV-1-Specific Cytotoxic T Lymphocyte (CTL) Responses Against Immunodominant Optimal Epitopes Slow the Progression of AIDS in China. Curr. HIV Res., 6(4):335-350, Jun 2008. PubMed ID: 18691032. Show all entries for this paper.


Displaying record number 61158

HXB2 Location Pol(132-140)
Protease(76-84)
DNA(2478..2504)
Pol Epitope Map
Author Location  
Epitope LVGPTPVNI Epitope Alignment
LVGPTPVNI epitope logo
Show epitope variants
Subtype B
Species (MHC/HLA) human, mouse
Immunogen HIV-1 infection, vaccine
Country Japan
Experimental methods CD8 T-cell Elispot - IFNγ, Other
Keywords vaccine-induced immune responses, vaccine antigen design

Vaccine Details

Vaccine type DNA, modified vaccinia Ankara (MVA), adenovirus
Vaccine strain B clade

Notes

References

Ondondo2016 Beatrice Ondondo, Hayato Murakoshi, Genevieve Clutton, Sultan Abdul-Jawad, Edmund G.-T. Wee, Hiroyuki Gatanaga, Shinichi Oka, Andrew J. McMichael, Masafumi Takiguchi, Bette Korber, and Tomáš Hanke. Novel Conserved-region T-cell Mosaic Vaccine With High Global HIV-1 Coverage Is Recognized by Protective Responses in Untreated Infection. Mol. Ther., 24(4):832-842, Apr 2016. PubMed ID: 26743582. Show all entries for this paper.


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