Search CTL/CD8+ T-Cell Epitope Database

Found 2 matching records:

Displaying record number 57632

HXB2 Location	Nef(76-84) DNA(9022..9048)	Nef Epitope Map
Author Location	Nef(76-84 consensus B)
Epitope	LRPMTYKAA	Epitope Alignment
Epitope Name	Nef 76-84
Subtype	B
Species (MHC/HLA)	human(B*2703)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining
Keywords	dendritic cells, optimal epitope

Notes

• The study showed for the first time that peptide-loaded, CD40L-matured dendritic cells from HI-1-infected persons on ART produced CD8 T cells for a much broader range and magnitude of Gag and Nef epitopes than did peptides without dendritic cells. Dendritic cells were used to reveal novel Gag and Nef epitopes.
• Novel optimal B*2703-restricted epitope LRPMTYKAA was mapped from a reactive 15mer.

References

Huang2010a Xiao-Li Huang, Zheng Fan, LuAnn Borowski, Robbie B. Mailliard, Morgane Rolland, James I. Mullins, Richard D. Day, and Charles R. Rinaldo. Dendritic Cells Reveal a Broad Range of MHC Class I Epitopes for HIV-1 in Persons with Suppressed Viral Load on Antiretroviral Therapy. PLoS One, 5(9):e12936, 2010. PubMed ID: 20886040. Show all entries for this paper.

Displaying record number 58610

HXB2 Location	Nef(76-84) DNA(9022..9048)	Nef Epitope Map
Author Location	Nef(76-84 consensus B)
Epitope	LRPMTYKAA	Epitope Alignment
Epitope Name	Nef 76-84
Subtype	B
Species (MHC/HLA)	human(B*2703)
Immunogen	HIV-1 infection
Country	United States
Experimental methods
Keywords	optimal epitope

Notes

• C. Brander noted this as an optimal B*2703 epitope based on data from <cite>Huang 2010a</cite>.

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.