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Displaying record number 54963

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HXB2 Location	Rev(13-21) DNA(6006..6032)	Rev Epitope Map
Author Location	Rev(13-21)
Epitope	LRAVRIIKI	Epitope Alignment
		Show epitope variants
Epitope Name	LI9
Subtype	A, B
Species (MHC/HLA)	human(B*57:01, B*57:03)
Immunogen	HIV-1 infection
Country	Kenya, United Kingdom
Experimental methods	CD8 T-cell Elispot - IFNγ, Chromium-release assay
Keywords	escape, optimal epitope

Notes

• The study describes the identification of a novel HLA-B*5701, B*5703 optimal epitope LRAVRIIKI, which accounted for 25% and 40% of the total CTL responses in two patients.
• R2K replacement (LkAVRIIKI) resulted in more efficient lysis. I9F (LRAVRIIKf) variant had reduced CTL recognition.

References

Makadzange2006 Azure T. Makadzange, Geraldine Gillespie, Joshua Kimani, Peter Kiama, Philippa Easterbrook, Job J. Bwayo, and Sarah L Rowland-Jones. Identification of a novel HLA B*57 Restricted Cytotoxic T-Lymphocyte Epitope within HIV-1 Rev. AIDS, 20(3):462-464, 14 Feb 2006. PubMed ID: 16439884. Show all entries for this paper.