Search CTL/CD8+ T-Cell Epitope Database

Found 2 matching records:

Displaying record number 55528

HXB2 Location	Pol(304-313) RT(149-158) DNA(2994..3023)	Pol Epitope Map
Author Location	Pol(303-312)
Epitope	LPQGWKGSPA	Epitope Alignment
Epitope Name	LA10
Subtype	B
Species (MHC/HLA)	human(B*5401)
Immunogen	HIV-1 infection
Country	Japan
Experimental methods	Chromium-release assay, Intracellular cytokine staining
Keywords	optimal epitope

Notes

• Asian-expressed HLA-B*5401-restricted epitopes were identified using overlapping-peptide methods and characterized. 5 epitopes from Pol and Nef induced CTL responses that killed target cells in more than 25% of B*5401-carrying tested patients.
• 7 peptides from Pol and Nef are listed in Fig. 2 as candidates for B*5401 restriction. No Gag-specific epitopes were identified in this study from the patient whose lymphocytes were screened.
• LPQGWKGSPA was defined as an optimal epitope for HLA-B*5401 restriction, using truncated peptides.

References

Kitano2008 Mitsutaka Kitano, Naoki Kobayashi, Yuka Kawashima, Tomohiro Akahoshi, Kiyoshi Nokihara, Shinichi Oka, and Masafumi Takighuchi. Identification and Characterization of HLA-B*5401-Restricted HIV-1-Nef and Pol-Specific CTL Epitopes. Microbes Infect, 10(7):7647-72, Jun 2008. PubMed ID: 18538615. Show all entries for this paper.

Displaying record number 58614

HXB2 Location	Pol(304-313) RT(149-158) DNA(2994..3023)	Pol Epitope Map
Author Location	Pol(303-312)
Epitope	LPQGWKGSPA	Epitope Alignment
Epitope Name	LA10
Subtype	B
Species (MHC/HLA)	human(B*5401)
Immunogen	HIV-1 infection
Country	Japan
Experimental methods
Keywords	optimal epitope

Notes

• C. Brander noted this as an optimal B*5401 epitope based on data from Kitano Microbes and Infection 10 (2008).

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.