HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 17 matching records:

Displaying record number 54027

HXB2 Location Pol(743-751)
Integrase(28-36)
DNA(4311..4337)
Pol Epitope Map
Author Location ( C consensus)
Epitope LPPIVAKEI Epitope Alignment
LPPIVAKEI epitope logo
Subtype C
Species (MHC/HLA) human(B*0705)
Immunogen HIV-1 infection
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, optimal epitope

Notes

References

Kiepiela2007 Photini Kiepiela, Kholiswa Ngumbela, Christina Thobakgale, Dhanwanthie Ramduth, Isobella Honeyborne, Eshia Moodley, Shabashini Reddy, Chantal de Pierres, Zenele Mncube, Nompumelelo Mkhwanazi, Karen Bishop, Mary van der Stok, Kriebashnie Nair, Nasreen Khan, Hayley Crawford, Rebecca Payne, Alasdair Leslie, Julia Prado, Andrew Prendergast, John Frater, Noel McCarthy, Christian Brander, Gerald H. Learn, David Nickle, Christine Rousseau, Hoosen Coovadia, James I. Mullins, David Heckerman, Bruce D. Walker, and Philip Goulder. CD8+ T-Cell Responses to Different HIV Proteins Have Discordant Associations with Viral Load. Nat. Med., 13(1):46-53, Jan 2007. PubMed ID: 17173051. Show all entries for this paper.


Displaying record number 62231

HXB2 Location Pol(743-751)
Integrase(28-36)
DNA(805..834)
Pol Epitope Map
Author Location Pol(743-751)
Epitope LPPIVAKEI Epitope Alignment
LPPIVAKEI epitope logo
Show epitope variants
Epitope Name Pol-LI9
Subtype C
Species (MHC/HLA) human(B*42)
Immunogen HIV-1 infection
Patient MHC/HLA 517-C: A*3002, A*6802, B*1510, B*4201, Cw*0304, Cw*1701; 517-M: A*3002, A*3004, B*4201, B*5802, Cw*0602, Cw*1701
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ, Other
Keywords responses in children, mother-to-infant transmission, rate of progression, escape

Notes

References

Leitman2017 Ellen M. Leitman, Christina F. Thobakgale, Emily Adland, M. Azim Ansari, Jayna Raghwani, Andrew J. Prendergast, Gareth Tudor-Williams, Photini Kiepiela, Joris Hemelaar, Jacqui Brener, Ming-Han Tsai, Masahiko Mori, Lynn Riddell, Graz Luzzi, Pieter Jooste, Thumbi Ndung'u, Bruce D. Walker, Oliver G. Pybus, Paul Kellam, Vivek Naranbhai, Philippa C. Matthews, Astrid Gall, and Philip J. R. Goulder. Role of HIV-Specific CD8+ T Cells in Pediatric HIV Cure Strategies after Widespread Early Viral Escape. J. Exp. Med., 214(11):3239-3261, 6 Nov 2017. PubMed ID: 28983013. Show all entries for this paper.


Displaying record number 55079

HXB2 Location Pol(743-751)
Integrase(28-36)
DNA(4311..4337)
Pol Epitope Map
Author Location Integrase(28-36)
Epitope LPPIVAKEI Epitope Alignment
LPPIVAKEI epitope logo
Epitope Name LI9
Species (MHC/HLA) human(B*4201)
Immunogen peptide-HLA interaction
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ, HLA binding, Intracellular cytokine staining
Keywords optimal epitope

Notes

References

Honeyborne2006 Isobella Honeyborne, Almas Rathod, Rico Buchli, Dhanwanthie Ramduth, Eshia Moodley, Prinisha Rathnavalu, Senica Chetty, Cheryl Day, Christian Brander, William Hildebrand, Bruce D. Walker, Photini Kiepiela, and Philip J. R. Goulder. Motif Inference Reveals Optimal CTL Epitopes Presented by HLA Class I Alleles Highly Prevalent in Southern Africa. J. Immunol., 176(8):4699-4705, 15 Apr 2006. PubMed ID: 16585563. Show all entries for this paper.


Displaying record number 53939

HXB2 Location Pol(743-751)
Integrase(28-36)
DNA(4311..4337)
Pol Epitope Map
Author Location ( C consensus)
Epitope LPPIVAKEI Epitope Alignment
LPPIVAKEI epitope logo
Subtype C
Species (MHC/HLA) human(B*4201)
Immunogen HIV-1 infection
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, optimal epitope

Notes

References

Kiepiela2007 Photini Kiepiela, Kholiswa Ngumbela, Christina Thobakgale, Dhanwanthie Ramduth, Isobella Honeyborne, Eshia Moodley, Shabashini Reddy, Chantal de Pierres, Zenele Mncube, Nompumelelo Mkhwanazi, Karen Bishop, Mary van der Stok, Kriebashnie Nair, Nasreen Khan, Hayley Crawford, Rebecca Payne, Alasdair Leslie, Julia Prado, Andrew Prendergast, John Frater, Noel McCarthy, Christian Brander, Gerald H. Learn, David Nickle, Christine Rousseau, Hoosen Coovadia, James I. Mullins, David Heckerman, Bruce D. Walker, and Philip Goulder. CD8+ T-Cell Responses to Different HIV Proteins Have Discordant Associations with Viral Load. Nat. Med., 13(1):46-53, Jan 2007. PubMed ID: 17173051. Show all entries for this paper.


Displaying record number 53303

HXB2 Location Pol(743-751)
Integrase(28-36)
DNA(4311..4337)
Pol Epitope Map
Author Location ( C consensus)
Epitope LPPIVAKEI Epitope Alignment
LPPIVAKEI epitope logo
Subtype C
Species (MHC/HLA) human(B*4201)
Immunogen HIV-1 infection
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords characterizing CD8+ T cells

Notes

References

Kiepiela2004 Photini Kiepiela, Alasdair J. Leslie, Isobella Honeyborne, Danni Ramduth, Christina Thobakgale, Senica Chetty, Prinisha Rathnavalu, Corey Moore, Katja J. Pfafferott, Louise Hilton, Peter Zimbwa, Sarah Moore, Todd Allen, Christian Brander, Marylyn M. Addo, Marcus Altfeld, Ian James, Simon Mallal, Michael Bunce, Linda D. Barber, James Szinger, Cheryl Day, Paul Klenerman, James Mullins, Bette Korber, Hoosen M. Coovadia, Bruce D. Walker, and Philip J. R. Goulder. Dominant Influence of HLA-B in Mediating the Potential Co-Evolution of HIV and HLA. Nature, 432(7018):769-775, 9 Dec 2004. LA-UR 04-5920. PubMed ID: 15592417. Show all entries for this paper.


Displaying record number 56500

HXB2 Location Pol(743-751)
Integrase(28-36)
DNA(4311..4337)
Pol Epitope Map
Author Location Integrase
Epitope LPPIVAKEI Epitope Alignment
LPPIVAKEI epitope logo
Subtype C
Species (MHC/HLA) human(B*4201)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords viral fitness and reversion, HLA associated polymorphism

Notes

References

Matthews2008 Philippa C. Matthews, Andrew Prendergast, Alasdair Leslie, Hayley Crawford, Rebecca Payne, Christine Rousseau, Morgane Rolland, Isobella Honeyborne, Jonathan Carlson, Carl Kadie, Christian Brander, Karen Bishop, Nonkululeko Mlotshwa, James I. Mullins, Hoosen Coovadia, Thumbi Ndung'u, Bruce D. Walker, David Heckerman, and Philip J. R. Goulder. Central Role of Reverting Mutations in HLA Associations with Human Immunodeficiency Virus Set Point. J. Virol., 82(17):8548-8559, Sep 2008. PubMed ID: 18596105. Show all entries for this paper.


Displaying record number 58000

HXB2 Location Pol(743-751)
Integrase(28-36)
DNA(4311..4337)
Pol Epitope Map
Author Location  
Epitope LPPIVAKEI Epitope Alignment
LPPIVAKEI epitope logo
Subtype C
Species (MHC/HLA) human(B*4201)
Immunogen HIV-1 infection
Country South Africa, United Kingdom
Experimental methods CD8 T-cell Elispot - IFNγ, Tetramer binding
Keywords computational epitope prediction, optimal epitope

Notes

References

ErupLarsen2011 Malene Erup Larsen, Henrik Kloverpris, Anette Stryhn, Catherine K. Koofhethile, Stuart Sims, Thumbi Ndung'u, Philip Goulder, Søren Buus, and Morten Nielsen. HLArestrictor---A Tool for Patient-Specific Predictions of HLA Restriction Elements and Optimal Epitopes within Peptides. Immunogenetics, 63(1):43-55, Jan 2011. PubMed ID: 21079948. Show all entries for this paper.


Displaying record number 58708

HXB2 Location Pol(743-751)
Integrase(28-36)
DNA(4311..4337)
Pol Epitope Map
Author Location Integrase(28-36)
Epitope LPPIVAKEI Epitope Alignment
LPPIVAKEI epitope logo
Show epitope variants
Epitope Name Int-LI9
Subtype C
Species (MHC/HLA) human(B*4201)
Immunogen HIV-1 infection
Patient MHC/HLA A*3001, B*4201, Cw*1701
Country Botswana, South Africa
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords HLA associated polymorphism

Notes

References

Kloverpris2012a Henrik N. Kløverpris, Mikkel Harndahl, Alasdair J. Leslie, Jonathan M. Carlson, Nasreen Ismail, Mary van der Stok, Kuan-Hsiang Gary Huang, Fabian Chen, Lynn Riddell, Dewald Steyn, Dominique Goedhals, Cloete van Vuuren, John Frater, Bruce D. Walker, Mary Carrington, Thumbi Ndung'u, Søren Buus, and Philip Goulder. HIV Control through a Single Nucleotide on the HLA-B Locus. J. Virol., 86(21):11493-11500, Nov 2012. PubMed ID: 22896606. Show all entries for this paper.


Displaying record number 59163

HXB2 Location Pol(743-751)
Integrase(28-36)
DNA(4311..4337)
Pol Epitope Map
Author Location Pol(743-751)
Epitope LPPIVAKEI Epitope Alignment
LPPIVAKEI epitope logo
Epitope Name LI9-RT
Subtype C
Species (MHC/HLA) human(B*4201)
Immunogen HIV-1 infection
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ, HLA binding, Tetramer binding
Keywords TCR usage, characterizing CD8+ T cells

Notes

References

Kloverpris2014a Henrik N. Kløverpris, Reuben McGregor, James E McLaren, Kristin Ladell, Anette Stryhn, Catherine Koofhethile, Jacqui Brener, Fabian Chen, Lynn Riddell, Luzzi Graziano, Paul Klenerman, Alasdair Leslie, Søren Buus, David A. Price, and Philip Goulder. Programmed Death-1 Expression on HIV-1-Specific CD8+ T Cells Is Shaped by Epitope Specificity, T-Cell Receptor Clonotype Usage and Antigen Load. AIDS, 28(14):2007-2021, 10 Sep 2014. PubMed ID: 24906112. Show all entries for this paper.


Displaying record number 59436

HXB2 Location Pol(743-751)
Integrase(28-36)
DNA(4311..4337)
Pol Epitope Map
Author Location Pol(743-751)
Epitope LPPIVAKEI Epitope Alignment
LPPIVAKEI epitope logo
Show epitope variants
Epitope Name Int-LI9
Subtype C
Species (MHC/HLA) human(B*4201)
Immunogen HIV-1 infection
Country Botswana, South Africa, United Kingdom
Experimental methods CD8 T-cell Elispot - IFNγ, Other, Tetramer binding
Keywords immunodominance, escape

Notes

References

Kloverpris2015 Henrik N Kløverpris, Reuben McGregor, James E. McLaren, Kristin Ladell, Mikkel Harndahl, Anette Stryhn, Jonathan M. Carlson, Catherine Koofhethile, Bram Gerritsen, Can Keşmir, Fabian Chen, Lynn Riddell, Graz Luzzi, Alasdair Leslie, Bruce D. Walker, Thumbi Ndung'u, Søren Buus, David A. Price, and Philip J. Goulder. CD8+ TCR Bias and Immunodominance in HIV-1 Infection. J. Immunol., 194(11):5329-5345, 1 Jun 2015. PubMed ID: 25911754. Show all entries for this paper.


Displaying record number 54103

HXB2 Location Pol(743-751)
Integrase(28-36)
DNA(4311..4337)
Pol Epitope Map
Author Location  
Epitope LPPIVAKEI Epitope Alignment
LPPIVAKEI epitope logo
Epitope Name LI9
Species (MHC/HLA) human(B*4201)
Immunogen  
Experimental methods  
Keywords optimal epitope

Notes

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 59311

HXB2 Location Pol(743-751)
Integrase(28-36)
DNA(4311..4337)
Pol Epitope Map
Author Location Integrase
Epitope LPPIVAKEI Epitope Alignment
LPPIVAKEI epitope logo
Epitope Name LI9
Species (MHC/HLA) human(B*51)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression

Notes

References

Streeck2014 Hendrik Streeck, Richard Lu, Noor Beckwith, Mark Milazzo, Michelle Liu, Jean-Pierre Routy, Susan Little, Heiko Jessen, Anthony D. Kelleher, Frederick Hecht, Rafick-Pierre Sekaly, Galit Alter, David Heckerman, Mary Carrington, Eric S. Rosenberg, and Marcus Altfeld. Emergence of Individual HIV-Specific CD8 T Cell Responses during Primary HIV-1 Infection Can Determine Long-Term Disease Outcome. J. Virol., 88(21):12793-12801, Nov 2014. PubMed ID: 25165102. Show all entries for this paper.


Displaying record number 54291

HXB2 Location Pol(743-751)
Integrase(28-36)
DNA(4311..4337)
Pol Epitope Map
Author Location Integrase
Epitope LPPIVAKEI Epitope Alignment
LPPIVAKEI epitope logo
Epitope Name LI9
Subtype B
Species (MHC/HLA) human(B*51)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords escape, HLA associated polymorphism

Notes

References

Bhattacharya2007 Tanmoy Bhattacharya, Marcus Daniels, David Heckerman, Brian Foley, Nicole Frahm, Carl Kadie, Jonathan Carlson, Karina Yusim, Ben McMahon, Brian Gaschen, Simon Mallal, James I. Mullins, David C. Nickle, Joshua Herbeck, Christine Rousseau, Gerald H. Learn, Toshiyuki Miura, Christian Brander, Bruce Walker, and Bette Korber. Founder Effects in the Assessment of HIV Polymorphisms and HLA Allele Associations. Science, 315(5818):1583-1586, 16 Mar 2007. PubMed ID: 17363674. Show all entries for this paper.


Displaying record number 53777

HXB2 Location Pol(743-751)
Integrase(28-36)
DNA(4311..4337)
Pol Epitope Map
Author Location Integrase(28-36)
Epitope LPPIVAKEI Epitope Alignment
LPPIVAKEI epitope logo
Show epitope variants
Epitope Name LI9
Subtype B, C
Species (MHC/HLA) human(B51)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, HLA binding
Keywords subtype comparisons, computational epitope prediction, mother-to-infant transmission, escape, viral fitness and reversion, optimal epitope

Notes

References

Leslie2005a Alasdair Leslie, Daniel Kavanagh, Isobella Honeyborne, Katja Pfafferott, Charles Edwards, Tilly Pillay, Louise Hilton, Christina Thobakgale, Danni Ramduth, Rika Draenert, Sylvie Le Gall, Graz Luzzi, Anne Edwards, Christian Brander, Andrew K. Sewell, Sarah Moore, James Mullins, Corey Moore, Simon Mallal, Nina Bhardwaj, Karina Yusim, Rodney Phillips, Paul Klenerman, Bette Korber, Photini Kiepiela, Bruce Walker, and Philip Goulder. Transmission and Accumulation of CTL Escape Variants Drive Negative Associations between HIV Polymorphisms and HLA. J. Exp. Med., 201(6):891-902, 21 Mar 2005. PubMed ID: 15781581. Show all entries for this paper.


Displaying record number 54028

HXB2 Location Pol(743-751)
Integrase(28-36)
DNA(4311..4337)
Pol Epitope Map
Author Location ( C consensus)
Epitope LPPIVAKEI Epitope Alignment
LPPIVAKEI epitope logo
Subtype C
Species (MHC/HLA) human(B*5101)
Immunogen HIV-1 infection
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, optimal epitope

Notes

References

Kiepiela2007 Photini Kiepiela, Kholiswa Ngumbela, Christina Thobakgale, Dhanwanthie Ramduth, Isobella Honeyborne, Eshia Moodley, Shabashini Reddy, Chantal de Pierres, Zenele Mncube, Nompumelelo Mkhwanazi, Karen Bishop, Mary van der Stok, Kriebashnie Nair, Nasreen Khan, Hayley Crawford, Rebecca Payne, Alasdair Leslie, Julia Prado, Andrew Prendergast, John Frater, Noel McCarthy, Christian Brander, Gerald H. Learn, David Nickle, Christine Rousseau, Hoosen Coovadia, James I. Mullins, David Heckerman, Bruce D. Walker, and Philip Goulder. CD8+ T-Cell Responses to Different HIV Proteins Have Discordant Associations with Viral Load. Nat. Med., 13(1):46-53, Jan 2007. PubMed ID: 17173051. Show all entries for this paper.


Displaying record number 56099

HXB2 Location Pol(743-751)
Integrase(28-36)
DNA(4311..4337)
Pol Epitope Map
Author Location Pol
Epitope LPPIVAKEI Epitope Alignment
LPPIVAKEI epitope logo
Epitope Name Pol1130
Subtype C
Species (MHC/HLA) human(B7)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, HLA binding
Keywords binding affinity, computational epitope prediction, HLA associated polymorphism

Notes

References

DeGroot2008 Anne S. De Groot, Daniel S. Rivera, Julie A. McMurry, Soren Buus, and William Martin. Identification of Immunogenic HLA-B7 ``Achilles' Heel'' Epitopes within Highly Conserved Regions of HIV. Vaccine, 26(24):3059-3071, 6 Jun 2008. PubMed ID: 18206276. Show all entries for this paper.


Displaying record number 54198

HXB2 Location Pol(743-751)
Integrase(28-36)
DNA(4311..4337)
Pol Epitope Map
Author Location Integrase(27-36)
Epitope LPPIVAKEI Epitope Alignment
LPPIVAKEI epitope logo
Epitope Name LI9
Subtype C
Species (MHC/HLA) human
Immunogen HIV-1 infection
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ, Other, Tetramer binding
Keywords supertype, HLA cross-presentation, TCR usage, HLA associated polymorphism

Notes

References

Leslie2006 Alasdair Leslie, David A. Price, Pamela Mkhize, Karen Bishop, Almas Rathod, Cheryl Day, Hayley Crawford, Isobella Honeyborne, Tedi E. Asher, Graz Luzzi, Anne Edwards, Christine M. Rousseau, James I. Mullins, Gareth Tudor-Williams, Vas Novelli, Christian Brander, Daniel C. Douek, Photini Kiepiela, Bruce D. Walker, and Philip J. R. Goulder. Differential Selection Pressure Exerted on HIV by CTL Targeting Identical Epitopes but Restricted by Distinct HLA Alleles from the Same HLA Supertype. J. Immunol., 177(7):4699-4708, 1 Oct 2006. PubMed ID: 16982909. Show all entries for this paper.


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