Search CTL/CD8+ T-Cell Epitope Database

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Displaying record number 789

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HXB2 Location	gp160(416-429) gp120(416-429) DNA(7470..7511)	gp160 Epitope Map
Author Location	gp120(410-429 H3DCG)
Epitope	LPCRIKQFINMWQE	Epitope Alignment
Species (MHC/HLA)	human(DR4)
Immunogen	HIV-1 infection
Experimental methods
Keywords	CD4+ CTL

Notes

• CD4+ CTL restricted by class II HLA-DR4, targets primed by CD4 mediated uptake of gp120.

References

Siliciano1988 R. Siliciano, T. Lawton, C. Knall, R. Karr, P. Berman, T. Gregory, and E. Reinherz. Analysis of Host-Virus Interactions in AIDS with Anti-gp120 T Cell Clones: Effect of HIV Sequence Variation and a Mechanism for CD4+ Cell Depletion. Cell, 54:561-575, 1988. This article demonstrated that a class II HLA-DR4 restricted response can be stimulated by CD4 uptake of gp120, suggesting a mechanism for T-cell depletion in vivo. This peptide containing the epitope was also able to stimulate a class I restricted, CD8+ CTL response. PubMed ID: 2969774. Show all entries for this paper.