HIV molecular immunology database


Search CTL/CD8+ T-Cell Epitope Database

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Displaying record number 789

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HXB2 Location gp160(416-429)
gp160 Epitope Map
Author Location gp120(410-429 H3DCG)
Epitope LPCRIKQFINMWQE Epitope Alignment
Species (MHC/HLA) human(DR4)
Immunogen HIV-1 infection
Experimental methods  
Keywords CD4+ CTL



Siliciano1988 R. Siliciano, T. Lawton, C. Knall, R. Karr, P. Berman, T. Gregory, and E. Reinherz. Analysis of Host-Virus Interactions in AIDS with Anti-gp120 T Cell Clones: Effect of HIV Sequence Variation and a Mechanism for CD4+ Cell Depletion. Cell, 54:561-575, 1988. This article demonstrated that a class II HLA-DR4 restricted response can be stimulated by CD4 uptake of gp120, suggesting a mechanism for T-cell depletion in vivo. This peptide containing the epitope was also able to stimulate a class I restricted, CD8+ CTL response. PubMed ID: 2969774. Show all entries for this paper.

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