HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 8 matching records:

Displaying record number 54321

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HXB2 Location Pol(956-964)
Integrase(241-249)
DNA(4950..4976)
Pol Epitope Map
Author Location RT(241-249)
Epitope LLWKGEGAV Epitope Alignment
LLWKGEGAV epitope logo
Species (MHC/HLA) human(A*02:01)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, Cytokine production, HLA binding, Other
Keywords vaccine-induced immune responses, HLA cross-presentation, HLA associated polymorphism

Notes

References

Reche2006 Pedro A. Reche, Derin B. Keskin, Rebecca E. Hussey, Petronela Ancuta, Dana Gabuzda, and Ellis L. Reinherz. Elicitation from Virus-Naive Individuals of Cytotoxic T Lymphocytes Directed against Conserved HIV-1 Epitopes. Med. Immunol., 5:1, 2006. PubMed ID: 16674822. Show all entries for this paper.


Displaying record number 52300

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HXB2 Location Pol(956-964)
Integrase(241-249)
DNA(4950..4976)
Pol Epitope Map
Author Location RT(956-964 HXB2R)
Epitope LLWKGEGAV Epitope Alignment
LLWKGEGAV epitope logo
Epitope Name LR28
Subtype B
Species (MHC/HLA) mouse(A*02:01)
Immunogen vaccine
Experimental methods  
Keywords binding affinity, vaccine-induced immune responses, immunodominance

Vaccine Details

Vaccine type peptide
Vaccine strain B clade LAI
Adjuvant Incomplete Freund's Adjuvant (IFA), Montanide (ISA 720), P30, PLG

Notes

References

Peter2001 Katrin Peter, Ying Men, Giuseppe Pantaleo, Bruno Gander, and Giampietro Corradin. Induction of a Cytotoxic T-Cell Response to HIV-1 Proteins with Short Synthetic Peptides and Human Compatible Adjuvants. Vaccine, 19(30):4121-4129, 20 Jul 2001. PubMed ID: 11457536. Show all entries for this paper.


Displaying record number 52301

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HXB2 Location Pol(956-964)
Integrase(241-249)
DNA(4950..4976)
Pol Epitope Map
Author Location RT(956-964 HXB2R)
Epitope LLWKGEGAV Epitope Alignment
LLWKGEGAV epitope logo
Epitope Name LR28
Subtype B
Species (MHC/HLA) mouse(A*02:01)
Immunogen vaccine
Experimental methods  
Keywords vaccine-induced immune responses, immunodominance

Vaccine Details

Vaccine type peptide
Vaccine strain B clade LAI
Adjuvant Incomplete Freund's Adjuvant (IFA), IL-12, P30

Notes

References

Peter2001 Katrin Peter, Ying Men, Giuseppe Pantaleo, Bruno Gander, and Giampietro Corradin. Induction of a Cytotoxic T-Cell Response to HIV-1 Proteins with Short Synthetic Peptides and Human Compatible Adjuvants. Vaccine, 19(30):4121-4129, 20 Jul 2001. PubMed ID: 11457536. Show all entries for this paper.

Peter2002 Katrin Peter, Michael J. Brunda, and Giampietro Corradin. IL-12 Administration Leads to a Transient Depletion of T Cells, B Cells, and APCs and Concomitant Abrogation of the HLA-A2.1-Restricted CTL Response in Transgenic Mice. J. Immunol., 169(1):63-67, 1 Jul 2002. PubMed ID: 12077229. Show all entries for this paper.


Displaying record number 53798

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HXB2 Location Pol(956-964)
Integrase(241-249)
DNA(4950..4976)
Pol Epitope Map
Author Location Pol
Epitope LLWKGEGAV Epitope Alignment
LLWKGEGAV epitope logo
Epitope Name L9V
Species (MHC/HLA) transgenic mouse(A*02:01)
Immunogen vaccine
Experimental methods Chromium-release assay, Flow cytometric T-cell cytokine assay
Keywords memory cells, vaccine antigen design, characterizing CD8+ T cells

Vaccine Details

Vaccine type measles virus (MV)
Vaccine strain multiple epitope immunogen
Vaccine component gp140, gp140ΔV3

Notes

References

Lorin2005a Clarisse Lorin, Frédéric Delebecque, Valérie Labrousse, Lucie Da Silva, François Lemonnier, Michel Brahic, and Frédéric Tangy. A Recombinant Live Attenuated Measles Vaccine Vector Primes Effective HLA-A0201-Restricted Cytotoxic T Lymphocytes and Broadly Neutralizing Antibodies against HIV-1 Conserved Epitopes. Vaccine, 23(36):4463-4472, 22 Aug 2005. PubMed ID: 15993518. Show all entries for this paper.


Displaying record number 586

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HXB2 Location Pol(956-964)
Integrase(241-249)
DNA(4950..4976)
Pol Epitope Map
Author Location Pol(576-584)
Epitope LLWKGEGAV Epitope Alignment
LLWKGEGAV epitope logo
Species (MHC/HLA) human(A*02:01)
Immunogen in vitro stimulation or selection
Experimental methods  
Keywords  

Notes

References

vanderBurg1996 S. H. van der Burg, M. J. W. Visseren, R. M. P. Brandt, W. M. Kast, and C. J. M. Melief. Immunogenicity of Peptides Bound to MHC Class I Molecules Depends on the MHC-Peptide Complex Stability. J. Immunol., 156:3308-3314, 1996. Peptide-MHC dissociation rate is highly correlated with immunogenicity. In this study, HLA-A*0201 restricted epitopes from HPV, HBV and HIV were studied, some in the context of immunogenicity in peptide immunized HLA-A*0201/K$^b$ transgenic mice. PubMed ID: 8617954. Show all entries for this paper.


Displaying record number 584

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HXB2 Location Pol(956-964)
Integrase(241-249)
DNA(4950..4976)
Pol Epitope Map
Author Location Pol(956-964 HXB2R)
Epitope LLWKGEGAV Epitope Alignment
LLWKGEGAV epitope logo
Species (MHC/HLA) human(A2)
Immunogen peptide-HLA interaction
Experimental methods  
Keywords  

Notes

References

Parker1992 K. C. Parker, M. A. Bednarek, L. K. Hull, U. Utz, B. Cunningham H. J. Zweerink, W. E. Biddison, and J. E. Coligan. Sequence Motifs Important for Peptide Binding to the Human MHC Class I Molecule, HLA-A2. J. Immunol., 149, 1992. PubMed ID: 1331239. Show all entries for this paper.

Parker1994 K. C. Parker, M. A. Bednarek, and J. E. Coligan. Scheme for Ranking Potential HLA-A2 Binding Peptides Based on Independent Binding of Individual Peptide Side-Chains. J. Immunol., 152, 1994. The authors conclude that peptide amino acid side-chain binding to the HLA-A2 molecule is independent of the sequence of the peptide, and developed a table of coefficients that can be used to help predict peptide binding to HLA-A2. PubMed ID: 8254189. Show all entries for this paper.


Displaying record number 585

Download this epitope record as JSON.

HXB2 Location Pol(956-964)
Integrase(241-249)
DNA(4950..4976)
Pol Epitope Map
Author Location Pol(956-964 HXB2R)
Epitope LLWKGEGAV Epitope Alignment
LLWKGEGAV epitope logo
Species (MHC/HLA) human(A2)
Immunogen peptide-HLA interaction
Experimental methods  
Keywords  

Notes

References

Brander1995b C. Brander, W. J. Pichler, and G. Corradin. Identification of HIV-Protein Derived CTL Epitopes for their Potential use as Synthetic Vaccine. Clin. Exp. Immunol., 101:107-113, 1995. PubMed ID: 7621579. Show all entries for this paper.


Displaying record number 583

Download this epitope record as JSON.

HXB2 Location Pol(956-964)
Integrase(241-249)
DNA(4950..4976)
Pol Epitope Map
Author Location Pol(956-964)
Epitope LLWKGEGAV Epitope Alignment
LLWKGEGAV epitope logo
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Experimental methods  
Keywords dendritic cells

Notes

References

Kundu1998 S. K. Kundu, E. Engleman, C. Benike, M. H. Shapero, M. Dupuis, W. C. van Schooten, M. Eibl, and T. C. Merigan. A Pilot Clinical Trial of HIV Antigen-Pulsed Allogeneic and Autologous Dendritic Cell Therapy in HIV-Infected Patients. AIDS Res. Hum. Retroviruses, 14:551-560, 1998. PubMed ID: 9591709. Show all entries for this paper.


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