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Displaying record number 56120

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HXB2 Location	gp160(799-808) gp41(288-297) DNA(8619..8648)	gp160 Epitope Map
Author Location	Env
Epitope	LLLYWGRELK	Epitope Alignment
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Patient MHC/HLA	A*02:01, A*02:05, B*27:03, B*42:01, C*02:02, C*17:01; A*02:01, A*02:05, B*15:03, B*58:01, C*04:01, C*07:01; A*68:02, A*74:01, B*15:10, B*49:01, C*03:04, C*07:01; A*01:01, A*23:01, B*07:02, B*45:01, C*07:02, C*16:01
Country	Kenya
Experimental methods	CD8 T-cell Elispot - IFNγ, Proliferation
Keywords	assay or method development

Notes

• To evaluate the use of IFN-gamma ELISpot and proliferation assays, the two were compared in a cohort of HIV-1-infected Kenyan sex-workers. ELISpot does not always correlate with viral load and replication or disease progression. The exclusive use of these assays makes definition of CTL response in disease incomplete, especially for memory T cells.
• Despite assaying for 24 INF-gamma and 41 proliferative responses, only 5 of these responses overlapped in the same subject. 18 peptide-epitopes including 10 epitopes and their variants were used in this study.
• LLLYWGRELK elicited proliferation in 4 subjects; and ELISpot response in 1 separate subject.

References

McKinnon2008 Lyle R. McKinnon, T. Blake Ball, Charles Wachihi, Nyakio Chinga, Anne Maingi, Ma Luo, Keith R. Fowke, and Francis A. Plummer. Substantial Intrapatient Differences in the Breadth and Specificity of HIV-Specific CD8+ T-Cell Interferon-gamma and Proliferation Responses. J. Acquir. Immune Defic. Syndr., 49(2):123-127, 1 Oct 2008. PubMed ID: 18769359. Show all entries for this paper.