HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

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Displaying record number 56629

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HXB2 Location Nef(90-97)
DNA(9064..9087)
Nef Epitope Map
Author Location Nef(89-97 LAI)
Epitope LLKEKGGL Epitope Alignment
LLKEKGGL epitope logo
Subtype B
Species (MHC/HLA) human(B8)
Immunogen HIV-1 infection
Patient MHC/HLA A1, B7, B8, C*07:01, C*07:02
Experimental methods Chromium-release assay, HLA binding
Keywords variant cross-reactivity

Notes

References

Price1997 D. A. Price, P. J. Goulder, P. Klenerman, A. K. Sewell, P. J. Easterbrook, M. Troop, C. R. Bangham, and R. E. Phillips. Positive Selection of HIV-1 Cytotoxic T Lymphocyte Escape Variants during Primary Infection. Proc. Natl. Acad. Sci. U.S.A., 94:1890-1895, 1997. Cytotoxic T lymphocytes (CTLs) are thought to play a crucial role in the termination of the acute primary HIV-1 syndrome, but clear evidence for this presumption has been lacking. Here we demonstrate positive selection of HIV-1 proviral sequences encoding variants within a CTL epitope in Nef, a gene product critical for viral pathogenicity, during and after seroconversion. These positively selected HIV-1 variants carried epitope sequence changes that either diminished or escaped CTL recognition. Other proviruses had mutations that abolished the Nef epitope altogether. These results provide clear evidence that CTLs exert selection pressure on the viral population in acute HIV-1 infection. PubMed ID: 9050875. Show all entries for this paper.


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