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Displaying record number 61528

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HXB2 Location	Gag(31-41) p17(31-41) DNA(880..912)	Gag Epitope Map
Author Location	p17(31-41)
Epitope	LKHIVWASREL	Epitope Alignment
		Show epitope variants
Epitope Name	Gag LL11
Subtype	B
Species (MHC/HLA)	human(A*02:06)
Immunogen	HIV-1 infection
Country	Japan
Experimental methods	CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining
Keywords	subtype comparisons, optimal epitope, novel epitope, chronic infection

Notes

• Polymorphic epitope regions can be targets for cross-clade CTL response. In addition to 6 conserved AE epitopes, 9 epitopes polymorphic between clades AE and B were identified in chronically infected Japanese subjects. This is the first comprehensive study to identify cross-clade CTL by using overlapping HIV-1 peptides.
• There were no significant differences in total magnitude of CTL response between 26 clade A/E-infected and 401 clade B-infected subjects when tested with 11-mers from HIV-B Nef, Gag and Pol. 6 epitopes were novel viz. Gag LL11, Pol SV9, Pol GI9, Gag RV8, Gag AP8 and Gag EG11.
• Novel clade B epitope Gag LL11, LKHIVWASREL, was found in 1182/1644 Clade B and 18/315 Clade A/E Los Alamos database HIV-1 sequences. It was found in 2/26 A/E-infected subjects of the KI cohort.
• CTL from A/E-infected subjects stimulated by the consensus B LL11 peptide used did not cross-recognize the clade A/E derived peptide, LL1-1M-4L.

References

Watanabe2013 Koji Watanabe, Hayato Murakoshi, Yoshiko Tamura, Madoka Koyanagi, Takayuki Chikata, Hiroyuki Gatanaga, Shinichi Oka, and Masafumi Takiguchi. Identification of Cross-Clade CTL Epitopes in HIV-1 Clade A/E-Infected Individuals by Using the Clade B Overlapping Peptides. Microbes Infect., 15(13):874-886, Nov 2013. PubMed ID: 23968885. Show all entries for this paper.