HIV molecular immunology database
Found 12 matching records:
Download this epitope record as JSON.
HXB2 Location | gp160(52-61) gp120(52-61) DNA(6378..6407) |
gp160 Epitope Map |
---|---|---|
Author Location | ||
Epitope |
LFCASDAKAY
|
Epitope Alignment
|
Species (MHC/HLA) | human(A24) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, HLA binding | |
Keywords | binding affinity, immunodominance, optimal epitope |
Bihl2006 Florian Bihl, Nicole Frahm, Loriana Di Giammarino, John Sidney, Mina John, Karina Yusim, Tonia Woodberry, Kaori Sango, Hannah S. Hewitt, Leah Henry, Caitlyn H. Linde, John V. Chisholm, III, Tauheed M. Zaman, Eunice Pae, Simon Mallal, Bruce D Walker, Alessandro Sette, Bette T. Korber, David Heckerman, and Christian Brander. Impact of HLA-B Alleles, Epitope Binding Affinity, Functional Avidity, and Viral Coinfection on the Immunodominance of Virus-Specific CTL Responses. J. Immunol., 176(7):4094-4101, 1 Apr 2006. PubMed ID: 16547245. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(52-61) gp120(52-61) DNA(6378..6407) |
gp160 Epitope Map |
---|---|---|
Author Location | gp120 | |
Epitope |
LFCASDAKAY
|
Epitope Alignment
|
Epitope Name | LY10(gp120) | |
Subtype | B | |
Species (MHC/HLA) | human(A24) | |
Immunogen | HIV-1 infection | |
Country | China | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | chronic infection |
Zhai2008 Song Zhai, Yan Zhuang, Yang Song, Shu Li, Dedong Huang, Wenzhen Kang, Xinhong Li, Qi Liao, Yanhou Liu, Zhongfang Zhao, Yichen Lu, and Yongtao Sun. HIV-1-Specific Cytotoxic T Lymphocyte (CTL) Responses Against Immunodominant Optimal Epitopes Slow the Progression of AIDS in China. Curr. HIV Res., 6(4):335-350, Jun 2008. PubMed ID: 18691032. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(52-61) gp120(52-61) DNA(6378..6407) |
gp160 Epitope Map |
---|---|---|
Author Location | gp120(53-62) | |
Epitope |
LFCASDAKAY
|
Epitope Alignment
|
Species (MHC/HLA) | human(A24) | |
Immunogen | HIV-1 exposed seronegative, HIV-1 infection | |
Experimental methods | ||
Keywords | HIV exposed persistently seronegative (HEPS) |
Kaul2001a R. Kaul, T. Dong, F. A. Plummer, J. Kimani, T. Rostron, P. Kiama, E. Njagi, E. Irungu, B. Farah, J. Oyugi, R. Chakraborty, K. S. MacDonald, J. J. Bwayo, A. McMichael, and S. L. Rowland-Jones. CD8(+) lymphocytes respond to different HIV epitopes in seronegative and infected subjects. J. Clin. Invest., 107(10):1303-10, May 2001. URL: http://www.jci.org/cgi/content/full/107/10/1303. PubMed ID: 11375420. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(52-61) gp120(52-61) DNA(6378..6407) |
gp160 Epitope Map |
---|---|---|
Author Location | gp120(53-62) | |
Epitope |
LFCASDAKAY
|
Epitope Alignment
|
Species (MHC/HLA) | human(A24) | |
Immunogen | HIV-1 infection | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ, CD8 T-cell Elispot granzyme B, T-cell Elispot | |
Keywords | characterizing CD8+ T cells |
Kleen2004 Thomas O. Kleen, Robert Asaad, Samuel J. Landry, Bernhard O. Boehm, and Magdalena Tary-Lehmann. Tc1 Effector Diversity Shows Dissociated Expression of Granzyme B and Interferon-gamma in HIV Infection. AIDS, 18(3):383-392, 20 Feb 2004. PubMed ID: 15090789. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(52-61) gp120(52-61) DNA(6378..6407) |
gp160 Epitope Map |
---|---|---|
Author Location | gp120 | |
Epitope |
LFCASDAKAY
|
Epitope Alignment
|
Epitope Name | A24-LY10(gp120) | |
Species (MHC/HLA) | human(A24) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | rate of progression, immunodominance, early-expressed proteins |
Altfeld2006 Marcus Altfeld, Elizabeth T. Kalife, Ying Qi, Hendrik Streeck, Mathias Lichterfeld, Mary N. Johnston, Nicole Burgett, Martha E. Swartz, Amy Yang, Galit Alter, Xu G. Yu, Angela Meier, Juergen K. Rockstroh, Todd M. Allen, Heiko Jessen, Eric S. Rosenberg, Mary Carrington, and Bruce D. Walker. HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8+ T Cell Response against HIV-1. PLoS Med., 3(10):e403, Oct 2006. PubMed ID: 17076553. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(52-61) gp120(52-61) DNA(6378..6407) |
gp160 Epitope Map |
---|---|---|
Author Location | gp120(59-68 HXB2) | |
Epitope |
LFCASDAKAY
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(A*24:02) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords |
Lieberman1992 J. Lieberman, J. A. Fabry, M.-C. Kuo, P. Earl, B. Moss, and P. R. Skolnik. Cytotoxic T Lymphocytes from HIV-1 Seropositive Individuals Recognize Immunodominant Epitopes in gp160 and Reverse Transcriptase. J. Immunol., 148:2738-2747, 1992. This paper does not use T-cell clones to map epitopes, but rather T-cell lines from HIV infected donors. 20 amino acid peptides were used to map the region of the reactive epitopes. HLA restriction was not tested for all epitopes. PubMed ID: 1374097. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(52-61) gp120(52-61) DNA(6378..6407) |
gp160 Epitope Map |
---|---|---|
Author Location | gp120(53-62 LAI) | |
Epitope |
LFCASDAKAY
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(A*24:02) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | optimal epitope, A-list |
Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(52-61) gp120(52-61) DNA(6378..6407) |
gp160 Epitope Map |
---|---|---|
Author Location | Env(52-61) | |
Epitope |
LFCASDAKAY
|
Epitope Alignment
|
Epitope Name | LY10 | |
Species (MHC/HLA) | human(B*07) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(52-61) gp120(52-61) DNA(6378..6407) |
gp160 Epitope Map |
---|---|---|
Author Location | Env(52-61) | |
Epitope |
LFCASDAKAY
|
Epitope Alignment
|
Epitope Name | LY10 | |
Species (MHC/HLA) | human(B*08) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(52-61) gp120(52-61) DNA(6378..6407) |
gp160 Epitope Map |
---|---|---|
Author Location | Env(52-61) | |
Epitope |
LFCASDAKAY
|
Epitope Alignment
|
Epitope Name | LY10 | |
Species (MHC/HLA) | human(C*12) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(52-61) gp120(52-61) DNA(6378..6407) |
gp160 Epitope Map |
---|---|---|
Author Location | Env(52-61) | |
Epitope |
LFCASDAKAY
|
Epitope Alignment
|
Epitope Name | LY10 | |
Species (MHC/HLA) | human(C*16) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(52-61) gp120(52-61) DNA(6378..6407) |
gp160 Epitope Map |
---|---|---|
Author Location | Env(52-61 consensus) | |
Epitope |
LFCASDAKAY
|
Epitope Alignment
|
Epitope Name | LY9 | |
Subtype | A, B | |
Species (MHC/HLA) | human | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | A*02:01, A*03:01, B*07:02, B*18:01, C*07:02, C*12:03 | |
Country | Spain | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | acute/early infection |
Dalmau2009 Judith Dalmau, Maria Carmen Puertas, Marta Azuara, Ana Mariño, Nicole Frahm, Beatriz Mothe, Nuria Izquierdo-Useros, Maria José Buzón, Roger Paredes, Lourdes Matas, Todd M. Allen, Christian Brander, Carlos Rodrigo, Bonaventura Clotet, and Javier Martinez-Picado. Contribution of Immunological and Virological Factors to Extremely Severe Primary HIV Type 1 Infection. Clin. Infect. Dis., 48(2):229-238, 15 Jan 2009. PubMed ID: 19093810. Show all entries for this paper.