HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 12 matching records:

Displaying record number 55022

HXB2 Location gp160(52-61)
gp120(52-61)
DNA(6378..6407)
gp160 Epitope Map
Author Location  
Epitope LFCASDAKAY Epitope Alignment
LFCASDAKAY epitope logo
Species (MHC/HLA) human(A24)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, HLA binding
Keywords binding affinity, immunodominance, optimal epitope

Notes

References

Bihl2006 Florian Bihl, Nicole Frahm, Loriana Di Giammarino, John Sidney, Mina John, Karina Yusim, Tonia Woodberry, Kaori Sango, Hannah S. Hewitt, Leah Henry, Caitlyn H. Linde, John V. Chisholm, III, Tauheed M. Zaman, Eunice Pae, Simon Mallal, Bruce D Walker, Alessandro Sette, Bette T. Korber, David Heckerman, and Christian Brander. Impact of HLA-B Alleles, Epitope Binding Affinity, Functional Avidity, and Viral Coinfection on the Immunodominance of Virus-Specific CTL Responses. J. Immunol., 176(7):4094-4101, 1 Apr 2006. PubMed ID: 16547245. Show all entries for this paper.


Displaying record number 56431

HXB2 Location gp160(52-61)
gp120(52-61)
DNA(6378..6407)
gp160 Epitope Map
Author Location gp120
Epitope LFCASDAKAY Epitope Alignment
LFCASDAKAY epitope logo
Epitope Name LY10(gp120)
Subtype B
Species (MHC/HLA) human(A24)
Immunogen HIV-1 infection
Country China
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords  

Notes

References

Zhai2008 Song Zhai, Yan Zhuang, Yang Song, Shu Li, Dedong Huang, Wenzhen Kang, Xinhong Li, Qi Liao, Yanhou Liu, Zhongfang Zhao, Yichen Lu, and Yongtao Sun. HIV-1-Specific Cytotoxic T Lymphocyte (CTL) Responses Against Immunodominant Optimal Epitopes Slow the Progression of AIDS in China. Curr. HIV Res., 6(4):335-350, Jun 2008. PubMed ID: 18691032. Show all entries for this paper.


Displaying record number 1661

HXB2 Location gp160(52-61)
gp120(52-61)
DNA(6378..6407)
gp160 Epitope Map
Author Location gp120(53-62)
Epitope LFCASDAKAY Epitope Alignment
LFCASDAKAY epitope logo
Species (MHC/HLA) human(A24)
Immunogen HIV-1 exposed seronegative, HIV-1 infection
Experimental methods  
Keywords HIV exposed persistently seronegative (HEPS)

Notes

References

Kaul2001a R. Kaul, T. Dong, F. A. Plummer, J. Kimani, T. Rostron, P. Kiama, E. Njagi, E. Irungu, B. Farah, J. Oyugi, R. Chakraborty, K. S. MacDonald, J. J. Bwayo, A. McMichael, and S. L. Rowland-Jones. CD8(+) lymphocytes respond to different HIV epitopes in seronegative and infected subjects. J. Clin. Invest., 107(10):1303-10, May 2001. URL: http://www.jci.org/cgi/content/full/107/10/1303. PubMed ID: 11375420. Show all entries for this paper.


Displaying record number 53013

HXB2 Location gp160(52-61)
gp120(52-61)
DNA(6378..6407)
gp160 Epitope Map
Author Location gp120(53-62)
Epitope LFCASDAKAY Epitope Alignment
LFCASDAKAY epitope logo
Species (MHC/HLA) human(A24)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, CD8 T-cell Elispot granzyme B, T-cell Elispot
Keywords characterizing CD8+ T cells

Notes

References

Kleen2004 Thomas O. Kleen, Robert Asaad, Samuel J. Landry, Bernhard O. Boehm, and Magdalena Tary-Lehmann. Tc1 Effector Diversity Shows Dissociated Expression of Granzyme B and Interferon-gamma in HIV Infection. AIDS, 18(3):383-392, 20 Feb 2004. PubMed ID: 15090789. Show all entries for this paper.


Displaying record number 54263

HXB2 Location gp160(52-61)
gp120(52-61)
DNA(6378..6407)
gp160 Epitope Map
Author Location gp120
Epitope LFCASDAKAY Epitope Alignment
LFCASDAKAY epitope logo
Epitope Name A24-LY10(gp120)
Species (MHC/HLA) human(A24)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, immunodominance, early-expressed proteins

Notes

References

Altfeld2006 Marcus Altfeld, Elizabeth T. Kalife, Ying Qi, Hendrik Streeck, Mathias Lichterfeld, Mary N. Johnston, Nicole Burgett, Martha E. Swartz, Amy Yang, Galit Alter, Xu G. Yu, Angela Meier, Juergen K. Rockstroh, Todd M. Allen, Heiko Jessen, Eric S. Rosenberg, Mary Carrington, and Bruce D. Walker. HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8+ T Cell Response against HIV-1. PLoS Med., 3(10):e403, Oct 2006. PubMed ID: 17076553. Show all entries for this paper.


Displaying record number 645

HXB2 Location gp160(52-61)
gp120(52-61)
DNA(6378..6407)
gp160 Epitope Map
Author Location gp120(59-68 HXB2)
Epitope LFCASDAKAY Epitope Alignment
LFCASDAKAY epitope logo
Subtype B
Species (MHC/HLA) human(A*2402)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Lieberman1992 J. Lieberman, J. A. Fabry, M.-C. Kuo, P. Earl, B. Moss, and P. R. Skolnik. Cytotoxic T Lymphocytes from HIV-1 Seropositive Individuals Recognize Immunodominant Epitopes in gp160 and Reverse Transcriptase. J. Immunol., 148:2738-2747, 1992. This paper does not use T-cell clones to map epitopes, but rather T-cell lines from HIV infected donors. 20 amino acid peptides were used to map the region of the reactive epitopes. HLA restriction was not tested for all epitopes. PubMed ID: 1374097. Show all entries for this paper.


Displaying record number 1130

HXB2 Location gp160(52-61)
gp120(52-61)
DNA(6378..6407)
gp160 Epitope Map
Author Location gp120(53-62 LAI)
Epitope LFCASDAKAY Epitope Alignment
LFCASDAKAY epitope logo
Subtype B
Species (MHC/HLA) human(A*2402)
Immunogen HIV-1 infection
Experimental methods  
Keywords optimal epitope

Notes

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 59982

HXB2 Location gp160(52-61)
gp120(52-61)
DNA(6378..6407)
gp160 Epitope Map
Author Location Env(52-61)
Epitope LFCASDAKAY Epitope Alignment
LFCASDAKAY epitope logo
Epitope Name LY10
Species (MHC/HLA) human(B*07)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 59983

HXB2 Location gp160(52-61)
gp120(52-61)
DNA(6378..6407)
gp160 Epitope Map
Author Location Env(52-61)
Epitope LFCASDAKAY Epitope Alignment
LFCASDAKAY epitope logo
Epitope Name LY10
Species (MHC/HLA) human(B*08)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 59981

HXB2 Location gp160(52-61)
gp120(52-61)
DNA(6378..6407)
gp160 Epitope Map
Author Location Env(52-61)
Epitope LFCASDAKAY Epitope Alignment
LFCASDAKAY epitope logo
Epitope Name LY10
Species (MHC/HLA) human(C*12)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 59980

HXB2 Location gp160(52-61)
gp120(52-61)
DNA(6378..6407)
gp160 Epitope Map
Author Location Env(52-61)
Epitope LFCASDAKAY Epitope Alignment
LFCASDAKAY epitope logo
Epitope Name LY10
Species (MHC/HLA) human(C*16)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 57116

HXB2 Location gp160(52-61)
gp120(52-61)
DNA(6378..6407)
gp160 Epitope Map
Author Location Env(52-61 consensus)
Epitope LFCASDAKAY Epitope Alignment
LFCASDAKAY epitope logo
Epitope Name LY9
Subtype A, B
Species (MHC/HLA) human
Immunogen HIV-1 infection
Patient MHC/HLA A*0201, A*0301, B*0702, B*1801, Cw*0702, Cw*1203
Country Spain
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords acute/early infection

Notes

References

Dalmau2009 Judith Dalmau, Maria Carmen Puertas, Marta Azuara, Ana Mariño, Nicole Frahm, Beatriz Mothe, Nuria Izquierdo-Useros, Maria José Buzón, Roger Paredes, Lourdes Matas, Todd M. Allen, Christian Brander, Carlos Rodrigo, Bonaventura Clotet, and Javier Martinez-Picado. Contribution of Immunological and Virological Factors to Extremely Severe Primary HIV Type 1 Infection. Clin. Infect. Dis., 48(2):229-238, 15 Jan 2009. PubMed ID: 19093810. Show all entries for this paper.


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