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Displaying record number 53178

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HXB2 Location	Nef(181-189) DNA(9337..9363)	Nef Epitope Map
Author Location	Nef(181-189)
Epitope	LEWRFDSRL	Epitope Alignment
Epitope Name	Nef181-189
Species (MHC/HLA)	human(A2)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	responses in children, immunodominance, characterizing CD8+ T cells

Notes

• Responses to five HLA-A2 presented epitopes in Nef were characterized in a population of 19 HIV infected adults and 21 children. The CD8 T-cell response to Nef was stronger and broader in adults than children, averaging 652 and 87 SFCs/10⁶ PBMC, and 2.6 and 0.9 recognized epitopes per person, respectively.
• This was not the immunodominant response.

References

Chandwani2004 R. Chandwani, K. A. Jordan, B. L. Shacklett, E. Papasavvas, L. J. Montaner, M. G. Rosenberg, D. F. Nixon, and J. K. Sandberg. Limited Magnitude and Breadth in the HLA-A2-Restricted CD8 T-Cell Response to Nef in Children with Vertically Acquired HIV-1 Infection. Scand. J. Immunol., 59(1):109-114, Jan 2004. PubMed ID: 14723629. Show all entries for this paper.