HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 4 matching records:

Displaying record number 61154

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HXB2 Location Pol(783-791)
Integrase(68-76)
DNA(4431..4457)
Pol Epitope Map
Author Location  
Epitope LEGKIILVA Epitope Alignment
LEGKIILVA epitope logo
Show epitope variants
Subtype B
Species (MHC/HLA) human, mouse(B*40:06)
Immunogen HIV-1 infection, vaccine
Country Japan
Experimental methods CD8 T-cell Elispot - IFNγ, Other
Keywords vaccine-induced immune responses, vaccine antigen design

Vaccine Details

Vaccine type DNA, modified vaccinia Ankara (MVA), adenovirus
Vaccine strain B clade
Adjuvant gp41 N-HR and C-HR helical peptides

Notes

References

Ondondo2016 Beatrice Ondondo, Hayato Murakoshi, Genevieve Clutton, Sultan Abdul-Jawad, Edmund G.-T. Wee, Hiroyuki Gatanaga, Shinichi Oka, Andrew J. McMichael, Masafumi Takiguchi, Bette Korber, and Tomáš Hanke. Novel Conserved-region T-cell Mosaic Vaccine With High Global HIV-1 Coverage Is Recognized by Protective Responses in Untreated Infection. Mol. Ther., 24(4):832-842, Apr 2016. PubMed ID: 26743582. Show all entries for this paper.


Displaying record number 61513

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HXB2 Location Pol(783-791)
Integrase(68-76)
DNA(4431..4457)
Pol Epitope Map
Author Location Pol(783-791)
Epitope LEGKIILVA Epitope Alignment
LEGKIILVA epitope logo
Show epitope variants
Epitope Name PolLA9
Subtype B
Species (MHC/HLA) human(B*40:06)
Immunogen HIV-1 infection
Patient MHC/HLA KI-763: ; KI-912: ; KI-756: ; KI-928:
Country Japan
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining, Other
Keywords optimal epitope, novel epitope, chronic infection

Notes

References

Murakoshi2015 Hayato Murakoshi, Tomohiro Akahoshi, Madoka Koyanagi, Takayuki Chikata, Takuya Naruto, Rie Maruyama, Yoshiko Tamura, Naoki Ishizuka, Hiroyuki Gatanaga, Shinichi Oka, and Masafumi Takiguchi. Clinical Control of HIV-1 by Cytotoxic T Cells Specific for Multiple Conserved Epitopes. J. Virol., 89(10):5330-5339, May 2015. PubMed ID: 25741000. Show all entries for this paper.


Displaying record number 61861

Download this epitope record as JSON.

HXB2 Location Pol(783-791)
Integrase(68-76)
DNA(4431..4457)
Pol Epitope Map
Author Location  
Epitope LEGKIILVA Epitope Alignment
LEGKIILVA epitope logo
Epitope Name LA9
Subtype B
Species (MHC/HLA) human(B*40:06)
Immunogen HIV-1 infection, vaccine
Country Japan
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining, Other
Keywords vaccine-induced immune responses

Notes

References

Zou2019 Chengcheng Zou, Hayato Murakoshi, Nozomi Kuse, Tomohiro Akahoshi, Takayuki Chikata, Hiroyuki Gatanaga, Shinichi Oka, Tomáš Hanke, and Masafumi Takiguchi. Effective Suppression of HIV-1 Replication by Cytotoxic T Lymphocytes Specific for Pol Epitopes in Conserved Mosaic Vaccine Immunogens. J. Virol., 93(7), 1 Apr 2019. PubMed ID: 30674626. Show all entries for this paper.


Displaying record number 61885

Download this epitope record as JSON.

HXB2 Location Pol(783-791)
Integrase(68-76)
DNA(4431..4457)
Pol Epitope Map
Author Location  
Epitope LEGKIILVA Epitope Alignment
LEGKIILVA epitope logo
Show epitope variants
Epitope Name Pol LA9
Subtype B
Species (MHC/HLA) human(B*40:06)
Immunogen HIV-1 infection, vaccine
Patient MHC/HLA KI-912: ; KI-808: B*40:06
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining, Other
Keywords vaccine-induced immune responses, viral replication

Notes

References

Murakoshi2019 Hayato Murakoshi, Nozomi Kuse, Tomohiro Akahoshi, Yu Zhang, Takayuki Chikata, Mohamed Ali Borghan, Hiroyuki Gatanaga, Shinichi Oka, Keiko Sakai, and Masafumi Takiguchi. Broad Recognition of Circulating HIV-1 by HIV-1-Specific Cytotoxic T-Lymphocytes with Strong Ability to Suppress HIV-1 Replication. J. Virol., 93(1), 1 Jan 2019. PubMed ID: 30333175. Show all entries for this paper.


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