Search CTL/CD8+ T-Cell Epitope Database

Found 2 matching records:

Displaying record number 52894

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HXB2 Location	Gag(401-410) p2p7p1p6(38-47) DNA(1990..2019)	Gag Epitope Map
Author Location	Gag
Epitope	LARNCRAPRK	Epitope Alignment
Epitope Name	1331
Subtype	multiple
Species (MHC/HLA)	human(A3)
Immunogen	HIV-1 infection
Patient MHC/HLA	A23, A3, B49, B57; A24, A3, B27, B57, C*18; A26, A3, B52, B8
Country	United States
Experimental methods	T-cell Elispot
Keywords	binding affinity, computational epitope prediction, novel epitope

Notes

• Epitopes defined using sequence parsing and matching algorithm Conservatrix, and epitope prediction tool EpiMatrix, were shown to be conserved in a broad range of HIV-1 sequences derived from different parts of the world. 31 novel highly conserved HIV-1 epitopes were found, among which four were recognized as promiscuous epitopes and five as MHC supertypes.
• Estimated binding probability for LARNCRAPRK: 35%. Immunodominant epitope.

References

DeGroot2003 Anne S. De Groot, Bill Jesdale, William Martin, Caitlin Saint Aubin, Hakima Sbai, Andrew Bosma, Judy Lieberman, Gail Skowron, Fadi Mansourati, and Kenneth H. Mayer. Mapping Cross-Clade HIV-1 Vaccine Epitopes Using a Bioinformatics Approach. Vaccine, 21(27-30):4486-4504, 1 Oct 2003. PubMed ID: 14505932. Show all entries for this paper.

Displaying record number 54283

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HXB2 Location	Gag(401-410) p2p7p1p6(38-47) DNA(1990..2019)	Gag Epitope Map
Author Location	p7(1996-)
Epitope	LARNCRAPRK	Epitope Alignment
Epitope Name	A*3101 LR9
Species (MHC/HLA)	human(A*31:01)
Immunogen	HIV-1 infection
Country	Australia
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	escape, HLA associated polymorphism

Notes

• Host HLA associated mutational patterns in HIV can be a consequence of immune escape, but to cleanly resolve whether or not such patterns are the result of lineage effects or immune pressure, it is helpful to incorporate the phylogenetic history of the virus into the test statistics. Most of the HLA associations that appeared to result from immune escape in an earlier study (Moore et al., Science 296:1439 2002) were found to be a consequence of the phylogenetic history of the virus, not immune escape. Other HLA associations were validated, and some additional HLA-associated mutations were identified through incorporating the viral phylogenetic tree in the analysis.
• The third position of the epitope LArNCRAPRK an HLA-A*3101 correlated amino acid, however which one of the two common forms, LArNCRAPRK or LAkNCRAPRK, was the escape or and which was the susceptible form depended on the patient tested. Testing was performed by IFN-gamma ELIspot (magnitude) and functional avidity studies.

References

Bhattacharya2007 Tanmoy Bhattacharya, Marcus Daniels, David Heckerman, Brian Foley, Nicole Frahm, Carl Kadie, Jonathan Carlson, Karina Yusim, Ben McMahon, Brian Gaschen, Simon Mallal, James I. Mullins, David C. Nickle, Joshua Herbeck, Christine Rousseau, Gerald H. Learn, Toshiyuki Miura, Christian Brander, Bruce Walker, and Bette Korber. Founder Effects in the Assessment of HIV Polymorphisms and HLA Allele Associations. Science, 315(5818):1583-1586, 16 Mar 2007. PubMed ID: 17363674. Show all entries for this paper.