HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 31 matching records:

Displaying record number 53

HXB2 Location Gag(28-36)
p17(28-36)
DNA(871..897)
Gag Epitope Map
Author Location p17(28-36 LAI)
Epitope KYKLKHIVW Epitope Alignment
KYKLKHIVW epitope logo
Subtype B
Species (MHC/HLA) human(A23)
Immunogen  
Experimental methods  
Keywords  

Notes

References

Goulder1999 P. J. Goulder and B. D. Walker. The Great Escape -- AIDS Viruses and Immune Control. Nat. Med., 5:1233-1235, 1999. PubMed ID: 10545982. Show all entries for this paper.


Displaying record number 57701

HXB2 Location Gag(28-36)
p17(28-36)
DNA(871..897)
Gag Epitope Map
Author Location Gag
Epitope KYKLKHIVW Epitope Alignment
KYKLKHIVW epitope logo
Show epitope variants
Species (MHC/HLA) human(A*23)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords supervised treatment interruptions (STI), escape

Notes

References

Schweighardt2010 Becky Schweighardt, Terri Wrin, Duncan A. Meiklejohn, Gerald Spotts, Christos J. Petropoulos, Douglas F. Nixon, and Frederick M. Hecht. Immune Escape Mutations Detected within HIV-1 Epitopes Associated with Viral Control During Treatment Interruption. J. Acquir. Immune Defic. Syndr., 53(1):36-46, Jan 2010. PubMed ID: 19910798. Show all entries for this paper.


Displaying record number 59974

HXB2 Location Gag(28-36)
p17(28-36)
DNA(871..897)
Gag Epitope Map
Author Location Gag(28-36)
Epitope KYKLKHIVW Epitope Alignment
KYKLKHIVW epitope logo
Epitope Name KW9
Species (MHC/HLA) human(A*23)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 1538

HXB2 Location Gag(28-36)
p17(28-36)
DNA(871..897)
Gag Epitope Map
Author Location p17(28-36 SF2)
Epitope KYKLKHIVW Epitope Alignment
KYKLKHIVW epitope logo
Species (MHC/HLA) human(A24)
Immunogen HIV-1 infection
Experimental methods  
Keywords HAART, ART, acute/early infection

Notes

References

Altfeld2001b M. Altfeld, E. S. Rosenberg, R. Shankarappa, J. S. Mukherjee, F. M. Hecht, R. L. Eldridge, M. M. Addo, S. H. Poon, M. N. Phillips, G. K. Robbins, P. E. Sax, S. Boswell, J. O. Kahn, C. Brander, P. J. Goulder, J. A. Levy, J. I. Mullins, and B. D. Walker. Cellular immune responses and viral diversity in individuals treated during acute and early HIV-1 infection. J. Exp. Med., 193(2):169-80, 15 Jan 2001. URL: http://www.jem.org/cgi/content/full/193/2/169. PubMed ID: 11148221. Show all entries for this paper.


Displaying record number 52742

HXB2 Location Gag(28-36)
p17(28-36)
DNA(871..897)
Gag Epitope Map
Author Location p17
Epitope KYKLKHIVW Epitope Alignment
KYKLKHIVW epitope logo
Epitope Name KW9
Species (MHC/HLA) human(A24)
Immunogen HIV-1 infection
Patient MHC/HLA A2, A24, B38, B60, Cw12, Cw2
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords supervised treatment interruptions (STI), acute/early infection

Notes

References

Montefiori2003 David C. Montefiori, Marcus Altfeld, Paul K. Lee, Miroslawa Bilska, Jintao Zhou, Mary N. Johnston, Feng Gao, Bruce D. Walker, and Eric S. Rosenberg. Viremia Control Despite Escape from a Rapid and Potent Autologous Neutralizing Antibody Response after Therapy Cessation in an HIV-1-Infected Individual. J. Immunol., 170(7):3906-3914, Apr 2003. PubMed ID: 12646660. Show all entries for this paper.


Displaying record number 53158

HXB2 Location Gag(28-36)
p17(28-36)
DNA(871..897)
Gag Epitope Map
Author Location p17(28-36)
Epitope KYKLKHIVW Epitope Alignment
KYKLKHIVW epitope logo
Show epitope variants
Species (MHC/HLA) human(A24)
Immunogen HIV-1 infection
Patient MHC/HLA A*0201, A*2402, B*52, B75, Cw*03; A*0207, A*2402, B*46, B*52, Cw*01; A*2402, A*26, B*07, B*5101, Cw*07
Country Japan
Experimental methods Chromium-release assay
Keywords epitope processing, escape

Notes

References

Yokomaku2004 Yoshiyuki Yokomaku, Hideka Miura, Hiroko Tomiyama, Ai Kawana-Tachikawa, Masafumi Takiguchi, Asato Kojima, Yoshiyuki Nagai, Aikichi Iwamoto, Zene Matsuda, and Koya Ariyoshi. Impaired Processing and Presentation of Cytotoxic-T-Lymphocyte (CTL) Epitopes Are Major Escape Mechanisms from CTL Immune Pressure in Human Immunodeficiency Virus Type 1 Infection. J. Virol., 78(3):1324-1332, Feb 2004. PubMed ID: 14722287. Show all entries for this paper.


Displaying record number 54262

HXB2 Location Gag(28-36)
p17(28-36)
DNA(871..897)
Gag Epitope Map
Author Location p17
Epitope KYKLKHIVW Epitope Alignment
KYKLKHIVW epitope logo
Epitope Name A24-KW9(p17)
Species (MHC/HLA) human(A24)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, immunodominance, early-expressed proteins

Notes

References

Altfeld2006 Marcus Altfeld, Elizabeth T. Kalife, Ying Qi, Hendrik Streeck, Mathias Lichterfeld, Mary N. Johnston, Nicole Burgett, Martha E. Swartz, Amy Yang, Galit Alter, Xu G. Yu, Angela Meier, Juergen K. Rockstroh, Todd M. Allen, Heiko Jessen, Eric S. Rosenberg, Mary Carrington, and Bruce D. Walker. HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8+ T Cell Response against HIV-1. PLoS Med., 3(10):e403, Oct 2006. PubMed ID: 17076553. Show all entries for this paper.


Displaying record number 51

HXB2 Location Gag(28-36)
p17(28-36)
DNA(871..897)
Gag Epitope Map
Author Location p17(28-36 LAI)
Epitope KYKLKHIVW Epitope Alignment
KYKLKHIVW epitope logo
Subtype B
Species (MHC/HLA) human(A24)
Immunogen  
Experimental methods  
Keywords  

Notes

References

Brander1996 Christian Brander and Bruce Walker. The HLA-Class I Restricted CTL Response in HIV-1 Infection: Systematic Identification of Optimal Epitopes. In The HLA-Class I Restricted CTL Response in HIV-1 Infection: Systematic Identification of Optimal Epitopes. pages IV--50--IV--60. Los Alamos National Laboratory, Theoretical Biology and Biophysics, Los Alamos, New Mexico, 1996. URL: http://hiv-web.lanl.gov/immunology. Show all entries for this paper.


Displaying record number 55206

HXB2 Location Gag(28-36)
p17(28-36)
DNA(871..897)
Gag Epitope Map
Author Location  
Epitope KYKLKHIVW Epitope Alignment
KYKLKHIVW epitope logo
Species (MHC/HLA) human(A24)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords supertype, HLA cross-presentation

Notes

References

Frahm2007b Nicole Frahm, Karina Yusim, Todd J. Suscovich, Sharon Adams, John Sidney, Peter Hraber, Hannah S. Hewitt, Caitlyn H. Linde, Daniel G. Kavanagh, Tonia Woodberry, Leah M. Henry, Kellie Faircloth, Jennifer Listgarten, Carl Kadie, Nebojsa Jojic, Kaori Sango, Nancy V. Brown, Eunice Pae, M. Tauheed Zaman, Florian Bihl, Ashok Khatri, Mina John, Simon Mallal, Francesco M. Marincola, Bruce D . Walker, Alessandro Sette, David Heckerman, Bette T. Korber, and Christian Brander. Extensive HLA Class I Allele Promiscuity among Viral CTL Epitopes. Eur. J. Immunol., 37(9):2419-2433, Sep 2007. PubMed ID: 17705138. Show all entries for this paper.


Displaying record number 55703

HXB2 Location Gag(28-36)
p17(28-36)
DNA(871..897)
Gag Epitope Map
Author Location Gag
Epitope KYKLKHIVW Epitope Alignment
KYKLKHIVW epitope logo
Epitope Name KW9-A24
Subtype B, F
Species (MHC/HLA) human(A24)
Immunogen HIV-1 infection
Country Argentina
Experimental methods  
Keywords dynamics, escape, HLA associated polymorphism

Notes

References

Dilernia2008 Dario Alberto Dilernia, Leandro Jones, Sabrina Rodriguez, Gabriela Turk, Andrea E Rubio, Sandra Pampuro, Manuel Gomez-Carrillo, Christian Bautista, Gabriel Deluchi, Jorge Benetucci, María Beatriz Lasala, Leonardo Lourtau, Marcelo Horacio Losso, Héctor Perez, Pedro Cahn, and Horacio Salomón. HLA-Driven Convergence of HIV-1 Viral Subtypes B and F Toward the Adaptation to Immune Responses in Human Populations. PLoS ONE, 3(10):e3429, 2008. PubMed ID: 18941505. Show all entries for this paper.


Displaying record number 1756

HXB2 Location Gag(28-36)
p17(28-36)
DNA(871..897)
Gag Epitope Map
Author Location p17(28-36 93TH253 subtype CRF01)
Epitope KYKLKHIVW Epitope Alignment
KYKLKHIVW epitope logo
Show epitope variants
Subtype CRF01_AE
Species (MHC/HLA) human(A*24)
Immunogen HIV-1 infection
Experimental methods  
Keywords subtype comparisons

Notes

References

Bond2001 K. B. Bond, B. Sriwanthana, T. W. Hodge, A. S. De Groot, T. D. Mastro, N. L. Young, N. Promadej, J. D. Altman, K. Limpakarnjanarat, and J. M. McNicholl. An HLA-directed molecular and bioinformatics approach identifies new HLA-A11 HIV-1 subtype E cytotoxic T lymphocyte epitopes in HIV-1-infected Thais. AIDS Res. Hum. Retroviruses, 17(8):703-17, 20 May 2001. PubMed ID: 11429111. Show all entries for this paper.


Displaying record number 59971

HXB2 Location Gag(28-36)
p17(28-36)
DNA(871..897)
Gag Epitope Map
Author Location Gag(28-36)
Epitope KYKLKHIVW Epitope Alignment
KYKLKHIVW epitope logo
Epitope Name KW9
Species (MHC/HLA) human(A*24)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 56358

HXB2 Location Gag(28-36)
p17(28-36)
DNA(871..897)
Gag Epitope Map
Author Location p17(28-36)
Epitope KYKLKHIVW Epitope Alignment
KYKLKHIVW epitope logo
Epitope Name KW9
Subtype B
Species (MHC/HLA) human(A*24)
Immunogen HIV-1 infection
Country Australia, Canada, Germany, United States
Experimental methods  
Keywords escape, HLA associated polymorphism

Notes

References

Brumme2008 Zabrina L. Brumme, Chanson J. Brumme, Jonathan Carlson, Hendrik Streeck, Mina John, Quentin Eichbaum, Brian L Block, Brett Baker, Carl Kadie, Martin Markowitz, Heiko Jessen, Anthony D. Kelleher, Eric Rosenberg, John Kaldor, Yuko Yuki, Mary Carrington, Todd M. Allen, Simon Mallal, Marcus Altfeld, David Heckerman, and Bruce D. Walker. Marked Epitope- and Allele-Specific Differences in Rates of Mutation in Human Immunodeficiency Type 1 (HIV-1) Gag, Pol, and Nef Cytotoxic T-Lymphocyte Epitopes in Acute/Early HIV-1 Infection. J. Virol., 82(18):9216-9227, Sep 2008. PubMed ID: 18614631. Show all entries for this paper.


Displaying record number 53841

HXB2 Location Gag(28-36)
p17(28-36)
DNA(871..897)
Gag Epitope Map
Author Location p17(28-36)
Epitope KYKLKHIVW Epitope Alignment
KYKLKHIVW epitope logo
Show epitope variants
Epitope Name QW9
Species (MHC/HLA) human(A*24)
Immunogen HIV-1 infection
Patient MHC/HLA M-1003: A*24, A*30, B*39, B*47, Cw*12, Cw*17; P-1189: A*23, A*24, B*07, B*39, Cw*12, Cw*17
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords responses in children, mother-to-infant transmission, escape, acute/early infection, viral fitness and reversion

Notes

References

Sanchez-Merino2005 Victor Sanchez-Merino, Siwei Nie, and Katherine Luzuriaga. HIV-1-Specific CD8+ T Cell Responses and Viral Evolution in Women and Infants. J. Immunol., 175(10):6976-6986, 15 Nov 2005. PubMed ID: 16272358. Show all entries for this paper.


Displaying record number 55769

HXB2 Location Gag(28-36)
p17(28-36)
DNA(871..897)
Gag Epitope Map
Author Location Gag
Epitope KYKLKHIVW Epitope Alignment
KYKLKHIVW epitope logo
Subtype B, C
Species (MHC/HLA) human(A*24)
Immunogen HIV-1 infection
Country Canada, South Africa
Experimental methods  
Keywords escape

Notes

References

Carlson2008 Jonathan M. Carlson, Zabrina L. Brumme, Christine M. Rousseau, Chanson J. Brumme, Philippa Matthews, Carl Kadie, James I. Mullins, Bruce D. Walker, P. Richard Harrigan, Philip J. R. Goulder, and David Heckerman. Phylogenetic Dependency Networks: Inferring Patterns of CTL Escape and Codon Covariation in HIV-1 Gag. PLoS Comput Biol, 4(11):e1000225, Nov 2008. PubMed ID: 19023406. Show all entries for this paper.


Displaying record number 60967

HXB2 Location Gag(28-36)
p17(28-36)
DNA(871..897)
Gag Epitope Map
Author Location p17(28-36)
Epitope KYKLKHIVW Epitope Alignment
KYKLKHIVW epitope logo
Subtype B
Species (MHC/HLA) human(A*2402)
Immunogen HIV-1 infection
Patient MHC/HLA 51729: A*2401, A*2401, B*3505, B*4001, C*0304, C*0401
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords acute/early infection

Notes

References

Kunwar2013 Pratima Kunwar, Natalie Hawkins, Warren L. Dinges, Yi Liu, Erin E. Gabriel, David A. Swan, Claire E. Stevens, Janine Maenza, Ann C. Collier, James I. Mullins, Tomer Hertz, Xuesong Yu, and Helen Horton. Superior Control of HIV-1 Replication by CD8+ T Cells Targeting Conserved Epitopes: Implications for HIV Vaccine Design. PLoS One, 8(5):e64405, 2013. PubMed ID: 23741326. Show all entries for this paper.


Displaying record number 61177

HXB2 Location Gag(28-36)
p17(28-36)
DNA(871..897)
Gag Epitope Map
Author Location Gag(28-36)
Epitope KYKLKHIVW Epitope Alignment
KYKLKHIVW epitope logo
Show epitope variants
Epitope Name KW9
Subtype B
Species (MHC/HLA) human(A*2402)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining, Other
Keywords acute/early infection, variant cross-reactivity

Notes

References

Du2016 Victor Y. Du, Anju Bansal, Jonathan Carlson, Jesus F. Salazar-Gonzalez, Maria G. Salazar, Kristin Ladell, Stephanie Gras, Tracy M. Josephs, Sonya L. Heath, David A. Price, Jamie Rossjohn, Eric Hunter, and Paul A. Goepfert. HIV-1-Specific CD8 T Cells Exhibit Limited Cross-Reactivity during Acute Infection. J. Immunol., 196(8):3276-3286, 15 Apr 2016. PubMed ID: 26983786. Show all entries for this paper.


Displaying record number 54

HXB2 Location Gag(28-36)
p17(28-36)
DNA(871..897)
Gag Epitope Map
Author Location p17(28-36 SF2)
Epitope KYKLKHIVW Epitope Alignment
KYKLKHIVW epitope logo
Species (MHC/HLA) human(A*2402)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

IkedaMoore1998 Y. Ikeda-Moore, H. Tomiyama, M. Ibe, S. Oka, K. Miwa, Y. Kaneko, and M. Takiguchi. Identification of a Novel HLA-A24-Restricted Cytotoxic T-Lymphocyte Epitope Derived from HIV-1 Gag Protein. AIDS, 12:2073-2074, 1998. PubMed ID: 9814877. Show all entries for this paper.


Displaying record number 54754

HXB2 Location Gag(28-36)
p17(28-36)
DNA(871..897)
Gag Epitope Map
Author Location p17
Epitope KYKLKHIVW Epitope Alignment
KYKLKHIVW epitope logo
Species (MHC/HLA) human(A*2402)
Immunogen peptide-HLA interaction
Experimental methods Tetramer binding
Keywords binding affinity

Notes

References

Gillespie2007 Geraldine M. A. Gillespie, Arman Bashirova, Tao Dong, Daniel W. McVicar, Sarah L. Rowland-Jones, and Mary Carrington. Lack of KIR3DS1 Binding to MHC Class I Bw4 Tetramers in Complex with CD8+ T Cell Epitopes. AIDS Res. Hum. Retroviruses, 23(3):451-455, Mar 2007. PubMed ID: 17411378. Show all entries for this paper.


Displaying record number 52

HXB2 Location Gag(28-36)
p17(28-36)
DNA(871..897)
Gag Epitope Map
Author Location p17(28-36 LAI)
Epitope KYKLKHIVW Epitope Alignment
KYKLKHIVW epitope logo
Subtype B
Species (MHC/HLA) human(A*2402)
Immunogen  
Experimental methods  
Keywords optimal epitope

Notes

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 57790

HXB2 Location Gag(28-36)
p17(28-36)
DNA(871..897)
Gag Epitope Map
Author Location Gag
Epitope KYKLKHIVW Epitope Alignment
KYKLKHIVW epitope logo
Subtype B
Species (MHC/HLA) human(A*2402)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords computational epitope prediction, HLA associated polymorphism

Notes

References

Almeida2011 Coral-Ann M. Almeida, Corine Bronke, Steven G. Roberts, Elizabeth McKinnon, Niamh M. Keane, Abha Chopra, Carl Kadie, Jonathan Carlson, David W. Haas, Sharon A. Riddler, Richard Haubrich, David Heckerman, Simon Mallal, and Mina John. Translation of HLA-HIV Associations to the Cellular Level: HIV Adapts to Inflate CD8 T Cell Responses against Nef and HLA-Adapted Variant Epitopes. J. Immunol., 187(5):2502-2513, 1 Sep 2011. PubMed ID: 21821798. Show all entries for this paper.


Displaying record number 58187

HXB2 Location Gag(28-36)
p17(28-36)
DNA(871..897)
Gag Epitope Map
Author Location Gag(28-36)
Epitope KYKLKHIVW Epitope Alignment
KYKLKHIVW epitope logo
Show epitope variants
Epitope Name Gag28-36
Subtype B
Species (MHC/HLA) human(A*2402)
Immunogen HIV-1 infection
Patient MHC/HLA KI-092: A*0206, A*2402, B*4801, B*5101, Cw*0801, Cw*1402; KI-102: A*0206, A*2402, B*0702, B*3501, Cw*0303, Cw*0702; KI-158: A*2402, A*3303, B*4403, B*5201, Cw*1202, Cw*1403; KI-161: A*2402, A*2601, B*3501, B*5401, Cw*0102, Cw*0303; KI-091: A*2402; KI-163: A*2402; KI-151: A*2402; KI-140: A*2402; KI-154: A*2402; KI-126: A*2402; KI-134: A*2402; KI-136: A*2402
Country Japan
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, Intracellular cytokine staining, Relative replication capacity assay, Tetramer binding
Keywords escape, variant cross-reactivity

Notes

References

Akahoshi2012 Tomohiro Akahoshi, Takayuki Chikata, Yoshiko Tamura, Hiroyuki Gatanaga, Shinichi Oka, and Masafumi Takiguchi. Selection and Accumulation of an HIV-1 Escape Mutant by Three Types of HIV-1-Specific Cytotoxic T Lymphocytes Recognizing Wild-Type and/or Escape Mutant Epitopes. J. Virol., 86(4):1971-1981, Feb 2012. PubMed ID: 22156528. Show all entries for this paper.


Displaying record number 58433

HXB2 Location Gag(28-36)
p17(28-36)
DNA(871..897)
Gag Epitope Map
Author Location Gag(28-36)
Epitope KYKLKHIVW Epitope Alignment
KYKLKHIVW epitope logo
Subtype A1
Species (MHC/HLA) human(A*2402, A*2602)
Immunogen HIV-1 infection
Country Kenya
Experimental methods Other
Keywords assay or method development

Notes

References

Liang2011 Binhua Liang, Ma Luo, Joel Scott-Herridge, Christina Semeniuk, Mark Mendoza, Rupert Capina, Brent Sheardown, Hezhao Ji, Joshua Kimani, Blake T. Ball, Gary Van Domselaar, Morag Graham, Shane Tyler, Steven J. M. Jones, and Francis A. Plummer. A Comparison of Parallel Pyrosequencing and Sanger Clone-Based Sequencing and Its Impact on the Characterization of the Genetic Diversity of HIV-1. PLoS One, 6(10):e26745, 2011. PubMed ID: 22039546. Show all entries for this paper.


Displaying record number 59972

HXB2 Location Gag(28-36)
p17(28-36)
DNA(871..897)
Gag Epitope Map
Author Location Gag(28-36)
Epitope KYKLKHIVW Epitope Alignment
KYKLKHIVW epitope logo
Epitope Name KW9
Species (MHC/HLA) human(A*29)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 59973

HXB2 Location Gag(28-36)
p17(28-36)
DNA(871..897)
Gag Epitope Map
Author Location Gag(28-36)
Epitope KYKLKHIVW Epitope Alignment
KYKLKHIVW epitope logo
Epitope Name KW9
Species (MHC/HLA) human(A*6802)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 59970

HXB2 Location Gag(28-36)
p17(28-36)
DNA(871..897)
Gag Epitope Map
Author Location Gag(28-36)
Epitope KYKLKHIVW Epitope Alignment
KYKLKHIVW epitope logo
Epitope Name KW9
Species (MHC/HLA) human(B*3502, B*3503, B*5301)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 59976

HXB2 Location Gag(28-36)
p17(28-36)
DNA(871..897)
Gag Epitope Map
Author Location Gag(28-36)
Epitope KYKLKHIVW Epitope Alignment
KYKLKHIVW epitope logo
Epitope Name KW9
Species (MHC/HLA) human(B*55)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 59975

HXB2 Location Gag(28-36)
p17(28-36)
DNA(871..897)
Gag Epitope Map
Author Location Gag(28-36)
Epitope KYKLKHIVW Epitope Alignment
KYKLKHIVW epitope logo
Epitope Name KW9
Species (MHC/HLA) human(C*02)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 61335

HXB2 Location Gag(28-36)
p17(28-36)
DNA(871..897)
Gag Epitope Map
Author Location Gag
Epitope KYKLKHIVW Epitope Alignment
KYKLKHIVW epitope logo
Species (MHC/HLA) human
Immunogen vaccine
Country Australia, Brazil, Canada, Dominican Republic, Haiti, Jamaica, Peru, Puerto Rico, United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords vaccine-induced immune responses, assay or method development, optimal epitope

Vaccine Details

Vaccine type adenovirus type 5 (Ad5)
Vaccine component Gag, Nef, Pol

Notes

References

Fiore-Gartland2016 Andrew Fiore-Gartland, Bryce A. Manso, David P. Friedrich, Erin E. Gabriel, Greg Finak, Zoe Moodie, Tomer Hertz, Stephen C. De Rosa, Nicole Frahm, Peter B. Gilbert, and M Juliana McElrath. Pooled-Peptide Epitope Mapping Strategies Are Efficient and Highly Sensitive: An Evaluation of Methods for Identifying Human T Cell Epitope Specificities in Large-Scale HIV Vaccine Efficacy Trials. PLoS One, 11(2):e0147812, 2016. PubMed ID: 26863315. Show all entries for this paper.


Displaying record number 56981

HXB2 Location Gag(28-36)
p17(28-36)
DNA(871..897)
Gag Epitope Map
Author Location Gag
Epitope KYKLKHIVW Epitope Alignment
KYKLKHIVW epitope logo
Subtype B, C
Species (MHC/HLA) human
Immunogen HIV-1 infection
Country Sweden
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords subtype comparisons, computational epitope prediction, vaccine antigen design

Notes

References

Perez2008 Carina L. Pérez, Mette V. Larsen, Rasmus Gustafsson, Melissa M. Norström, Ann Atlas, Douglas F. Nixon, Morten Nielsen, Ole Lund, and Annika C. Karlsson. Broadly Immunogenic HLA Class I Supertype-Restricted Elite CTL Epitopes Recognized in a Diverse Population Infected with Different HIV-1 Subtypes. J. Immunol., 180(7):5092-5100, 1 Apr 2008. PubMed ID: 18354235. Show all entries for this paper.


Displaying record number 58018

HXB2 Location Gag(28-36)
p17(28-36)
DNA(871..897)
Gag Epitope Map
Author Location Gag
Epitope KYKLKHIVW Epitope Alignment
KYKLKHIVW epitope logo
Subtype B
Species (MHC/HLA) human
Immunogen vaccine
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords vaccine-induced immune responses

Vaccine Details

Vaccine type adenovirus type 5 (Ad5), DNA prime with Ad5 boost
Vaccine strain B clade IIIB, B clade JRFL, B clade CAM-1
Vaccine component Gag, Nef, Pol

Notes

References

Li2011a Fusheng Li, Adam C. Finnefrock, Sheri A. Dubey, Bette T. M. Korber, James Szinger, Suzanne Cole, M. Juliana McElrath, John W. Shiver, Danilo R. Casimiro, Lawrence Corey, and Steven G Self. Mapping HIV-1 Vaccine Induced T-Cell Responses: Bias Towards Less-Conserved Regions and Potential Impact on Vaccine Efficacy in the Step Study. PLoS One, 6(6):e20479, 2011. PubMed ID: 21695251. Show all entries for this paper.


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