Search CTL/CD8+ T-Cell Epitope Database

Found 2 matching records:

Displaying record number 1180

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HXB2 Location	Gag(264-277) p24(132-145) DNA(1579..1620)	Gag Epitope Map
Author Location	Gag
Epitope	KWILGLNKIVRMY	Epitope Alignment
Species (MHC/HLA)	human(B27)
Immunogen	HIV-1 infection
Experimental methods
Keywords	TCR usage

Notes

• Peptide 728: Almost all CD8+ T cells are CD28+ at birth, and the proportion of CD28-CD8+ cells increases with age -- this study examines the contribution of CD8+CD28- cells to CTL memory pools for CTL clones specific for two persistent human viruses, CMV and HIV -- clones were found to be similarly distributed the CD28 depleted cell population.
• HIV CTL responses to 3 Env and 2 Gag peptides were studied.
• The clonal composition of the TCR Vβ responses were studied and was found to be highly focused, with one TCR beta-chain sequence tending to dominate the peptide-specific response -- clones to this epitope were Vβ22.1.

References

Weekes1999 M. P. Weekes, M. R. Wills, K. Mynard, R. Hicks, J. G. Sissons, and A. J. Carmichael. Large Clonal Expansions of Human Virus-Specific Memory Cytotoxic T Lymphocytes within the CD57+ CD28- CD8+ T Cell Population. Immunology, 98:443-449, 1999. PubMed ID: 10583606. Show all entries for this paper.

Displaying record number 1181

Download this epitope record as JSON.

HXB2 Location	Gag(264-277) p24(132-145) DNA(1579..1620)	Gag Epitope Map
Author Location	Gag
Epitope	KWILGLNKIVRMY	Epitope Alignment
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Experimental methods
Keywords

Notes

• Peptide 728: Memory CTL specific for HIV-1 may contribute to oligoclonal expansions within the CD57+ CD28- CD8+ CTLp populations.

References

Weekes1999a M. P. Weekes, A. J. Carmichael, M. R. Wills, K. Mynard, and J. G. Sissons. Human CD28-CD8+ T Cells Contain Greatly Expanded Functional Virus-Specific Memory CTL Clones. J. Immunol., 162:7569-7577, 1999. PubMed ID: 10358214. Show all entries for this paper.