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Displaying record number 1753

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HXB2 Location	gp160(828-836) gp41(317-325) DNA(8706..8732)	gp160 Epitope Map
Author Location	gp41(829-837 CM243 subtype CRF01)
Epitope	KVIEVAQGA	Epitope Alignment
Subtype	CRF01_AE
Species (MHC/HLA)	human(A*02)
Immunogen	HIV-1 infection
Experimental methods
Keywords	subtype comparisons

Notes

• More than half of a cohort of HIV+ female sex workers (FSW) from Northern Thailand were HLA-A*11 positive, and this study concentrated on A*11 epitopes in this group, although E clade versions of previously defined B-clade A*02 and A*24 epitopes were also tested.
• 1/4 tested FSWs recognized the E clade version of this epitope, which differs from the previously defined B clade version by three amino acids, RvievLqRa.
• This epitope was only conserved in CRF01 (subtype E), and identities were rare.

References

Bond2001 K. B. Bond, B. Sriwanthana, T. W. Hodge, A. S. De Groot, T. D. Mastro, N. L. Young, N. Promadej, J. D. Altman, K. Limpakarnjanarat, and J. M. McNicholl. An HLA-directed molecular and bioinformatics approach identifies new HLA-A11 HIV-1 subtype E cytotoxic T lymphocyte epitopes in HIV-1-infected Thais. AIDS Res. Hum. Retroviruses, 17(8):703-17, 20 May 2001. PubMed ID: 11429111. Show all entries for this paper.