HIV molecular immunology database
Found 18 matching records:
Download this epitope record as JSON.
HXB2 Location | Pol(888-896) Integrase(173-181) DNA(4746..4772) |
Pol Epitope Map |
---|---|---|
Author Location | Pol(888-896) | |
Epitope |
KTAVQMAVF
|
Epitope Alignment
|
Epitope Name | KF9 | |
Species (MHC/HLA) | human(B*15:24) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(888-896) Integrase(173-181) DNA(4746..4772) |
Pol Epitope Map |
---|---|---|
Author Location | Pol(888-896) | |
Epitope |
KTAVQMAVF
|
Epitope Alignment
|
Epitope Name | KF9 | |
Species (MHC/HLA) | human(B*35:02, B*35:03, B*53:01) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(888-896) Integrase(173-181) DNA(4746..4772) |
Pol Epitope Map |
---|---|---|
Author Location | Pol(888-896) | |
Epitope |
KTAVQMAVF
|
Epitope Alignment
|
Epitope Name | KF9 | |
Species (MHC/HLA) | human(B*40) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(888-896) Integrase(173-181) DNA(4746..4772) |
Pol Epitope Map |
---|---|---|
Author Location | Integrase | |
Epitope |
KTAVQMAVF
|
Epitope Alignment
|
Epitope Name | KF9 | |
Species (MHC/HLA) | human(B*57) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | rate of progression |
Streeck2014 Hendrik Streeck, Richard Lu, Noor Beckwith, Mark Milazzo, Michelle Liu, Jean-Pierre Routy, Susan Little, Heiko Jessen, Anthony D. Kelleher, Frederick Hecht, Rafick-Pierre Sekaly, Galit Alter, David Heckerman, Mary Carrington, Eric S. Rosenberg, and Marcus Altfeld. Emergence of Individual HIV-Specific CD8 T Cell Responses during Primary HIV-1 Infection Can Determine Long-Term Disease Outcome. J. Virol., 88(21):12793-12801, Nov 2014. PubMed ID: 25165102. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(888-896) Integrase(173-181) DNA(4746..4772) |
Pol Epitope Map |
---|---|---|
Author Location | Pol(888-896) | |
Epitope |
KTAVQMAVF
|
Epitope Alignment
|
Epitope Name | KF9 | |
Species (MHC/HLA) | human(B*57) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(888-896) Integrase(173-181) DNA(4746..4772) |
Pol Epitope Map |
---|---|---|
Author Location | ||
Epitope |
KTAVQMAVF
|
Epitope Alignment
|
Epitope Name | KF9 | |
Species (MHC/HLA) | human(B*57) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | escape |
Bailey2006 Justin R. Bailey, Thomas M. Williams, Robert F. Siliciano, and Joel N. Blankson. Maintenance of Viral Suppression in HIV-1-Infected HLA-B*57+ Elite Suppressors Despite CTL Escape Mutations. J. Exp. Med., 203(5):1357-1369, 15 May 2006. PubMed ID: 16682496. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(888-896) Integrase(173-181) DNA(4746..4772) |
Pol Epitope Map |
---|---|---|
Author Location | Integrase(173-181) | |
Epitope |
KTAVQMAVF
|
Epitope Alignment
|
Epitope Name | intKF9 | |
Species (MHC/HLA) | human(B*57) | |
Immunogen | HIV-1 infection | |
Country | Kenya, United Kingdom | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | TCR usage, structure, characterizing CD8+ T cells |
Gillespie2006 Geraldine M. A. Gillespie, Guillaume Stewart-Jones, Jaya Rengasamy, Tara Beattie, Job J. Bwayo, Francis A. Plummer, Rupert Kaul, Andrew J. McMichael, Philippa Easterbrook, Tao Dong, E. Yvonne Jones, and Sarah L. Rowland-Jones. Strong TCR Conservation and Altered T Cell Cross-Reactivity Characterize a B*57-Restricted Immune Response in HIV-1 Infection. J. Immunol., 177(6):3893-3902, 15 Sep 2006. PubMed ID: 16951352. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(888-896) Integrase(173-181) DNA(4746..4772) |
Pol Epitope Map |
---|---|---|
Author Location | Integrase | |
Epitope |
KTAVQMAVF
|
Epitope Alignment
|
Epitope Name | B57-KF9(int) | |
Species (MHC/HLA) | human(B*57) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining | |
Keywords | acute/early infection, protective allele |
Altfeld2003a Marcus Altfeld, Marylyn M. Addo, Eric S. Rosenberg, Frederick M. Hecht, Paul K. Lee, Martin Vogel, Xu G. Yu, Rika Draenert, Mary N. Johnston, Daryld Strick, Todd M. Allen, Margaret E. Feeney, James O. Kahn, Rafick P. Sekaly, Jay A. Levy, Jürgen K. Rockstroh, Philip J. Goulder, and Bruce D. Walker. Influence of HLA-B57 on Clinical Presentation and Viral Control during Acute HIV-1 Infection. AIDS, 17(18):2581-2591, 5 Dec 2003. PubMed ID: 14685052. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(888-896) Integrase(173-181) DNA(4746..4772) |
Pol Epitope Map |
---|---|---|
Author Location | Pol(888-896) | |
Epitope |
KTAVQMAVF
|
Epitope Alignment
|
Species (MHC/HLA) | human(B57) | |
Immunogen | ||
Experimental methods | ||
Keywords |
Hay1999 C. Hay. Personal communication, 1999. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(888-896) Integrase(173-181) DNA(4746..4772) |
Pol Epitope Map |
---|---|---|
Author Location | Pol | |
Epitope |
KTAVQMAVF
|
Epitope Alignment
|
Epitope Name | KF9 | |
Subtype | B | |
Species (MHC/HLA) | human(B57) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | subtype comparisons, escape, characterizing CD8+ T cells, viral fitness and reversion |
Allen2005a Todd M. Allen, Marcus Altfeld, Shaun C. Geer, Elizabeth T. Kalife, Corey Moore, Kristin M. O'Sullivan, Ivna DeSouza, Margaret E. Feeney, Robert L. Eldridge, Erica L. Maier, Daniel E. Kaufmann, Matthew P. Lahaie, Laura Reyor, Giancarlo Tanzi, Mary N. Johnston, Christian Brander, Rika Draenert, Jurgen K. Rockstroh, Heiko Jessen, Eric S. Rosenberg, Simon A. Mallal, and Bruce D. Walker. Selective Escape from CD8+ T-Cell Responses Represents a Major Driving Force of Human Immunodeficiency Virus Type 1 (HIV-1) Sequence Diversity and Reveals Constraints on HIV-1 Evolution. J. Virol., 79(21):13239-13249, Nov 2005. PubMed ID: 16227247. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(888-896) Integrase(173-181) DNA(4746..4772) |
Pol Epitope Map |
---|---|---|
Author Location | Pol(889-897) | |
Epitope |
KTAVQMAVF
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(B57) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | A1, A3, B57, B7, Cw6, Cw7 | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords |
Allen2005a Todd M. Allen, Marcus Altfeld, Shaun C. Geer, Elizabeth T. Kalife, Corey Moore, Kristin M. O'Sullivan, Ivna DeSouza, Margaret E. Feeney, Robert L. Eldridge, Erica L. Maier, Daniel E. Kaufmann, Matthew P. Lahaie, Laura Reyor, Giancarlo Tanzi, Mary N. Johnston, Christian Brander, Rika Draenert, Jurgen K. Rockstroh, Heiko Jessen, Eric S. Rosenberg, Simon A. Mallal, and Bruce D. Walker. Selective Escape from CD8+ T-Cell Responses Represents a Major Driving Force of Human Immunodeficiency Virus Type 1 (HIV-1) Sequence Diversity and Reveals Constraints on HIV-1 Evolution. J. Virol., 79(21):13239-13249, Nov 2005. PubMed ID: 16227247. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(888-896) Integrase(173-181) DNA(4746..4772) |
Pol Epitope Map |
---|---|---|
Author Location | ||
Epitope |
KTAVQMAVF
|
Epitope Alignment
|
Species (MHC/HLA) | human(B57) | |
Immunogen | HIV-1 infection, vaccine | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | vaccine-induced immune responses, characterizing CD8+ T cells |
Vaccine type | canarypox, canarypox prime with recombinant protein boost |
---|---|
Vaccine strain | B clade BRU, B clade LAI, B clade MN, multiple epitope immunogen |
Vaccine component | Gag, gp120, gp41, Nef, Pol, Protease |
Horton2006 Helen Horton, Ian Frank, Ruth Baydo, Emilie Jalbert, Justin Penn, Sean Wilson, John P. McNevin, Matthew D. McSweyn, Deborah Lee, Yunda Huang, Stephen C. De Rosa, and M. Juliana McElrath. Preservation of T Cell Proliferation Restricted by Protective HLA Alleles Is Critical for Immune Control of HIV-1 Infection. J. Immunol., 177(10):7406-7415, 15 Nov 2006. PubMed ID: 17082660. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(888-896) Integrase(173-181) DNA(4746..4772) |
Pol Epitope Map |
---|---|---|
Author Location | ||
Epitope |
KTAVQMAVF
|
Epitope Alignment
|
Species (MHC/HLA) | human(B*58:01, B57) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Chromium-release assay | |
Keywords | responses in children, mother-to-infant transmission, escape |
Feeney2005a Margaret E. Feeney, Yanhua Tang, Katja Pfafferott, Kathleen A. Roosevelt, Rika Draenert, Alicja Trocha, Xu G. Yu, Cori Verrill, Todd Allen, Corey Moore, Simon Mallal, Sandra Burchett, Kenneth McIntosh, Stephen I. Pelton, M. Anne St. John, Rohan Hazra, Paul Klenerman, Marcus Altfeld, Bruce D. Walker, and Philip J. R. Goulder. HIV-1 Viral Escape in Infancy Followed by Emergence of a Variant-Specific CTL Response. J. Immunol., 174(12):7524-7530, 15 Jun 2005. PubMed ID: 15944251. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(888-896) Integrase(173-181) DNA(4746..4772) |
Pol Epitope Map |
---|---|---|
Author Location | Pol(888-896) | |
Epitope |
KTAVQMAVF
|
Epitope Alignment
|
Species (MHC/HLA) | human(B*57:01) | |
Immunogen | ||
Experimental methods | ||
Keywords | optimal epitope, A-list |
Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(888-896) Integrase(173-181) DNA(4746..4772) |
Pol Epitope Map |
---|---|---|
Author Location | Integrase | |
Epitope |
KTAVQMAVF
|
Epitope Alignment
|
Epitope Name | KF9 Int | |
Subtype | C | |
Species (MHC/HLA) | human(B*57:03, B*58:01) | |
Immunogen | HIV-1 infection | |
Country | Botswana, South Africa, Zimbabwe | |
Experimental methods | CD8 T-cell Elispot - IFNγ, HLA binding, Intracellular cytokine staining, Tetramer binding | |
Keywords | optimal epitope, HLA associated polymorphism, novel epitope |
Kloverpris2012 Henrik N. Kloverpris, Anette Stryhn, Mikkel Harndahl, Mary van der Stok, Rebecca P. Payne, Philippa C. Matthews, Fabian Chen, Lynn Riddell, Bruce D. Walker, Thumbi Ndung'u, Søren Buus, and Philip Goulder. HLA-B*57 Micropolymorphism Shapes HLA Allele-Specific Epitope Immunogenicity, Selection Pressure, and HIV Immune Control. J. Virol., 86(2):919-929, Jan 2012. PubMed ID: 22090105. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(888-896) Integrase(173-181) DNA(4746..4772) |
Pol Epitope Map |
---|---|---|
Author Location | Integrase | |
Epitope |
KTAVQMAVF
|
Epitope Alignment
|
Subtype | C | |
Species (MHC/HLA) | human(B*58:01) | |
Immunogen | HIV-1 infection | |
Country | South Africa | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | rate of progression, acute/early infection |
Chopera2011 D. R. Chopera, M. Mlotshwa, Z. Woodman, K. Mlisana, D. de Assis Rosa, D. P. Martin, S. Abdool Karim, C. M. Gray, C. Williamson, and CAPRISA 002 Study Team. Virological and Immunological Factors Associated with HIV-1 Differential Disease Progression in HLA-B*58:01-Positive Individuals. J. Virol., 85(14):7070-7080, Jul 2011. PubMed ID: 21613398. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(888-896) Integrase(173-181) DNA(4746..4772) |
Pol Epitope Map |
---|---|---|
Author Location | Integrase | |
Epitope |
KTAVQMAVF
|
Epitope Alignment
|
Subtype | C | |
Species (MHC/HLA) | human(B*58:01) | |
Immunogen | HIV-1 infection | |
Country | South Africa | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | rate of progression, acute/early infection |
Chopera2011 D. R. Chopera, M. Mlotshwa, Z. Woodman, K. Mlisana, D. de Assis Rosa, D. P. Martin, S. Abdool Karim, C. M. Gray, C. Williamson, and CAPRISA 002 Study Team. Virological and Immunological Factors Associated with HIV-1 Differential Disease Progression in HLA-B*58:01-Positive Individuals. J. Virol., 85(14):7070-7080, Jul 2011. PubMed ID: 21613398. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(888-896) Integrase(173-181) DNA(4746..4772) |
Pol Epitope Map |
---|---|---|
Author Location | ||
Epitope |
KTAVQMAVF
|
Epitope Alignment
|
Species (MHC/HLA) | macaque | |
Immunogen | vaccine | |
Experimental methods | CD8 T-cell RecycleSpot - IFNγ | |
Keywords | vaccine-induced immune responses, vaccine antigen design |
Vaccine type | DNA, modified vaccinia Ankara (MVA), Semliki-Forest Virus, adenovirus, Long Peptides, HIVconsv |
---|---|
Adjuvant | Montanide (ISA 51) |
Rosario2010 Maximillian Rosario, Anne Bridgeman, Esther D. Quakkelaar, Maire F. Quigley, Brenna J. Hill, Maria L. Knudsen, Virginia Ammendola, Karl Ljungberg, Nicola Borthwick, Eung-Jun Im, Andrew J. McMichael, Jan W. Drijfhout, Hui Yee Greenaway, Vanessa Venturi, Daniel C. Douek, Stefano Colloca, Peter Liljeström, Alfredo Nicosia, David A. Price, Cornelis J. M. Melief, and Tomáš Hanke. Long Peptides Induce Polyfunctional T Cells against Conserved Regions of HIV-1 with Superior Breadth to Single-Gene Vaccines in Macaques. Eur. J. Immunol., 40(7):1973-1984, Jul 2010. PubMed ID: 20468055. Show all entries for this paper.