HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 18 matching records:

Displaying record number 59962

HXB2 Location Pol(888-896)
Integrase(173-181)
DNA(4746..4772)
Pol Epitope Map
Author Location Pol(888-896)
Epitope KTAVQMAVF Epitope Alignment
KTAVQMAVF epitope logo
Epitope Name KF9
Species (MHC/HLA) human(B*1524)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 59959

HXB2 Location Pol(888-896)
Integrase(173-181)
DNA(4746..4772)
Pol Epitope Map
Author Location Pol(888-896)
Epitope KTAVQMAVF Epitope Alignment
KTAVQMAVF epitope logo
Epitope Name KF9
Species (MHC/HLA) human(B*3502, B*3503, B*5301)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 59961

HXB2 Location Pol(888-896)
Integrase(173-181)
DNA(4746..4772)
Pol Epitope Map
Author Location Pol(888-896)
Epitope KTAVQMAVF Epitope Alignment
KTAVQMAVF epitope logo
Epitope Name KF9
Species (MHC/HLA) human(B*40)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 53494

HXB2 Location Pol(888-896)
Integrase(173-181)
DNA(4746..4772)
Pol Epitope Map
Author Location Pol
Epitope KTAVQMAVF Epitope Alignment
KTAVQMAVF epitope logo
Epitope Name KF9
Subtype B
Species (MHC/HLA) human(B57)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords subtype comparisons, escape, characterizing CD8+ T cells, viral fitness and reversion

Notes

References

Allen2005a Todd M. Allen, Marcus Altfeld, Shaun C. Geer, Elizabeth T. Kalife, Corey Moore, Kristin M. O'Sullivan, Ivna DeSouza, Margaret E. Feeney, Robert L. Eldridge, Erica L. Maier, Daniel E. Kaufmann, Matthew P. Lahaie, Laura Reyor, Giancarlo Tanzi, Mary N. Johnston, Christian Brander, Rika Draenert, Jurgen K. Rockstroh, Heiko Jessen, Eric S. Rosenberg, Simon A. Mallal, and Bruce D. Walker. Selective Escape from CD8+ T-Cell Responses Represents a Major Driving Force of Human Immunodeficiency Virus Type 1 (HIV-1) Sequence Diversity and Reveals Constraints on HIV-1 Evolution. J. Virol., 79(21):13239-13249, Nov 2005. PubMed ID: 16227247. Show all entries for this paper.


Displaying record number 54890

HXB2 Location Pol(888-896)
Integrase(173-181)
DNA(4746..4772)
Pol Epitope Map
Author Location  
Epitope KTAVQMAVF Epitope Alignment
KTAVQMAVF epitope logo
Species (MHC/HLA) human(B57)
Immunogen HIV-1 infection, vaccine
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords vaccine-induced immune responses, characterizing CD8+ T cells

Vaccine Details

Vaccine type canarypox, canarypox prime with recombinant protein boost
Vaccine strain B clade BRU, B clade LAI, B clade MN, multiple epitope immunogen
Vaccine component Gag, gp120, gp41, Nef, Pol, Protease

Notes

References

Horton2006 Helen Horton, Ian Frank, Ruth Baydo, Emilie Jalbert, Justin Penn, Sean Wilson, John P. McNevin, Matthew D. McSweyn, Deborah Lee, Yunda Huang, Stephen C. De Rosa, and M. Juliana McElrath. Preservation of T Cell Proliferation Restricted by Protective HLA Alleles Is Critical for Immune Control of HIV-1 Infection. J. Immunol., 177(10):7406-7415, 15 Nov 2006. PubMed ID: 17082660. Show all entries for this paper.


Displaying record number 53552

HXB2 Location Pol(888-896)
Integrase(173-181)
DNA(4746..4772)
Pol Epitope Map
Author Location Pol(889-897)
Epitope KTAVQMAVF Epitope Alignment
KTAVQMAVF epitope logo
Subtype B
Species (MHC/HLA) human(B57)
Immunogen HIV-1 infection
Patient MHC/HLA A1, A3, B57, B7, Cw6, Cw7
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords  

Notes

References

Allen2005a Todd M. Allen, Marcus Altfeld, Shaun C. Geer, Elizabeth T. Kalife, Corey Moore, Kristin M. O'Sullivan, Ivna DeSouza, Margaret E. Feeney, Robert L. Eldridge, Erica L. Maier, Daniel E. Kaufmann, Matthew P. Lahaie, Laura Reyor, Giancarlo Tanzi, Mary N. Johnston, Christian Brander, Rika Draenert, Jurgen K. Rockstroh, Heiko Jessen, Eric S. Rosenberg, Simon A. Mallal, and Bruce D. Walker. Selective Escape from CD8+ T-Cell Responses Represents a Major Driving Force of Human Immunodeficiency Virus Type 1 (HIV-1) Sequence Diversity and Reveals Constraints on HIV-1 Evolution. J. Virol., 79(21):13239-13249, Nov 2005. PubMed ID: 16227247. Show all entries for this paper.


Displaying record number 581

HXB2 Location Pol(888-896)
Integrase(173-181)
DNA(4746..4772)
Pol Epitope Map
Author Location Pol(888-896)
Epitope KTAVQMAVF Epitope Alignment
KTAVQMAVF epitope logo
Species (MHC/HLA) human(B57)
Immunogen  
Experimental methods  
Keywords  

Notes

References

Hay1999 C. Hay. Personal communication, 1999. Show all entries for this paper.


Displaying record number 53646

HXB2 Location Pol(888-896)
Integrase(173-181)
DNA(4746..4772)
Pol Epitope Map
Author Location  
Epitope KTAVQMAVF Epitope Alignment
KTAVQMAVF epitope logo
Species (MHC/HLA) human(B*5801, B57)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay
Keywords responses in children, mother-to-infant transmission, escape

Notes

References

Feeney2005a Margaret E. Feeney, Yanhua Tang, Katja Pfafferott, Kathleen A. Roosevelt, Rika Draenert, Alicja Trocha, Xu G. Yu, Cori Verrill, Todd Allen, Corey Moore, Simon Mallal, Sandra Burchett, Kenneth McIntosh, Stephen I. Pelton, M. Anne St. John, Rohan Hazra, Paul Klenerman, Marcus Altfeld, Bruce D. Walker, and Philip J. R. Goulder. HIV-1 Viral Escape in Infancy Followed by Emergence of a Variant-Specific CTL Response. J. Immunol., 174(12):7524-7530, 15 Jun 2005. PubMed ID: 15944251. Show all entries for this paper.


Displaying record number 61566

HXB2 Location Pol(888-896)
Integrase(173-181)
DNA(4746..4772)
Pol Epitope Map
Author Location Integrase
Epitope KTAVQMAVF Epitope Alignment
KTAVQMAVF epitope logo
Epitope Name B57-KF9(int)
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining
Keywords acute/early infection, protective allele

Notes

References

Altfeld2003a Marcus Altfeld, Marylyn M. Addo, Eric S. Rosenberg, Frederick M. Hecht, Paul K. Lee, Martin Vogel, Xu G. Yu, Rika Draenert, Mary N. Johnston, Daryld Strick, Todd M. Allen, Margaret E. Feeney, James O. Kahn, Rafick P. Sekaly, Jay A. Levy, Jürgen K. Rockstroh, Philip J. Goulder, and Bruce D. Walker. Influence of HLA-B57 on Clinical Presentation and Viral Control during Acute HIV-1 Infection. AIDS, 17(18):2581-2591, 5 Dec 2003. PubMed ID: 14685052. Show all entries for this paper.


Displaying record number 54382

HXB2 Location Pol(888-896)
Integrase(173-181)
DNA(4746..4772)
Pol Epitope Map
Author Location  
Epitope KTAVQMAVF Epitope Alignment
KTAVQMAVF epitope logo
Epitope Name KF9
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords escape

Notes

References

Bailey2006 Justin R. Bailey, Thomas M. Williams, Robert F. Siliciano, and Joel N. Blankson. Maintenance of Viral Suppression in HIV-1-Infected HLA-B*57+ Elite Suppressors Despite CTL Escape Mutations. J. Exp. Med., 203(5):1357-1369, 15 May 2006. PubMed ID: 16682496. Show all entries for this paper.


Displaying record number 54820

HXB2 Location Pol(888-896)
Integrase(173-181)
DNA(4746..4772)
Pol Epitope Map
Author Location Integrase(173-181)
Epitope KTAVQMAVF Epitope Alignment
KTAVQMAVF epitope logo
Epitope Name intKF9
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Country Kenya, United Kingdom
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords TCR usage, structure, characterizing CD8+ T cells

Notes

References

Gillespie2006 Geraldine M. A. Gillespie, Guillaume Stewart-Jones, Jaya Rengasamy, Tara Beattie, Job J. Bwayo, Francis A. Plummer, Rupert Kaul, Andrew J. McMichael, Philippa Easterbrook, Tao Dong, E. Yvonne Jones, and Sarah L. Rowland-Jones. Strong TCR Conservation and Altered T Cell Cross-Reactivity Characterize a B*57-Restricted Immune Response in HIV-1 Infection. J. Immunol., 177(6):3893-3902, 15 Sep 2006. PubMed ID: 16951352. Show all entries for this paper.


Displaying record number 59309

HXB2 Location Pol(888-896)
Integrase(173-181)
DNA(4746..4772)
Pol Epitope Map
Author Location Integrase
Epitope KTAVQMAVF Epitope Alignment
KTAVQMAVF epitope logo
Epitope Name KF9
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression

Notes

References

Streeck2014 Hendrik Streeck, Richard Lu, Noor Beckwith, Mark Milazzo, Michelle Liu, Jean-Pierre Routy, Susan Little, Heiko Jessen, Anthony D. Kelleher, Frederick Hecht, Rafick-Pierre Sekaly, Galit Alter, David Heckerman, Mary Carrington, Eric S. Rosenberg, and Marcus Altfeld. Emergence of Individual HIV-Specific CD8 T Cell Responses during Primary HIV-1 Infection Can Determine Long-Term Disease Outcome. J. Virol., 88(21):12793-12801, Nov 2014. PubMed ID: 25165102. Show all entries for this paper.


Displaying record number 59960

HXB2 Location Pol(888-896)
Integrase(173-181)
DNA(4746..4772)
Pol Epitope Map
Author Location Pol(888-896)
Epitope KTAVQMAVF Epitope Alignment
KTAVQMAVF epitope logo
Epitope Name KF9
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 582

HXB2 Location Pol(888-896)
Integrase(173-181)
DNA(4746..4772)
Pol Epitope Map
Author Location Pol(888-896)
Epitope KTAVQMAVF Epitope Alignment
KTAVQMAVF epitope logo
Species (MHC/HLA) human(B*5701)
Immunogen  
Experimental methods  
Keywords optimal epitope

Notes

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 58826

HXB2 Location Pol(888-896)
Integrase(173-181)
DNA(4746..4772)
Pol Epitope Map
Author Location Integrase
Epitope KTAVQMAVF Epitope Alignment
KTAVQMAVF epitope logo
Epitope Name KF9 Int
Subtype C
Species (MHC/HLA) human(B*5703, B*5801)
Immunogen HIV-1 infection
Country Botswana, South Africa, Zimbabwe
Experimental methods CD8 T-cell Elispot - IFNγ, HLA binding, Intracellular cytokine staining, Tetramer binding
Keywords optimal epitope, HLA associated polymorphism, novel epitope

Notes

References

Kloverpris2012 Henrik N. Kloverpris, Anette Stryhn, Mikkel Harndahl, Mary van der Stok, Rebecca P. Payne, Philippa C. Matthews, Fabian Chen, Lynn Riddell, Bruce D. Walker, Thumbi Ndung'u, Søren Buus, and Philip Goulder. HLA-B*57 Micropolymorphism Shapes HLA Allele-Specific Epitope Immunogenicity, Selection Pressure, and HIV Immune Control. J. Virol., 86(2):919-929, Jan 2012. PubMed ID: 22090105. Show all entries for this paper.


Displaying record number 57890

HXB2 Location Pol(888-896)
Integrase(173-181)
DNA(4746..4772)
Pol Epitope Map
Author Location Integrase
Epitope KTAVQMAVF Epitope Alignment
KTAVQMAVF epitope logo
Subtype C
Species (MHC/HLA) human(B*5801)
Immunogen HIV-1 infection
Patient MHC/HLA A*0205, A*2601, B*0705, B*5801, Cw*0701, Cw*0702
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, acute/early infection

Notes

References

Chopera2011 D. R. Chopera, M. Mlotshwa, Z. Woodman, K. Mlisana, D. de Assis Rosa, D. P. Martin, S. Abdool Karim, C. M. Gray, C. Williamson, and CAPRISA 002 Study Team. Virological and Immunological Factors Associated with HIV-1 Differential Disease Progression in HLA-B*58:01-Positive Individuals. J. Virol., 85(14):7070-7080, Jul 2011. PubMed ID: 21613398. Show all entries for this paper.


Displaying record number 57881

HXB2 Location Pol(888-896)
Integrase(173-181)
DNA(4746..4772)
Pol Epitope Map
Author Location Integrase
Epitope KTAVQMAVF Epitope Alignment
KTAVQMAVF epitope logo
Subtype C
Species (MHC/HLA) human(B*5801)
Immunogen HIV-1 infection
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, acute/early infection

Notes

References

Chopera2011 D. R. Chopera, M. Mlotshwa, Z. Woodman, K. Mlisana, D. de Assis Rosa, D. P. Martin, S. Abdool Karim, C. M. Gray, C. Williamson, and CAPRISA 002 Study Team. Virological and Immunological Factors Associated with HIV-1 Differential Disease Progression in HLA-B*58:01-Positive Individuals. J. Virol., 85(14):7070-7080, Jul 2011. PubMed ID: 21613398. Show all entries for this paper.


Displaying record number 57664

HXB2 Location Pol(888-896)
Integrase(173-181)
DNA(4746..4772)
Pol Epitope Map
Author Location  
Epitope KTAVQMAVF Epitope Alignment
KTAVQMAVF epitope logo
Species (MHC/HLA) macaque
Immunogen vaccine
Experimental methods CD8 T-cell RecycleSpot - IFNγ
Keywords vaccine-induced immune responses, vaccine antigen design

Vaccine Details

Vaccine type DNA, modified vaccinia Ankara (MVA), Semliki-Forest Virus, adenovirus, Long Peptides, HIVconsv
Adjuvant Montanide (ISA 51)

Notes

References

Rosario2010 Maximillian Rosario, Anne Bridgeman, Esther D. Quakkelaar, Maire F. Quigley, Brenna J. Hill, Maria L. Knudsen, Virginia Ammendola, Karl Ljungberg, Nicola Borthwick, Eung-Jun Im, Andrew J. McMichael, Jan W. Drijfhout, Hui Yee Greenaway, Vanessa Venturi, Daniel C. Douek, Stefano Colloca, Peter Liljeström, Alfredo Nicosia, David A. Price, Cornelis J. M. Melief, and Tomáš Hanke. Long Peptides Induce Polyfunctional T Cells against Conserved Regions of HIV-1 with Superior Breadth to Single-Gene Vaccines in Macaques. Eur. J. Immunol., 40(7):1973-1984, Jul 2010. PubMed ID: 20468055. Show all entries for this paper.


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