Search CTL/CD8+ T-Cell Epitope Database

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Displaying record number 281

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HXB2 Location	Gag(263-272) p24(131-140) DNA(1576..1605)	Gag Epitope Map
Author Location	p24(263-272)
Epitope	KRWIIMGNK	Epitope Alignment
		Show epitope variants
Species (MHC/HLA)	human(B27)
Immunogen	HIV-1 infection
Experimental methods
Keywords	escape

Notes

• Longitudinal study of CTL response and immune escape -- the consensus form KRWIIlGNK was also found, and both forms stimulate CTL. KRWIIMGNK is the predominant circulating form.

References

Nowak1995 M. A. Nowak, R. M. May, R. E. Phillips, S. Rowland-Jones, D. G. Lalloo, S. McAdam, P. Klenerman, B. Koppe, K. Sigmund, C. R. M. Bangham, and A. J. McMichael. Antigenic Oscillations and Shifting Immunodominance in HIV-1 Infections. Nature, 375:606-611, 1995. This paper presents longitudinal studies of epitope variation and corresponding CTL responses in two patients. A mathematical model was created to provide a framework to explain the observed shifts in epitope and CTLp frequencies. For discussion, see also: J. M. Coffin, Nature 375:534-535 (1995). PubMed ID: 7791879. Show all entries for this paper.