HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 9 matching records:

Displaying record number 62761

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HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location Gag(263-272)
Epitope KRWIIMGLNK Epitope Alignment
KRWIIMGLNK epitope logo
Show epitope variants
Epitope Name KK10
Subtype B
Species (MHC/HLA) human(B*27)
Immunogen in vitro stimulation or selection
Experimental methods Chromium-release assay, Cytokine production, Gene expression assay/analyses, Other
Keywords characterizing CD8+ T cells

Notes

References

Grossman2019 Mark A. Grossman, Christian Hofmann, Hwee L. Ng, and Otto O. Yang. Suboptimal Stimulation by Weak Agonist Epitope Variants Does Not Drive Dysfunction of HIV-1-Specific Cytotoxic T Lymphocyte Clones. AIDS, 33(10):1565-1574, 1 Aug 2019. PubMed ID: 31306165. Show all entries for this paper.


Displaying record number 276

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HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location p24(263-272)
Epitope KRWIIMGLNK Epitope Alignment
KRWIIMGLNK epitope logo
Species (MHC/HLA) human(B27)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Klenerman1995 P. Klenerman, U.-C. Meier, R. E. Phillips, and A. J. McMichael. The Effects of Natural Altered Peptide Ligands on the Whole Blood Cytotoxic T Lymphocyte Response to Human Immunodeficiency Virus. Eur. J. Immunol., 25:1927-1931, 1995. This paper explores naturally occurring altered peptide ligands and their ability to sustain CTL, serve as antagonists to CTL specific for other variants, and to allow cell killing. The authors propose that a CTL response may be sustained in vivo that fails to recognize viral variants as they arise, proposing a mechanism for T-cell original antigenic sin. PubMed ID: 7542596. Show all entries for this paper.


Displaying record number 283

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HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location p24(263-272)
Epitope KRWIIMGLNK Epitope Alignment
KRWIIMGLNK epitope logo
Show epitope variants
Species (MHC/HLA) human(B27)
Immunogen HIV-1 infection
Experimental methods  
Keywords review, immunodominance, escape

Notes

References

Goulder1997b P. J. R. Goulder, R. E. Phillips, R. A. Colbert, S. McAdam, G. Ogg, M. A. Nowak, P. Giangrande, G. Luzzi, B. Morgan, A. Edwards, A. McMichael, and S. Rowland-Jones. Late Escape from an Immunodominant Cytotoxic T-Lymphocyte Response Associated with Progression to AIDS. Nat. Med., 3:212-216, 1997. The CTL response was studied in six HIV+ individuals who make a strong immunodominat response to the same B27 epitope. In two donors an escape mutation arose after close to 10 years of epitope stability, around the time of progression to AIDS. PubMed ID: 9018241. Show all entries for this paper.

Goulder1997e P. Goulder, D. Price, M. Nowak, S. Rowland-Jones, R. Phillips, and A. McMichael. Co-Evolution of Human Immunodeficiency Virus and Cytotoxic T-Lymphocyte Responses. Immunol. Rev., 159:17-29, 1997. PubMed ID: 9416500. Show all entries for this paper.


Displaying record number 275

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HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location p24(263-272)
Epitope KRWIIMGLNK Epitope Alignment
KRWIIMGLNK epitope logo
Species (MHC/HLA) human(B27)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Klenerman1994 P. Klenerman, S. Rowland-Jones, S. McAdam, J. Edwards, S. Daenke, D. Lalloo, B. Koppe, W. Rosenberg, D. Boyd, A. Edwards, P. Giangrande, R. E. Phillips, and A. J. McMichael. Cytotoxic T Cell Activity Antagonized by Naturally Occurring HIV-1 Gag Variants. Nature, 369:403-407, 1994. This paper documents that naturally occurring peptide variants can serve as antagonists, that is they can inhibit normal lysis of cells presenting the original epitope. The variants studied could serve as antagonists when they were processed from recombinant vaccinia, replicated HIV, or when they were synthetic peptides. Both agonist and antagonist sequences were found in the study subjects from whom the CTL clones were derived. PubMed ID: 7515165. Show all entries for this paper.


Displaying record number 53215

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HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location  
Epitope KRWIIMGLNK Epitope Alignment
KRWIIMGLNK epitope logo
Epitope Name KK10
Species (MHC/HLA) human(B27)
Immunogen HIV-1 infection
Experimental methods  
Keywords review, responses in children, rate of progression, vaccine-induced immune responses, escape

Notes

References

Goulder2004 Philip J R Goulder and David I Watkins. HIV and SIV CTL Escape: Implications for Vaccine Design. Nat. Rev. Immunol., 4(8):630-640, Aug 2004. PubMed ID: 15286729. Show all entries for this paper.


Displaying record number 54674

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HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location p24(131-140)
Epitope KRWIIMGLNK Epitope Alignment
KRWIIMGLNK epitope logo
Species (MHC/HLA) human(B27)
Immunogen HIV-1 infection
Patient MHC/HLA A1, A3, B*27:05, B35; A2, A22, B*27:05, B35
Experimental methods CD8 T-cell Elispot - IFNγ, HLA binding
Keywords HAART, ART, escape, viral fitness and reversion

Notes

References

Asquith2006 Becca Asquith, Charles T. T. Edwards, Marc Lipsitch, and Angela R. McLean. Inefficient Cytotoxic T Lymphocyte-Mediated Killing of HIV-1-Infected Cells In Vivo. PLoS Biol., 4(4):e90, Apr 2006. PubMed ID: 16515366. Show all entries for this paper.


Displaying record number 55217

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HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location p24
Epitope KRWIIMGLNK Epitope Alignment
KRWIIMGLNK epitope logo
Epitope Name KK10 (263-272)
Subtype B
Species (MHC/HLA) human(B27)
Immunogen HIV-1 infection
Patient MHC/HLA A2, A32, B27, B39; A24, A3, B27, B7; A3, A32, B27, B35
Country France
Experimental methods CD8 T-cell Elispot - IFNγ, Other
Keywords binding affinity, immunodominance, characterizing CD8+ T cells

Notes

References

Almeida2007 Jorge R. Almeida, David A. Price, Laura Papagno, Zaïna Aït Arkoub, Delphine Sauce, Ethan Bornstein, Tedi E. Asher, Assia Samri, Aurélie Schnuriger, Ioannis Theodorou, Dominique Costagliola, Christine Rouzioux, Henri Agut, Anne-Geneviève Marcelin, Daniel Douek, Brigitte Autran, and Victor Appay. Superior Control of HIV-1 Replication by CD8+ T Cells Is Reflected by their Avidity, Polyfunctionality, and Clonal Turnover. J. Exp. Med., 204(10):2473-2485, 1 Oct 2007. PubMed ID: 17893201. Show all entries for this paper.


Displaying record number 52176

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HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location p24(263-272 LAI)
Epitope KRWIIMGLNK Epitope Alignment
KRWIIMGLNK epitope logo
Subtype B
Species (MHC/HLA) human(B27)
Immunogen HIV-1 infection
Experimental methods  
Keywords HAART, ART, epitope processing, immunodominance

Notes

References

Kelleher2001a A. D. Kelleher, B. L. Booth, Jr., A. K. Sewell, A. Oxenius, V. Cerundolo, A. J. McMichael, R. E. Phillips, and D. A. Price. Effects of Retroviral Protease Inhibitors on Proteasome Function and Processing of HIV-Derived MHC Class I-Restricted Cytotoxic T Lymphocyte Epitopes. AIDS Res. Hum. Retroviruses, 17(11):1063-1066, 20 Jul 2001. PubMed ID: 11485623. Show all entries for this paper.


Displaying record number 1707

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HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location p24(263-272)
Epitope KRWIIMGLNK Epitope Alignment
KRWIIMGLNK epitope logo
Species (MHC/HLA) human(B*27:05)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Appay2000 V. Appay, D. F. Nixon, S. M. Donahoe, G. M. Gillespie, T. Dong, A. King, G. S. Ogg, H. M. Spiegel, C. Conlon, C. A. Spina, D. V. Havlir, D. D. Richman, A. Waters, P. Easterbrook, A. J. McMichael, and S. L. Rowland-Jones. HIV-specific CD8(+) T cells produce antiviral cytokines but are impaired in cytolytic function. J. Exp. Med., 192(1):63-75, 3 Jul 2000. URL: http://www.jem.org/cgi/content/full/192/1/63. PubMed ID: 10880527. Show all entries for this paper.


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