HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 118 matching records:

Displaying record number 57522

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location  
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Epitope Name KK10
Species (MHC/HLA) human(A*0201)
Immunogen in vitro stimulation or selection
Experimental methods Tetramer binding
Keywords  

Notes

References

Brockman2009 Mark A. Brockman, Douglas S. Kwon, Daniel P. Tighe, David F. Pavlik, Pamela C. Rosato, Jennifer Sela, Filippos Porichis, Sylvie Le Gall, Michael T. Waring, Kristin Moss, Heiko Jessen, Florencia Pereyra, Daniel G. Kavanagh, Bruce D. Walker, and Daniel E. Kaufmann. IL-10 Is Up-Regulated in Multiple Cell Types During Viremic HIV Infection and Reversibly Inhibits Virus-Specific T Cells. Blood, 114(2):346-356, 9 Jul 2009. PubMed ID: 19365081. Show all entries for this paper.


Displaying record number 59957

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location Gag(263-272)
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Epitope Name KK10
Species (MHC/HLA) human(A*24)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 61237

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location Gag(263-272)
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Show epitope variants
Epitope Name KK10
Species (MHC/HLA) human(A*2705)
Immunogen HIV-1 infection
Experimental methods Other
Keywords review, TCR usage

Notes

References

Lissina2016 Anna Lissina, Lisa A. Chakrabarti, Masafumi Takiguchi, and Victor Appay. TCR Clonotypes: Molecular Determinants of T-Cell Efficacy against HIV. Curr. Opin. Virol., 16:77-85, Feb 2016. PubMed ID: 26874617. Show all entries for this paper.


Displaying record number 59956

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location Gag(263-272)
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Epitope Name KK10
Species (MHC/HLA) human(A*30)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 62115

HXB2 Location Gag(263-272)
p24(131-140)
Gag Epitope Map
Author Location p24(263-272 NL4-3)
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Epitope Name KK10
Species (MHC/HLA) human(B*08)
Immunogen computer prediction
Experimental methods Other, Relative replication capacity assay
Keywords vaccine antigen design, viral fitness and reversion

Notes

References

Ferguson2013a Andrew L. Ferguson, Jaclyn K. Mann, Saleha Omarjee, Thumbi Ndung'u, Bruce D Walker, and Arup K. Chakraborty. Translating HIV Sequences into Quantitative Fitness Landscapes Predicts Viral Vulnerabilities for Rational Immunogen Design. Immunity, 38(3):606-617, 21 Mar 2013. PubMed ID: 23521886. Show all entries for this paper.


Displaying record number 56266

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location  
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Show epitope variants
Subtype B
Species (MHC/HLA) human(B27)
Immunogen HIV-1 infection
Country Australia
Experimental methods CD8 T-cell Elispot - IFNγ, Proliferation
Keywords rate of progression, escape, elite controllers

Notes

References

Dyer2008 Wayne B. Dyer, John J. Zaunders, Fang Fang Yuan, Bin Wang, Jennifer C. Learmont, Andrew F. Geczy, Nitin K. Saksena, Dale A. McPhee, Paul R. Gorry, and John S. Sullivan. Mechanisms of HIV Non-Progression; Robust and Sustained CD4+ T-Cell Proliferative Responses to p24 Antigen Correlate with Control of Viraemia and Lack of Disease Progression after Long-Term Transfusion-Acquired HIV-1 Infection. Retrovirology, 5:112, 2008. PubMed ID: 19077215. Show all entries for this paper.


Displaying record number 272

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location p24(263-272 LAI)
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Subtype B
Species (MHC/HLA) human(B27)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Buseyne1993 F. Buseyne, M. McChesney, F. Porrot, S. Kovarik, B. Guy, and Y. Riviere. Gag-Specific Cytotoxic T Lymphocytes from Human Immunodeficiency Virus Type 1-Infected Individuals: Gag Epitopes Are Clustered in Three Regions of the p24 Gag Protein. J. Virol., 67:694-702, 1993. Using autologous Epstein-Barr virus-transformed cells that were infected with vaccinia constructs carrying p18, p24 and p55 proteins of LAI, or truncations of p24, it was shown that epitopes within p24 were most commonly recognized in a set of cell lines derived from 29 infected subjects. The autologous transformed cells coated with synthetic peptides were used to identify several regions of p24 where CTL epitopes tended to cluster. HLA restriction was determined CTL-responsive to four of the peptides. Among the four epitopes that had determined HLA specificities were the two peptides in the study that proved to stimulate CTL from the highest fraction of the cell lines: peptide p24(263-272) HLA-B27 and peptide p24(256-270) HLA-A33; these peptides were each able to stimulate CTL response from 14\% of the cell lines. PubMed ID: 7678303. Show all entries for this paper.


Displaying record number 265

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location p24(263-272 LAI)
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Subtype B
Species (MHC/HLA) human(B27)
Immunogen HIV-1 infection
Experimental methods  
Keywords dendritic cells

Notes

References

Fan1997 Z. Fan, X. L. Huang, L. Zheng, C. Wilson, L. Borowski, J. Liebmann, P. Gupta, J. Margolick, and C. Rinaldo. Cultured Blood Dendritic Cells Retain HIV-1 Antigen-Presenting Capacity for Memory CTL During Progressive HIV-1 Infection. J. Immunol., 159:4973-4982, 1997. PubMed ID: 9366424. Show all entries for this paper.


Displaying record number 274

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location p24(263-272 LAI)
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Subtype B
Species (MHC/HLA) human(B27)
Immunogen HIV-1 infection
Experimental methods  
Keywords review

Notes

References

McMichael1994 A. J. McMichael and B. D. Walker. Cytotoxic T Lymphocytes Epitopes: Implications for HIV Vaccine. AIDS, 8S:S155-S173, 1994. Comprehensive review summarizing CTL epitopes that have known HLA type and are fine mapped to indicate epitope boundaries. Anchor residues are indicated when known for different HLA restricted epitopes. Includes a summary of the published literature, as well as much work that was in press or submitted for publication. Show all entries for this paper.


Displaying record number 277

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location p24(265-274)
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Species (MHC/HLA) human(B27)
Immunogen HIV-1 infection
Experimental methods  
Keywords dynamics, TCR usage

Notes

References

Moss1995 P. A. H. Moss, S. L. Rowland-Jones, P. M. Frodsham, S. McAdam, P. Giangrande, A. McMichael, and J. I. Bell. Persistent High Frequency of Human Immunodeficiency Virus-Specific Cytotoxic T Cells in Peripheral Blood of Infected Donors. Proc. Natl. Acad. Sci. U.S.A., 92:5773-5777, 1995. PubMed ID: 7597028. Show all entries for this paper.


Displaying record number 278

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location p24(265-276)
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Species (MHC/HLA) human(B27)
Immunogen  
Experimental methods  
Keywords  

Notes

References

Carreno1992 B. M. Carreno, S. Koenig, J. E. Coligan, and W. E. Biddison. The Peptide Binding Specificity of HLA Class I Molecules Is Largely Allele-Specific and Non-Overlapping. Mol. Immunol., 29:1131-1140, 1992. Peptide competition experiments for presentation of viral peptides restricted by HLA-A3 and HLA-B27 were performed to study the specificity of peptide binding to class I molecules. HIV-1 Nef (74-82) presentation by HLA-A3 was among the epitopes studied. PubMed ID: 1379681. Show all entries for this paper.


Displaying record number 279

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location p24(265-274 SF2)
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Show epitope variants
Species (MHC/HLA) human(B27)
Immunogen HIV-1 infection
Experimental methods  
Keywords dynamics, review, immunodominance, escape

Notes

References

Goulder1997e P. Goulder, D. Price, M. Nowak, S. Rowland-Jones, R. Phillips, and A. McMichael. Co-Evolution of Human Immunodeficiency Virus and Cytotoxic T-Lymphocyte Responses. Immunol. Rev., 159:17-29, 1997. PubMed ID: 9416500. Show all entries for this paper.

Phillips1991 R. E. Phillips, S. Rowland-Jones, D. F. Nixon, F. M. Gotch, J. P. Edwards, A. O. Ogunlesi, J. G. Elvin, J. A. Rothbard, C. R. Bangham, C. R. Rizza, and A. J. McMichael. Human Immunodeficiency Virus Genetic Variation That Can Escape Cytotoxic T Cell Recognition. Nature, 354:453-459, 1991. Fluctuations in the specificity of cytotoxic T-cells for HIV were correlated with variability in proviral gag (DNA) epitope sequences. PubMed ID: 1721107. Show all entries for this paper.


Displaying record number 280

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location p24(263-272)
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Species (MHC/HLA) human(B27)
Immunogen HIV-1 infection
Experimental methods  
Keywords review, escape

Notes

References

Goulder1997e P. Goulder, D. Price, M. Nowak, S. Rowland-Jones, R. Phillips, and A. McMichael. Co-Evolution of Human Immunodeficiency Virus and Cytotoxic T-Lymphocyte Responses. Immunol. Rev., 159:17-29, 1997. PubMed ID: 9416500. Show all entries for this paper.

Nietfeld1995 W. Nietfeld, M. Bauer, M. Fevrier, R. Maier, B. Holzwarth, R. Frank, B. Maier, Y. Riviere, and A. Meyerhans. Sequence Constraints and Recognition by CTL of an HLA-B27-Restricted HIV-1 Gag Epitope. J. Immunol., 154:2188-2197, 1995. Single point mutations were introduced into this epitope in the viral strain LAI, and the ability of comparable peptides to sensitize target strains was tested. The change of anchor residue R 264 to (L or G), results in infectious virus, and corresponding peptide has reduced binding affinities for HLA-B27. The change of G 267 to K or E abrogated infectivity, and the peptide bound to HLA-B27, but did not serve as a target; thus nonrecognition of peptides derived from quasispecies analysis of a small region might not really be associated with an escape mutant, but rather a non-viable mutant. PubMed ID: 7868892. Show all entries for this paper.


Displaying record number 284

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location p24
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Species (MHC/HLA) human(B27)
Immunogen  
Experimental methods  
Keywords  

Notes

References

Rowland-Jones1999 S. L. Rowland-Jones, T. Dong, L. Dorrell, G. Ogg, P. Hansasuta, P. Krausa, J. Kimani, S. Sabally, K. Ariyoshi, J. Oyugi, K. S. MacDonald, J. Bwayo, H. Whittle, F. A. Plummer, and A. J. McMichael. Broadly Cross-Reactive HIV-Specific Cytotoxic T Lymphocytes in Highly-Exposed Persistently Seronegative Donors. Immunol. Lett., 66:9-14, 1999. PubMed ID: 10203028. Show all entries for this paper.


Displaying record number 285

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location Gag(263-)
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Species (MHC/HLA) (B27)
Immunogen computer prediction
Experimental methods  
Keywords subtype comparisons

Notes

References

Schafer1998 J. R. Schafer, B. M. Jesdale, J. A. George, N. M. Kouttab, and A. S. De Groot. Prediction of Well-Conserved HIV-1 Ligands Using a Matrix-Based Algorithm, EpiMatrix. Vaccine, 16:1880-1884, 1998. PubMed ID: 9795396. Show all entries for this paper.


Displaying record number 286

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location p24(263-282)
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Species (MHC/HLA) human(B27)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Bernard1998 N. F. Bernard, K. Pederson, F. Chung, L. Ouellet, M. A. Wainberg, and C. M. Tsoukas. HIV-Specific Cytotoxic T-Lymphocyte Activity in Immunologically Normal HIV-Infected Persons. AIDS, 12:2125-2139, 1998. PubMed ID: 9833853. Show all entries for this paper.


Displaying record number 1567

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location p24(265-274 SF2)
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Species (MHC/HLA) human(B27)
Immunogen HIV-1 infection
Experimental methods  
Keywords HAART, ART, acute/early infection

Notes

References

Altfeld2001b M. Altfeld, E. S. Rosenberg, R. Shankarappa, J. S. Mukherjee, F. M. Hecht, R. L. Eldridge, M. M. Addo, S. H. Poon, M. N. Phillips, G. K. Robbins, P. E. Sax, S. Boswell, J. O. Kahn, C. Brander, P. J. Goulder, J. A. Levy, J. I. Mullins, and B. D. Walker. Cellular immune responses and viral diversity in individuals treated during acute and early HIV-1 infection. J. Exp. Med., 193(2):169-80, 15 Jan 2001. URL: http://www.jem.org/cgi/content/full/193/2/169. PubMed ID: 11148221. Show all entries for this paper.


Displaying record number 1681

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location p24(263-272)
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Show epitope variants
Species (MHC/HLA) human(B27)
Immunogen HIV-1 exposed seronegative, HIV-1 infection
Experimental methods  
Keywords HIV exposed persistently seronegative (HEPS)

Notes

References

Kaul2001a R. Kaul, T. Dong, F. A. Plummer, J. Kimani, T. Rostron, P. Kiama, E. Njagi, E. Irungu, B. Farah, J. Oyugi, R. Chakraborty, K. S. MacDonald, J. J. Bwayo, A. McMichael, and S. L. Rowland-Jones. CD8(+) lymphocytes respond to different HIV epitopes in seronegative and infected subjects. J. Clin. Invest., 107(10):1303-10, May 2001. URL: http://www.jci.org/cgi/content/full/107/10/1303. PubMed ID: 11375420. Show all entries for this paper.


Displaying record number 1818

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location p24(131-140)
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Show epitope variants
Epitope Name KK10
Species (MHC/HLA) human(B27)
Immunogen HIV-1 infection
Experimental methods  
Keywords responses in children, mother-to-infant transmission, immunodominance, escape, acute/early infection

Notes

References

Goulder2001c P. J. Goulder, C. Brander, Y. Tang, C. Tremblay, R. A. Colbert, M. M. Addo, E. S. Rosenberg, T. Nguyen, R. Allen, A. Trocha, M. Altfeld, S. He, M. Bunce, R. Funkhouser, S. I. Pelton, S. K. Burchett, K. McIntosh, B. T. Korber, and B. D. Walker. Evolution and transmission of stable CTL escape mutations in HIV infection. Nature, 412(6844):334-8, 19 Jul 2001. PubMed ID: 11460164. Show all entries for this paper.


Displaying record number 1995

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location p24
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Epitope Name Gag-KK10; p24-KK10
Subtype B
Species (MHC/HLA) human(B27)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords HAART, ART

Notes

References

Sabbaj2003 Steffanie Sabbaj, Anju Bansal, G. Douglas Ritter, Christopher Perkins, Bradley H. Edwards, Ethan Gough, Jianming Tang, James J. Szinger, Bette Korber, Craig M. Wilson, Richard A. Kaslow, Mark J. Mulligan, and Paul A. Goepfert. Cross-Reactive CD8+ T Cell Epitopes Identified in US Adolescent Minorities. J. Acquir. Immune Defic. Syndr., 33(4):426-438, 1 Aug 2003. PubMed ID: 12869831. Show all entries for this paper.


Displaying record number 52272

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location p24
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Epitope Name B27-KK10(p24)
Subtype B
Species (MHC/HLA) human(B27)
Immunogen HIV-1 infection
Patient MHC/HLA A24, B27, B7; A30, A32, B18, B27
Experimental methods  
Keywords HAART, ART, supervised treatment interruptions (STI)

Notes

References

Altfeld2002 Marcus Altfeld, Jan van Lunzen, Nicole Frahm, Xu G. Yu, Claus Schneider, Robert L. Eldridge, Margaret E. Feeney, Dirk Meyer-Olson, Hans-Juergen Stellbrink, and Bruce D. Walker. Expansion of Pre-existing, Lymph Node-localized CD8+ T Cells During Supervised Treatment Interruptions in Chronic HIV-1 Infection. J. Clin. Invest., 109(6):837-843, Mar 2002. PubMed ID: 11901192. Show all entries for this paper.


Displaying record number 52329

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location Gag(263-272)
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Show epitope variants
Subtype CRF01_AE
Species (MHC/HLA) human(B27)
Immunogen HIV-1 infection
Patient MHC/HLA B27
Experimental methods  
Keywords subtype comparisons

Notes

References

Currier2002b Jeffrey R Currier, Mark deSouza, Penprapa Chanbancherd, Wendy Bernstein, Deborah L Birx, and Josephine H Cox. Comprehensive Screening for Human Immunodeficiency Virus Type 1 Subtype-Specific CD8 Cytotoxic T Lymphocytes and Definition of Degenerate Epitopes Restricted by HLA-A0207 and -Cw0304 Alleles. J. Virol., 76(10):4971-4986, May 2002. PubMed ID: 11967314. Show all entries for this paper.


Displaying record number 52932

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location Gag
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Show epitope variants
Epitope Name KK10
Species (MHC/HLA) human(B27)
Immunogen HIV-1 infection
Patient MHC/HLA A26, B27
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords responses in children, rate of progression, immunodominance, escape

Notes

References

Feeney2004 M. E. Feeney, Y. Tang, K. A. Roosevelt, A. J. Leslie, K. McIntosh, N. Karthas, B. D. Walker, and P. J. R. Goulder. Immune Escape Precedes Breakthrough Human Immunodeficiency Virus Type 1 Viremia and Broadening of the Cytotoxic T-Lymphocyte Response in an HLA-B27-Positive Long-Term-Nonprogressing Child. J. Virol., 78(16):8927-8930, Aug 2004. PubMed ID: 15280502. Show all entries for this paper.


Displaying record number 53497

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location Gag
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Epitope Name KK10
Subtype B
Species (MHC/HLA) human(B27)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords subtype comparisons, escape, characterizing CD8+ T cells, viral fitness and reversion

Notes

References

Allen2005a Todd M. Allen, Marcus Altfeld, Shaun C. Geer, Elizabeth T. Kalife, Corey Moore, Kristin M. O'Sullivan, Ivna DeSouza, Margaret E. Feeney, Robert L. Eldridge, Erica L. Maier, Daniel E. Kaufmann, Matthew P. Lahaie, Laura Reyor, Giancarlo Tanzi, Mary N. Johnston, Christian Brander, Rika Draenert, Jurgen K. Rockstroh, Heiko Jessen, Eric S. Rosenberg, Simon A. Mallal, and Bruce D. Walker. Selective Escape from CD8+ T-Cell Responses Represents a Major Driving Force of Human Immunodeficiency Virus Type 1 (HIV-1) Sequence Diversity and Reveals Constraints on HIV-1 Evolution. J. Virol., 79(21):13239-13249, Nov 2005. PubMed ID: 16227247. Show all entries for this paper.


Displaying record number 53731

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location Gag(263-272 BRU)
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Subtype B, CRF02_AG
Species (MHC/HLA) human(B27)
Immunogen HIV-1 infection
Country Cote D'Ivoire
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords subtype comparisons

Notes

References

Inwoley2005 André Inwoley, Patricia Recordon-Pinson, Marion Dupuis, Jessintha Gaston, Mathieu Genête, Albert Minga, Franck Letourneur, François Rouet, Jeannine Choppin, Hervé Fleury, Jean-Gérard Guillet, Muriel Andrieu, and ANRS 1220 PRIMO-CI Study Group. Cross-Clade Conservation of HIV Type 1 Nef Immunodominant Regions Recognized by CD8+ T Cells of HIV Type 1 CRF02\_AG-Infected Ivorian (West Africa). AIDS Res. Hum. Retroviruses, 21(7):620-628, Jul 2005. PubMed ID: 16060833. Show all entries for this paper.


Displaying record number 53785

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location p24
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Epitope Name KK10
Species (MHC/HLA) (B27)
Immunogen  
Experimental methods  
Keywords review, immunodominance, escape, acute/early infection, early-expressed proteins, kinetics, viral fitness and reversion

Notes

References

Lichterfeld2005 Mathias Lichterfeld, Xu G. Yu, Sylvie Le Gall, and Marcus Altfeld. Immunodominance of HIV-1-Specific CD8+ T-Cell Responses in Acute HIV-1 Infection: At the Crossroads of Viral and Host Genetics. Trends Immunol., 26(3):166-171, Mar 2005. PubMed ID: 15745859. Show all entries for this paper.


Displaying record number 53834

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location Gag(263-272)
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Show epitope variants
Subtype B
Species (MHC/HLA) human(B27)
Immunogen HIV-1 infection
Country Barbados
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords responses in children, mother-to-infant transmission, escape, acute/early infection

Notes

References

Pillay2005 Thillagavathie Pillay, Hua-Tang Zhang, Jan W. Drijfhout, Nicola Robinson, Helen Brown, Munira Khan, Jagadesa Moodley, Miriam Adhikari, Katja Pfafferott, Margaret E. Feeney, Anne St. John, Edward C. Holmes, Hoosen M. Coovadia, Paul Klenerman, Philip J. R. Goulder, and Rodney E. Phillips. Unique Acquisition of Cytotoxic T-Lymphocyte Escape Mutants in Infant Human Immunodeficiency Virus Type 1 Infection. J. Virol., 79(18):12100-12105, Sep 2005. PubMed ID: 16140787. Show all entries for this paper.


Displaying record number 53925

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location Gag(263-272)
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Show epitope variants
Species (MHC/HLA) human(B27)
Immunogen HIV-1 infection
Country Australia
Experimental methods CD8 T-cell Elispot - IFNγ, HLA binding
Keywords binding affinity, rate of progression, immunodominance, escape

Notes

References

Ammaranond2005 Palanee Ammaranond, John Zaunders, Claudette Satchell, David van Bockel, David A. Cooper, and Anthony D. Kelleher. A New Variant Cytotoxic T Lymphocyte Escape Mutation in HLA-B27-Positive Individuals Infected with HIV Type 1. AIDS Res. Hum. Retroviruses, 21(5):395-397, May 2005. PubMed ID: 15929701. Show all entries for this paper.


Displaying record number 266

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location Gag(263-272)
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Species (MHC/HLA) human(B27)
Immunogen HIV-1 infection
Experimental methods  
Keywords epitope processing, dendritic cells

Notes

References

Zheng1999 L. Zheng, X. L. Huang, Z. Fan, L. Borowski, C. C. Wilson, and C. R. Rinaldo. Delivery of Liposome-Encapsulated HIV Type 1 Proteins to Human Dendritic Cells for Stimulation of HIV Type 1-Specific Memory Cytotoxic T Lymphocyte Responses. AIDS Res. Hum. Retroviruses, 15:1011-1020, 1999. PubMed ID: 10445813. Show all entries for this paper.


Displaying record number 54354

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location p24
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Epitope Name B27-KK10(p24)
Species (MHC/HLA) human(B27)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, immunodominance, early-expressed proteins

Notes

References

Altfeld2006 Marcus Altfeld, Elizabeth T. Kalife, Ying Qi, Hendrik Streeck, Mathias Lichterfeld, Mary N. Johnston, Nicole Burgett, Martha E. Swartz, Amy Yang, Galit Alter, Xu G. Yu, Angela Meier, Juergen K. Rockstroh, Todd M. Allen, Heiko Jessen, Eric S. Rosenberg, Mary Carrington, and Bruce D. Walker. HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8+ T Cell Response against HIV-1. PLoS Med., 3(10):e403, Oct 2006. PubMed ID: 17076553. Show all entries for this paper.


Displaying record number 54528

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location p24(131-140)
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Subtype B
Species (MHC/HLA) human(B27)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords binding affinity, subtype comparisons, acute/early infection

Notes

References

Malhotra2007 Uma Malhotra, Jessica Nolin, James I. Mullins, and M. Juliana McElrath. Comprehensive Epitope Analysis of Cross-Clade Gag-Specific T-Cell Responses in Individuals with Early HIV-1 Infection in the US Epidemic. Vaccine, 25(2):381-390, 4 Jan 2007. PubMed ID: 17112643. Show all entries for this paper.


Displaying record number 269

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location p24(263-272 LAI)
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Subtype B
Species (MHC/HLA) human(B27)
Immunogen HIV-1 infection
Experimental methods  
Keywords dynamics, TCR usage

Notes

References

Wilson1998 J. D. Wilson, G. S. Ogg, R. L. Allen, P. J. Goulder, A. Kelleher, A. K. Sewell, C. A. O'Callaghan, S. L. Rowland-Jones, M. F. Callan, and A. J. McMichael. Oligoclonal Expansions of CD8+ T Cells in Chronic HIV Infection Are Antigen Specific. J. Exp. Med., 188(4):785-790, 1998. PubMed ID: 9705961. Show all entries for this paper.


Displaying record number 54866

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location  
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Epitope Name KK10
Species (MHC/HLA) human, mouse(B27)
Immunogen HIV-1 infection, peptide-HLA interaction
Experimental methods Chromium-release assay, HLA binding, Tetramer binding
Keywords review, epitope processing, escape, structure, assay or method development, optimal epitope

Notes

References

McMichael2007a Andrew J McMichael. From Influenza to HIV---and Back? Nat. Immunol., 8(11):1149-1151, Nov 2007. PubMed ID: 17952038. Show all entries for this paper.


Displaying record number 54883

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location  
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Species (MHC/HLA) human(B27)
Immunogen HIV-1 infection, vaccine
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords vaccine-induced immune responses, characterizing CD8+ T cells

Vaccine Details

Vaccine type canarypox, canarypox prime with recombinant protein boost
Vaccine strain B clade BRU, B clade LAI, B clade MN, multiple epitope immunogen
Vaccine component Gag, gp120, gp41, Nef, Pol, Protease

Notes

References

Horton2006 Helen Horton, Ian Frank, Ruth Baydo, Emilie Jalbert, Justin Penn, Sean Wilson, John P. McNevin, Matthew D. McSweyn, Deborah Lee, Yunda Huang, Stephen C. De Rosa, and M. Juliana McElrath. Preservation of T Cell Proliferation Restricted by Protective HLA Alleles Is Critical for Immune Control of HIV-1 Infection. J. Immunol., 177(10):7406-7415, 15 Nov 2006. PubMed ID: 17082660. Show all entries for this paper.


Displaying record number 57977

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location p24(131-140)
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Epitope Name KK10
Subtype B
Species (MHC/HLA) human(B27)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, CTL suppression of replication, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining
Keywords immunodominance, elite controllers

Notes

References

Akinsiku2011 Olusimidele T. Akinsiku, Anju Bansal, Steffanie Sabbaj, Sonya L. Heath, and Paul A. Goepfert. Interleukin-2 Production by Polyfunctional HIV-1-Specific CD8 T Cells Is Associated with Enhanced Viral Suppression. J. Acquir. Immune Defic. Syndr., 58(2):132-140, 1 Oct 2011. PubMed ID: 21637109. Show all entries for this paper.


Displaying record number 57787

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location p24(131-140)
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Show epitope variants
Epitope Name KK10
Species (MHC/HLA) human(B27)
Immunogen in vitro stimulation or selection
Experimental methods Cytotoxicity assay
Keywords dendritic cells

Notes

References

Aldy2011 Kim N. Aldy, Nathan C. Horton, Porunelloor A. Mathew, and Stephen O. Mathew. 2B4+ CD8+ T Cells Play an Inhibitory Role against Constrained HIV Epitopes. Biochem. Biophys. Res. Commun., 405(3):503-507, 18 Feb 2011. PubMed ID: 21256826. Show all entries for this paper.


Displaying record number 57690

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location  
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Epitope Name KK10
Subtype B
Species (MHC/HLA) human(B27)
Immunogen HIV-1 infection
Country Germany, United States
Experimental methods Flow cytometric T-cell cytokine assay, Tetramer binding
Keywords memory cells

Notes

References

Meyer-Olson2010 Dirk Meyer-Olson, Brenna C. Simons, Joseph A. Conrad, Rita M. Smith, Louise Barnett, Shelly L. Lorey, Coley B. Duncan, Ramesh Ramalingam, and Spyros A. Kalams. Clonal Expansion and TCR-Independent Differentiation Shape the HIV-Specific CD8+ Effector-Memory T-Cell Repertoire In Vivo. Blood, 116(3):396-405, Jul 22 2010. PubMed ID: 20424187. Show all entries for this paper.


Displaying record number 57601

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location p24
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Epitope Name KK10
Subtype B
Species (MHC/HLA) human(B27)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, immunodominance, genital and mucosal immunity

Notes

References

Ferre2010 April L. Ferre, Donna Lemongello, Peter W. Hunt, Megan M. Morris, Juan Carlos Garcia, Richard B. Pollard, Hal F. Yee, Jr., Jeffrey N. Martin, Steven G. Deeks, and Barbara L. Shacklett. Immunodominant HIV-Specific CD8+ T-Cell Responses Are Common to Blood and Gastrointestinal Mucosa, and Gag-Specific Responses Dominate in Rectal Mucosa of HIV Controllers. J. Virol., 84(19):10354-10365, Oct 2010. PubMed ID: 20668079. Show all entries for this paper.


Displaying record number 57164

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location p24(131-140)
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Epitope Name KK10
Subtype B
Species (MHC/HLA) human(B27)
Immunogen HIV-1 infection
Patient MHC/HLA A26, A32, B27, Cw1, Cw2
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords HIV exposed persistently seronegative (HEPS), acute/early infection

Notes

References

Liu2009b Yi Liu, Amanda Woodward, Haiying Zhu, Thomas Andrus, John McNevin, Jean Lee, James I. Mullins, Lawrence Corey, M. Juliana McElrath, and Tuofu Zhu. Preinfection Human Immunodeficiency Virus (HIV)-Specific Cytotoxic T Lymphocytes Failed to Prevent HIV Type 1 Infection from Strains Genetically Unrelated to Viruses in Long-Term Exposed Partners. J. Virol., 83(20):10821-10829, Oct 2009. PubMed ID: 19706711. Show all entries for this paper.


Displaying record number 270

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location p24
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Species (MHC/HLA) human(B27)
Immunogen HIV-1 infection
Experimental methods  
Keywords review

Notes

References

RowlandJones1997 S. Rowland-Jones, R. Tan, and A. McMichael. Role of Cellular Immunity in Protection against HIV Infection. Adv. Immunol., 65:277-346, 1997. A comprehensive, excellent review of CTL immunity. PubMed ID: 9238512. Show all entries for this paper.


Displaying record number 55440

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location p24
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Show epitope variants
Epitope Name KK10
Subtype B
Species (MHC/HLA) human(B27)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Tetramer binding
Keywords immunodominance, superinfection

Notes

References

Streeck2008a Hendrik Streeck, Bin Li, Art F. Y. Poon, Arne Schneidewind, Adrianne D. Gladden, Karen A. Power, Demetre Daskalakis, Suzane Bazner, Rosario Zuniga, Christian Brander, Eric S. Rosenberg, Simon D. W. Frost, Marcus Altfeld, and Todd M. Allen. Immune-Driven Recombination and Loss of Control after HIV Superinfection. J. Exp. Med., 205(8):1789-1796, 4 Aug 2008. PubMed ID: 18625749. Show all entries for this paper.


Displaying record number 55510

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location p24
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Epitope Name KK10
Subtype B
Species (MHC/HLA) human(B27)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Tetramer binding
Keywords characterizing CD8+ T cells

Notes

References

Streeck2008 Hendrik Streeck, Zabrina L. Brumme, Michael Anastario, Kristin W. Cohen, Jonathan S. Jolin, Angela Meier, Chanson J. Brumme, Eric S. Rosenberg, Galit Alter, Todd M. Allen, Bruce D. Walker, and Marcus Altfeld. Antigen Load and Viral Sequence Diversification Determine the Functional Profile of HIV-1-Specific CD8+ T Cells. PLoS Med, 5(5):e100, 6 May 2008. PubMed ID: 18462013. Show all entries for this paper.


Displaying record number 55617

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location Gag
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Epitope Name KK10
Subtype B
Species (MHC/HLA) human(B27)
Immunogen HIV-1 infection
Country Netherlands
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords computational epitope prediction

Notes

References

Schellens2008 Ingrid M. M. Schellens, Can Kesmir, Frank Miedema, Debbie van Baarle, and José A. M. Borghans. An Unanticipated Lack of Consensus Cytotoxic T Lymphocyte Epitopes in HIV-1 Databases: The Contribution of Prediction Programs. AIDS, 22(1):33-37, 2 Jan 2008. PubMed ID: 18090389. Show all entries for this paper.


Displaying record number 55105

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location Gag
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Epitope Name KK10
Subtype B
Species (MHC/HLA) human(B27)
Immunogen HIV-1 infection
Country Australia, Canada, United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, immunodominance, escape, mutation acquisition, optimal epitope

Notes

References

Streeck2007a Hendrik Streeck, Mathias Lichterfeld, Galit Alter, Angela Meier, Nickolas Teigen, Bader Yassine-Diab, Harlyn K. Sidhu, Susan Little, Anthony Kelleher, Jean-Pierre Routy, Eric S. Rosenberg, Rafick-Pierre Sekaly, Bruce D. Walker, and Marcus Altfeld. Recognition of a Defined Region within p24 Gag by CD8+ T Cells during Primary Human Immunodeficiency Virus Type 1 Infection in Individuals Expressing Protective HLA Class I Alleles. J. Virol., 81(14):7725-7731, Jul 2007. PubMed ID: 17494064. Show all entries for this paper.


Displaying record number 271

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location p24(263-272 LAI)
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Show epitope variants
Subtype B
Species (MHC/HLA) human(B*2705, B27)
Immunogen HIV-1 infection
Experimental methods  
Keywords review, rate of progression, immunodominance, escape

Notes

References

Goulder1997d P. J. Goulder, A. Edwards, R. E. Phillips, and A. J. McMichael. Identification of a Novel HLA-B*2705-Restricted Cytotoxic T Lymphocyte Epitope within a Conserved Region of HIV-1 Nef. AIDS, 11:536-538, 1997. PubMed ID: 9084804. Show all entries for this paper.

Goulder1997e P. Goulder, D. Price, M. Nowak, S. Rowland-Jones, R. Phillips, and A. McMichael. Co-Evolution of Human Immunodeficiency Virus and Cytotoxic T-Lymphocyte Responses. Immunol. Rev., 159:17-29, 1997. PubMed ID: 9416500. Show all entries for this paper.


Displaying record number 62169

HXB2 Location Gag(263-272)
p24(131-140)
Gag Epitope Map
Author Location Gag
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Epitope Name KK10
Species (MHC/HLA) human(B*27)
Immunogen HIV-1 infection
Experimental methods  
Keywords review

Notes

References

Carlson2015 Jonathan M. Carlson, Anh Q. Le, Aniqa Shahid, and Zabrina L. Brumme. HIV-1 adaptation to HLA: a window into virus-host immune interactions. Trends Microbiol, 23(4):212-24 doi, Apr 2015. PubMed ID: 25613992 Show all entries for this paper.


Displaying record number 267

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location p24(263-272)
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Species (MHC/HLA) human(B*27)
Immunogen HIV-1 infection
Experimental methods  
Keywords HAART, ART

Notes

References

Huang2000 X. L. Huang, Z. Fan, C. Kalinyak, J. W. Mellors, and C. R. Rinaldo. CD8+ T Cell Gamma Interferon Production Specific for Human Immunodeficiency Virus Type 1 (HIV-1) in HIV-1-Infected Subjects. Clin. Diagn. Lab. Immunol., 7:279-287, 2000. PubMed ID: 10702505. Show all entries for this paper.


Displaying record number 268

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location p24(263-272 SF2)
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Species (MHC/HLA) human(B*27)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

McAdam1998 S. McAdam, P. Kaleebu, P. Krausa, P. Goulder, N. French, B. Collin, T. Blanchard, J. Whitworth, A. McMichael, and F. Gotch. Cross-Clade Recognition of p55 by Cytotoxic T Lymphocytes in HIV-1 Infection. AIDS, 12:571-579, 1998. PubMed ID: 9583596. Show all entries for this paper.


Displaying record number 54279

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location Gag
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Epitope Name KK10
Species (MHC/HLA) human(B*27)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords variant cross-reactivity

Notes

References

Bailey2006 Justin R. Bailey, Thomas M. Williams, Robert F. Siliciano, and Joel N. Blankson. Maintenance of Viral Suppression in HIV-1-Infected HLA-B*57+ Elite Suppressors Despite CTL Escape Mutations. J. Exp. Med., 203(5):1357-1369, 15 May 2006. PubMed ID: 16682496. Show all entries for this paper.


Displaying record number 54618

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location p24(131-140)
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Show epitope variants
Epitope Name KK10
Subtype B
Species (MHC/HLA) human(B*27)
Immunogen HIV-1 infection
Country Switzerland
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, escape, HLA associated polymorphism, elite controllers

Notes

References

Frater2007 A. J. Frater, H. Brown, A. Oxenius, H. F. Günthard, B. Hirschel, N. Robinson, A. J. Leslie, R. Payne, H. Crawford, A. Prendergast, C. Brander, P. Kiepiela, B. D. Walker, P. J. R. Goulder, A. McLean, and R. E. Phillips. Effective T-Cell Responses Select Human Immunodeficiency Virus Mutants and Slow Disease Progression. J. Virol., 81(12):6742-6751, Jun 2007. PubMed ID: 17409157. Show all entries for this paper.


Displaying record number 55275

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location  
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Subtype B
Species (MHC/HLA) human(B*27)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords characterizing CD8+ T cells

Notes

References

Addo2007 Marylyn M. Addo, Rika Draenert, Almas Rathod, Cori L. Verrill, Benjamin T. Davis, Rajesh T. Gandhi, Gregory K. Robbins, Nesli O. Basgoz, David R. Stone, Daniel E. Cohen, Mary N. Johnston, Theresa Flynn, Alysse G. Wurcel, Eric S. Rosenberg, Marcus Altfeld, and Bruce D. Walker. Fully Differentiated HIV-1 Specific CD8+ T Effector Cells Are More Frequently Detectable in Controlled than in Progressive HIV-1 Infection. PLoS ONE, 2(3):e321, 2007. PubMed ID: 17389912. Show all entries for this paper.


Displaying record number 55334

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location p24(131-140)
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Epitope Name KK10
Subtype B
Species (MHC/HLA) human(B*27)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining
Keywords rate of progression, acute/early infection, memory cells

Notes

References

Sabbaj2007 Steffanie Sabbaj, Sonya L. Heath, Anju Bansal, Sameera Vohra, J Michael Kilby, Allan J. Zajac, and Paul A. Goepfert. Functionally Competent Antigen-Specific CD127(hi) Memory CD8+ T Cells Are Preserved Only in HIV-Infected Individuals Receiving Early Treatment. J. Infect. Dis., 195(1):108-117, 1 Jan 2007. PubMed ID: 17152014. Show all entries for this paper.


Displaying record number 56155

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location Gag
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Epitope Name KK10
Subtype B
Species (MHC/HLA) human(B*27)
Immunogen HIV-1 infection
Country Canada
Experimental methods  
Keywords HLA associated polymorphism

Notes

References

Brumme2008a Zabrina L. Brumme, Iris Tao, Sharon Szeto, Chanson J. Brumme, Jonathan M. Carlson, Dennison Chan, Carl Kadie, Nicole Frahm, Christian Brander, Bruce Walker, David Heckerman, and P Richard Harrigan. Human Leukocyte Antigen-Specific Polymorphisms in HIV-1 Gag and Their Association with Viral Load in Chronic Untreated Infection. AIDS, 22(11):1277-1286, 11 Jul 2008. PubMed ID: 18580606. Show all entries for this paper.


Displaying record number 56158

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location Gag(263-272)
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Epitope Name KK10
Subtype B
Species (MHC/HLA) human(B*27)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, CTL suppression of replication, Intracellular cytokine staining, Proliferation
Keywords rate of progression, escape, elite controllers

Notes

References

Bailey2008 Justin R. Bailey, Karen O'Connell, Hung-Chih Yang, Yefei Han, Jie Xu, Benjamin Jilek, Thomas M. Williams, Stuart C. Ray, Robert F. Siliciano, and Joel N. Blankson. Transmission of Human Immunodeficiency Virus Type 1 from a Patient Who Developed AIDS to an Elite Suppressor. J. Virol., 82(15):7395-7410, Aug 2008. PubMed ID: 18495769. Show all entries for this paper.


Displaying record number 56340

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location Gag(263-272)
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Epitope Name KK10
Subtype B, C
Species (MHC/HLA) human(B*27)
Immunogen HIV-1 infection
Country Canada, South Africa
Experimental methods  
Keywords escape, HLA associated polymorphism, compensatory mutation

Notes

References

Carlson2008 Jonathan M. Carlson, Zabrina L. Brumme, Christine M. Rousseau, Chanson J. Brumme, Philippa Matthews, Carl Kadie, James I. Mullins, Bruce D. Walker, P. Richard Harrigan, Philip J. R. Goulder, and David Heckerman. Phylogenetic Dependency Networks: Inferring Patterns of CTL Escape and Codon Covariation in HIV-1 Gag. PLoS Comput Biol, 4(11):e1000225, Nov 2008. PubMed ID: 19023406. Show all entries for this paper.


Displaying record number 56372

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location p24(263-272)
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Epitope Name KK10
Subtype B
Species (MHC/HLA) human(B*27)
Immunogen HIV-1 infection
Country Australia, Canada, Germany, United States
Experimental methods  
Keywords escape, mutation acquisition, HLA associated polymorphism

Notes

References

Brumme2008 Zabrina L. Brumme, Chanson J. Brumme, Jonathan Carlson, Hendrik Streeck, Mina John, Quentin Eichbaum, Brian L Block, Brett Baker, Carl Kadie, Martin Markowitz, Heiko Jessen, Anthony D. Kelleher, Eric Rosenberg, John Kaldor, Yuko Yuki, Mary Carrington, Todd M. Allen, Simon Mallal, Marcus Altfeld, David Heckerman, and Bruce D. Walker. Marked Epitope- and Allele-Specific Differences in Rates of Mutation in Human Immunodeficiency Type 1 (HIV-1) Gag, Pol, and Nef Cytotoxic T-Lymphocyte Epitopes in Acute/Early HIV-1 Infection. J. Virol., 82(18):9216-9227, Sep 2008. PubMed ID: 18614631. Show all entries for this paper.


Displaying record number 56872

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location Gag
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Epitope Name KK10
Subtype B
Species (MHC/HLA) human(B*27)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, CTL neutralization assay, Chromium-release assay, Other
Keywords elite controllers, neutralization by CTL

Notes

References

Chen2009a Huabiao Chen, Alicja Piechocka-Trocha, Toshiyuki Miura, Mark A. Brockman, Boris D. Julg, Brett M. Baker, Alissa C. Rothchild, Brian L. Block, Arne Schneidewind, Tomohiko Koibuchi, Florencia Pereyra, Todd M. Allen, and Bruce D. Walker. Differential Neutralization of Human Immunodeficiency Virus (HIV) Replication in Autologous CD4 T Cells by HIV-Specific Cytotoxic T Lymphocytes. J. Virol., 83(7):3138-3149, Apr 2009. PubMed ID: 19158248. Show all entries for this paper.


Displaying record number 56881

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location  
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Epitope Name KK10
Species (MHC/HLA) (B*27)
Immunogen  
Experimental methods Relative replication capacity assay
Keywords elite controllers

Notes

References

OConnell2010a Karen A. O'Connell, Robert K. Pelz, Jason B. Dinoso, Eric Dunlop, John Paik-Tesch, Thomas M. Williams, and Joel N. Blankson. Prolonged Control of an HIV Type 1 Escape Variant Following Treatment Interruption in an HLA-B*27-Positive Patient. AIDS Res. Hum. Retroviruses, 26(12):1307-1311, Dec 2010. PubMed ID: 20854198. Show all entries for this paper.


Displaying record number 57130

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location Gag(263-272)
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Species (MHC/HLA) (B*27)
Immunogen HIV-1 infection
Experimental methods Intracellular cytokine staining, Relative replication capacity assay
Keywords escape, HLA associated polymorphism

Notes

References

Kawashima2009 Yuka Kawashima, Katja Pfafferott, John Frater, Philippa Matthews, Rebecca Payne, Marylyn Addo, Hiroyuki Gatanaga, Mamoru Fujiwara, Atsuko Hachiya, Hirokazu Koizumi, Nozomi Kuse, Shinichi Oka, Anna Duda, Andrew Prendergast, Hayley Crawford, Alasdair Leslie, Zabrina Brumme, Chanson Brumme, Todd Allen, Christian Brander, Richard Kaslow, James Tang, Eric Hunter, Susan Allen, Joseph Mulenga, Songee Branch, Tim Roach, Mina John, Simon Mallal, Anthony Ogwu, Roger Shapiro, Julia G. Prado, Sarah Fidler, Jonathan Weber, Oliver G. Pybus, Paul Klenerman, Thumbi Ndung'u, Rodney Phillips, David Heckerman, P. Richard Harrigan, Bruce D. Walker, Masafumi Takiguchi, and Philip Goulder. Adaptation of HIV-1 to Human Leukocyte Antigen Class I. Nature, 458(7238):641-645, 2 Apr 2009. PubMed ID: 19242411. Show all entries for this paper.


Displaying record number 57181

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location Gag(263-272)
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Epitope Name KK10
Subtype B
Species (MHC/HLA) human(B*27)
Immunogen HIV-1 infection
Country Australia, Canada, Germany, United States
Experimental methods  
Keywords escape, acute/early infection, elite controllers

Notes

References

Schneidewind2009a Arne Schneidewind, Zabrina L. Brumme, Chanson J. Brumme, Karen A. Power, Laura L. Reyor, Kristin. O'Sullivan, Adrianne Gladden, Ursula Hempel, Thomas Kuntzen, Yaoyu E. Wang, Cesar Oniangue-Ndza, Heiko Jessen, Martin Markowitz, Eric S. Rosenberg, Rafick-Pierre Sékaly, Anthony D. Kelleher, Bruce D. Walker, and Todd M. Allen. Transmission and Long-Term Stability of Compensated CD8 Escape Mutations. J. Virol., 83(8):3993-3997, Apr 2009. PubMed ID: 19091871. Show all entries for this paper.


Displaying record number 57296

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location p24(131-140)
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Epitope Name KK10
Subtype B
Species (MHC/HLA) human(B*27)
Immunogen peptide-HLA interaction
Experimental methods CD8 T-cell Elispot - IFNγ, HLA binding, Other
Keywords epitope processing

Notes

References

Tenzer2009 Stefan Tenzer, Edmund Wee, Anne Burgevin, Guillaume Stewart-Jones, Lone Friis, Kasper Lamberth, Chih-hao Chang, Mikkel Harndahl, Mirjana Weimershaus, Jan Gerstoft, Nadja Akkad, Paul Klenerman, Lars Fugger, E. Yvonne Jones, Andrew J. McMichael, Søren Buus, Hansjörg Schild, Peter van Endert, and Astrid K. N. Iversen. Antigen Processing Influences HIV-Specific Cytotoxic T Lymphocyte Immunodominance. Nat. Immunol., 10(6):636-646, Jun 2009. PubMed ID: 19412183. Show all entries for this paper.


Displaying record number 57346

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location p24(263-272)
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Epitope Name KK10
Subtype B
Species (MHC/HLA) human(B*27)
Immunogen peptide-HLA interaction
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining, Other
Keywords dendritic cells

Notes

References

Huang2009 Xiao-Li Huang, Zheng Fan, LuAnn Borowski, and Charles R. Rinaldo. Multiple T-Cell Responses to Human Immunodeficiency Virus Type 1 Are Enhanced by Dendritic Cells. Clin. Vaccine Immunol., 16(10):1504-1516, Oct 2009. PubMed ID: 19692626. Show all entries for this paper.


Displaying record number 57582

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location p24(131-140)
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Epitope Name KK10
Subtype B
Species (MHC/HLA) (B*27)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords acute/early infection

Notes

References

Dinges2010 Warren L. Dinges, Julia Richardt, David Friedrich, Emilie Jalbert, Yi Liu, Claire E. Stevens, Janine Maenza, Ann C. Collier, Daniel E. Geraghty, Jeremy Smith, Zoe Moodie, James I. Mullins, M. Juliana McElrath, and Helen Horton. Virus-Specific CD8+ T-Cell Responses Better Define HIV Disease Progression than HLA Genotype. J. Virol., 84(9):4461-4468, May 2010. PubMed ID: 20147397. Show all entries for this paper.


Displaying record number 57637

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location  
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Epitope Name RK10
Subtype B
Species (MHC/HLA) (B*27)
Immunogen HIV-1 infection
Country United States
Experimental methods Flow cytometric T-cell cytokine assay, Intracellular cytokine staining, Proliferation
Keywords acute/early infection

Notes

References

Heath2011 Sonya L. Heath, Steffanie Sabbaj, Anju Bansal, J Michael Kilby, and Paul A. Goepfert. CD8 T-Cell Proliferative Capacity Is Compromised in Primary HIV-1 Infection. J. Acquir. Immune Defic. Syndr., 56(3):213-221, Mar 2011. PubMed ID: 21079516. Show all entries for this paper.


Displaying record number 57692

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location Gag(263-272)
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Subtype B
Species (MHC/HLA) human(B*27)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Buranapraditkun2011 Supranee Buranapraditkun, Ursula Hempel, Patrawadee Pitakpolrat, Rachel L. Allgaier, Pattarawat Thantivorasit, Sven-Iver Lorenzen, Sunee Sirivichayakul, William H. Hildebrand, Marcus Altfeld, Christian Brander, Bruce D. Walker, Praphan Phanuphak, Pokrath Hansasuta, Sarah L. Rowland-Jones, Todd M. Allen, and Kiat Ruxrungtham. A Novel Immunodominant CD8+ T Cell Response Restricted by a Common HLA-C Allele Targets a Conserved Region of Gag HIV-1 clade CRF01\_AE Infected Thais. PLoS One, 6(8):e23603, 2011. PubMed ID: 21887282. Show all entries for this paper.


Displaying record number 57821

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location Gag(263-272)
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Show epitope variants
Epitope Name KK10
Subtype B
Species (MHC/HLA) human(B*27)
Immunogen HIV-1 infection
Country Australia
Experimental methods CD8 T-cell Elispot - IFNγ, Tetramer binding
Keywords rate of progression, immunodominance, escape, TCR usage

Notes

References

Ammaranond2011 Palanee Ammaranond, David J. van Bockel, Kathy Petoumenos, Marylin McMurchie, Robert Finlayson, Melanie G. Middleton, Miles P. Davenport, Vanessa Venturi, Kazuo Suzuki, Linda Gelgor, John M. Kaldor, David A. Cooper, and Anthony D. Kelleher. HIV Immune Escape at an Immunodominant Epitope in HLA-B*27-Positive Individuals Predicts Viral Load Outcome. J. Immunol., 186(1):479-488, 1 Jan 2011. PubMed ID: 21115730. Show all entries for this paper.


Displaying record number 58009

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location p24
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Show epitope variants
Epitope Name KK10
Subtype B
Species (MHC/HLA) human(B*27)
Immunogen in vitro stimulation or selection
Experimental methods Chromium-release assay, Cytotoxicity assay, Other
Keywords epitope processing, escape

Notes

References

Lazaro2011 Estibaliz Lazaro, Carl Kadie, Pamela Stamegna, Shao Chong Zhang, Pauline Gourdain, Nicole Y. Lai, Mei Zhang, Sergio A. Martinez, David Heckerman, and Sylvie Le Gall. Variable HIV Peptide Stability in Human Cytosol Is Critical to Epitope Presentation and Immune Escape. J. Clin. Invest., 121(6):2480-2492, Jun 2011. PubMed ID: 21555856. Show all entries for this paper.


Displaying record number 58192

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location  
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Epitope Name KK10
Species (MHC/HLA) human(B*27)
Immunogen peptide-HLA interaction
Experimental methods HLA binding
Keywords structure

Notes

References

Seebach2011 Dieter Seebach, Aneta Lukaszuk, Krystyna Patora-Komisarska, Dominika Podwysocka, James Gardiner, Marc-Olivier Ebert, Jean Claude Reubi, Renzo Cescato, Beatrice Waser, Peter Gmeiner, Harald Hübner, and Catherine Rougeot. On the Terminal Homologation of Physiologically Active Peptides as a Means of Increasing Stability in Human Serum -- Neurotensin, Opiorphin, B27-KK10 Epitope, NPY. Chem. Biodivers., 8(5):711-739, May 2011. PubMed ID: 21560227. Show all entries for this paper.


Displaying record number 58280

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location  
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Show epitope variants
Epitope Name KK10
Subtype B
Species (MHC/HLA) human(B*27)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining, Tetramer binding
Keywords variant cross-reactivity, characterizing CD8+ T cells

Notes

References

Conrad2011 Joseph A. Conrad, Ramesh K. Ramalingam, Rita M. Smith, Louise Barnett, Shelly L. Lorey, Jie Wei, Brenna C. Simons, Shanmugalakshmi Sadagopal, Dirk Meyer-Olson, and Spyros A. Kalams. Dominant Clonotypes within HIV-Specific T Cell Responses Are Programmed Death-1 High and CD127 Low and Display Reduced Variant Cross-Reactivity. J. Immunol., 186(12):6871-6885, 15 Jun 2011. PubMed ID: 21562156. Show all entries for this paper.


Displaying record number 58335

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location p24
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Epitope Name KK10
Species (MHC/HLA) human(B*27)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, Cytotoxicity assay, Flow cytometric T-cell cytokine assay
Keywords assay or method development, elite controllers

Notes

References

Varadarajan2011 Navin Varadarajan, Boris Julg, Yvonne J. Yamanaka, Huabiao Chen, Adebola O. Ogunniyi, Elizabeth McAndrew, Lindsay C. Porter, Alicja Piechocka-Trocha, Brenna J. Hill, Daniel C. Douek, Florencia Pereyra, Bruce D. Walker, and J. Christopher Love. A High-Throughput Single-Cell Analysis of Human CD8+ T Cell Functions Reveals Discordance for Cytokine Secretion and Cytolysis. J. Clin. Invest., 121(11):4322-4331, Nov 2011. PubMed ID: 21965332. Show all entries for this paper.


Displaying record number 58502

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location Gag(131-140)
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Subtype B
Species (MHC/HLA) human(B*27)
Immunogen HIV-1 infection
Country Canada
Experimental methods Other
Keywords characterizing CD8+ T cells, elite controllers

Notes

References

Peretz2011 Yoav Peretz, Olivia Marra, Réjean Thomas, Danielle Legault, Pierre Côté, Mohamed-Rachid Boulassel, Danielle Rouleau, Jean-Pierre Routy, Rafick-Pierre Sékaly, Christos M Tsoukas, Cécile Tremblay, and Nicole F. Bernard. Relative Contribution of HIV-Specific Functional Lymphocyte Subsets Restricted by Protective and Non-Protective HLA Alleles. Viral Immunol, 24(3):189-198, Jun 2011. PubMed ID: 21668360. Show all entries for this paper.


Displaying record number 58551

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location p24
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Epitope Name B15-GY9
Subtype B
Species (MHC/HLA) human(B*27)
Immunogen HIV-1 infection
Country United States
Experimental methods  
Keywords review, rate of progression, acute/early infection

Notes

References

Streeck2010 Hendrik Streeck and Douglas F. Nixon. T Cell Immunity in Acute HIV-1 Infection. J. Infect. Dis., 202(Suppl 2):S302-8, 15 Oct 2010. PubMed ID: 20846037. Show all entries for this paper.


Displaying record number 59114

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location Gag
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Show epitope variants
Epitope Name KK10
Subtype CRF01_AE
Species (MHC/HLA) human(B*27)
Immunogen HIV-1 infection
Patient MHC/HLA N094: A*0201, A*3201, B*1302, B*1401, Cw*0602, Cw*0802; N107: A*0201, A*0201, B*2705, B*5701, Cw*0102, Cw*0602
Country United Kingdom
Experimental methods CD8 T-cell Elispot - IFNγ, Tetramer binding
Keywords rate of progression

Notes

References

Brener2015 Jacqui Brener, Astrid Gall, Rebecca Batorsky, Lynn Riddell, Soren Buus, Ellen Leitman, Paul Kellam, Todd Allen, Philip Goulder, and Philippa C. Matthews. Disease Progression Despite Protective HLA Expression in an HIV-Infected Transmission Pair. Retrovirology, 12:55, 2015. PubMed ID: 26123575. Show all entries for this paper.


Displaying record number 59123

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location p24(263-272)
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Show epitope variants
Epitope Name KK10
Subtype B
Species (MHC/HLA) human(B*27)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, CTL suppression of replication, Intracellular cytokine staining, Tetramer binding
Keywords binding affinity, TCR usage

Notes

References

Lissina2014 Anna Lissina, Solène Fastenackels, Maria C. Inglesias, Kristin Ladell, James E. McLaren, Olivia Briceño, Emma Gostick, Laura Papagno, Brigitte Autran, Delphine Sauce, David A. Price, Asier Saez-Cirion, and Victor Appay. The Link between CD8+ T-Cell Antigen-Sensitivity and HIV-Suppressive Capacity Depends on HLA Restriction, Target Epitope and Viral Isolate. AIDS, 28(4):477-486, 20 Feb 2014. PubMed ID: 24384691. Show all entries for this paper.


Displaying record number 59205

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location Gag(263-272)
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Epitope Name Gag 263-272
Subtype B
Species (MHC/HLA) human(B*27)
Immunogen vaccine
Country France
Experimental methods CD8 T-cell Elispot - IFNγ, Degranulation, CD107a and b cell surface mobilization, Intracellular cytokine staining, Tetramer binding
Keywords vaccine-induced immune responses

Vaccine Details

Vaccine type lipopeptide

Notes

References

Figueiredo2014 Suzanne Figueiredo, Benedicte Charmeteau, Mathieu Surenaud, Dominique Salmon, Odile Launay, Jean-Gérard Guillet, Anne Hosmalin, and Hanne Gahery. Memory CD8+ T Cells Elicited by HIV-1 Lipopeptide Vaccines Display Similar Phenotypic Profiles but Differences in Term of Magnitude and Multifunctionality Compared with FLU- or EBV-Specific Memory T Cells in Humans. Vaccine, 32(4):492-501, 16 Jan 2014. PubMed ID: 24291199. Show all entries for this paper.


Displaying record number 59299

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location p24
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Epitope Name KK10
Species (MHC/HLA) human(B*27)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression

Notes

References

Streeck2014 Hendrik Streeck, Richard Lu, Noor Beckwith, Mark Milazzo, Michelle Liu, Jean-Pierre Routy, Susan Little, Heiko Jessen, Anthony D. Kelleher, Frederick Hecht, Rafick-Pierre Sekaly, Galit Alter, David Heckerman, Mary Carrington, Eric S. Rosenberg, and Marcus Altfeld. Emergence of Individual HIV-Specific CD8 T Cell Responses during Primary HIV-1 Infection Can Determine Long-Term Disease Outcome. J. Virol., 88(21):12793-12801, Nov 2014. PubMed ID: 25165102. Show all entries for this paper.


Displaying record number 59955

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location Gag(263-272)
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Epitope Name KK10
Species (MHC/HLA) human(B*27)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 61476

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location Gag( NL4-3)
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Show epitope variants
Epitope Name KK10
Subtype B
Species (MHC/HLA) human(B*27)
Immunogen HIV-1 infection
Experimental methods Other
Keywords escape, structure, viral fitness and reversion

Notes

References

Schommers2016 P. Schommers, G. Martrus, U. Matschl, M. Sirignano, M. Lütgehetmann, L. Richert, T. J. Hope, G. Fätkenheuer, and M. Altfeld. Changes in HIV-1 Capsid Stability Induced by Common Cytotoxic-T-Lymphocyte-Driven Viral Sequence Mutations. J. Virol., 90(16):7579-7586, 15 Aug 2016. PubMed ID: 27279617. Show all entries for this paper.


Displaying record number 60659

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location p24(131-140)
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Epitope Name KK-10
Subtype B, C
Species (MHC/HLA) human(B*27, B*2705)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Tenzer2014 Stefan Tenzer, Hayley Crawford, Phillip Pymm, Robert Gifford, Vattipally B. Sreenu, Mirjana Weimershaus, Tulio de Oliveira, Anne Burgevin, Jan Gerstoft, Nadja Akkad, Daniel Lunn, Lars Fugger, John Bell, Hansjörg Schild, Peter van Endert, and Astrid K. N. Iversen. HIV-1 Adaptation to Antigen Processing Results in Population-Level Immune Evasion and Affects Subtype Diversification. Cell Rep., 7(2):448-463, 24 Apr 2014. PubMed ID: 24726370. Show all entries for this paper.


Displaying record number 57997

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location  
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Subtype C
Species (MHC/HLA) human(B*2705)
Immunogen HIV-1 infection
Country South Africa, United Kingdom
Experimental methods CD8 T-cell Elispot - IFNγ, Tetramer binding
Keywords computational epitope prediction, optimal epitope

Notes

References

ErupLarsen2011 Malene Erup Larsen, Henrik Kloverpris, Anette Stryhn, Catherine K. Koofhethile, Stuart Sims, Thumbi Ndung'u, Philip Goulder, Søren Buus, and Morten Nielsen. HLArestrictor---A Tool for Patient-Specific Predictions of HLA Restriction Elements and Optimal Epitopes within Peptides. Immunogenetics, 63(1):43-55, Jan 2011. PubMed ID: 21079948. Show all entries for this paper.


Displaying record number 57945

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location p24(131-140)
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Epitope Name KK10
Subtype A1, B, C
Species (MHC/HLA) human(B*2705)
Immunogen vaccine
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining
Keywords vaccine-induced immune responses

Vaccine Details

Vaccine type adenovirus
Vaccine strain B clade HXB2, A clade 92RW020, C clade 97ZA012
Vaccine component Env, Gag-Pol

Notes

References

Friedrich2011 David Friedrich, Emilie Jalbert, Warren L. Dinges, John Sidney, Alex Sette, Yunda Huang, M. Juliana McElrath, and Helen Horton. Vaccine-Induced HIV-Specific CD8+ T Cells Utilize Preferential HLA Alleles and Target-Specific Regions of HIV-1. J. Acquir. Immune Defic. Syndr., 58(3):248-252, 1 Nov 2011. PubMed ID: 21709567. Show all entries for this paper.


Displaying record number 1352

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location p24(263-272)
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Show epitope variants
Species (MHC/HLA) human(B*2705)
Immunogen HIV-1 infection
Experimental methods  
Keywords escape

Notes

References

Kelleher2001 A. D. Kelleher, C. Long, E. C. Holmes, R. L. Allen, J. Wilson, C. Conlon, C. Workman, S. Shaunak, K. Olson, P. Goulder, C. Brander, G. Ogg, J. S. Sullivan, W. Dyer, I. Jones, A. J. McMichael, S. Rowland-Jones, and R. E. Phillips. Clustered mutations in HIV-1 gag are consistently required for escape from HLA-B27-restricted cytotoxic T lymphocyte responses. J. Exp. Med., 193(3):375-86, 5 Feb 2001. URL: http://www.jem.org/cgi/content/full/193/3/375. PubMed ID: 11157057. Show all entries for this paper.


Displaying record number 55037

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location  
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Species (MHC/HLA) human(B*2705)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, HLA binding
Keywords binding affinity, immunodominance, optimal epitope

Notes

References

Bihl2006 Florian Bihl, Nicole Frahm, Loriana Di Giammarino, John Sidney, Mina John, Karina Yusim, Tonia Woodberry, Kaori Sango, Hannah S. Hewitt, Leah Henry, Caitlyn H. Linde, John V. Chisholm, III, Tauheed M. Zaman, Eunice Pae, Simon Mallal, Bruce D Walker, Alessandro Sette, Bette T. Korber, David Heckerman, and Christian Brander. Impact of HLA-B Alleles, Epitope Binding Affinity, Functional Avidity, and Viral Coinfection on the Immunodominance of Virus-Specific CTL Responses. J. Immunol., 176(7):4094-4101, 1 Apr 2006. PubMed ID: 16547245. Show all entries for this paper.


Displaying record number 53619

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location Gag(263-272)
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Show epitope variants
Epitope Name KK10
Subtype B
Species (MHC/HLA) human(B*2705)
Immunogen HIV-1 infection, vaccine
Patient MHC/HLA A2, B27, B44, Cw2, Cw5
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, Degranulation, CD107a and b cell surface mobilization, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining, Tetramer binding
Keywords vaccine-induced immune responses, immunodominance, escape, TCR usage, characterizing CD8+ T cells

Vaccine Details

Vaccine type canarypox
Vaccine strain B clade LAI, B clade MN
Vaccine component Gag, gp120, gp41, Protease

Notes

References

Betts2005 Michael R. Betts, Barbara Exley, David A. Price, Anju Bansal, Zenaido Tres Camacho, Vanessa Teaberry, Sadie M. West, David R. Ambrozak, Georgia Tomaras, Mario Roederer, J. Michael Kilby, Jim Tartaglia, Robert Belshe, Feng Gao, Daniel C. Douek, Kent J. Weinhold, Richard A. Koup, Paul Goepfert, and Guido Ferrari. Characterization of Functional and Phenotypic Changes in Anti-Gag Vaccine-Induced T Cell Responses and Their Role in Protection after HIV-1 Infection. Proc. Natl. Acad. Sci. U.S.A., 102(12):4512-4517, 22 Mar 2005. PubMed ID: 15753288. Show all entries for this paper.


Displaying record number 57716

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location p24(263-272)
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Show epitope variants
Epitope Name KK10
Subtype B
Species (MHC/HLA) human(B*2705)
Immunogen HIV-1 infection
Country Australia
Experimental methods Other
Keywords immunodominance, variant cross-reactivity, memory cells

Notes

References

vanBockel2011 David J. van Bockel, David A. Price, Mee Ling Munier, Vanessa Venturi, Tedi E. Asher, Kristin Ladell, Hui Yee Greenaway, John Zaunders, Daniel C. Douek, David A. Cooper, Miles P. Davenport, and Anthony D. Kelleher. Persistent Survival of Prevalent Clonotypes within an Immunodominant HIV Gag-Specific CD8+ T Cell Response. J. Immunol., 186(1):359-371, 1 Jan 2011. PubMed ID: 21135165. Show all entries for this paper.


Displaying record number 57768

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location Gag(263-272)
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Show epitope variants
Epitope Name KK10
Subtype B
Species (MHC/HLA) human(B*2705)
Immunogen HIV-1 infection
Country United Kingdom
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining, Other
Keywords rate of progression, immunodominance

Notes

References

Payne2010 Rebecca P. Payne, Henrik Kløverpris, Jonah B. Sacha, Zabrina Brumme, Chanson Brumme, Søren Buus, Stuart Sims, Stephen Hickling, Lynn Riddell, Fabian Chen, Graz Luzzi, Anne Edwards, Rodney Phillips, Julia G. Prado, and Philip J. R. Goulder. Efficacious Early Antiviral Activity of HIV Gag- and Pol-Specific HLA-B*2705-Restricted CD8+ T Cells. J. Virol., 84(20):10543-10557, Oct 2010. PubMed ID: 20686036. Show all entries for this paper.


Displaying record number 55005

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location p24(131-140)
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Epitope Name KRW
Species (MHC/HLA) human(B*2705)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, TCR usage, variant cross-reactivity, characterizing CD8+ T cells

Notes

References

Turnbull2006 Emma L. Turnbull, A. Ross Lopes, Nicola A. Jones, David Cornforth, Phillipa Newton, Diana Aldam, Pierre Pellegrino, Jo Turner, Ian Williams, Craig M. Wilson, Paul A. Goepfert, Mala K. Maini, and Persephone Borrow. HIV-1 Epitope-Specific CD8+ T Cell Responses Strongly Associated with Delayed Disease Progression Cross-Recognize Epitope Variants Efficiently. J. Immunol., 176(10):6130-6146, 15 May 2006. PubMed ID: 16670322. Show all entries for this paper.


Displaying record number 57918

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location  
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Species (MHC/HLA) human(B*2705)
Immunogen peptide-HLA interaction
Experimental methods Tetramer binding
Keywords  

Notes

References

Fadda2011 Lena Fadda, Geraldine M. O'Connor, Swati Kumar, Alicja Piechocka-Trocha, Clair M. Gardiner, Mary Carrington, Daniel W. McVicar, and Marcus Altfeld. Common HIV-1 Peptide Variants Mediate Differential Binding of KIR3DL1 to HLA-Bw4 Molecules. J Virol, 85(12):5970-5974, Jun 2011. PubMed ID: 21471246. Show all entries for this paper.


Displaying record number 57953

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location Gag(263-272)
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Show epitope variants
Epitope Name KK10
Species (MHC/HLA) human(B*2705)
Immunogen HIV-1 infection, in vitro stimulation or selection
Experimental methods CD8 T-cell Elispot - IFNγ, Other, TCR binding
Keywords escape, TCR usage

Notes

References

Iglesias2011 Maria Candela Iglesias, Jorge R. Almeida, Solène Fastenackels, David J. van Bockel, Masao Hashimoto, Vanessa Venturi, Emma Gostick, Alejandra Urrutia, Linda Wooldridge, Mathew Clement, Stéphanie Gras, Pascal G. Wilmann, Brigitte Autran, Arnaud Moris, Jamie Rossjohn, Miles P. Davenport, Masafumi Takiguchi, Christian Brander, Daniel C. Douek, Anthony D. Kelleher, David A. Price, and Victor Appay. Escape from Highly Effective Public CD8+ T-Cell Clonotypes by HIV. Blood, 118(8):2138-2149, 25 Aug 2011. PubMed ID: 21734237. Show all entries for this paper.


Displaying record number 61205

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location Gag
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Show epitope variants
Epitope Name KK10
Subtype B
Species (MHC/HLA) human(B*2705)
Immunogen HIV-1 infection
Experimental methods Other
Keywords review, escape, HLA associated polymorphism

Notes

References

Kloverpris2015a Henrik N. Kløverpris, Alasdair Leslie, and Philip Goulder. Role of HLA Adaptation in HIV Evolution. Front. Immunol., 6:665, 18 Jan 2016. PubMed ID: 26834742. Show all entries for this paper.


Displaying record number 61221

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location p24
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Epitope Name KK10
Species (MHC/HLA) human(B*2705)
Immunogen HIV-2 infection
Country France
Experimental methods CTL suppression of replication, Intracellular cytokine staining
Keywords HIV-2

Notes

References

Angin2016 Mathieu Angin, Glenn Wong, Laura Papagno, Pierre Versmisse, Annie David, Charles Bayard, Bénédicte Charmeteau-De Muylder, Amel Besseghir, Rodolphe Thiébaut, Faroudy Boufassa, Gianfranco Pancino, Delphine Sauce, Olivier Lambotte, Françoise Brun-Vézinet, Sophie Matheron, Sarah L. Rowland-Jones, Rémi Cheynier, Asier Sáez-Cirión, Victor Appay, and ANRS CO5 IMMUNOVIR-2 Study Group. Preservation of Lymphopoietic Potential and Virus Suppressive Capacity by CD8+ T Cells in HIV-2-Infected Controllers. J. Immunol., 197(7):2787-2795, 1 Oct 2016. PubMed ID: 27566819. Show all entries for this paper.


Displaying record number 58360

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location p24
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Epitope Name B27 KK10
Subtype B, C
Species (MHC/HLA) human(B*2705)
Immunogen HIV-1 infection, in vitro stimulation or selection, vaccine
Country South Africa, United States
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining, Tetramer binding
Keywords vaccine antigen design

Vaccine Details

Vaccine type adenovirus type 5 (Ad5)
Vaccine strain B clade, C clade
Vaccine component Gag

Notes

References

Ndhlovu2011 Zaza M. Ndhlovu, Alicja Piechocka-Trocha, Seanna Vine, Ashley McMullen, Kegakilwe C. Koofhethile, Phillip J. R. Goulder, Thumbi Ndung'u, Dan H. Barouch, and Bruce D. Walker. Mosaic HIV-1 Gag Antigens Can Be Processed and Presented to Human HIV-Specific CD8+ T Cells. J. Immunol., 186(12):6914-6924, 15 Jun 2011. PubMed ID: 21576505. Show all entries for this paper.


Displaying record number 52424

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location p24
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Subtype A, B, C, D
Species (MHC/HLA) human(B*2705)
Immunogen HIV-1 infection, vaccine
Experimental methods  
Keywords subtype comparisons, epitope processing, vaccine-induced immune responses, immunodominance

Vaccine Details

Vaccine type DNA prime with modified vaccinia Ankara (MVA) boost
Vaccine strain A clade
Vaccine component p17 Gag, p24 Gag

Notes

References

Hanke2000 Tomas Hanke and Andrew J. McMichael. Design and construction of an experimental HIV-1 vaccine for a year-2000 clinical trial in Kenya. Nat. Med., 6(9):951-955, Sep 2000. PubMed ID: 10973301. Show all entries for this paper.

Wee2002 Edmund G.-T. Wee, Sandip Patel, Andrew J. McMichael, and Tomáš Hanke. A DNA/MVA-Based Candidate Human Immunodeficiency Virus Vaccine for Kenya Induces Multi-Specific T Cell Responses in Rhesus Macaques. J. Gen. Virol., 83(Pt 1):75-80, Jan 2002. PubMed ID: 11752703. Show all entries for this paper.


Displaying record number 58778

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location Gag(263-272 NL4-3)
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Epitope Name KK10
Subtype B
Species (MHC/HLA) human(B*2705)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, Degranulation, CD107a and b cell surface mobilization, Intracellular cytokine staining, Tetramer binding
Keywords elite controllers

Notes

References

Chen2012a Huabiao Chen, Zaza M. Ndhlovu, Dongfang Liu, Lindsay C. Porter, Justin W. Fang, Sam Darko, Mark A. Brockman, Toshiyuki Miura, Zabrina L. Brumme, Arne Schneidewind, Alicja Piechocka-Trocha, Kevin T. Cesa, Jennifer Sela, Thai D. Cung, Ildiko Toth, Florencia Pereyra, Xu G. Yu, Daniel C. Douek, Daniel E. Kaufmann, Todd M. Allen, and Bruce D. Walker. TCR Clonotypes Modulate the Protective Effect of HLA Class I Molecules in HIV-1 Infection. Nat. Immunol., 13(7):691-700, Jul 2012. PubMed ID: 22683743. Show all entries for this paper.


Displaying record number 58786

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location p24(262-270)
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Species (MHC/HLA) human(B*2705)
Immunogen  
Experimental methods  
Keywords review

Notes

References

Goulder2012 Philip J. R. Goulder and Bruce D. Walker. HIV and HLA Class I: An Evolving Relationship. Immunity, 37(3):426-440, 21 Sep 2012. PubMed ID: 22999948. Show all entries for this paper.


Displaying record number 58843

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location Gag
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Epitope Name KK10
Subtype B
Species (MHC/HLA) human(B*2705)
Immunogen HIV-1 infection
Patient MHC/HLA A*0101, A*0301, B*2705, B*5701
Country United States
Experimental methods Flow cytometric T-cell cytokine assay
Keywords rate of progression

Notes

References

Norstrom2012 Melissa M. Norström, Marcus Buggert, Johanna Tauriainen, Wendy Hartogensis, Mattia C. Prosperi, Mark A. Wallet, Frederick M. Hecht, Marco Salemi, and Annika C. Karlsson. Combination of Immune and Viral Factors Distinguishes Low-Risk Versus High-Risk HIV-1 Disease Progression in HLA-B*5701 Subjects. J. Virol., 86(18):9802-9816, Sep 2012. PubMed ID: 22761389. Show all entries for this paper.


Displaying record number 58961

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location p24(131-140)
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Epitope Name KK10
Subtype B
Species (MHC/HLA) human(B*2705)
Immunogen HIV-1 infection
Patient MHC/HLA 53617: A*0201, A*0205, B*2705, B*4901, C*0202, C*0701; 20786: A*0201, A*1101, B*2705, B*4002, Cw*0202, Cw*0202; 79379: A*0101, A*0101, B*2705, B*5201, Cw*0201, Cw*1202
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords acute/early infection

Notes

References

Kunwar2013 Pratima Kunwar, Natalie Hawkins, Warren L. Dinges, Yi Liu, Erin E. Gabriel, David A. Swan, Claire E. Stevens, Janine Maenza, Ann C. Collier, James I. Mullins, Tomer Hertz, Xuesong Yu, and Helen Horton. Superior Control of HIV-1 Replication by CD8+ T Cells Targeting Conserved Epitopes: Implications for HIV Vaccine Design. PLoS One, 8(5):e64405, 2013. PubMed ID: 23741326. Show all entries for this paper.


Displaying record number 58975

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location Gag(263-272)
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Subtype B
Species (MHC/HLA) human(B*2705)
Immunogen HIV-1 infection
Country Australia, Canada, Spain, Switzerland
Experimental methods Other
Keywords mutation acquisition

Notes

References

Bartha2013 István Bartha, Jonathan M. Carlson, Chanson J. Brumme, Paul J. McLaren, Zabrina L. Brumme, Mina John, David W. Haas, Javier Martinez-Picado, Judith Dalmau, Cecilio López-Galíndez, Concepción Casado, Andri Rauch, Huldrych F. Günthard, Enos Bernasconi, Pietro Vernazza, Thomas Klimkait, Sabine Yerly, Stephen J. O'Brien, Jennifer Listgarten, Nico Pfeifer, Christoph Lippert, Nicolo Fusi, Zoltán Kutalik, Todd M. Allen, Viktor Müller, P. Richard Harrigan, David Heckerman, Amalio Telenti, and Jacques Fellay. A Genome-to-Genome Analysis of Associations between Human Genetic Variation, HIV-1 Sequence Diversity, and Viral Control. eLife, 2:e01123, 2013. PubMed ID: 24171102. Show all entries for this paper.


Displaying record number 59014

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location Gag(263-272)
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Show epitope variants
Epitope Name KK10
Species (MHC/HLA) human(B*2705)
Immunogen HIV-1 infection
Country France
Experimental methods Chromium-release assay, Other
Keywords escape, structure, variant cross-reactivity, mutation acquisition

Notes

References

Ladell2013 Kristin Ladell, Masao Hashimoto, Maria Candela Iglesias, Pascal G. Wilmann, James E. McLaren, Stéphanie Gras, Takayuki Chikata, Nozomi Kuse, Solène Fastenackels, Emma Gostick, John S. Bridgeman, Vanessa Venturi, Zaïna Aït Arkoub, Henri Agut, David J. van Bockel, Jorge R. Almeida, Daniel C. Douek, Laurence Meyer, Alain Venet, Masafumi Takiguchi, Jamie Rossjohn, David A. Price, and Victor Appay. A Molecular Basis for the Control of Preimmune Escape Variants by HIV-Specific CD8+ T Cells. Immunity, 38(3):425-436, 21 Mar 2013. PubMed ID: 23521884. Show all entries for this paper.


Displaying record number 55745

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location p24(263-272)
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Show epitope variants
Epitope Name KK10
Subtype B
Species (MHC/HLA) human(B*2705)
Immunogen HIV-1 infection
Country United States
Experimental methods Chromium-release assay, Other
Keywords escape, compensatory mutation

Notes

References

Schneidewind2008 Arne Schneidewind, Mark A Brockman, John Sidney, Yaoyu E Wang, Huabiao Chen, Todd J Suscovich, Bin Li, Rahma I Adam, Rachel L Allgaier, Bianca R Mothé, Thomas Kuntzen, Cesar Oniangue-Ndza, Alicja Trocha, Xu G Yu, Christian Brander, Alessandro Sette, Bruce D Walker, and Todd M Allen. Structural and Functional Constraints Limit Options for Cytotoxic T-Lymphocyte Escape in the Immunodominant HLA-B27-Restricted Epitope in Human Immunodeficiency Virus Type 1 Capsid. J. Virol., 82(11):5594-5605, Jun 2008. PubMed ID: 18385228. Show all entries for this paper.


Displaying record number 59030

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location Gag(263-272 NL4-3)
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Epitope Name KK10Gag
Subtype B
Species (MHC/HLA) human(B*2705)
Immunogen HIV-1 infection
Patient MHC/HLA R039: A*0101, A*3101, B*2705, B*5701, Cw*0202, Cw*0602
Country United Kingdom
Experimental methods Intracellular cytokine staining, Other
Keywords cell-line isolated antibody

Notes

References

Kloverpris2013 Henrik N. Kløverpris, Rebecca P. Payne, Jonah B. Sacha, Jane T. Rasaiyaah, Fabian Chen, Masafumi Takiguchi, Otto O. Yang, Greg J. Towers, Philip Goulder, and Julia G. Prado. Early Antigen Presentation of Protective HIV-1 KF11Gag and KK10Gag Epitopes from Incoming Viral Particles Facilitates Rapid Recognition of Infected Cells by Specific CD8+ T Cells. J. Virol., 87(5):2628-2638, Mar 2013. PubMed ID: 23255798. Show all entries for this paper.


Displaying record number 273

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location p24(263-272 LAI)
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Subtype B
Species (MHC/HLA) human(B*2705)
Immunogen HIV-1 infection
Experimental methods  
Keywords optimal epitope

Notes

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 56725

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location  
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Epitope Name KK10
Species (MHC/HLA) human(B*2705)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, Flow cytometric T-cell cytokine assay, Tetramer binding
Keywords TCR usage, characterizing CD8+ T cells

Notes

References

Almeida2009 Jorge R. Almeida, Delphine Sauce, David A. Price, Laura Papagno, So Youn Shin, Arnaud Moris, Martin Larsen, Gianfranco Pancino, Daniel C. Douek, Brigitte Autran, Asier Sáez-Cirion, and Victor Appay. Antigen Sensitivity Is a Major Determinant of CD8+ T-Cell Polyfunctionality and HIV-Suppressive Activity. Blood, 113(25):6351-6360, 18 Jun 2009. PubMed ID: 19389882. Show all entries for this paper.


Displaying record number 56730

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location p24
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Species (MHC/HLA) human, macaque(B*2705)
Immunogen peptide-HLA interaction
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords binding affinity

Notes

References

Loffredo2009 John T. Loffredo, John Sidney, Alex T. Bean, Dominic R. Beal, Wilfried Bardet, Angela Wahl, Oriana E. Hawkins, Shari Piaskowski, Nancy A. Wilson, William H. Hildebrand, David I. Watkins, and Alessandro Sette. Two MHC Class I Molecules Associated with Elite Control of Immunodeficiency Virus Replication, Mamu-B*08 and HLA-B*2705, Bind Peptides with Sequence Similarity. J. Immunol., 182(12):7763-7775, 15 Jun 2009. PubMed ID: 19494300. Show all entries for this paper.


Displaying record number 61573

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location Gag(263-272)
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Species (MHC/HLA) human(B*2705)
Immunogen vaccine
Experimental methods Other
Keywords review, vaccine-induced immune responses, vaccine antigen design, protective allele

Notes

References

Goulder2008 Philip J. R. Goulder and David I. Watkins. Impact of MHC Class I Diversity on Immune Control of Immunodeficiency Virus Replication. Nat. Rev. Immunol., 8(8):619-630, Aug 2008. PubMed ID: 18617886. Show all entries for this paper.


Displaying record number 59176

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location Gag(263-272)
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Epitope Name gag 020-028
Subtype B
Species (MHC/HLA) human(B*2705)
Immunogen HIV-1 infection
Country France
Experimental methods CD8 T-cell Elispot - IFNγ, CTL suppression of replication, HLA binding, Intracellular cytokine staining, Other
Keywords binding affinity, elite controllers

Notes

References

Lecuroux2014 Camille Lécuroux, Asier Sáez-Cirión, Isabelle Girault, Pierre Versmisse, Faroudy Boufassa, Véronique Avettand-Fenoël, Christine Rouzioux, Laurence Meyer, Gianfranco Pancino, Olivier Lambotte, Martine Sinet, and Alain Venet. Both HLA-B*57 and Plasma HIV RNA Levels Contribute to the HIV-Specific CD8+ T Cell Response in HIV Controllers. J. Virol., 88(1):176-187, Jan 2014. PubMed ID: 24131719. Show all entries for this paper.


Displaying record number 61673

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location Gag
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Epitope Name KK10
Species (MHC/HLA) human(B*2705)
Immunogen HIV-1 infection, in vitro stimulation or selection
Experimental methods Chromium-release assay, Other
Keywords TCR usage

Notes

References

Flerin2017 Nina C. Flerin, Huabiao Chen, Tynisha D. Glover, Pedro A. Lamothe, Jian Hua Zheng, Justin W. Fang, Zaza M. Ndhlovu, Evan W. Newell, Mark M. Davis, Bruce D. Walker, and Harris Goldstein. T-Cell Receptor (TCR) Clonotype-Specific Differences in Inhibitory Activity of HIV-1 Cytotoxic T-Cell Clones Is Not Mediated by TCR Alone. J. Virol., 91(6), 15 Mar 2017. PubMed ID: 28077649. Show all entries for this paper.


Displaying record number 55103

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location Gag
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Show epitope variants
Epitope Name KK10
Subtype B
Species (MHC/HLA) human(B*2705)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Cytokine production, Other, Proliferation
Keywords binding affinity, escape, dendritic cells, mutation acquisition

Notes

References

Lichterfeld2007a Mathias Lichterfeld, Daniel G. Kavanagh, Katie L. Williams, Beenu Moza, Stanley K. Mui, ToshiYuki Miura, Rohini Sivamurthy, Rachel Allgaier, Florencia Pereyra, Alicja Trocha, Margaret Feeney, Rajesh T. Gandhi, Eric S. Rosenberg, Marcus Altfeld, Todd M. Allen, Rachel Allen, Bruce D. Walker, Eric J. Sundberg, and Xu G. Yu. A Viral CTL Escape Mutation Leading to Immunoglobulin-Like Transcript 4-Mediated Functional Inhibition of Myelomonocytic Cells. J. Exp. Med., 204(12):2813-2824, 26 Nov 2007. PubMed ID: 18025130. Show all entries for this paper.


Displaying record number 59224

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location Gag( NL4-3)
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Epitope Name KK10
Subtype B
Species (MHC/HLA) human(B*2705)
Immunogen in vitro stimulation or selection
Patient MHC/HLA 285873: A*0201, A*0301, B*5101, Cw*1402, Cw*1502; 828656: A*0301, A*2601, B*1501, B*2705, Cw*0202, Cw*0303
Experimental methods Other
Keywords kinetics

Notes

References

Foley2014 Maria Hottelet Foley, Talitha Forcier, Elizabeth McAndrew, Michael Gonzalez, Huabiao Chen, Boris Juelg, Bruce D. Walker, and Darrell J. Irvine. High Avidity CD8+ T Cells Efficiently Eliminate Motile HIV-Infected Targets and Execute a Locally Focused Program of Anti-Viral Function. PLoS One, 9(2):e87873, 2014. PubMed ID: 24551068. Show all entries for this paper.


Displaying record number 59424

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location Gag
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Show epitope variants
Epitope Name KK10
Species (MHC/HLA) human(B*2705)
Immunogen HIV-1 infection
Experimental methods Chromium-release assay, Other
Keywords structure

Notes

References

Xia2014 Zhen Xia, Huabiao Chen, Seung-gu Kang, Tien Huynh, Justin W. Fang, Pedro A. Lamothe, Bruce D. Walker, and Ruhong Zhou. The Complex and Specific pMHC Interactions with Diverse HIV-1 TCR Clonotypes Reveal a Structural Basis for Alterations in CTL Function. Sci. Rep., 4:4087, 2014. PubMed ID: 24522437. Show all entries for this paper.


Displaying record number 59958

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location Gag(263-272)
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Epitope Name KK10
Species (MHC/HLA) human(B*81)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 54949

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location  
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Species (MHC/HLA) human
Immunogen HIV-1 infection, vaccine
Patient MHC/HLA A3, A33; B15 (63), B27
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords vaccine-induced immune responses

Vaccine Details

Vaccine type canarypox prime with gp120 boost
Vaccine strain other
Vaccine component gp160

Notes

References

Horton2006a Helen Horton, Colin Havenar-Daughton, Deborah Lee, Erin Moore, Jianhong Cao, John McNevin, Thomas Andrus, Haiying Zhu, Abbe Rubin, Tuofu Zhu, Connie Celum, and M. Juliana McElrath. Induction of Human Immunodeficiency Virus Type 1 (HIV-1)-Specific T-Cell Responses in HIV Vaccine Trial Participants Who Subsequently Acquire HIV-1 Infection. J. Virol., 80(19):9779-9788, Oct 2006. PubMed ID: 16973582. Show all entries for this paper.


Displaying record number 62016

HXB2 Location Gag(263-272)
p24(131-140)
Gag Epitope Map
Author Location Gag
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Show epitope variants
Epitope Name KK10
Species (MHC/HLA) human
Immunogen HIV-1 infection, in vitro stimulation or selection
Experimental methods CTL suppression of replication, HLA binding, Intracellular cytokine staining, Other
Keywords characterizing CD8+ T cells, elite controllers

Notes

References

Joglekar2018 Alok V. Joglekar, Zhe Liu, Jeffrey K. Weber, Yong Ouyang, John D. Jeppson, Won Jun Noh, Pedro A. Lamothe-Molina, Huabiao Chen, Seung-Gu Kang, Michael T. Bethune, Ruhong Zhou, Bruce D. Walker, and David Baltimore. T Cell Receptors for the HIV KK10 Epitope from Patients with Differential Immunologic Control Are Functionally Indistinguishable. Proc. Natl. Acad. Sci. U.S.A., 115(8):1877-1882, 20 Feb 2018. PubMed ID: 29437954. Show all entries for this paper.


Displaying record number 54865

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location Gag(263-272 B27)
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Show epitope variants
Epitope Name KK10 (263-272)
Subtype B
Species (MHC/HLA) human
Immunogen HIV-1 infection
Experimental methods  
Keywords review, immunodominance, escape, dendritic cells, mutation acquisition, viral fitness and reversion, compensatory mutation

Notes

References

McMichael2007 Andrew J McMichael. Triple Bypass: Complicated Paths to HIV Escape. J. Exp. Med., 204(12):2785-2758, 26 Nov 2007. PubMed ID: 18025124. Show all entries for this paper.


Displaying record number 55101

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location Gag(263-272)
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Show epitope variants
Epitope Name KK10
Subtype B
Species (MHC/HLA) human
Immunogen HIV-1 infection
Experimental methods Other
Keywords escape, acute/early infection, mutation acquisition, viral fitness and reversion, optimal epitope, compensatory mutation

Notes

References

Schneidewind2007 Arne Schneidewind, Mark A. Brockman, Ruifeng Yang, Rahma I. Adam, Bin Li, Sylvie Le Gall, Charles R. Rinaldo, Sharon L. Craggs, Rachel L. Allgaier, Karen A. Power, Thomas Kuntzen, Chang-Shung Tung, Montiago X. LaBute, Sandra M. Mueller, Thomas Harrer, Andrew J. McMichael, Philip J. R. Goulder, Christopher Aiken, Christian Brander, Anthony D. Kelleher, and Todd M. Allen. Escape from the Dominant HLA-B27-Restricted Cytotoxic T-Lymphocyte Response in Gag Is Associated with a Dramatic Reduction in Human Immunodeficiency Virus Type 1 Replication. J. Virol., 81(22):12382-12393, Nov 2007. PubMed ID: 17804494. Show all entries for this paper.


Displaying record number 61457

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location Gag(263-272)
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Show epitope variants
Epitope Name KK10-B27
Subtype CRF01_AE
Species (MHC/HLA) human
Immunogen HIV-1 infection
Patient MHC/HLA Subject 2: A*02, A*29, B*27, B*40, Cw*02, Cw*03
Country China
Experimental methods CD8 T-cell Elispot - IFNγ, Other
Keywords acute/early infection, kinetics

Notes

References

Jiang2016 Xifeng Jiang, Qiyan Jia, Lu Lu, Fei Yu, Jishen Zheng, Weiguo Shi, Lifeng Cai, Shibo Jiang, and Keliang Liu. A Novel Bispecific Peptide HIV-1 Fusion Inhibitor Targeting the N-Terminal Heptad Repeat and Fusion Peptide Domains in gp41. Amino Acids, 48(12):2867-2873, Dec 2016. PubMed ID: 27631437. Show all entries for this paper.


Displaying record number 60508

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location p24
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Show epitope variants
Epitope Name B27-KK10
Species (MHC/HLA) human
Immunogen HIV-1 infection
Patient MHC/HLA ACS 19957: A*01, A*02, B*0801, B*15; ACS 19885: A*01, A*02, B*0801, B*27; ACS 19861: A*01, A*02, B*0801, B*51; ACS 19453: A*01, A*02, B*0801, B*38; ACS 19342: A*01, A*02, B*0801, B*40; ACS 18840: A*02, B*0801, B*27; ACS 18839: A*0207, B*0801, B*27; ACS 18785: A*01, A*02, B*07, B*0801
Country Netherlands
Experimental methods Other, Tetramer binding
Keywords TCR usage

Notes

References

Costa2015 Ana I. Costa, Dan Koning, Kristin Ladell, James E. McLaren, Bart P. X. Grady, Ingrid M. M. Schellens, Petra van Ham, Monique Nijhuis, José A. M. Borghans, Can Keşmir, David A. Price, and Debbie van Baarle. Complex T-Cell Receptor Repertoire Dynamics Underlie the CD8+ T-Cell Response to HIV-1. J. Virol., 89(1):110-119, Jan 2015. PubMed ID: 25320304. Show all entries for this paper.


Displaying record number 55099

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location  
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Species (MHC/HLA) human
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining, Other
Keywords binding affinity, acute/early infection

Notes

References

Lichterfeld2007 Mathias Lichterfeld, Xu G. Yu, Stanley K. Mui, Katie L. Williams, Alicja Trocha, Mark A. Brockman, Rachel L. Allgaier, Michael T. Waring, Tomohiko Koibuchi, Mary N. Johnston, Daniel Cohen, Todd M. Allen, Eric S. Rosenberg, Bruce D. Walker, and Marcus Altfeld. Selective Depletion of High-Avidity Human Immunodeficiency Virus Type 1 (HIV-1)-Specific CD8+ T Cells after Early HIV-1 Infection. J. Virol., 81(8):4199-4214, Apr 2007. PubMed ID: 17287271. Show all entries for this paper.


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