HIV molecular immunology database
Found 16 matching records:
Download this epitope record as JSON.
HXB2 Location | Nef(105-115) DNA(9109..9141) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(105-115) | |
Epitope |
KRQEILDLWVY
|
Epitope Alignment
|
Epitope Name | KY11 | |
Species (MHC/HLA) | human(B*13) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(105-115) DNA(9109..9141) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(105-115) | |
Epitope |
KRQEILDLWVY
|
Epitope Alignment
|
Epitope Name | KY11 | |
Species (MHC/HLA) | human(B*18) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(105-115) DNA(9109..9141) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(105-115) | |
Epitope |
KRQEILDLWVY
|
Epitope Alignment
|
Epitope Name | KY11 | |
Subtype | C | |
Species (MHC/HLA) | human(B18, C*07:01) | |
Immunogen | HIV-1 infection | |
Country | South Africa, Zambia | |
Experimental methods | ||
Keywords | viral fitness and reversion, HLA associated polymorphism |
Goepfert2008 Paul A. Goepfert, Wendy Lumm, Paul Farmer, Philippa Matthews, Andrew Prendergast, Jonathan M. Carlson, Cynthia A. Derdeyn, Jianming Tang, Richard A. Kaslow, Anju Bansal, Karina Yusim, David Heckerman, Joseph Mulenga, Susan Allen, Philip J. R. Goulder, and Eric Hunter. Transmission of HIV-1 Gag Immune Escape Mutations Is Associated with Reduced Viral Load in Linked Recipients. J. Exp. Med., 205(5):1009-1017, 12 May 2008. PubMed ID: 18426987. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(105-115) DNA(9109..9141) |
Nef Epitope Map |
---|---|---|
Author Location | Nef | |
Epitope |
KRQEILDLWVY
|
Epitope Alignment
|
Subtype | C | |
Species (MHC/HLA) | human(B*18:01, B*44:03) | |
Immunogen | HIV-1 infection | |
Country | South Africa | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | viral fitness and reversion, HLA associated polymorphism |
Matthews2008 Philippa C. Matthews, Andrew Prendergast, Alasdair Leslie, Hayley Crawford, Rebecca Payne, Christine Rousseau, Morgane Rolland, Isobella Honeyborne, Jonathan Carlson, Carl Kadie, Christian Brander, Karen Bishop, Nonkululeko Mlotshwa, James I. Mullins, Hoosen Coovadia, Thumbi Ndung'u, Bruce D. Walker, David Heckerman, and Philip J. R. Goulder. Central Role of Reverting Mutations in HLA Associations with Human Immunodeficiency Virus Set Point. J. Virol., 82(17):8548-8559, Sep 2008. PubMed ID: 18596105. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(105-115) DNA(9109..9141) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(105-115) | |
Epitope |
KRQEILDLWVY
|
Epitope Alignment
|
Epitope Name | KY11 | |
Species (MHC/HLA) | human(B*27) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(105-115) DNA(9109..9141) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(105-115) | |
Epitope |
KRQEILDLWVY
|
Epitope Alignment
|
Epitope Name | KY11 | |
Species (MHC/HLA) | human(B*44) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(105-115) DNA(9109..9141) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(105-115) | |
Epitope |
KRQEILDLWVY
|
Epitope Alignment
|
Epitope Name | KY11 | |
Species (MHC/HLA) | human(B*57) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(105-115) DNA(9109..9141) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(105-115) | |
Epitope |
KRQEILDLWVY
|
Epitope Alignment
|
Epitope Name | KY11 | |
Species (MHC/HLA) | human(B*58:01) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(105-115) DNA(9109..9141) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(105-115) | |
Epitope |
KRQEILDLWVY
|
Epitope Alignment
|
Species (MHC/HLA) | human(C*07) | |
Immunogen | ||
Experimental methods | ||
Keywords | optimal epitope, A-list |
Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(105-115) DNA(9109..9141) |
Nef Epitope Map |
---|---|---|
Author Location | ||
Epitope |
KRQEILDLWVY
|
Epitope Alignment
|
Epitope Name | KY11 | |
Subtype | C | |
Species (MHC/HLA) | human(C*07) | |
Immunogen | HIV-1 infection | |
Country | South Africa | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | immunodominance, characterizing CD8+ T cells |
Mkhwanazi2010 Nompumelelo Mkhwanazi, Christina F. Thobakgale, Mary van der Stok, Shabashini Reddy, Zenele Mncube, Fundisiwe Chonco, Bruce D. Walker, Marcus Altfeld, Philip J. R. Goulder, and Thumbi Ndung'u. Immunodominant HIV-1-Specific HLA-B- and HLA-C-Restricted CD8+ T Cells Do Not Differ in Polyfunctionality. Virology, 405(2):483-491, 30 Sep 2010. PubMed ID: 20638093. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(105-115) DNA(9109..9141) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(105-115) | |
Epitope |
KRQEILDLWVY
|
Epitope Alignment
|
Epitope Name | KY11 | |
Species (MHC/HLA) | human(C*07) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(105-115) DNA(9109..9141) |
Nef Epitope Map |
---|---|---|
Author Location | Nef | |
Epitope |
KRQEILDLWVY
|
Epitope Alignment
|
Species (MHC/HLA) | human(C*07:01) | |
Immunogen | HIV-1 infection | |
Country | Kenya | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Chromium-release assay, Flow cytometric T-cell cytokine assay | |
Keywords | subtype comparisons, HLA cross-presentation, variant cross-reactivity |
Currier2006 Jeffrey R. Currier, Unchalee Visawapoka, Sodsai Tovanabutra, Carl J. Mason, Deborah L. Birx, Francine E. McCutchan, and Josephine H. Cox. CTL Epitope Distribution Patterns in the Gag and Nef Proteins of HIV-1 from Subtype A Infected Subjects in Kenya: Use of Multiple Peptide Sets Increases the Detectable Breadth of the CTL Response. BMC Immunol, 7:8, 2006. PubMed ID: 16620386. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(105-115) DNA(9109..9141) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(105-115) | |
Epitope |
KRQEILDLWVY
|
Epitope Alignment
|
Show epitope variants | ||
Epitope Name | KEY11 | |
Subtype | B | |
Species (MHC/HLA) | human(C*07:01) | |
Immunogen | HIV-1 infection | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining, Other | |
Keywords | acute/early infection, variant cross-reactivity |
Du2016 Victor Y. Du, Anju Bansal, Jonathan Carlson, Jesus F. Salazar-Gonzalez, Maria G. Salazar, Kristin Ladell, Stephanie Gras, Tracy M. Josephs, Sonya L. Heath, David A. Price, Jamie Rossjohn, Eric Hunter, and Paul A. Goepfert. HIV-1-Specific CD8 T Cells Exhibit Limited Cross-Reactivity during Acute Infection. J. Immunol., 196(8):3276-3286, 15 Apr 2016. PubMed ID: 26983786. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(105-115) DNA(9109..9141) |
Nef Epitope Map |
---|---|---|
Author Location | ( C consensus) | |
Epitope |
KRQEILDLWVY
|
Epitope Alignment
|
Subtype | C | |
Species (MHC/HLA) | human(C*07:01, C*07:02) | |
Immunogen | HIV-1 infection | |
Country | South Africa | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | HLA cross-presentation, characterizing CD8+ T cells |
Kiepiela2004 Photini Kiepiela, Alasdair J. Leslie, Isobella Honeyborne, Danni Ramduth, Christina Thobakgale, Senica Chetty, Prinisha Rathnavalu, Corey Moore, Katja J. Pfafferott, Louise Hilton, Peter Zimbwa, Sarah Moore, Todd Allen, Christian Brander, Marylyn M. Addo, Marcus Altfeld, Ian James, Simon Mallal, Michael Bunce, Linda D. Barber, James Szinger, Cheryl Day, Paul Klenerman, James Mullins, Bette Korber, Hoosen M. Coovadia, Bruce D. Walker, and Philip J. R. Goulder. Dominant Influence of HLA-B in Mediating the Potential Co-Evolution of HIV and HLA. Nature, 432(7018):769-775, 9 Dec 2004. LA-UR 04-5920. PubMed ID: 15592417. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(105-115) DNA(9109..9141) |
Nef Epitope Map |
---|---|---|
Author Location | Nef | |
Epitope |
KRQEILDLWVY
|
Epitope Alignment
|
Epitope Name | KY11 | |
Subtype | B | |
Species (MHC/HLA) | human(Cw7) | |
Immunogen | HIV-1 infection | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ, TCR binding | |
Keywords | rate of progression, TCR usage, optimal epitope |
Berger2011 Christoph T. Berger, Nicole Frahm, David A. Price, Beatriz Mothe, Musie Ghebremichael, Kari L. Hartman, Leah M. Henry, Jason M. Brenchley, Laura E. Ruff, Vanessa Venturi, Florencia Pereyra, John Sidney, Alessandro Sette, Daniel C. Douek, Bruce D. Walker, Daniel E. Kaufmann, and Christian Brander. High-Functional-Avidity Cytotoxic T Lymphocyte Responses to HLA-B-Restricted Gag-Derived Epitopes Associated with Relative HIV Control. J. Virol., 85(18):9334-9345, Sep 2011. PubMed ID: 21752903. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(105-115) DNA(9109..9141) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(105-115) | |
Epitope |
KRQEILDLWVY
|
Epitope Alignment
|
Epitope Name | KY11 | |
Subtype | B | |
Species (MHC/HLA) | human(Cw7) | |
Immunogen | HIV-1 infection | |
Country | Australia, Canada, Germany, United States | |
Experimental methods | ||
Keywords | HLA associated polymorphism |
Brumme2008 Zabrina L. Brumme, Chanson J. Brumme, Jonathan Carlson, Hendrik Streeck, Mina John, Quentin Eichbaum, Brian L Block, Brett Baker, Carl Kadie, Martin Markowitz, Heiko Jessen, Anthony D. Kelleher, Eric Rosenberg, John Kaldor, Yuko Yuki, Mary Carrington, Todd M. Allen, Simon Mallal, Marcus Altfeld, David Heckerman, and Bruce D. Walker. Marked Epitope- and Allele-Specific Differences in Rates of Mutation in Human Immunodeficiency Type 1 (HIV-1) Gag, Pol, and Nef Cytotoxic T-Lymphocyte Epitopes in Acute/Early HIV-1 Infection. J. Virol., 82(18):9216-9227, Sep 2008. PubMed ID: 18614631. Show all entries for this paper.