HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 7 matching records:

Displaying record number 56248

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HXB2 Location Nef(105-115)
DNA(9109..9141)
Nef Epitope Map
Author Location  
Epitope KRQDILDLWVY Epitope Alignment
KRQDILDLWVY epitope logo
Subtype C
Species (MHC/HLA) human(C*07:01)
Immunogen HIV-1 infection
Patient MHC/HLA A*23:01, B*08:01, B*15:10, C*07:01, C*16:01
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay
Keywords rate of progression

Notes

References

Gray2009 Clive M. Gray, Mandla Mlotshwa, Catherine Riou, Tiyani Mathebula, Debra de Assis Rosa, Tumelo Mashishi, Cathal Seoighe, Nobubelo Ngandu, Francois van Loggerenberg, Lynn Morris, Koleka Mlisana, Carolyn Williamson, Salim Abdool Karim, and CAPRISA 002 Acute Infection Study Team. Human Immunodeficiency Virus-Specific gamma Interferon Enzyme-Linked Immunospot Assay Responses Targeting Specific Regions of the Proteome during Primary Subtype C Infection Are Poor Predictors of the Course of Viremia and Set Point. J. Virol., 83(1):470-478, Jan 2009. PubMed ID: 18945774. Show all entries for this paper.


Displaying record number 56652

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HXB2 Location Nef(105-115)
DNA(9109..9141)
Nef Epitope Map
Author Location Nef(105-115)
Epitope KRQDILDLWVY Epitope Alignment
KRQDILDLWVY epitope logo
Show epitope variants
Species (MHC/HLA) human(C*07:01)
Immunogen HIV-1 infection
Patient MHC/HLA A*01:01, A*23:01, B*14:02, B*57:01, C*07:01, C*08:02
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining, Other
Keywords escape, acute/early infection

Notes

References

Goonetilleke2009 Nilu Goonetilleke, Michael K. P. Liu, Jesus F. Salazar-Gonzalez, Guido Ferrari, Elena Giorgi, Vitaly V. Ganusov, Brandon F. Keele, Gerald H. Learn, Emma L. Turnbull, Maria G Salazar, Kent J Weinhold, Stephen Moore, CHAVI Clinical Core B, Norman Letvin, Barton F. Haynes, Myron S. Cohen, Peter Hraber, Tanmoy Bhattacharya, Persephone Borrow, Alan S. Perelson, Beatrice H. Hahn, George M. Shaw, Bette T. Korber, and Andrew J. McMichael. The first T cell response to transmitted/founder virus contributes to the control of acute viremia in HIV-1 infection. J. Exp. Med., 206(6):1253-1272, 8 Jun 2009. PubMed ID: 19487423. Show all entries for this paper.


Displaying record number 54543

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HXB2 Location Nef(105-115)
DNA(9109..9141)
Nef Epitope Map
Author Location Nef(105-115)
Epitope KRQDILDLWVY Epitope Alignment
KRQDILDLWVY epitope logo
Show epitope variants
Epitope Name KY11
Subtype B
Species (MHC/HLA) human(Cw7)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords escape, acute/early infection, assay or method development, mutation acquisition

Notes

References

Malhotra2007a Uma Malhotra, Fusheng Li, Jessica Nolin, Megan Allison, Hong Zhao, James I. Mullins, Steve Self, and M. Juliana McElrath. Enhanced Detection of Human Immunodeficiency Virus Type 1 (HIV-1) Nef-Specific T Cells Recognizing Multiple Variants in Early HIV-1 Infection. J. Virol., 81(10):5225-5237, May 2007. PubMed ID: 17329342. Show all entries for this paper.


Displaying record number 60966

Download this epitope record as JSON.

HXB2 Location Nef(105-115)
DNA(9109..9141)
Nef Epitope Map
Author Location Nef(105-115)
Epitope KRQDILDLWVY Epitope Alignment
KRQDILDLWVY epitope logo
Subtype B
Species (MHC/HLA) human(Cw7)
Immunogen HIV-1 infection
Patient MHC/HLA 25122: A*01:01, A*03:01, B*07:02, B*37:01, C*06:02, C*07:02
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords acute/early infection

Notes

References

Kunwar2013 Pratima Kunwar, Natalie Hawkins, Warren L. Dinges, Yi Liu, Erin E. Gabriel, David A. Swan, Claire E. Stevens, Janine Maenza, Ann C. Collier, James I. Mullins, Tomer Hertz, Xuesong Yu, and Helen Horton. Superior Control of HIV-1 Replication by CD8+ T Cells Targeting Conserved Epitopes: Implications for HIV Vaccine Design. PLoS One, 8(5):e64405, 2013. PubMed ID: 23741326. Show all entries for this paper.


Displaying record number 55503

Download this epitope record as JSON.

HXB2 Location Nef(105-115)
DNA(9109..9141)
Nef Epitope Map
Author Location Nef
Epitope KRQDILDLWVY Epitope Alignment
KRQDILDLWVY epitope logo
Epitope Name KY11
Subtype B
Species (MHC/HLA) human(Cw7)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Tetramer binding
Keywords dynamics, characterizing CD8+ T cells, chronic infection

Notes

References

Streeck2008 Hendrik Streeck, Zabrina L. Brumme, Michael Anastario, Kristin W. Cohen, Jonathan S. Jolin, Angela Meier, Chanson J. Brumme, Eric S. Rosenberg, Galit Alter, Todd M. Allen, Bruce D. Walker, and Marcus Altfeld. Antigen Load and Viral Sequence Diversification Determine the Functional Profile of HIV-1-Specific CD8+ T Cells. PLoS Med, 5(5):e100, 6 May 2008. PubMed ID: 18462013. Show all entries for this paper.


Displaying record number 55789

Download this epitope record as JSON.

HXB2 Location Nef(105-115)
DNA(9109..9141)
Nef Epitope Map
Author Location Nef(105-115)
Epitope KRQDILDLWVY Epitope Alignment
KRQDILDLWVY epitope logo
Subtype B
Species (MHC/HLA) human
Immunogen HIV-1 infection, vaccine
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Other
Keywords  

Vaccine Details

Vaccine type DNA
Vaccine strain B clade
Vaccine component Gag
Adjuvant aluminum phosphate

Notes

References

Balamurugan2008 Arumugam Balamurugan, Martha J. Lewis, Christina M. R. Kitchen, Michael N. Robertson, John W. Shiver, Eric S. Daar, Jacqueline Pitt, Ayub Ali, Hwee L. Ng, Judith S. Currier, and Otto O. Yang. Primary Human Immunodeficiency Virus Type 1 (HIV-1) Infection during HIV-1 Gag Vaccination. J. Virol., 82(6):2784-2791, Mar 2008. PubMed ID: 18199650. Show all entries for this paper.


Displaying record number 57500

Download this epitope record as JSON.

HXB2 Location Nef(105-115)
DNA(9109..9141)
Nef Epitope Map
Author Location Nef
Epitope KRQDILDLWVY Epitope Alignment
KRQDILDLWVY epitope logo
Show epitope variants
Subtype B
Species (MHC/HLA) human
Immunogen HIV-1 infection
Country Australia
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords assay or method development, HLA associated polymorphism, chronic infection

Notes

References

Almeida2010 Coral-Ann M. Almeida, Steven G. Roberts, Rebecca Laird, Elizabeth McKinnon, Imran Ahmad, Niamh M. Keane, Abha Chopra, Carl Kadie, David Heckerman, Simon Mallal, and Mina John. Exploiting Knowledge of Immune Selection in HIV-1 to Detect HIV-Specific CD8 T-Cell Responses. Vaccine, 28(37):6052-6057, 23 Aug 2010. PubMed ID: 20619380. Show all entries for this paper.


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