HIV molecular immunology database
Found 19 matching records:
Download this epitope record as JSON.
HXB2 Location | Pol(901-909) Integrase(186-194) DNA(4785..4811) |
Pol Epitope Map |
---|---|---|
Author Location | Pol(901-909) | |
Epitope |
KRKGGIGGY
|
Epitope Alignment
|
Epitope Name | KY9 | |
Species (MHC/HLA) | human(B*15:03) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(901-909) Integrase(186-194) DNA(4785..4811) |
Pol Epitope Map |
---|---|---|
Author Location | Integrase | |
Epitope |
KRKGGIGGY
|
Epitope Alignment
|
Epitope Name | KY9 | |
Species (MHC/HLA) | human(B*27) | |
Immunogen | HIV-1 infection | |
Country | Netherlands | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Tetramer binding | |
Keywords | binding affinity, elite controllers |
Schellens2014 Ingrid M. M. Schellens, Hilde B. Spits, Marjon Navis, Geertje H. A. Westerlaken, Nening M. Nanlohy, Luc E. Coffeng, Neeltje Kootstra, Frank Miedema, Hanneke Schuitemaker, José A. M. Borghans, and Debbie van Baarle. Differential Characteristics of Cytotoxic T Lymphocytes Restricted by the Protective HLA Alleles B*27 and B*57 in HIV-1 Infection. J. Acquir. Immune Defic. Syndr., 67(3):236-245, 1 Nov 2014. PubMed ID: 25171732. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(901-909) Integrase(186-194) DNA(4785..4811) |
Pol Epitope Map |
---|---|---|
Author Location | Pol(901-909) | |
Epitope |
KRKGGIGGY
|
Epitope Alignment
|
Epitope Name | KY9 | |
Species (MHC/HLA) | human(B*27) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(901-909) Integrase(186-194) DNA(4785..4811) |
Pol Epitope Map |
---|---|---|
Author Location | Pol | |
Epitope |
KRKGGIGGY
|
Epitope Alignment
|
Epitope Name | KY9 | |
Subtype | CRF01_AE | |
Species (MHC/HLA) | human(B*27) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | N094: A*02:01, A*32:01, B*13:02, B*14:01, C*06:02, C*08:02; N107: A*02:01, A*02:01, B*27:05, B*57:01, C*01:02, C*06:02 | |
Country | United Kingdom | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Tetramer binding | |
Keywords | dynamics, rate of progression, transmission pair |
Brener2015 Jacqui Brener, Astrid Gall, Rebecca Batorsky, Lynn Riddell, Soren Buus, Ellen Leitman, Paul Kellam, Todd Allen, Philip Goulder, and Philippa C. Matthews. Disease Progression Despite Protective HLA Expression in an HIV-Infected Transmission Pair. Retrovirology, 12:55, 2015. PubMed ID: 26123575. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(901-909) Integrase(186-194) DNA(4785..4811) |
Pol Epitope Map |
---|---|---|
Author Location | Integrase | |
Epitope |
KRKGGIGGY
|
Epitope Alignment
|
Epitope Name | B27-KY9 | |
Subtype | B | |
Species (MHC/HLA) | human(B*27) | |
Immunogen | HIV-1 infection | |
Country | Canada | |
Experimental methods | Chromium-release assay, Other | |
Keywords | epitope processing, escape |
Zhang2012 Shao Chong Zhang, Eric Martin, Mariko Shimada, Sasha Blue Godfrey, Jennifer Fricke, Shirley Locastro, Nicole Y. Lai, Paul Liebesny, Jonathan M. Carlson, Chanson J. Brumme, Oluwatobi Awele Ogbechie, Huabiao Chen, Bruce D. Walker, Zabrina L. Brumme, Daniel G. Kavanagh, and Sylvie Le Gall. Aminopeptidase Substrate Preference Affects HIV Epitope Presentation and Predicts Immune Escape Patterns in HIV-Infected Individuals. J. Immunol., 188(12):5924-5934, 15 Jun 2012. PubMed ID: 22586036. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(901-909) Integrase(186-194) DNA(4785..4811) |
Pol Epitope Map |
---|---|---|
Author Location | Pol | |
Epitope |
KRKGGIGGY
|
Epitope Alignment
|
Epitope Name | KY9 | |
Subtype | B | |
Species (MHC/HLA) | human(B27) | |
Immunogen | HIV-1 infection | |
Country | Netherlands | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | computational epitope prediction |
Schellens2008 Ingrid M. M. Schellens, Can Kesmir, Frank Miedema, Debbie van Baarle, and José A. M. Borghans. An Unanticipated Lack of Consensus Cytotoxic T Lymphocyte Epitopes in HIV-1 Databases: The Contribution of Prediction Programs. AIDS, 22(1):33-37, 2 Jan 2008. PubMed ID: 18090389. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(901-909) Integrase(186-194) DNA(4785..4811) |
Pol Epitope Map |
---|---|---|
Author Location | Pol(901-909) | |
Epitope |
KRKGGIGGY
|
Epitope Alignment
|
Epitope Name | KY9, Pol KY9 | |
Subtype | B | |
Species (MHC/HLA) | human(B*27:02) | |
Immunogen | HIV-1 infection | |
Country | United Kingdom | |
Experimental methods | Other, Tetramer binding | |
Keywords | binding affinity, immunodominance, HLA cross-presentation, chronic infection, protective allele |
Adland2018 Emily Adland, Matilda Hill, Nora Lavandier, Anna Csala, Anne Edwards, Fabian Chen, Marek Radkowski, Justyna D. Kowalska, Dimitrios Paraskevis, Angelos Hatzakis, Humberto Valenzuela-Ponce, Katja Pfafferott, Ian Williams, Pierre Pellegrino, Persephone Borrow, Masahiko Mori, Jürgen Rockstroh, Julia G. Prado, Beatriz Mothe, Judith Dalmau, Javier Martinez-Picado, Gareth Tudor-Williams, John Frater, Anette Stryhn, Soren Buus, Gustavo Reyes Teran, Simon Mallal, Mina John, Susan Buchbinder, Gregory Kirk, Jeffrey Martin, Nelson Michael, Jacques Fellay, Steve Deeks, Bruce Walker, Santiago Avila-Rios, David Cole, Christian Brander, Mary Carrington, and Philip Goulder. Differential Immunodominance Hierarchy of CD8+ T-Cell Responses in HLA-B*27:05- and -B*27:02-Mediated Control of HIV-1 Infection. J. Virol., 92(4), 15 Feb 2018. PubMed ID: 29167337. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(901-909) Integrase(186-194) DNA(4785..4811) |
Pol Epitope Map |
---|---|---|
Author Location | Integrase(186-194) | |
Epitope |
KRKGGIGGY
|
Epitope Alignment
|
Epitope Name | KY9 | |
Subtype | B | |
Species (MHC/HLA) | human(B*27:05) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | 53617: A*02:01, A*02:05, B*27:05, B*49:01, C*02:02, C*07:01; 20786: A*02:01, A*11:01, B*27:05, B*40:02, C*02:02, C*02:02; 79379: A*01:01, B*27:05:02G, B*52:01:01G, C*02:02:02, C*12:02:01G | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | acute/early infection |
Kunwar2013 Pratima Kunwar, Natalie Hawkins, Warren L. Dinges, Yi Liu, Erin E. Gabriel, David A. Swan, Claire E. Stevens, Janine Maenza, Ann C. Collier, James I. Mullins, Tomer Hertz, Xuesong Yu, and Helen Horton. Superior Control of HIV-1 Replication by CD8+ T Cells Targeting Conserved Epitopes: Implications for HIV Vaccine Design. PLoS One, 8(5):e64405, 2013. PubMed ID: 23741326. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(901-909) Integrase(186-194) DNA(4785..4811) |
Pol Epitope Map |
---|---|---|
Author Location | Pol(186-194 NL4-3) | |
Epitope |
KRKGGIGGY
|
Epitope Alignment
|
Epitope Name | KY9Pol | |
Subtype | B | |
Species (MHC/HLA) | human(B*27:05) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | R039: A*01:01, A*31:01, B*27:05, B*57:01, C*02:02, C*06:02 | |
Country | United Kingdom | |
Experimental methods | Intracellular cytokine staining, Other | |
Keywords | cell-line isolated antibody |
Kloverpris2013 Henrik N. Kløverpris, Rebecca P. Payne, Jonah B. Sacha, Jane T. Rasaiyaah, Fabian Chen, Masafumi Takiguchi, Otto O. Yang, Greg J. Towers, Philip Goulder, and Julia G. Prado. Early Antigen Presentation of Protective HIV-1 KF11Gag and KK10Gag Epitopes from Incoming Viral Particles Facilitates Rapid Recognition of Infected Cells by Specific CD8+ T Cells. J. Virol., 87(5):2628-2638, Mar 2013. PubMed ID: 23255798. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(901-909) Integrase(186-194) DNA(4785..4811) |
Pol Epitope Map |
---|---|---|
Author Location | Pol(901-909) | |
Epitope |
KRKGGIGGY
|
Epitope Alignment
|
Show epitope variants | ||
Epitope Name | KY9 | |
Subtype | B | |
Species (MHC/HLA) | human(B*27:05) | |
Immunogen | HIV-1 infection | |
Experimental methods | Other | |
Keywords | review, escape, HLA associated polymorphism |
Kloverpris2015a Henrik N. Kløverpris, Alasdair Leslie, and Philip Goulder. Role of HLA Adaptation in HIV Evolution. Front. Immunol., 6:665, 18 Jan 2016. PubMed ID: 26834742. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(901-909) Integrase(186-194) DNA(4785..4811) |
Pol Epitope Map |
---|---|---|
Author Location | Pol(901-909) | |
Epitope |
KRKGGIGGY
|
Epitope Alignment
|
Epitope Name | KY9, Pol KY9 | |
Subtype | B | |
Species (MHC/HLA) | human(B*27:05) | |
Immunogen | HIV-1 infection | |
Country | United Kingdom | |
Experimental methods | Other, Tetramer binding | |
Keywords | binding affinity, immunodominance, HLA cross-presentation, chronic infection, protective allele |
Adland2018 Emily Adland, Matilda Hill, Nora Lavandier, Anna Csala, Anne Edwards, Fabian Chen, Marek Radkowski, Justyna D. Kowalska, Dimitrios Paraskevis, Angelos Hatzakis, Humberto Valenzuela-Ponce, Katja Pfafferott, Ian Williams, Pierre Pellegrino, Persephone Borrow, Masahiko Mori, Jürgen Rockstroh, Julia G. Prado, Beatriz Mothe, Judith Dalmau, Javier Martinez-Picado, Gareth Tudor-Williams, John Frater, Anette Stryhn, Soren Buus, Gustavo Reyes Teran, Simon Mallal, Mina John, Susan Buchbinder, Gregory Kirk, Jeffrey Martin, Nelson Michael, Jacques Fellay, Steve Deeks, Bruce Walker, Santiago Avila-Rios, David Cole, Christian Brander, Mary Carrington, and Philip Goulder. Differential Immunodominance Hierarchy of CD8+ T-Cell Responses in HLA-B*27:05- and -B*27:02-Mediated Control of HIV-1 Infection. J. Virol., 92(4), 15 Feb 2018. PubMed ID: 29167337. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(901-909) Integrase(186-194) DNA(4785..4811) |
Pol Epitope Map |
---|---|---|
Author Location | ||
Epitope |
KRKGGIGGY
|
Epitope Alignment
|
Species (MHC/HLA) | (B*27:05) | |
Immunogen | ||
Experimental methods | ||
Keywords | optimal epitope |
PayneGoulderPerCom2009 R. P. Payne and P. J. Goulder. Personal communication, 2009. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(901-909) Integrase(186-194) DNA(4785..4811) |
Pol Epitope Map |
---|---|---|
Author Location | ||
Epitope |
KRKGGIGGY
|
Epitope Alignment
|
Species (MHC/HLA) | (B*27:05) | |
Immunogen | ||
Experimental methods | ||
Keywords | optimal epitope, A-list |
Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(901-909) Integrase(186-194) DNA(4785..4811) |
Pol Epitope Map |
---|---|---|
Author Location | ||
Epitope |
KRKGGIGGY
|
Epitope Alignment
|
Epitope Name | KY9 | |
Species (MHC/HLA) | human(B*27:05) | |
Immunogen | ||
Experimental methods | ||
Keywords | optimal epitope, A-list |
Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(901-909) Integrase(186-194) DNA(4785..4811) |
Pol Epitope Map |
---|---|---|
Author Location | Pol(901-909) | |
Epitope |
KRKGGIGGY
|
Epitope Alignment
|
Show epitope variants | ||
Epitope Name | KY9 | |
Subtype | B | |
Species (MHC/HLA) | human(B*27:05) | |
Immunogen | HIV-1 infection | |
Country | United Kingdom | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining, Other | |
Keywords | rate of progression, immunodominance, escape, optimal epitope |
Payne2010 Rebecca P. Payne, Henrik Kløverpris, Jonah B. Sacha, Zabrina Brumme, Chanson Brumme, Søren Buus, Stuart Sims, Stephen Hickling, Lynn Riddell, Fabian Chen, Graz Luzzi, Anne Edwards, Rodney Phillips, Julia G. Prado, and Philip J. R. Goulder. Efficacious Early Antiviral Activity of HIV Gag- and Pol-Specific HLA-B*2705-Restricted CD8+ T Cells. J. Virol., 84(20):10543-10557, Oct 2010. PubMed ID: 20686036. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(901-909) Integrase(186-194) DNA(4785..4811) |
Pol Epitope Map |
---|---|---|
Author Location | Pol | |
Epitope |
KRKGGIGGY
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(B*27:05) | |
Immunogen | HIV-1 infection | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | computational epitope prediction, HLA associated polymorphism |
Almeida2011 Coral-Ann M. Almeida, Corine Bronke, Steven G. Roberts, Elizabeth McKinnon, Niamh M. Keane, Abha Chopra, Carl Kadie, Jonathan Carlson, David W. Haas, Sharon A. Riddler, Richard Haubrich, David Heckerman, Simon Mallal, and Mina John. Translation of HLA-HIV Associations to the Cellular Level: HIV Adapts to Inflate CD8 T Cell Responses against Nef and HLA-Adapted Variant Epitopes. J. Immunol., 187(5):2502-2513, 1 Sep 2011. PubMed ID: 21821798. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(901-909) Integrase(186-194) DNA(4785..4811) |
Pol Epitope Map |
---|---|---|
Author Location | ||
Epitope |
KRKGGIGGY
|
Epitope Alignment
|
Subtype | C | |
Species (MHC/HLA) | human(B*27:05) | |
Immunogen | HIV-1 infection | |
Country | South Africa, United Kingdom | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Tetramer binding | |
Keywords | computational epitope prediction, optimal epitope |
ErupLarsen2011 Malene Erup Larsen, Henrik Kloverpris, Anette Stryhn, Catherine K. Koofhethile, Stuart Sims, Thumbi Ndung'u, Philip Goulder, Søren Buus, and Morten Nielsen. HLArestrictor---A Tool for Patient-Specific Predictions of HLA Restriction Elements and Optimal Epitopes within Peptides. Immunogenetics, 63(1):43-55, Jan 2011. PubMed ID: 21079948. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(901-909) Integrase(186-194) DNA(4785..4811) |
Pol Epitope Map |
---|---|---|
Author Location | Pol(901-909) | |
Epitope |
KRKGGIGGY
|
Epitope Alignment
|
Epitope Name | KY9 | |
Species (MHC/HLA) | human(C*03) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(901-909) Integrase(186-194) DNA(4785..4811) |
Pol Epitope Map |
---|---|---|
Author Location | Pol | |
Epitope |
KRKGGIGGY
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human | |
Immunogen | vaccine | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | vaccine-induced immune responses |
Vaccine type | adenovirus type 5 (Ad5), DNA prime with Ad5 boost |
---|---|
Vaccine strain | B clade IIIB, B clade JRFL, B clade CAM-1 |
Vaccine component | Gag, Nef, Pol |
Li2011a Fusheng Li, Adam C. Finnefrock, Sheri A. Dubey, Bette T. M. Korber, James Szinger, Suzanne Cole, M. Juliana McElrath, John W. Shiver, Danilo R. Casimiro, Lawrence Corey, and Steven G Self. Mapping HIV-1 Vaccine Induced T-Cell Responses: Bias Towards Less-Conserved Regions and Potential Impact on Vaccine Efficacy in the Step Study. PLoS One, 6(6):e20479, 2011. PubMed ID: 21695251. Show all entries for this paper.