HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 17 matching records:

Displaying record number 59946

HXB2 Location Pol(901-909)
Integrase(186-194)
DNA(4785..4811)
Pol Epitope Map
Author Location Pol(901-909)
Epitope KRKGGIGGY Epitope Alignment
KRKGGIGGY epitope logo
Epitope Name KY9
Species (MHC/HLA) human(B*1503)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 59112

HXB2 Location Pol(901-909)
Integrase(186-194)
DNA(4785..4811)
Pol Epitope Map
Author Location Pol
Epitope KRKGGIGGY Epitope Alignment
KRKGGIGGY epitope logo
Epitope Name KY9
Subtype CRF01_AE
Species (MHC/HLA) human(B*27)
Immunogen HIV-1 infection
Patient MHC/HLA N094: A*0201, A*3201, B*1302, B*1401, Cw*0602, Cw*0802; N107: A*0201, A*0201, B*2705, B*5701, Cw*0102, Cw*0602
Country United Kingdom
Experimental methods CD8 T-cell Elispot - IFNγ, Tetramer binding
Keywords rate of progression

Notes

References

Brener2015 Jacqui Brener, Astrid Gall, Rebecca Batorsky, Lynn Riddell, Soren Buus, Ellen Leitman, Paul Kellam, Todd Allen, Philip Goulder, and Philippa C. Matthews. Disease Progression Despite Protective HLA Expression in an HIV-Infected Transmission Pair. Retrovirology, 12:55, 2015. PubMed ID: 26123575. Show all entries for this paper.


Displaying record number 61639

HXB2 Location Pol(901-909)
Integrase(186-194)
DNA(4785..4811)
Pol Epitope Map
Author Location Integrase
Epitope KRKGGIGGY Epitope Alignment
KRKGGIGGY epitope logo
Epitope Name B27-KY9
Subtype B
Species (MHC/HLA) human(B*27)
Immunogen HIV-1 infection
Country Canada
Experimental methods Chromium-release assay, Other
Keywords epitope processing, escape

Notes

References

Zhang2012 Shao Chong Zhang, Eric Martin, Mariko Shimada, Sasha Blue Godfrey, Jennifer Fricke, Shirley Locastro, Nicole Y. Lai, Paul Liebesny, Jonathan M. Carlson, Chanson J. Brumme, Oluwatobi Awele Ogbechie, Huabiao Chen, Bruce D. Walker, Zabrina L. Brumme, Daniel G. Kavanagh, and Sylvie Le Gall. Aminopeptidase Substrate Preference Affects HIV Epitope Presentation and Predicts Immune Escape Patterns in HIV-Infected Individuals. J. Immunol., 188(12):5924-5934, 15 Jun 2012. PubMed ID: 22586036. Show all entries for this paper.


Displaying record number 59945

HXB2 Location Pol(901-909)
Integrase(186-194)
DNA(4785..4811)
Pol Epitope Map
Author Location Pol(901-909)
Epitope KRKGGIGGY Epitope Alignment
KRKGGIGGY epitope logo
Epitope Name KY9
Species (MHC/HLA) human(B*27)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 59117

HXB2 Location Pol(901-909)
Integrase(186-194)
DNA(4785..4811)
Pol Epitope Map
Author Location Integrase
Epitope KRKGGIGGY Epitope Alignment
KRKGGIGGY epitope logo
Epitope Name KY9
Species (MHC/HLA) human(B*27)
Immunogen HIV-1 infection
Country Netherlands
Experimental methods CD8 T-cell Elispot - IFNγ, Tetramer binding
Keywords binding affinity, elite controllers

Notes

References

Schellens2014 Ingrid M. M. Schellens, Hilde B. Spits, Marjon Navis, Geertje H. A. Westerlaken, Nening M. Nanlohy, Luc E. Coffeng, Neeltje Kootstra, Frank Miedema, Hanneke Schuitemaker, José A. M. Borghans, and Debbie van Baarle. Differential Characteristics of Cytotoxic T Lymphocytes Restricted by the Protective HLA Alleles B*27 and B*57 in HIV-1 Infection. J. Acquir. Immune Defic. Syndr., 67(3):236-245, 1 Nov 2014. PubMed ID: 25171732. Show all entries for this paper.


Displaying record number 55584

HXB2 Location Pol(901-909)
Integrase(186-194)
DNA(4785..4811)
Pol Epitope Map
Author Location Pol
Epitope KRKGGIGGY Epitope Alignment
KRKGGIGGY epitope logo
Epitope Name KY9
Subtype B
Species (MHC/HLA) human(B27)
Immunogen HIV-1 infection
Country Netherlands
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords computational epitope prediction

Notes

References

Schellens2008 Ingrid M. M. Schellens, Can Kesmir, Frank Miedema, Debbie van Baarle, and José A. M. Borghans. An Unanticipated Lack of Consensus Cytotoxic T Lymphocyte Epitopes in HIV-1 Databases: The Contribution of Prediction Programs. AIDS, 22(1):33-37, 2 Jan 2008. PubMed ID: 18090389. Show all entries for this paper.


Displaying record number 56213

HXB2 Location Pol(901-909)
Integrase(186-194)
DNA(4785..4811)
Pol Epitope Map
Author Location  
Epitope KRKGGIGGY Epitope Alignment
KRKGGIGGY epitope logo
Species (MHC/HLA) (B*2705)
Immunogen  
Experimental methods  
Keywords optimal epitope

Notes

References

PayneGoulderPerCom2009 R. P. Payne and P. J. Goulder. Personal communication, 2009. Show all entries for this paper.


Displaying record number 61207

HXB2 Location Pol(901-909)
Integrase(186-194)
DNA(4785..4811)
Pol Epitope Map
Author Location Pol(901-909)
Epitope KRKGGIGGY Epitope Alignment
KRKGGIGGY epitope logo
Show epitope variants
Epitope Name KY9
Subtype B
Species (MHC/HLA) human(B*2705)
Immunogen HIV-1 infection
Experimental methods Other
Keywords review, escape, HLA associated polymorphism

Notes

References

Kloverpris2015a Henrik N. Kløverpris, Alasdair Leslie, and Philip Goulder. Role of HLA Adaptation in HIV Evolution. Front. Immunol., 6:665, 18 Jan 2016. PubMed ID: 26834742. Show all entries for this paper.


Displaying record number 57998

HXB2 Location Pol(901-909)
Integrase(186-194)
DNA(4785..4811)
Pol Epitope Map
Author Location  
Epitope KRKGGIGGY Epitope Alignment
KRKGGIGGY epitope logo
Subtype C
Species (MHC/HLA) human(B*2705)
Immunogen HIV-1 infection
Country South Africa, United Kingdom
Experimental methods CD8 T-cell Elispot - IFNγ, Tetramer binding
Keywords computational epitope prediction, optimal epitope

Notes

References

ErupLarsen2011 Malene Erup Larsen, Henrik Kloverpris, Anette Stryhn, Catherine K. Koofhethile, Stuart Sims, Thumbi Ndung'u, Philip Goulder, Søren Buus, and Morten Nielsen. HLArestrictor---A Tool for Patient-Specific Predictions of HLA Restriction Elements and Optimal Epitopes within Peptides. Immunogenetics, 63(1):43-55, Jan 2011. PubMed ID: 21079948. Show all entries for this paper.


Displaying record number 58962

HXB2 Location Pol(901-909)
Integrase(186-194)
DNA(4785..4811)
Pol Epitope Map
Author Location Integrase(186-194)
Epitope KRKGGIGGY Epitope Alignment
KRKGGIGGY epitope logo
Epitope Name KY9
Subtype B
Species (MHC/HLA) human(B*2705)
Immunogen HIV-1 infection
Patient MHC/HLA 53617: A*0201, A*0205, B*2705, B*4901, C*0202, C*0701; 20786: A*0201, A*1101, B*2705, B*4002, Cw*0202, Cw*0202; 79379: A*0101, A*0101, B*2705, B*5201, Cw*0201, Cw*1202
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords acute/early infection

Notes

References

Kunwar2013 Pratima Kunwar, Natalie Hawkins, Warren L. Dinges, Yi Liu, Erin E. Gabriel, David A. Swan, Claire E. Stevens, Janine Maenza, Ann C. Collier, James I. Mullins, Tomer Hertz, Xuesong Yu, and Helen Horton. Superior Control of HIV-1 Replication by CD8+ T Cells Targeting Conserved Epitopes: Implications for HIV Vaccine Design. PLoS One, 8(5):e64405, 2013. PubMed ID: 23741326. Show all entries for this paper.


Displaying record number 59031

HXB2 Location Pol(901-909)
Integrase(186-194)
DNA(4785..4811)
Pol Epitope Map
Author Location Pol(186-194 NL4-3)
Epitope KRKGGIGGY Epitope Alignment
KRKGGIGGY epitope logo
Epitope Name KY9Pol
Subtype B
Species (MHC/HLA) human(B*2705)
Immunogen HIV-1 infection
Patient MHC/HLA R039: A*0101, A*3101, B*2705, B*5701, Cw*0202, Cw*0602
Country United Kingdom
Experimental methods Intracellular cytokine staining, Other
Keywords cell-line isolated antibody

Notes

References

Kloverpris2013 Henrik N. Kløverpris, Rebecca P. Payne, Jonah B. Sacha, Jane T. Rasaiyaah, Fabian Chen, Masafumi Takiguchi, Otto O. Yang, Greg J. Towers, Philip Goulder, and Julia G. Prado. Early Antigen Presentation of Protective HIV-1 KF11Gag and KK10Gag Epitopes from Incoming Viral Particles Facilitates Rapid Recognition of Infected Cells by Specific CD8+ T Cells. J. Virol., 87(5):2628-2638, Mar 2013. PubMed ID: 23255798. Show all entries for this paper.


Displaying record number 57797

HXB2 Location Pol(901-909)
Integrase(186-194)
DNA(4785..4811)
Pol Epitope Map
Author Location Pol
Epitope KRKGGIGGY Epitope Alignment
KRKGGIGGY epitope logo
Subtype B
Species (MHC/HLA) human(B*2705)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords computational epitope prediction, HLA associated polymorphism

Notes

References

Almeida2011 Coral-Ann M. Almeida, Corine Bronke, Steven G. Roberts, Elizabeth McKinnon, Niamh M. Keane, Abha Chopra, Carl Kadie, Jonathan Carlson, David W. Haas, Sharon A. Riddler, Richard Haubrich, David Heckerman, Simon Mallal, and Mina John. Translation of HLA-HIV Associations to the Cellular Level: HIV Adapts to Inflate CD8 T Cell Responses against Nef and HLA-Adapted Variant Epitopes. J. Immunol., 187(5):2502-2513, 1 Sep 2011. PubMed ID: 21821798. Show all entries for this paper.


Displaying record number 57769

HXB2 Location Pol(901-909)
Integrase(186-194)
DNA(4785..4811)
Pol Epitope Map
Author Location Pol(901-909)
Epitope KRKGGIGGY Epitope Alignment
KRKGGIGGY epitope logo
Show epitope variants
Epitope Name KY9
Subtype B
Species (MHC/HLA) human(B*2705)
Immunogen HIV-1 infection
Country United Kingdom
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining, Other
Keywords rate of progression, immunodominance, escape, optimal epitope

Notes

References

Payne2010 Rebecca P. Payne, Henrik Kløverpris, Jonah B. Sacha, Zabrina Brumme, Chanson Brumme, Søren Buus, Stuart Sims, Stephen Hickling, Lynn Riddell, Fabian Chen, Graz Luzzi, Anne Edwards, Rodney Phillips, Julia G. Prado, and Philip J. R. Goulder. Efficacious Early Antiviral Activity of HIV Gag- and Pol-Specific HLA-B*2705-Restricted CD8+ T Cells. J. Virol., 84(20):10543-10557, Oct 2010. PubMed ID: 20686036. Show all entries for this paper.


Displaying record number 56552

HXB2 Location Pol(901-909)
Integrase(186-194)
DNA(4785..4811)
Pol Epitope Map
Author Location  
Epitope KRKGGIGGY Epitope Alignment
KRKGGIGGY epitope logo
Epitope Name KY9
Species (MHC/HLA) human(B*2705)
Immunogen  
Experimental methods  
Keywords optimal epitope

Notes

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 56550

HXB2 Location Pol(901-909)
Integrase(186-194)
DNA(4785..4811)
Pol Epitope Map
Author Location  
Epitope KRKGGIGGY Epitope Alignment
KRKGGIGGY epitope logo
Species (MHC/HLA) (B*2705)
Immunogen  
Experimental methods  
Keywords optimal epitope

Notes

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 59947

HXB2 Location Pol(901-909)
Integrase(186-194)
DNA(4785..4811)
Pol Epitope Map
Author Location Pol(901-909)
Epitope KRKGGIGGY Epitope Alignment
KRKGGIGGY epitope logo
Epitope Name KY9
Species (MHC/HLA) human(C*03)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 58080

HXB2 Location Pol(901-909)
Integrase(186-194)
DNA(4785..4811)
Pol Epitope Map
Author Location Pol
Epitope KRKGGIGGY Epitope Alignment
KRKGGIGGY epitope logo
Subtype B
Species (MHC/HLA) human
Immunogen vaccine
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords vaccine-induced immune responses

Vaccine Details

Vaccine type adenovirus type 5 (Ad5), DNA prime with Ad5 boost
Vaccine strain B clade IIIB, B clade JRFL, B clade CAM-1
Vaccine component Gag, Nef, Pol

Notes

References

Li2011a Fusheng Li, Adam C. Finnefrock, Sheri A. Dubey, Bette T. M. Korber, James Szinger, Suzanne Cole, M. Juliana McElrath, John W. Shiver, Danilo R. Casimiro, Lawrence Corey, and Steven G Self. Mapping HIV-1 Vaccine Induced T-Cell Responses: Bias Towards Less-Conserved Regions and Potential Impact on Vaccine Efficacy in the Step Study. PLoS One, 6(6):e20479, 2011. PubMed ID: 21695251. Show all entries for this paper.


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