HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 16 matching records:

Displaying record number 59938

HXB2 Location Pol(328-336)
RT(173-181)
DNA(3066..3092)
Pol Epitope Map
Author Location Pol(328-336)
Epitope KQNPDIVIY Epitope Alignment
KQNPDIVIY epitope logo
Epitope Name KY9
Species (MHC/HLA) human(A*30)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 55205

HXB2 Location Pol(328-336)
RT(173-181)
DNA(3066..3092)
Pol Epitope Map
Author Location  
Epitope KQNPDIVIY Epitope Alignment
KQNPDIVIY epitope logo
Species (MHC/HLA) human(A30)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords supertype, HLA cross-presentation

Notes

References

Frahm2007b Nicole Frahm, Karina Yusim, Todd J. Suscovich, Sharon Adams, John Sidney, Peter Hraber, Hannah S. Hewitt, Caitlyn H. Linde, Daniel G. Kavanagh, Tonia Woodberry, Leah M. Henry, Kellie Faircloth, Jennifer Listgarten, Carl Kadie, Nebojsa Jojic, Kaori Sango, Nancy V. Brown, Eunice Pae, M. Tauheed Zaman, Florian Bihl, Ashok Khatri, Mina John, Simon Mallal, Francesco M. Marincola, Bruce D . Walker, Alessandro Sette, David Heckerman, Bette T. Korber, and Christian Brander. Extensive HLA Class I Allele Promiscuity among Viral CTL Epitopes. Eur. J. Immunol., 37(9):2419-2433, Sep 2007. PubMed ID: 17705138. Show all entries for this paper.


Displaying record number 56433

HXB2 Location Pol(328-336)
RT(173-181)
DNA(3066..3092)
Pol Epitope Map
Author Location RT
Epitope KQNPDIVIY Epitope Alignment
KQNPDIVIY epitope logo
Epitope Name KY9(RT)
Subtype B
Species (MHC/HLA) human(A30)
Immunogen HIV-1 infection
Country China
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords  

Notes

References

Zhai2008 Song Zhai, Yan Zhuang, Yang Song, Shu Li, Dedong Huang, Wenzhen Kang, Xinhong Li, Qi Liao, Yanhou Liu, Zhongfang Zhao, Yichen Lu, and Yongtao Sun. HIV-1-Specific Cytotoxic T Lymphocyte (CTL) Responses Against Immunodominant Optimal Epitopes Slow the Progression of AIDS in China. Curr. HIV Res., 6(4):335-350, Jun 2008. PubMed ID: 18691032. Show all entries for this paper.


Displaying record number 1197

HXB2 Location Pol(328-336)
RT(173-181)
DNA(3066..3092)
Pol Epitope Map
Author Location RT(173-181 LAI)
Epitope KQNPDIVIY Epitope Alignment
KQNPDIVIY epitope logo
Subtype B
Species (MHC/HLA) human(A*3002)
Immunogen  
Experimental methods  
Keywords optimal epitope

Notes

References

Goulder2001 P. J. Goulder, M. M. Addo, M. A. Altfeld, E. S. Rosenberg, Y. Tang, U. Govender, N. Mngqundaniso, K. Annamalai, T. U. Vogel, M. Hammond, M. Bunce, H. M. Coovadia, and B. D. Walker. Rapid Definition of Five Novel HLA-A*3002-Restricted Human Immunodeficiency Virus-Specific Cytotoxic T-Lymphocyte Epitopes by Elispot and Intracellular Cytokine Staining Assays. J. Virol., 75(3):1339-1347, Feb 2001. URL: http://jvi.asm.org/cgi/content/full/75/3/1339. PubMed ID: 11152507. Show all entries for this paper.

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 1763

HXB2 Location Pol(328-336)
RT(173-181)
DNA(3066..3092)
Pol Epitope Map
Author Location RT
Epitope KQNPDIVIY Epitope Alignment
KQNPDIVIY epitope logo
Epitope Name KY9 (RT-53)
Species (MHC/HLA) human(A*3002)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Goulder2001 P. J. Goulder, M. M. Addo, M. A. Altfeld, E. S. Rosenberg, Y. Tang, U. Govender, N. Mngqundaniso, K. Annamalai, T. U. Vogel, M. Hammond, M. Bunce, H. M. Coovadia, and B. D. Walker. Rapid Definition of Five Novel HLA-A*3002-Restricted Human Immunodeficiency Virus-Specific Cytotoxic T-Lymphocyte Epitopes by Elispot and Intracellular Cytokine Staining Assays. J. Virol., 75(3):1339-1347, Feb 2001. URL: http://jvi.asm.org/cgi/content/full/75/3/1339. PubMed ID: 11152507. Show all entries for this paper.


Displaying record number 59936

HXB2 Location Pol(328-336)
RT(173-181)
DNA(3066..3092)
Pol Epitope Map
Author Location Pol(328-336)
Epitope KQNPDIVIY Epitope Alignment
KQNPDIVIY epitope logo
Epitope Name KY9
Species (MHC/HLA) human(B*1501)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 59935

HXB2 Location Pol(328-336)
RT(173-181)
DNA(3066..3092)
Pol Epitope Map
Author Location Pol(328-336)
Epitope KQNPDIVIY Epitope Alignment
KQNPDIVIY epitope logo
Epitope Name KY9
Species (MHC/HLA) human(B*1503)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 55071

HXB2 Location Pol(328-336)
RT(173-181)
DNA(3066..3092)
Pol Epitope Map
Author Location RT
Epitope KQNPDIVIY Epitope Alignment
KQNPDIVIY epitope logo
Show epitope variants
Subtype B
Species (MHC/HLA) human(B*1503)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords subtype comparisons, rate of progression, immunodominance

Notes

References

Frahm2006 Nicole Frahm, Photini Kiepiela, Sharon Adams, Caitlyn H. Linde, Hannah S. Hewitt, Kaori Sango, Margaret E. Feeney, Marylyn M. Addo, Mathias Lichterfeld, Matthew P. Lahaie, Eunice Pae, Alysse G. Wurcel, Timothy Roach, M Anne. St. John, Marcus Altfeld, Francesco M. Marincola, Corey Moore, Simon Mallal, Mary Carrington, David Heckerman, Todd M. Allen, James I. Mullins, Bette T. Korber, Philip J. R. Goulder, Bruce D. Walker, and Christian Brander. Control of Human Immunodeficiency Virus Replication by Cytotoxic T Lymphocytes Targeting Subdominant Epitopes. Nat. Immunol., 7(2):173-178, Feb 2006. PubMed ID: 16369537. Show all entries for this paper.


Displaying record number 59939

HXB2 Location Pol(328-336)
RT(173-181)
DNA(3066..3092)
Pol Epitope Map
Author Location Pol(328-336)
Epitope KQNPDIVIY Epitope Alignment
KQNPDIVIY epitope logo
Epitope Name KY9
Species (MHC/HLA) human(B*18)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 59937

HXB2 Location Pol(328-336)
RT(173-181)
DNA(3066..3092)
Pol Epitope Map
Author Location Pol(328-336)
Epitope KQNPDIVIY Epitope Alignment
KQNPDIVIY epitope logo
Epitope Name KY9
Species (MHC/HLA) human(B*3502, B*3503, B*5301)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 61553

HXB2 Location Pol(328-336)
RT(173-181)
DNA(3066..3092)
Pol Epitope Map
Author Location RT(173-181)
Epitope KQNPDIVIY Epitope Alignment
KQNPDIVIY epitope logo
Show epitope variants
Epitope Name KY9
Subtype B
Species (MHC/HLA) human(Cw*1202)
Immunogen HIV-1 infection
Patient MHC/HLA KI-504: Cw*1202; KI-108: A*2402, B*5201, Cw*1202
Country Japan
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, Intracellular cytokine staining
Keywords subtype comparisons, variant cross-reactivity, mutation acquisition, drug resistance

Notes

References

Kuse2015 Nozomi Kuse, Mohammad Arif Rahman, Hayato Murakoshi, Giang Van Tran, Takayuki Chikata, Madoka Koyanagi, Kinh Van Nguyen, Hiroyuki Gatanaga, Shinichi Oka, and Masafumi Takiguchi. Different Effects of Nonnucleoside Reverse Transcriptase Inhibitor Resistance Mutations on Cytotoxic T Lymphocyte Recognition between HIV-1 Subtype B and Subtype A/E Infections. J. Virol., 89(14):7363-7372, Jul 2015. PubMed ID: 25972553. Show all entries for this paper.


Displaying record number 57920

HXB2 Location Pol(328-336)
RT(173-181)
DNA(3066..3092)
Pol Epitope Map
Author Location Pol(328-336)
Epitope KQNPDIVIY Epitope Alignment
KQNPDIVIY epitope logo
Epitope Name Pol 11-164 or Pol 328-9 or KY9
Subtype B
Species (MHC/HLA) human(Cw*1202)
Immunogen HIV-1 infection
Country Japan
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, Intracellular cytokine staining
Keywords optimal epitope, novel epitope

Notes

References

Honda2011 Kazutaka Honda, Nan Zheng, Hayato Murakoshi, Masao Hashimoto, Keiko Sakai, Mohamed Ali Borghan, Takayuki Chikata, Madoka Koyanagi, Yoshiko Tamura, Hiroyuki Gatanaga, Shinichi Oka, and Masafumi Takiguchi. Selection of Escape Mutant by HLA-C-Restricted HIV-1 Pol-Specific Cytotoxic T Lymphocytes Carrying Strong Ability to Suppress HIV-1 Replication. Eur. J. Immunol., 41(1):197-106, Jan 2011. PubMed ID: 21182081. Show all entries for this paper.


Displaying record number 61493

HXB2 Location Pol(328-336)
RT(173-181)
DNA(3066..3092)
Pol Epitope Map
Author Location Pol
Epitope KQNPDIVIY Epitope Alignment
KQNPDIVIY epitope logo
Epitope Name KY9
Subtype B
Species (MHC/HLA) human(Cw*1202)
Immunogen HIV-1 infection
Patient MHC/HLA KI-504: Cw*1202; KI-698: A*0201, A*2402, B*5101, B*5201, Cw*1202, Cw*1502; KI-801: Cw*1202
Country Japan
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, Intracellular cytokine staining, Other
Keywords optimal epitope, NK cells, novel epitope, chronic infection

Notes

References

Chikata2017 Takayuki Chikata, Hayato Murakoshi, Madoka Koyanagi, Kazutaka Honda, Hiroyuki Gatanaga, Shinichi Oka, and Masafumi Takiguchi. Control of HIV-1 by an HLA-B*52:01-C*12:02 Protective Haplotype. J. Infect. Dis., 216(11):1415-1424, 12 Dec 2017. PubMed ID: 28968792. Show all entries for this paper.


Displaying record number 58626

HXB2 Location Pol(328-336)
RT(173-181)
DNA(3066..3092)
Pol Epitope Map
Author Location Pol(328-336)
Epitope KQNPDIVIY Epitope Alignment
KQNPDIVIY epitope logo
Epitope Name Pol 11-164 or Pol 328-9 or KY9
Subtype B
Species (MHC/HLA) human(Cw*1202)
Immunogen HIV-1 infection
Country Japan
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, Intracellular cytokine staining
Keywords optimal epitope, novel epitope

Notes

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 58079

HXB2 Location Pol(328-336)
RT(173-181)
DNA(3066..3092)
Pol Epitope Map
Author Location Pol
Epitope KQNPDIVIY Epitope Alignment
KQNPDIVIY epitope logo
Subtype B
Species (MHC/HLA) human
Immunogen vaccine
Patient MHC/HLA A*0101, A*1101, B*1501, B*4403, Cw*0304, Cw*1601; A*2402, A*6801, B*1503, B*4006, Cw*0202, Cw*1502
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords vaccine-induced immune responses

Vaccine Details

Vaccine type adenovirus type 5 (Ad5), DNA prime with Ad5 boost
Vaccine strain B clade IIIB, B clade JRFL, B clade CAM-1
Vaccine component Gag, Nef, Pol

Notes

References

Li2011a Fusheng Li, Adam C. Finnefrock, Sheri A. Dubey, Bette T. M. Korber, James Szinger, Suzanne Cole, M. Juliana McElrath, John W. Shiver, Danilo R. Casimiro, Lawrence Corey, and Steven G Self. Mapping HIV-1 Vaccine Induced T-Cell Responses: Bias Towards Less-Conserved Regions and Potential Impact on Vaccine Efficacy in the Step Study. PLoS One, 6(6):e20479, 2011. PubMed ID: 21695251. Show all entries for this paper.


Displaying record number 61270

HXB2 Location Pol(328-336)
RT(173-181)
DNA(3066..3092)
Pol Epitope Map
Author Location RT
Epitope KQNPDIVIY Epitope Alignment
KQNPDIVIY epitope logo
Show epitope variants
Subtype B
Species (MHC/HLA) human
Immunogen HIV-1 infection
Country Mexico, Spain
Experimental methods CD8 T-cell Elispot - IFNγ, Other
Keywords drug resistance

Notes

References

Blanco-Heredia2016 Juan Blanco-Heredia, Aarón Lecanda, Humberto Valenzuela-Ponce, Christian Brander, Santiago Ávila-Rios, and Gustavo Reyes-Terán. Identification of Immunogenic Cytotoxic T Lymphocyte Epitopes Containing Drug Resistance Mutations in Antiretroviral Treatment-Naive HIV-Infected Individuals. PLoS One, 11(1):e0147571, 2016. PubMed ID: 26808823. Show all entries for this paper.


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