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Displaying record number 53810

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HXB2 Location	gp160(155-163) gp120(155-163) DNA(6687..6713)	gp160 Epitope Map
Author Location	gp160
Epitope	`KNCSFNMTT`	Epitope Alignment
		Show epitope variants
Subtype	A, B, C, D
Species (MHC/HLA)	human
Immunogen	HIV-1 infection, vaccine
Patient MHC/HLA	A24:02, A32:01, B51:01, B53:01, C04:01, C16:04
Country	Kenya
Experimental methods	CD8 T-cell Elispot - IFNγ, Other
Keywords	subtype comparisons, variant cross-reactivity

Vaccine Details

Vaccine type	vaccinia
Vaccine strain	A clade, B clade, D clade NDK, C clade consensus
Vaccine component	Env

Notes

Interclade cross-reactivity of clades A, B, C, and D was tested using recombinant vaccinia-based IFN-gamma Elispot assay. 47/74 women had a positive Elispot response to at least one clade, and cross-clade responses were frequent. Clade A responses were most frequent, as expected, as clade A dominates the Kenyan epidemic (85% of the 47 women responded to clade A Env, 74% to B, 62% to C, and 43% to D). Cross-clade CD8 T-cell responses were common and directed at conserved epitopes.
There was a greater magnitude of response to A clade peptides in individuals who responded to more than 1 clade; a 2-fold higher response was observed in clade A in 36% (9/25) of these individuals, and the response to A peptides was never lower. VTEEFNMWK responses were detected in 2 women who had Env responses to all 4 clades, and clade A gave the highest responses; a VnEEFNMWK variant was in clade B and D, and the clade C Env carried VnEEFNMWe. One woman also reacted with RAIEAQQHL, the other one with KNCSFNMTT. KNCSFNMTT was identical in clades A and C, while clade B carried KNCSFNMis, clade D carried KNiSFNMTT.

References

McKinnon2005 Lyle R. McKinnon, T. Blake Ball, Joshua Kimani, Charles Wachihi, Lucy Matu, Ma Luo, Joanne Embree, Keith R. Fowke, and Francis A. Plummer. Cross-Clade CD8+ T-Cell Responses With a Preference for the Predominant Circulating Clade. J. Acquir. Immune Defic. Syndr., 40(3):245-249, 1 Nov 2005. PubMed ID: 16249696. Show all entries for this paper.