HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 4 matching records:

Displaying record number 627

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HXB2 Location gp160(33-42)
gp120(33-42)
DNA(6321..6350)
gp160 Epitope Map
Author Location Env(32-41 LAI)
Epitope KLWVTVYYGV Epitope Alignment
KLWVTVYYGV epitope logo
Epitope Name Env32-41
Subtype B
Species (MHC/HLA) human(A*02:01)
Immunogen vaccine
Country United States
Experimental methods Chromium-release assay
Keywords dendritic cells, enhancing activity

Vaccine Details

Vaccine type protein
Vaccine strain B clade MN
Vaccine component gp160

Notes

References

Dupuis1995 M. Dupuis, S. K. Kundu, and T. C. Merigan. Characterization of HLA-A*0201-Restricted Cytotoxic T Cell Epitopes in Conserved Regions of the HIV Type 1 gp160 Protein. J. Immunol., 155:2232-2239, 1995. Five HLA-A2 HIV-1 seropositive HIV-1 MN rec gp160 vaccinees had their CTL activity assessed using peptides known to bind with high affinity to HLA-A*0201. Four of the patients had specific CTL activity for a minimum of at least three epitopes, thus the response appears heterogeneous. One of the four peptides was confirmed to be HLA A2 restricted. Epitopes were highly conserved. PubMed ID: 7543542. Show all entries for this paper.


Displaying record number 628

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HXB2 Location gp160(33-42)
gp120(33-42)
DNA(6321..6350)
gp160 Epitope Map
Author Location Env(32-41 subtype B)
Epitope KLWVTVYYGV Epitope Alignment
KLWVTVYYGV epitope logo
Subtype B
Species (MHC/HLA) human(A*02:01)
Immunogen HIV-1 infection, vaccine
Experimental methods  
Keywords binding affinity

Vaccine Details

Vaccine type protein
Vaccine strain B clade MN
Vaccine component gp160

Notes

References

Kundu1998a S. K. Kundu, M. Dupuis, A. Sette, E. Celis, F. Dorner, M. Eibl, and T. C. Merigan. Role of preimmunization virus sequences in cellular immunity in HIV- infected patients during HIV type 1 MN recombinant gp160 immunization. AIDS Res. Hum. Retroviruses, 14:1669-78, 1998. PubMed ID: 9870321. Show all entries for this paper.


Displaying record number 57079

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HXB2 Location gp160(33-42)
gp120(33-42)
DNA(6321..6350)
gp160 Epitope Map
Author Location gp120(33-42 DU422)
Epitope KLWVTVYYGV Epitope Alignment
KLWVTVYYGV epitope logo
Subtype B
Species (MHC/HLA) human(A*02:01)
Immunogen in vitro stimulation or selection
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, Tetramer binding
Keywords dendritic cells

Notes

References

Colleton2009 Bonnie A. Colleton, Xiao-Li Huang, Nada M. Melhem, Zheng Fan, Luann Borowski, Giovanna Rappocciolo, and Charles R. Rinaldo. Primary Human Immunodeficiency Virus Type 1-Specific CD8+ T-Cell Responses Induced by Myeloid Dendritic Cells. J. Virol., 83(12):6288-6299, Jun 2009. PubMed ID: 19357176. Show all entries for this paper.


Displaying record number 55290

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HXB2 Location gp160(33-42)
gp120(33-42)
DNA(6321..6350)
gp160 Epitope Map
Author Location Env
Epitope KLWVTVYYGV Epitope Alignment
KLWVTVYYGV epitope logo
Show epitope variants
Subtype B
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Patient MHC/HLA A1, A19, B*35:01, B44, C*16, Cw7; A*02:01, A19, B14, B44, C*16, Cw8
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords HAART, ART, mother-to-infant transmission, rate of progression, escape, co-receptor, mutation acquisition, HLA associated polymorphism

Notes

References

Reinis2007 Milan Reinis, Barbara Weiser, Carla Kuiken, Tao Dong, Dorothy Lang, Sharon Nachman, Yonghong Zhang, Sarah Rowland-Jones, and Harold Burger. Genomic Analysis of HIV Type 1 Strains Derived from a Mother and Child Pair of Long-Term Nonprogressors. AIDS Res. Hum. Retroviruses, 23(2):309-315, Feb 2007. PubMed ID: 17331038. Show all entries for this paper.


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