HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 33 matching records:

Displaying record number 666

Download this epitope record as JSON.

HXB2 Location gp160(121-129)
gp120(121-129)
DNA(6585..6611)
gp160 Epitope Map
Author Location gp120(120-128)
Epitope KLTPLCVTL Epitope Alignment
KLTPLCVTL epitope logo
Species (MHC/HLA) human(A*02)
Immunogen vaccine
Experimental methods  
Keywords  

Vaccine Details

Vaccine type vaccinia

Notes

References

Woodberry1999 T. Woodberry, J. Gardner, L. Mateo, D. Eisen, J. Medveczky, I. A. Ramshaw, S. A. Thomson, R. A. Ffrench, S. L. Elliott, H. Firat, F. A. Lemonnier, and A. Suhrbier. Immunogenicity of a Human Immunodeficiency Virus (HIV) Polytope Vaccine. J. Virol., 73:5320-5325, 1999. PubMed ID: 10364278. Show all entries for this paper.


Displaying record number 54560

Download this epitope record as JSON.

HXB2 Location gp160(121-129)
gp120(121-129)
DNA(6585..6611)
gp160 Epitope Map
Author Location Env(121-129)
Epitope KLTPLCVTL Epitope Alignment
KLTPLCVTL epitope logo
Subtype B
Species (MHC/HLA) human(A*02)
Immunogen HIV-1 infection
Country United States
Experimental methods Intracellular cytokine staining, Other
Keywords rate of progression, escape, mutation acquisition

Notes

References

Karlsson2007 Annika C. Karlsson, Astrid K. N. Iversen, Joan M. Chapman, Tulio de Oliviera, Gerald Spotts, Andrew J. McMichael, Miles P. Davenport, Frederick M. Hecht, and Douglas F. Nixon. Sequential Broadening of CTL Responses in Early HIV-1 Infection Is Associated with Viral Escape. PLoS ONE, 2:e225, 2007. PubMed ID: 17311088. Show all entries for this paper.


Displaying record number 59929

Download this epitope record as JSON.

HXB2 Location gp160(121-129)
gp120(121-129)
DNA(6585..6611)
gp160 Epitope Map
Author Location Env(121-129)
Epitope KLTPLCVTL Epitope Alignment
KLTPLCVTL epitope logo
Epitope Name KL9
Species (MHC/HLA) human(A*02)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope, chronic infection

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 62123

Download this epitope record as JSON.

HXB2 Location gp160(121-129)
gp120(121-129)
DNA(6585..6611)
gp160 Epitope Map
Author Location gp120(121-129)
Epitope KLTPLCVTL Epitope Alignment
KLTPLCVTL epitope logo
Epitope Name A*02-KL9
Subtype B
Species (MHC/HLA) human(A*02)
Immunogen computer prediction
Experimental methods Other, Relative replication capacity assay
Keywords binding affinity, structure, assay or method development, contact residues

Notes

References

Gaiha2019 Gaurav D. Gaiha, Elizabeth J. Rossin, Jonathan Urbach, Christian Landeros, David R. Collins, Chioma Nwonu, Itai Muzhingi, Melis N. Anahtar, Olivia M. Waring, Alicja Piechocka-Trocha, Michael Waring, Daniel P. Worrall, Musie S. Ghebremichael, Ruchi M. Newman, Karen A. Power, Todd M. Allen, James Chodosh, and Bruce D. Walker. Structural Topology Defines Protective CD8+ T Cell Epitopes in the HIV Proteome. Science, 364(6439):480-484, 3 May 2019. PubMed ID: 31048489. Show all entries for this paper.


Displaying record number 671

Download this epitope record as JSON.

HXB2 Location gp160(121-129)
gp120(121-129)
DNA(6585..6611)
gp160 Epitope Map
Author Location Env(120-128 subtype B)
Epitope KLTPLCVTL Epitope Alignment
KLTPLCVTL epitope logo
Subtype B
Species (MHC/HLA) human(A*02:01)
Immunogen vaccine
Experimental methods  
Keywords binding affinity

Vaccine Details

Vaccine type protein
Vaccine strain B clade MN
Vaccine component gp160

Notes

References

Kundu1998a S. K. Kundu, M. Dupuis, A. Sette, E. Celis, F. Dorner, M. Eibl, and T. C. Merigan. Role of preimmunization virus sequences in cellular immunity in HIV- infected patients during HIV type 1 MN recombinant gp160 immunization. AIDS Res. Hum. Retroviruses, 14:1669-78, 1998. PubMed ID: 9870321. Show all entries for this paper.


Displaying record number 1217

Download this epitope record as JSON.

HXB2 Location gp160(121-129)
gp120(121-129)
DNA(6585..6611)
gp160 Epitope Map
Author Location Env(120-128)
Epitope KLTPLCVTL Epitope Alignment
KLTPLCVTL epitope logo
Species (MHC/HLA) human(A*02:01)
Immunogen HIV-1 infection
Experimental methods  
Keywords binding affinity, TCR usage

Notes

References

Kmieciak1998b D. Kmieciak, I. Bednarek, M. Takiguchi, T. J. Wasik, J. Bratosiewicz, A. Wierzbicki, H. Teppler, J. Pientka, S. H. Hsu, Y. Kaneko, and D. Kozbor. The Effect of Epitope Variation on the Profile of Cytotoxic T Lymphocyte Responses to the HIV Envelope Glycoprotein. Int. Immunol., 10:1789-1799, 1998. PubMed ID: 9885899. Show all entries for this paper.


Displaying record number 1308

Download this epitope record as JSON.

HXB2 Location gp160(121-129)
gp120(121-129)
DNA(6585..6611)
gp160 Epitope Map
Author Location Env(134-)
Epitope KLTPLCVTL Epitope Alignment
KLTPLCVTL epitope logo
Epitope Name Env-134
Species (MHC/HLA) human(A*02:01)
Immunogen HIV-1 infection
Experimental methods  
Keywords binding affinity, supertype, computational epitope prediction, HLA cross-presentation

Notes

References

Altfeld2001 M. A. Altfeld, B. Livingston, N. Reshamwala, P. T. Nguyen, M. M. Addo, A. Shea, M. Newman, J. Fikes, J. Sidney, P. Wentworth, R. Chesnut, R. L. Eldridge, E. S. Rosenberg, G. K. Robbins, C. Brander, P. E. Sax, S. Boswell, T. Flynn, S. Buchbinder, P. J. Goulder, B. D. Walker, A. Sette, and S. A. Kalams. Identification of novel HLA-A2-restricted human immunodeficiency virus type 1-specific cytotoxic T-lymphocyte epitopes predicted by the HLA-A2 supertype peptide-binding motif. J. Virol., 75(3):1301-11, Feb 2001. URL: http://jvi.asm.org/cgi/content/full/75/3/1301. PubMed ID: 11152503. Show all entries for this paper.


Displaying record number 53067

Download this epitope record as JSON.

HXB2 Location gp160(121-129)
gp120(121-129)
DNA(6585..6611)
gp160 Epitope Map
Author Location Env
Epitope KLTPLCVTL Epitope Alignment
KLTPLCVTL epitope logo
Show epitope variants
Epitope Name Env 134
Species (MHC/HLA) human, humanized mouse(A*02:01)
Immunogen in vitro stimulation or selection, vaccine
Experimental methods Cytokine production, T-cell Elispot
Keywords subtype comparisons, computational epitope prediction, escape, TCR usage, variant cross-reactivity

Vaccine Details

Vaccine type DNA

Notes

References

McKinney2004 Denise M. McKinney, Rhonda Skvoretz, Brian D. Livingston, Cara C. Wilson, Michelle Anders, Robert W. Chesnut, Alessandro Sette, Max Essex, Vladimir Novitsky, and Mark J. Newman. Recognition of Variant HIV-1 Epitopes from Diverse Viral Subtypes by Vaccine-Induced CTL. J. Immunol., 173(3):1941-1950, 1 Aug 2004. PubMed ID: 15265928. Show all entries for this paper.


Displaying record number 53799

Download this epitope record as JSON.

HXB2 Location gp160(121-129)
gp120(121-129)
DNA(6585..6611)
gp160 Epitope Map
Author Location Env
Epitope KLTPLCVTL Epitope Alignment
KLTPLCVTL epitope logo
Epitope Name K9L
Species (MHC/HLA) transgenic mouse(A*02:01)
Immunogen vaccine
Experimental methods Chromium-release assay, Flow cytometric T-cell cytokine assay
Keywords memory cells, vaccine antigen design, characterizing CD8+ T cells

Vaccine Details

Vaccine type measles virus (MV)
Vaccine strain multiple epitope immunogen
Vaccine component gp140, gp140ΔV3

Notes

References

Lorin2005a Clarisse Lorin, Frédéric Delebecque, Valérie Labrousse, Lucie Da Silva, François Lemonnier, Michel Brahic, and Frédéric Tangy. A Recombinant Live Attenuated Measles Vaccine Vector Primes Effective HLA-A0201-Restricted Cytotoxic T Lymphocytes and Broadly Neutralizing Antibodies against HIV-1 Conserved Epitopes. Vaccine, 23(36):4463-4472, 22 Aug 2005. PubMed ID: 15993518. Show all entries for this paper.


Displaying record number 56188

Download this epitope record as JSON.

HXB2 Location gp160(121-129)
gp120(121-129)
DNA(6585..6611)
gp160 Epitope Map
Author Location Env(134-)
Epitope KLTPLCVTL Epitope Alignment
KLTPLCVTL epitope logo
Species (MHC/HLA) human(A*02:01)
Immunogen vaccine
Country Botswana, United States
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay
Keywords vaccine antigen design

Vaccine Details

Vaccine type DNA, polyepitope
Vaccine strain multiple epitope immunogen

Notes

References

Gorse2008a Geoffrey J. Gorse, Lindsey R. Baden, Margaret Wecker, Mark J. Newman, Guido Ferrari, Kent J. Weinhold, Brian D. Livingston, Tonya L. Villafana, Hongli Li, Elizabeth Noonan, Nina D. Russell, and HIV Vaccine Trials Network. Safety and Immunogenicity of Cytotoxic T-Lymphocyte Poly-Epitope, DNA Plasmid (EP HIV-1090) Vaccine in Healthy, Human Immunodeficiency Virus Type 1 (HIV-1)-Uninfected Adults. Vaccine, 26(2):215-223, 10 Jan 2008. PubMed ID: 18055072. Show all entries for this paper.


Displaying record number 57083

Download this epitope record as JSON.

HXB2 Location gp160(121-129)
gp120(121-129)
DNA(6585..6611)
gp160 Epitope Map
Author Location gp120(121-129 DU422)
Epitope KLTPLCVTL Epitope Alignment
KLTPLCVTL epitope logo
Subtype B
Species (MHC/HLA) human(A*02:01)
Immunogen in vitro stimulation or selection
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, Tetramer binding
Keywords dendritic cells

Notes

References

Colleton2009 Bonnie A. Colleton, Xiao-Li Huang, Nada M. Melhem, Zheng Fan, Luann Borowski, Giovanna Rappocciolo, and Charles R. Rinaldo. Primary Human Immunodeficiency Virus Type 1-Specific CD8+ T-Cell Responses Induced by Myeloid Dendritic Cells. J. Virol., 83(12):6288-6299, Jun 2009. PubMed ID: 19357176. Show all entries for this paper.


Displaying record number 58638

Download this epitope record as JSON.

HXB2 Location gp160(121-129)
gp120(121-129)
DNA(6585..6611)
gp160 Epitope Map
Author Location Env(120-128)
Epitope KLTPLCVTL Epitope Alignment
KLTPLCVTL epitope logo
Epitope Name Env120-128
Subtype B
Species (MHC/HLA) human(A*02:01)
Immunogen peptide-HLA interaction
Country United States
Experimental methods Chromium-release assay
Keywords enhancing activity

Notes

References

Dupuis1997 M. Dupuis, M. V. Peshwa, C. Benike, S.K> Kundu, E. G. Engleman, W. C. Van Schooten, and T. C. Merigan. Allogeneic Dendritic Cell Induction of HIV-Specific Cytotoxic T Lymphocyte Responses from T Cells of HIV Type 1-Infected and Uninfected Individuals. AIDS Res. Hum. Retroviruses, 13:33-39, 1997. The potential benefit of T cell-based vaccination for HIV-1 infection remains to be determined. Cytotoxic T lymphocytes (CTLs) appear to clear substantial populations of HIV-1 virus in vivo, although CTL activity may contribute to the decline in CD4+ T cell count observed in the course of the disease. To investigate further the role of specific CTL responses in the control of HIV-1 replication, we raised primary CTL lines against a panel of conserved HIV-1 epitopes using blood-derived dendritic cells as antigen-presenting cells (APCs). Specific primary human CTL responses were induced against HLA-A*0201-restricted peptides with dendritic cells from HIV-1-seronegative donors. This method of immunization elicited cytotoxic activities capable of recognizing endogenously processed antigen. The CTL induction protocol was extended in order to explore the capacity of HLA-matched allogeneic dendritic cells to evoke novel CTL responses in T cells from an HIV-seropositive asymptomatic individual. Allogeneic peptide-pulsed dendritic cells from a healthy sibling were capable of eliciting a CTL response directed against an HIV epitope (env814: SLLNATDIAV) that was initially not detected in the CTL effector population of the HIV-1- infected patient. The possibility of manipulating CTL specificity directed against multiple conserved HIV-1 epitopes represents a significant step in the evaluation of T cell-based vaccination for treatment of disease. PubMed ID: 8989425. Show all entries for this paper.


Displaying record number 58643

Download this epitope record as JSON.

HXB2 Location gp160(121-129)
gp120(121-129)
DNA(6585..6611)
gp160 Epitope Map
Author Location Env(120-128 LAI)
Epitope KLTPLCVTL Epitope Alignment
KLTPLCVTL epitope logo
Epitope Name Env120-128
Subtype B
Species (MHC/HLA) human(A*02:01)
Immunogen vaccine
Country United States
Experimental methods Chromium-release assay
Keywords dendritic cells, enhancing activity, novel epitope

Vaccine Details

Vaccine type protein
Vaccine strain B clade MN
Vaccine component gp160

Notes

References

Dupuis1995 M. Dupuis, S. K. Kundu, and T. C. Merigan. Characterization of HLA-A*0201-Restricted Cytotoxic T Cell Epitopes in Conserved Regions of the HIV Type 1 gp160 Protein. J. Immunol., 155:2232-2239, 1995. Five HLA-A2 HIV-1 seropositive HIV-1 MN rec gp160 vaccinees had their CTL activity assessed using peptides known to bind with high affinity to HLA-A*0201. Four of the patients had specific CTL activity for a minimum of at least three epitopes, thus the response appears heterogeneous. One of the four peptides was confirmed to be HLA A2 restricted. Epitopes were highly conserved. PubMed ID: 7543542. Show all entries for this paper.


Displaying record number 61353

Download this epitope record as JSON.

HXB2 Location gp160(121-129)
gp120(121-129)
DNA(6585..6611)
gp160 Epitope Map
Author Location Env(120-128)
Epitope KLTPLCVTL Epitope Alignment
KLTPLCVTL epitope logo
Species (MHC/HLA) human(A*02:01)
Immunogen in vitro stimulation or selection
Country China
Experimental methods Intracellular cytokine staining, Other
Keywords T-cell crossreactivity to human proteins, bispecific/trispecific

Notes

References

Zhou2016 Chao-Ying Zhou, Qian Wen, Xiao-Jie Chen, Rui-Ning Wang, Wen-Ting He, Shi-Meng Zhang, Xia-Lin Du, and Li Ma. Human CD8+ T Cells Transduced with an Additional Receptor Bispecific for Both Mycobacterium tuberculosis and HIV-1 Recognize Both Epitopes. J. Cell. Mol. Med., 20(10):1984-1998, Oct 2016. PubMed ID: 27113787. Show all entries for this paper.


Displaying record number 670

Download this epitope record as JSON.

HXB2 Location gp160(121-129)
gp120(121-129)
DNA(6585..6611)
gp160 Epitope Map
Author Location Env
Epitope KLTPLCVTL Epitope Alignment
KLTPLCVTL epitope logo
Species (MHC/HLA) transgenic mouse(A*02:01)
Immunogen vaccine
Experimental methods  
Keywords  

Vaccine Details

Vaccine type DNA

Notes

References

Ishioka1999 G. Y. Ishioka, J. Fikes, G. Hermanson, B. Livingston, C. Crimi, M. Qin, M. F. del Guercio, C. Oseroff, C. Dahlberg, J. Alexander, R. W. Chesnut, and A. Sette. Utilization of MHC Class I Transgenic Mice for Development of Minigene. J. Immunol., 162:3915-3925, 1999. PubMed ID: 10201910. Show all entries for this paper.


Displaying record number 59930

Download this epitope record as JSON.

HXB2 Location gp160(121-129)
gp120(121-129)
DNA(6585..6611)
gp160 Epitope Map
Author Location Env(121-129)
Epitope KLTPLCVTL Epitope Alignment
KLTPLCVTL epitope logo
Epitope Name KL9
Species (MHC/HLA) human(A*11)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope, chronic infection

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 55014

Download this epitope record as JSON.

HXB2 Location gp160(121-129)
gp120(121-129)
DNA(6585..6611)
gp160 Epitope Map
Author Location  
Epitope KLTPLCVTL Epitope Alignment
KLTPLCVTL epitope logo
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, HLA binding
Keywords binding affinity, immunodominance, optimal epitope

Notes

References

Bihl2006 Florian Bihl, Nicole Frahm, Loriana Di Giammarino, John Sidney, Mina John, Karina Yusim, Tonia Woodberry, Kaori Sango, Hannah S. Hewitt, Leah Henry, Caitlyn H. Linde, John V. Chisholm, III, Tauheed M. Zaman, Eunice Pae, Simon Mallal, Bruce D Walker, Alessandro Sette, Bette T. Korber, David Heckerman, and Christian Brander. Impact of HLA-B Alleles, Epitope Binding Affinity, Functional Avidity, and Viral Coinfection on the Immunodominance of Virus-Specific CTL Responses. J. Immunol., 176(7):4094-4101, 1 Apr 2006. PubMed ID: 16547245. Show all entries for this paper.


Displaying record number 55398

Download this epitope record as JSON.

HXB2 Location gp160(121-129)
gp120(121-129)
DNA(6585..6611)
gp160 Epitope Map
Author Location  
Epitope KLTPLCVTL Epitope Alignment
KLTPLCVTL epitope logo
Show epitope variants
Epitope Name Env 121
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Country Denmark
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining
Keywords immunodominance

Notes

References

Thorn2007 Mette Thorn, Sheila Tang, Dominic Therrien, Henrik Kløverpris, Lasse Vinner, Gitte Kronborg, Jan Gerstoft, Sylvie Corbet, and Anders Fomsgaard. Sequence Conservation of Subdominant HLA-A2-Binding CTL Epitopes in HIV-1 Clinical Isolates and CD8+ T-Lymphocyte Cross-Recognition May Explain the Immune Reaction in Infected Individuals. APMIS, 115(6):757-768, Jun 2007. PubMed ID: 17550385. Show all entries for this paper.


Displaying record number 55909

Download this epitope record as JSON.

HXB2 Location gp160(121-129)
gp120(121-129)
DNA(6585..6611)
gp160 Epitope Map
Author Location gp120
Epitope KLTPLCVTL Epitope Alignment
KLTPLCVTL epitope logo
Epitope Name KL9(gp120)
Subtype B
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Country China
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords chronic infection

Notes

References

Zhai2008 Song Zhai, Yan Zhuang, Yang Song, Shu Li, Dedong Huang, Wenzhen Kang, Xinhong Li, Qi Liao, Yanhou Liu, Zhongfang Zhao, Yichen Lu, and Yongtao Sun. HIV-1-Specific Cytotoxic T Lymphocyte (CTL) Responses Against Immunodominant Optimal Epitopes Slow the Progression of AIDS in China. Curr. HIV Res., 6(4):335-350, Jun 2008. PubMed ID: 18691032. Show all entries for this paper.


Displaying record number 56067

Download this epitope record as JSON.

HXB2 Location gp160(121-129)
gp120(121-129)
DNA(6585..6611)
gp160 Epitope Map
Author Location Env(121-)
Epitope KLTPLCVTL Epitope Alignment
KLTPLCVTL epitope logo
Epitope Name Env121
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Country Denmark
Experimental methods Flow cytometric T-cell cytokine assay
Keywords rate of progression, acute/early infection

Notes

References

Fomsgaard2008 Anders Fomsgaard, Lasse Vinner, Dominic Therrien, Louise B. Jørgensen, Claus Nielsen, Lars Mathiesen, Court Pedersen, and Sylvie Corbet. Full-Length Characterization of A1/D Intersubtype Recombinant Genomes from a Therapy-Induced HIV Type 1 Controller during Acute Infection and His Noncontrolling Partner. AIDS Res. Hum. Retroviruses, 24(3):463-472, Mar 2008. PubMed ID: 18373434. Show all entries for this paper.


Displaying record number 667

Download this epitope record as JSON.

HXB2 Location gp160(121-129)
gp120(121-129)
DNA(6585..6611)
gp160 Epitope Map
Author Location gp120(120-128)
Epitope KLTPLCVTL Epitope Alignment
KLTPLCVTL epitope logo
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Experimental methods  
Keywords dendritic cells

Notes

References

Kundu1998 S. K. Kundu, E. Engleman, C. Benike, M. H. Shapero, M. Dupuis, W. C. van Schooten, M. Eibl, and T. C. Merigan. A Pilot Clinical Trial of HIV Antigen-Pulsed Allogeneic and Autologous Dendritic Cell Therapy in HIV-Infected Patients. AIDS Res. Hum. Retroviruses, 14:551-560, 1998. PubMed ID: 9591709. Show all entries for this paper.


Displaying record number 56529

Download this epitope record as JSON.

HXB2 Location gp160(121-129)
gp120(121-129)
DNA(6585..6611)
gp160 Epitope Map
Author Location Env
Epitope KLTPLCVTL Epitope Alignment
KLTPLCVTL epitope logo
Epitope Name Env134
Subtype B
Species (MHC/HLA) human(A2)
Immunogen vaccine
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords vaccine antigen design

Vaccine Details

Vaccine type DNA, polyepitope
Vaccine component other

Notes

References

Wilson2008 Cara C. Wilson, Mark J. Newman, Brian D. Livingston, Samantha MaWhinney, Jeri E. Forster, Jim Scott, Robert T. Schooley, and Constance A. Benson. Clinical Phase 1 Testing of the Safety and Immunogenicity of an Epitope-Based DNA Vaccine in Human Immunodeficiency Virus Type 1-Infected Subjects Receiving Highly Active Antiretroviral Therapy. Clin. Vaccine Immunol., 15(6):986-994, Jun 2008. PubMed ID: 18400976. Show all entries for this paper.


Displaying record number 56978

Download this epitope record as JSON.

HXB2 Location gp160(121-129)
gp120(121-129)
DNA(6585..6611)
gp160 Epitope Map
Author Location Env
Epitope KLTPLCVTL Epitope Alignment
KLTPLCVTL epitope logo
Subtype B
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Country Sweden
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords subtype comparisons, computational epitope prediction, vaccine antigen design

Notes

References

Perez2008 Carina L. Pérez, Mette V. Larsen, Rasmus Gustafsson, Melissa M. Norström, Ann Atlas, Douglas F. Nixon, Morten Nielsen, Ole Lund, and Annika C. Karlsson. Broadly Immunogenic HLA Class I Supertype-Restricted Elite CTL Epitopes Recognized in a Diverse Population Infected with Different HIV-1 Subtypes. J. Immunol., 180(7):5092-5100, 1 Apr 2008. PubMed ID: 18354235. Show all entries for this paper.


Displaying record number 54234

Download this epitope record as JSON.

HXB2 Location gp160(121-129)
gp120(121-129)
DNA(6585..6611)
gp160 Epitope Map
Author Location gp160
Epitope KLTPLCVTL Epitope Alignment
KLTPLCVTL epitope logo
Epitope Name A2-KL9(gp160)
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, immunodominance, early-expressed proteins

Notes

References

Altfeld2006 Marcus Altfeld, Elizabeth T. Kalife, Ying Qi, Hendrik Streeck, Mathias Lichterfeld, Mary N. Johnston, Nicole Burgett, Martha E. Swartz, Amy Yang, Galit Alter, Xu G. Yu, Angela Meier, Juergen K. Rockstroh, Todd M. Allen, Heiko Jessen, Eric S. Rosenberg, Mary Carrington, and Bruce D. Walker. HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8+ T Cell Response against HIV-1. PLoS Med., 3(10):e403, Oct 2006. PubMed ID: 17076553. Show all entries for this paper.


Displaying record number 53586

Download this epitope record as JSON.

HXB2 Location gp160(121-129)
gp120(121-129)
DNA(6585..6611)
gp160 Epitope Map
Author Location gp160(121-129)
Epitope KLTPLCVTL Epitope Alignment
KLTPLCVTL epitope logo
Subtype B
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, HLA binding
Keywords acute/early infection, optimal epitope

Notes

References

Altfeld2005a Marcus Altfeld, Todd M. Allen, Elizabeth T. Kalife, Nicole Frahm, Marylyn M. Addo, Bianca R. Mothe, Almas Rathod, Laura L. Reyor, Jason Harlow, Xu G. Yu, Beth Perkins, Loren K. Robinson, John Sidney, Galit Alter, Mathias Lichterfeld, Alessandro Sette, Eric S. Rosenberg, Philip J. R. Goulder, Christian Brander, and Bruce D. Walker. The Majority of Currently Circulating Human Immunodeficiency Virus Type 1 Clade B Viruses Fail To Prime Cytotoxic T-Lymphocyte Responses against an Otherwise Immunodominant HLA-A2-Restricted Epitope: Implications for Vaccine Design. J. Virol., 79(8):5000-5005, Apr 2005. PubMed ID: 15795285. Show all entries for this paper.


Displaying record number 53626

Download this epitope record as JSON.

HXB2 Location gp160(121-129)
gp120(121-129)
DNA(6585..6611)
gp160 Epitope Map
Author Location Env(121-129 HXB2)
Epitope KLTPLCVTL Epitope Alignment
KLTPLCVTL epitope logo
Epitope Name D1
Subtype B
Species (MHC/HLA) transgenic mouse(A2)
Immunogen vaccine
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, Cytokine production
Keywords vaccine-induced immune responses, vaccine antigen design

Vaccine Details

Vaccine type DNA
Vaccine strain multiple epitope immunogen
Vaccine component p17/p24 Gag, Pol
Adjuvant IL-12

Notes

References

Bolesta2005a Elizabeth Bolesta, Jaroslaw Gzyl, Andrzej Wierzbicki, Dariusz Kmieciak, Aleksandra Kowalczyk, Yutaro Kaneko, Alagarsamy Srinivasan, and Danuta Kozbor. Clustered Epitopes within the Gag-Pol Fusion Protein DNA Vaccine Enhance Immune Responses and Protection against Challenge with Recombinant Vaccinia Viruses Expressing HIV-1 Gag and Pol Antigens. Virology, 332(2):467-479, 20 Feb 2005. PubMed ID: 15680412. Show all entries for this paper.


Displaying record number 668

Download this epitope record as JSON.

HXB2 Location gp160(121-129)
gp120(121-129)
DNA(6585..6611)
gp160 Epitope Map
Author Location gp120(120-128)
Epitope KLTPLCVTL Epitope Alignment
KLTPLCVTL epitope logo
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Kmieciak1998 D. Kmieciak, T. J. Wasik, H. Teppler, J. Pientka, S. H. Hsu, H. Takahashi, K. Okumura, Y. Kaneko, and D. Kozbor. The effect of deletion of the V3 loop of gp120 on cytotoxic T cell responses and HIV gp120-mediated pathogenesis. J. Immunol., 160:5676-83, 1998. PubMed ID: 9605175. Show all entries for this paper.


Displaying record number 52090

Download this epitope record as JSON.

HXB2 Location gp160(121-129)
gp120(121-129)
DNA(6585..6611)
gp160 Epitope Map
Author Location gp120(121-129 IIIB)
Epitope KLTPLCVTL Epitope Alignment
KLTPLCVTL epitope logo
Epitope Name D1
Subtype B
Species (MHC/HLA) transgenic mouse(A2)
Immunogen vaccine
Experimental methods  
Keywords vaccine-induced immune responses

Vaccine Details

Vaccine type DNA, DNA with protein boost
Vaccine strain B clade IIIB
Vaccine component gp160, gp160ΔV3
Adjuvant IL-12

Notes

References

Kiszka2002 Irena Kiszka, Dariusz Kmieciak, Jaroslaw Gzyl, Toshio Naito, Elizabeth Bolesta, Aleksander Sieron, Satya P. Singh, Alagarsamy Srinivasan, Giorgio Trinchieri, Yutaro Kaneko, and Danuta Kozbor. Effect of the V3 Loop Deletion of Envelope Glycoprotein on Cellular Responses and Protection against Challenge with Recombinant Vaccinia Virus Expressing gp160 of Primary Human Immunodeficiency Virus Type 1 Isolates. J. Virol., 76(9):4222-4232, May 2002. PubMed ID: 11932387. Show all entries for this paper.


Displaying record number 52696

Download this epitope record as JSON.

HXB2 Location gp160(121-129)
gp120(121-129)
DNA(6585..6611)
gp160 Epitope Map
Author Location Env(121-)
Epitope KLTPLCVTL Epitope Alignment
KLTPLCVTL epitope logo
Epitope Name Env121
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, Flow cytometric T-cell cytokine assay
Keywords binding affinity, subtype comparisons, computational epitope prediction

Notes

References

Corbet2003 Sylvie Corbet, Henrik Vedel Nielsen, Lasse Vinner, Sanne Lauemoller, Dominic Therrien, Sheila Tang, Gitte Kronborg, Lars Mathiesen, Paul Chaplin, Søren Brunak, Søren Buus, and Anders Fomsgaard. Optimization and Immune Recognition of Multiple Novel Conserved HLA-A2, Human Immunodeficiency Virus Type 1-Specific CTL Epitopes. J. Gen. Virol., 84(Pt 9):2409-2421, Sep 2003. PubMed ID: 12917462. Show all entries for this paper.


Displaying record number 57628

Download this epitope record as JSON.

HXB2 Location gp160(121-129)
gp120(121-129)
DNA(6585..6611)
gp160 Epitope Map
Author Location  
Epitope KLTPLCVTL Epitope Alignment
KLTPLCVTL epitope logo
Epitope Name KLT
Subtype A, B, C
Species (MHC/HLA) transgenic mouse(A2)
Immunogen vaccine
Experimental methods Flow cytometric T-cell cytokine assay
Keywords epitope processing, vaccine antigen design

Vaccine Details

Vaccine type DNA prime with vaccinia boost, polyepitope
Vaccine strain A clade, B clade, C clade
Vaccine component Env, Gag, Nef, Pol, Vpr

Notes

References

Bazhan2010 S. I. Bazhan, L. I. Karpenko, T. N. Ilyicheva, P. A. Belavin, S. V. Seregin, N. K. Danilyuk, D. V. Antonets, and A. A. Ilyichev. Rational Design Based Synthetic Polyepitope DNA Vaccine for Eliciting HIV-Specific CD8+ T Cell Responses. Mol Immunol, 47(7-8):1507-1515, Apr 2010. PubMed ID: 20189249. Show all entries for this paper.


Displaying record number 1599

Download this epitope record as JSON.

HXB2 Location gp160(121-129)
gp120(121-129)
DNA(6585..6611)
gp160 Epitope Map
Author Location Env(134-142)
Epitope KLTPLCVTL Epitope Alignment
KLTPLCVTL epitope logo
Species (MHC/HLA) human(A2 supertype)
Immunogen HIV-1 infection
Experimental methods  
Keywords supertype, rate of progression

Notes

References

Propato2001 A. Propato, E. Schiaffella, E. Vicenzi, V. Francavilla, L. Baloni, M. Paroli, L. Finocchi, N. Tanigaki, S. Ghezzi, R. Ferrara, R. Chesnut, B. Livingston, A. Sette, R. Paganelli, F. Aiuti, G. Poli, and V. Barnaba. Spreading of HIV-specific CD8+ T-cell repertoire in long-term nonprogressors and its role in the control of viral load and disease activity. Hum. Immunol., 62(6):561-76, Jun 2001. PubMed ID: 11390031. Show all entries for this paper.


Displaying record number 56509

Download this epitope record as JSON.

HXB2 Location gp160(121-129)
gp120(121-129)
DNA(6585..6611)
gp160 Epitope Map
Author Location Env
Epitope KLTPLCVTL Epitope Alignment
KLTPLCVTL epitope logo
Epitope Name Env134
Subtype A, B, C, D
Species (MHC/HLA) human, mouse(A2 supertype)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Other
Keywords binding affinity, supertype, vaccine-induced immune responses, HLA cross-presentation

Notes

References

Wilson2003 Cara C. Wilson, Denise McKinney, Michelle Anders, Samantha MaWhinney, Jeri Forster, Claire Crimi, Scott Southwood, Alessandro Sette, Robert Chesnut, Mark J Newman, and Brian D Livingston. Development of a DNA Vaccine Designed to Induce Cytotoxic T Lymphocyte Responses to Multiple Conserved Epitopes in HIV-1. J. Immunol., 171(10):5611-5623, 15 Nov 2003. PubMed ID: 14607970. Show all entries for this paper.


Displaying record number 58810

Download this epitope record as JSON.

HXB2 Location gp160(121-129)
gp120(121-129)
DNA(6585..6611)
gp160 Epitope Map
Author Location gp120
Epitope KLTPLCVTL Epitope Alignment
KLTPLCVTL epitope logo
Species (MHC/HLA) humanized mouse
Immunogen vaccine
Experimental methods Cytotoxicity assay, Other
Keywords vaccine-induced immune responses

Vaccine Details

Vaccine component gp120, other

Notes

References

Nanjundappa2012 Roopa Hebbandi Nanjundappa, Rong Wang, Yufeng Xie, Channakeshava Sokke Umeshappa, and Jim Xiang. Novel CD8+ T Cell-Based Vaccine Stimulates Gp120-Specific CTL Responses Leading to Therapeutic and Long-Term Immunity in Transgenic HLA-A2 Mice. Vaccine, 30(24):3519-3525, 21 May 2012. PubMed ID: 22484292. Show all entries for this paper.


Questions or comments? Contact us at immuno@lanl.gov
 
Managed by Triad National Security, LLC for the U.S. Department of Energy’s National Nuclear Security Administration
Copyright © 2022 Triad National Security, LLC | Disclaimer/Privacy

Dept of Health & Human Services Los Alamos National Institutes of Health