Search CTL/CD8+ T-Cell Epitope Database

Found 2 matching records:

Displaying record number 53801

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HXB2 Location	gp160(121-129) gp120(121-129) DNA(6585..6611)	gp160 Epitope Map
Author Location	Env
Epitope	KLTPLCVSL	Epitope Alignment
Epitope Name	P10L
Species (MHC/HLA)	transgenic mouse(A*02:01)
Immunogen	vaccine
Experimental methods	Chromium-release assay, Flow cytometric T-cell cytokine assay
Keywords	memory cells, vaccine antigen design, characterizing CD8+ T cells

Vaccine Details

Notes

• A recombinant measles MVSchw virus expressing an HIV-1-derived polyepitope effectively primed HLA-A*0201-restricted CTL responses against multiple conserved HIV-1 epitopes in HLA-A*0201 transgenic mice. Also, a recombinant MVSchw virus expressing gp140 with deleted V1, V2, and V3 loops successfully induces neutralizing antibodies against HIV-1. A live attenuated measles vaccine could provide a safe and efficient pediatric vaccination vector for simultaneous vaccination against HIV and measles.

References

Lorin2005a Clarisse Lorin, Frédéric Delebecque, Valérie Labrousse, Lucie Da Silva, François Lemonnier, Michel Brahic, and Frédéric Tangy. A Recombinant Live Attenuated Measles Vaccine Vector Primes Effective HLA-A0201-Restricted Cytotoxic T Lymphocytes and Broadly Neutralizing Antibodies against HIV-1 Conserved Epitopes. Vaccine, 23(36):4463-4472, 22 Aug 2005. PubMed ID: 15993518. Show all entries for this paper.

Displaying record number 669

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HXB2 Location	gp160(121-129) gp120(121-129) DNA(6585..6611)	gp160 Epitope Map
Author Location	gp120(121-129)
Epitope	KLTPLCVSL	Epitope Alignment
Species (MHC/HLA)	human(A2)
Immunogen	in vitro stimulation or selection
Experimental methods
Keywords	dendritic cells

Notes

• This study compares the ability of macrophages and dendritic cells to stimulate primary responses in CD8+ lymphocytes isolated from HLA-appropriate HIV-uninfected donors using peptide-pulsed APC -- the dendritic cells performed better as APC for the stimulation of primary responses.
• Strong CTL responses were elicited by the epitopes DRFYKTLRA and GEIYKRWII when presented by either immature or mature dendritic cells -- macrophages were not able to prime a CTL response against DRFYKTLRA.
• A weak response to KLTPLCVSL was stimulated using macrophages as the APC.
• No detectable response was observed for the following previously-defined HIV epitopes: KIRLRPGGK, ILKEPVHGV, IRLRPGGK, GPKVKQWPL.

References

Zarling1999 A. L. Zarling, J. G. Johnson, R. W. Hoffman, and D. R. Lee. Induction of Primary Human CD8+ T Lymphocyte Responses In Vitro Using Dendritic Cells. J. Immunol., 162:5197-5204, 1999. PubMed ID: 10227993. Show all entries for this paper.