HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 4 matching records:

Displaying record number 52686

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HXB2 Location Pol(606-614)
RT(451-459)
DNA(3900..3926)
Pol Epitope Map
Author Location Pol(606-)
Epitope KLGKAGYVT Epitope Alignment
KLGKAGYVT epitope logo
Epitope Name Pol606
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection, vaccine
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, Flow cytometric T-cell cytokine assay
Keywords binding affinity, subtype comparisons, computational epitope prediction

Vaccine Details

Vaccine type peptide
Vaccine component RT
Adjuvant Incomplete Freund's Adjuvant (IFA)

Notes

References

Corbet2003 Sylvie Corbet, Henrik Vedel Nielsen, Lasse Vinner, Sanne Lauemoller, Dominic Therrien, Sheila Tang, Gitte Kronborg, Lars Mathiesen, Paul Chaplin, Søren Brunak, Søren Buus, and Anders Fomsgaard. Optimization and Immune Recognition of Multiple Novel Conserved HLA-A2, Human Immunodeficiency Virus Type 1-Specific CTL Epitopes. J. Gen. Virol., 84(Pt 9):2409-2421, Sep 2003. PubMed ID: 12917462. Show all entries for this paper.


Displaying record number 55376

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HXB2 Location Pol(606-614)
RT(451-459)
DNA(3900..3926)
Pol Epitope Map
Author Location  
Epitope KLGKAGYVT Epitope Alignment
KLGKAGYVT epitope logo
Show epitope variants
Epitope Name Pol 606
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Country Denmark
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining
Keywords immunodominance, variant cross-reactivity

Notes

References

Thorn2007 Mette Thorn, Sheila Tang, Dominic Therrien, Henrik Kløverpris, Lasse Vinner, Gitte Kronborg, Jan Gerstoft, Sylvie Corbet, and Anders Fomsgaard. Sequence Conservation of Subdominant HLA-A2-Binding CTL Epitopes in HIV-1 Clinical Isolates and CD8+ T-Lymphocyte Cross-Recognition May Explain the Immune Reaction in Infected Individuals. APMIS, 115(6):757-768, Jun 2007. PubMed ID: 17550385. Show all entries for this paper.


Displaying record number 56064

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HXB2 Location Pol(606-614)
RT(451-459)
DNA(3900..3926)
Pol Epitope Map
Author Location Pol(606-)
Epitope KLGKAGYVT Epitope Alignment
KLGKAGYVT epitope logo
Show epitope variants
Epitope Name Pol606
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Country Denmark
Experimental methods Flow cytometric T-cell cytokine assay
Keywords rate of progression, escape, acute/early infection

Notes

References

Fomsgaard2008 Anders Fomsgaard, Lasse Vinner, Dominic Therrien, Louise B. Jørgensen, Claus Nielsen, Lars Mathiesen, Court Pedersen, and Sylvie Corbet. Full-Length Characterization of A1/D Intersubtype Recombinant Genomes from a Therapy-Induced HIV Type 1 Controller during Acute Infection and His Noncontrolling Partner. AIDS Res. Hum. Retroviruses, 24(3):463-472, Mar 2008. PubMed ID: 18373434. Show all entries for this paper.


Displaying record number 61949

Download this epitope record as JSON.

HXB2 Location Pol(606-614)
RT(451-459)
DNA(3900..3926)
Pol Epitope Map
Author Location Pol(606-)
Epitope KLGKAGYVT Epitope Alignment
KLGKAGYVT epitope logo
Epitope Name KT9
Subtype A3, B, C, CRF02_AG
Species (MHC/HLA) human
Immunogen HIV-1 infection
Country Denmark, Guinea-Bissau
Experimental methods HLA binding, Intracellular cytokine staining, Tetramer binding
Keywords binding affinity, vaccine antigen design, non-susceptible form

Notes

References

Karlsson2012 Ingrid Karlsson, Henrik Kløverpris, Kristoffer Jarlov Jensen, Anette Stryhn, Søren Buus, Annika Karlsson, Lasse Vinner, Philip Goulder, and Anders Fomsgaard. Identification of Conserved Subdominant HIV Type 1 CD8+ T Cell Epitopes Restricted within Common HLA Supertypes for Therapeutic HIV Type 1 Vaccines. AIDS Res. Hum. Retroviruses, 28(11):1434-1443, Nov 2012. PubMed ID: 22747336. Show all entries for this paper.


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