HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 13 matching records:

Displaying record number 53099

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HXB2 Location Gag(18-27)
p17(18-27)
DNA(841..870)
Gag Epitope Map
Author Location p17(18-27)
Epitope KIRLRPGGKK Epitope Alignment
KIRLRPGGKK epitope logo
Species (MHC/HLA) human(A*03)
Immunogen HIV-1 infection
Country Spain
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Proliferation
Keywords HAART, ART, supervised treatment interruptions (STI)

Notes

References

Plana2004 Montserrat Plana, Felipe Garcia, Annette Oxenius, Gabriel M. Ortiz, Anna Lopez, Anna Cruceta, Gabriel Mestre, Emilio Fumero, Catherine Fagard, Maria Antonia Sambeat, Ferran Segura, José M. Miró, Mireia Arnedo, L. Lopalcos, Tomas Pumarola, Bernard Hirschel, Rodney E. Phillips, Douglas F. Nixon, Teresa Gallart, and Jose M. Gatell. Relevance of HIV-1-Specific CD4+ Helper T-Cell Responses During Structured Treatment Interruptions in Patients With CD4+ T-Cell Nadir Above 400/mm3. J. Acquir. Immune Defic. Syndr., 36(3):791-799, 1 Jul 2004. PubMed ID: 15213562. Show all entries for this paper.


Displaying record number 58492

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HXB2 Location Gag(18-27)
p17(18-27)
DNA(841..870)
Gag Epitope Map
Author Location Gag(18-27)
Epitope KIRLRPGGKK Epitope Alignment
KIRLRPGGKK epitope logo
Subtype B
Species (MHC/HLA) human(A*03, A*11, B*07, B*27)
Immunogen HIV-1 infection
Country Canada
Experimental methods Other
Keywords rate of progression, characterizing CD8+ T cells, elite controllers

Notes

References

Peretz2011 Yoav Peretz, Olivia Marra, Réjean Thomas, Danielle Legault, Pierre Côté, Mohamed-Rachid Boulassel, Danielle Rouleau, Jean-Pierre Routy, Rafick-Pierre Sékaly, Christos M Tsoukas, Cécile Tremblay, and Nicole F. Bernard. Relative Contribution of HIV-Specific Functional Lymphocyte Subsets Restricted by Protective and Non-Protective HLA Alleles. Viral Immunol, 24(3):189-198, Jun 2011. PubMed ID: 21668360. Show all entries for this paper.


Displaying record number 53325

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HXB2 Location Gag(18-27)
p17(18-27)
DNA(841..870)
Gag Epitope Map
Author Location ( C consensus)
Epitope KIRLRPGGKK Epitope Alignment
KIRLRPGGKK epitope logo
Subtype C
Species (MHC/HLA) human(A*03:01)
Immunogen HIV-1 infection
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords characterizing CD8+ T cells

Notes

References

Kiepiela2004 Photini Kiepiela, Alasdair J. Leslie, Isobella Honeyborne, Danni Ramduth, Christina Thobakgale, Senica Chetty, Prinisha Rathnavalu, Corey Moore, Katja J. Pfafferott, Louise Hilton, Peter Zimbwa, Sarah Moore, Todd Allen, Christian Brander, Marylyn M. Addo, Marcus Altfeld, Ian James, Simon Mallal, Michael Bunce, Linda D. Barber, James Szinger, Cheryl Day, Paul Klenerman, James Mullins, Bette Korber, Hoosen M. Coovadia, Bruce D. Walker, and Philip J. R. Goulder. Dominant Influence of HLA-B in Mediating the Potential Co-Evolution of HIV and HLA. Nature, 432(7018):769-775, 9 Dec 2004. LA-UR 04-5920. PubMed ID: 15592417. Show all entries for this paper.


Displaying record number 54839

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HXB2 Location Gag(18-27)
p17(18-27)
DNA(841..870)
Gag Epitope Map
Author Location Gag( Henan isolate)
Epitope KIRLRPGGKK Epitope Alignment
KIRLRPGGKK epitope logo
Subtype B
Species (MHC/HLA) human(A11)
Immunogen HIV-1 infection
Country China
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords  

Notes

References

Gong2006 Xiaoyan Gong, Xien Gui, Yuxia Zhang, and Po Tien. Screening for CD8 Cytotoxic T Lymphocytes Specific for Gag of Human Immunodeficiency Virus Type 1 Subtype B' Henan Isolate from China and Identification of Novel Epitopes Restricted by the HLA-A2 and HLA-A11 Alleles. J. Gen. Virol., 87(Pt 1):151-158, Jan 2006. PubMed ID: 16361427. Show all entries for this paper.


Displaying record number 52872

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HXB2 Location Gag(18-27)
p17(18-27)
DNA(841..870)
Gag Epitope Map
Author Location Gag
Epitope KIRLRPGGKK Epitope Alignment
KIRLRPGGKK epitope logo
Epitope Name 1272
Subtype multiple
Species (MHC/HLA) human(A11)
Immunogen HIV-1 infection
Country United States
Experimental methods T-cell Elispot
Keywords binding affinity, computational epitope prediction, HLA cross-presentation, novel epitope

Notes

References

DeGroot2003 Anne S. De Groot, Bill Jesdale, William Martin, Caitlin Saint Aubin, Hakima Sbai, Andrew Bosma, Judy Lieberman, Gail Skowron, Fadi Mansourati, and Kenneth H. Mayer. Mapping Cross-Clade HIV-1 Vaccine Epitopes Using a Bioinformatics Approach. Vaccine, 21(27-30):4486-4504, 1 Oct 2003. PubMed ID: 14505932. Show all entries for this paper.


Displaying record number 62509

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HXB2 Location Gag(18-27)
p17(18-27)
DNA(841..870)
Gag Epitope Map
Author Location Gag
Epitope KIRLRPGGKK Epitope Alignment
KIRLRPGGKK epitope logo
Epitope Name KK10
Species (MHC/HLA) human(B*27)
Immunogen HIV-1 infection
Country Netherlands
Experimental methods  
Keywords review, escape

Notes

References

Kaur2009 G. Kaur and N. Mehra. Genetic Determinants of HIV-1 Infection and Progression to AIDS: Immune Response Genes. Tissue Antigens, 74(5):373-385, Nov 2009. PubMed ID: 19765261. Show all entries for this paper.


Displaying record number 62486

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HXB2 Location Gag(18-27)
p17(18-27)
DNA(841..870)
Gag Epitope Map
Author Location  
Epitope KIRLRPGGKK Epitope Alignment
KIRLRPGGKK epitope logo
Epitope Name KK10
Species (MHC/HLA) human(B*27)
Immunogen HIV-1 infection
Experimental methods  
Keywords review, immunodominance, variant cross-reactivity, protective allele

Notes

References

Li2018 Liuzhe Li, Yan Liu, and Miroslaw K. Gorny. Association of Diverse Genotypes and Phenotypes of Immune Cells and Immunoglobulins With the Course of HIV-1 Infection. Front. Immunol., 9:2735, 2018. PubMed ID: 30534128. Show all entries for this paper.


Displaying record number 55616

Download this epitope record as JSON.

HXB2 Location Gag(18-27)
p17(18-27)
DNA(841..870)
Gag Epitope Map
Author Location Gag
Epitope KIRLRPGGKK Epitope Alignment
KIRLRPGGKK epitope logo
Epitope Name KK10
Subtype B
Species (MHC/HLA) human(B27)
Immunogen HIV-1 infection
Country Netherlands
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords computational epitope prediction

Notes

References

Schellens2008 Ingrid M. M. Schellens, Can Kesmir, Frank Miedema, Debbie van Baarle, and José A. M. Borghans. An Unanticipated Lack of Consensus Cytotoxic T Lymphocyte Epitopes in HIV-1 Databases: The Contribution of Prediction Programs. AIDS, 22(1):33-37, 2 Jan 2008. PubMed ID: 18090389. Show all entries for this paper.


Displaying record number 9

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HXB2 Location Gag(18-27)
p17(18-27)
DNA(841..870)
Gag Epitope Map
Author Location p17(18-27)
Epitope KIRLRPGGKK Epitope Alignment
KIRLRPGGKK epitope logo
Species (MHC/HLA) human(B27)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Birk1998 M. Birk, A. Vahlne, A. Sonnerborg, and M. Sallberg. Nonsynonymous Mutations within the Human Immunodeficiency Virus Type 1 p17 Gene Are Clustered to Sequences Binding to the Host Human Leukocyte Antigen Class I Molecules. AIDS Res. Hum. Retroviruses, 14:241-248, 1998. PubMed ID: 9491914. Show all entries for this paper.


Displaying record number 8

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HXB2 Location Gag(18-27)
p17(18-27)
DNA(841..870)
Gag Epitope Map
Author Location p17(18-27 LAI)
Epitope KIRLRPGGKK Epitope Alignment
KIRLRPGGKK epitope logo
Subtype B
Species (MHC/HLA) human(B27)
Immunogen  
Experimental methods  
Keywords  

Notes

References

Brander1996 Christian Brander and Bruce Walker. The HLA-Class I Restricted CTL Response in HIV-1 Infection: Systematic Identification of Optimal Epitopes. In The HLA-Class I Restricted CTL Response in HIV-1 Infection: Systematic Identification of Optimal Epitopes. pages IV--50--IV--60. Los Alamos National Laboratory, Theoretical Biology and Biophysics, Los Alamos, New Mexico, 1996. URL: http://hiv-web.lanl.gov/immunology. Show all entries for this paper.


Displaying record number 53673

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HXB2 Location Gag(18-27)
p17(18-27)
DNA(841..870)
Gag Epitope Map
Author Location Gag
Epitope KIRLRPGGKK Epitope Alignment
KIRLRPGGKK epitope logo
Epitope Name KK10
Species (MHC/HLA) human(B27)
Immunogen HIV-1 infection
Experimental methods Other
Keywords rate of progression, escape

Notes

References

Gao2005 Xiaojiang Gao, Arman Bashirova, Astrid K. N. Iversen, John Phair, James J. Goedert, Susan Buchbinder, Keith Hoots, David Vlahov, Marcus Altfeld, Stephen J. O'Brien, and Mary Carrington. AIDS Restriction HLA Allotypes Target Distinct Intervals of HIV-1 Pathogenesis. Nat. Med., 11(12):1290-1292, Dec 2005. PubMed ID: 16288280. Show all entries for this paper.


Displaying record number 57842

Download this epitope record as JSON.

HXB2 Location Gag(18-27)
p17(18-27)
DNA(841..870)
Gag Epitope Map
Author Location p24
Epitope KIRLRPGGKK Epitope Alignment
KIRLRPGGKK epitope logo
Epitope Name KK10
Subtype B
Species (MHC/HLA) human(B27, B35)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, TCR binding
Keywords rate of progression, TCR usage, optimal epitope

Notes

References

Berger2011 Christoph T. Berger, Nicole Frahm, David A. Price, Beatriz Mothe, Musie Ghebremichael, Kari L. Hartman, Leah M. Henry, Jason M. Brenchley, Laura E. Ruff, Vanessa Venturi, Florencia Pereyra, John Sidney, Alessandro Sette, Daniel C. Douek, Bruce D. Walker, Daniel E. Kaufmann, and Christian Brander. High-Functional-Avidity Cytotoxic T Lymphocyte Responses to HLA-B-Restricted Gag-Derived Epitopes Associated with Relative HIV Control. J. Virol., 85(18):9334-9345, Sep 2011. PubMed ID: 21752903. Show all entries for this paper.


Displaying record number 57856

Download this epitope record as JSON.

HXB2 Location Gag(18-27)
p17(18-27)
DNA(841..870)
Gag Epitope Map
Author Location  
Epitope KIRLRPGGKK Epitope Alignment
KIRLRPGGKK epitope logo
Epitope Name KK10
Species (MHC/HLA) human(B*27:05)
Immunogen HIV-1 infection
Country United Kingdom
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining
Keywords rate of progression, early treatment

Notes

References

Cellerai2011 Cristina Cellerai, Alexandre Harari, Hans Stauss, Sabine Yerly, Anna-Maria Geretti, Anne Carroll, Thynn Yee, Jonathan Ainsworth, Ian Williams, John Sweeney, Andrew Freedman, Margaret Johnson, Giuseppe Pantaleo, and Sabine Kinloch-de Loes. Early and Prolonged Antiretroviral Therapy Is Associated with an HIV-1-Specific T-Cell Profile Comparable to That of Long-Term Non-Progressors. PLoS One, 6(4):e18164, 2011. PubMed ID: 21483676. Show all entries for this paper.


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