HIV molecular immunology database
Found 19 matching records:
Download this epitope record as JSON.
HXB2 Location | Pol(934-942) Integrase(219-227) DNA(4884..4910) |
Pol Epitope Map |
---|---|---|
Author Location | Pol | |
Epitope |
KIQNFRVYY
|
Epitope Alignment
|
Epitope Name | Pol934 | |
Subtype | A | |
Species (MHC/HLA) | human(A*01) | |
Immunogen | HIV-1 infection, vaccine | |
Patient MHC/HLA | P4: A*30:02, A*68:01, B*56:01, B*58:01 | |
Country | Guinea-Bissau | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | vaccine-induced immune responses, vaccine antigen design, therapeutic vaccine, chronic infection |
Vaccine type | peptide |
---|---|
Vaccine strain | A clade |
Adjuvant | CAF01 |
Roman2013 Victor Raúl Gómez Román, Kristoffer Jarlov Jensen, Sanne Skov Jensen, Christian Leo-Hansen, Sanne Jespersen, David da Silva Té, Candida Medina Rodrigues, Christoph Mikkel Janitzek, Lasse Vinner, Terese Lea Katzenstein, Peter Andersen, Ingrid Kromann, Lars Vibe Andreasen, Ingrid Karlsson, and Anders Fomsgaard. Therapeutic Vaccination Using Cationic Liposome-Adjuvanted HIV Type 1 Peptides Representing HLA-Supertype-Restricted Subdominant T Cell Epitopes: Safety, Immunogenicity, and Feasibility in Guinea-Bissau. AIDS Res Hum Retroviruses, 29(11):1504-1512, Nov 2013. PubMed ID: 23634822. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(934-942) Integrase(219-227) DNA(4884..4910) |
Pol Epitope Map |
---|---|---|
Author Location | Pol(934-) | |
Epitope |
KIQNFRVYY
|
Epitope Alignment
|
Epitope Name | KY9 | |
Subtype | A3, B, C, CRF02_AG | |
Species (MHC/HLA) | human(A*03:01, A*11:01, A*29:02, A*30:01, A*30:02, A*32:01, A*80:01) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | 1213: A*30:01, A*30:02, B*07:02, B*58:01 | |
Country | Denmark, Guinea-Bissau | |
Experimental methods | HLA binding, Intracellular cytokine staining, Tetramer binding | |
Keywords | binding affinity, vaccine antigen design |
Karlsson2012 Ingrid Karlsson, Henrik Kløverpris, Kristoffer Jarlov Jensen, Anette Stryhn, Søren Buus, Annika Karlsson, Lasse Vinner, Philip Goulder, and Anders Fomsgaard. Identification of Conserved Subdominant HIV Type 1 CD8+ T Cell Epitopes Restricted within Common HLA Supertypes for Therapeutic HIV Type 1 Vaccines. AIDS Res. Hum. Retroviruses, 28(11):1434-1443, Nov 2012. PubMed ID: 22747336. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(934-942) Integrase(219-227) DNA(4884..4910) |
Pol Epitope Map |
---|---|---|
Author Location | Pol | |
Epitope |
KIQNFRVYY
|
Epitope Alignment
|
Epitope Name | Pol934 | |
Subtype | B, CRF02_AG | |
Species (MHC/HLA) | human(A1) | |
Immunogen | HIV-1 infection | |
Country | Cote D'Ivoire, Denmark, Ghana, Guinea-Bissau, Mali, Senegal | |
Experimental methods | Intracellular cytokine staining, Pentamer labeling | |
Keywords | vaccine antigen design |
Perez2008 Carina L. Pérez, Mette V. Larsen, Rasmus Gustafsson, Melissa M. Norström, Ann Atlas, Douglas F. Nixon, Morten Nielsen, Ole Lund, and Annika C. Karlsson. Broadly Immunogenic HLA Class I Supertype-Restricted Elite CTL Epitopes Recognized in a Diverse Population Infected with Different HIV-1 Subtypes. J. Immunol., 180(7):5092-5100, 1 Apr 2008. PubMed ID: 18354235. Show all entries for this paper.
Vinner2011 Lasse Vinner, Birgitta Holmgren, Kristoffer J. Jensen, Joakim Esbjornsson, Marie Borggren, Julie L. Hentze, Ingrid Karlsson, Betina S. Andresen, Gregers J. Gram, Henrik Kloverpris, Peter Aaby, Zacarias José Da Silva, Eva-Maria Fenyö, and Anders Fomsgaard. Sequence Analysis of HIV-1 Isolates from Guinea-Bissau: Selection of Vaccine Epitopes Relevant in Both West African and European Countries. APMIS, 119(8):487-497, Aug 2011. PubMed ID: 21749448. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(934-942) Integrase(219-227) DNA(4884..4910) |
Pol Epitope Map |
---|---|---|
Author Location | Pol(934-942) | |
Epitope |
KIQNFRVYY
|
Epitope Alignment
|
Epitope Name | KYY9 | |
Species (MHC/HLA) | human(A*11) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(934-942) Integrase(219-227) DNA(4884..4910) |
Pol Epitope Map |
---|---|---|
Author Location | Integrase | |
Epitope |
KIQNFRVYY
|
Epitope Alignment
|
Epitope Name | A30-KYY9 | |
Subtype | B | |
Species (MHC/HLA) | human(A*30) | |
Immunogen | HIV-1 infection | |
Country | United States | |
Experimental methods | ||
Keywords | review, rate of progression, acute/early infection |
Streeck2010 Hendrik Streeck and Douglas F. Nixon. T Cell Immunity in Acute HIV-1 Infection. J. Infect. Dis., 202(Suppl 2):S302-8, 15 Oct 2010. PubMed ID: 20846037. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(934-942) Integrase(219-227) DNA(4884..4910) |
Pol Epitope Map |
---|---|---|
Author Location | Pol(934-942) | |
Epitope |
KIQNFRVYY
|
Epitope Alignment
|
Epitope Name | KYY9 | |
Species (MHC/HLA) | human(A*30) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(934-942) Integrase(219-227) DNA(4884..4910) |
Pol Epitope Map |
---|---|---|
Author Location | Integrase | |
Epitope |
KIQNFRVYY
|
Epitope Alignment
|
Epitope Name | KY9(Integrase) | |
Subtype | B | |
Species (MHC/HLA) | human(A30) | |
Immunogen | HIV-1 infection | |
Country | China | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | chronic infection |
Zhai2008 Song Zhai, Yan Zhuang, Yang Song, Shu Li, Dedong Huang, Wenzhen Kang, Xinhong Li, Qi Liao, Yanhou Liu, Zhongfang Zhao, Yichen Lu, and Yongtao Sun. HIV-1-Specific Cytotoxic T Lymphocyte (CTL) Responses Against Immunodominant Optimal Epitopes Slow the Progression of AIDS in China. Curr. HIV Res., 6(4):335-350, Jun 2008. PubMed ID: 18691032. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(934-942) Integrase(219-227) DNA(4884..4910) |
Pol Epitope Map |
---|---|---|
Author Location | Integrase | |
Epitope |
KIQNFRVYY
|
Epitope Alignment
|
Epitope Name | KY9 | |
Species (MHC/HLA) | human(A30) | |
Immunogen | HIV-1 infection | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Chromium-release assay, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining | |
Keywords | epitope processing, supervised treatment interruptions (STI), immunodominance |
Rodriguez2004 William R. Rodriguez, Marylyn M. Addo, Almas Rathod, Cecily A. Fitzpatrick, Xu G. Yu, Beth Perkins, Eric S. Rosenberg, Marcus Altfeld, and Bruce D. Walker. CD8+ T Lymphocyte Responses Target Functionally Important Regions of Protease and Integrase in HIV-1 Infected Subjects. J. Transl. Med., 2(1):15, 21 May 2004. PubMed ID: 15154967. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(934-942) Integrase(219-227) DNA(4884..4910) |
Pol Epitope Map |
---|---|---|
Author Location | Integrase(219-227) | |
Epitope |
KIQNFRVYY
|
Epitope Alignment
|
Epitope Name | Pol-KY9; IN-KY9 | |
Subtype | B | |
Species (MHC/HLA) | human(A*30:02) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | A*02:05, A*30:02, B*14:02, B*53:01, C*04:01, C*08:02; 00RCH28: A*02:05, A*30:02, B*14:02, B*53:01, C*04:01, C*08:02 | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Chromium-release assay | |
Keywords | novel epitope |
Sabbaj2003 Steffanie Sabbaj, Anju Bansal, G. Douglas Ritter, Christopher Perkins, Bradley H. Edwards, Ethan Gough, Jianming Tang, James J. Szinger, Bette Korber, Craig M. Wilson, Richard A. Kaslow, Mark J. Mulligan, and Paul A. Goepfert. Cross-Reactive CD8+ T Cell Epitopes Identified in US Adolescent Minorities. J. Acquir. Immune Defic. Syndr., 33(4):426-438, 1 Aug 2003. PubMed ID: 12869831. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(934-942) Integrase(219-227) DNA(4884..4910) |
Pol Epitope Map |
---|---|---|
Author Location | Integrase(219-227) | |
Epitope |
KIQNFRVYY
|
Epitope Alignment
|
Species (MHC/HLA) | human(A*30:02) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | optimal epitope, A-list |
Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(934-942) Integrase(219-227) DNA(4884..4910) |
Pol Epitope Map |
---|---|---|
Author Location | ( C consensus) | |
Epitope |
KIQNFRVYY
|
Epitope Alignment
|
Subtype | C | |
Species (MHC/HLA) | human(A*30:02) | |
Immunogen | HIV-1 infection | |
Country | South Africa | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | characterizing CD8+ T cells |
Kiepiela2004 Photini Kiepiela, Alasdair J. Leslie, Isobella Honeyborne, Danni Ramduth, Christina Thobakgale, Senica Chetty, Prinisha Rathnavalu, Corey Moore, Katja J. Pfafferott, Louise Hilton, Peter Zimbwa, Sarah Moore, Todd Allen, Christian Brander, Marylyn M. Addo, Marcus Altfeld, Ian James, Simon Mallal, Michael Bunce, Linda D. Barber, James Szinger, Cheryl Day, Paul Klenerman, James Mullins, Bette Korber, Hoosen M. Coovadia, Bruce D. Walker, and Philip J. R. Goulder. Dominant Influence of HLA-B in Mediating the Potential Co-Evolution of HIV and HLA. Nature, 432(7018):769-775, 9 Dec 2004. LA-UR 04-5920. PubMed ID: 15592417. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(934-942) Integrase(219-227) DNA(4884..4910) |
Pol Epitope Map |
---|---|---|
Author Location | Integrase(219-227) | |
Epitope |
KIQNFRVYY
|
Epitope Alignment
|
Species (MHC/HLA) | human(A*30:02) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Chromium-release assay, Cytokine production, HLA binding, Other | |
Keywords | vaccine-induced immune responses, HLA cross-presentation, HLA associated polymorphism |
Reche2006 Pedro A. Reche, Derin B. Keskin, Rebecca E. Hussey, Petronela Ancuta, Dana Gabuzda, and Ellis L. Reinherz. Elicitation from Virus-Naive Individuals of Cytotoxic T Lymphocytes Directed against Conserved HIV-1 Epitopes. Med. Immunol., 5:1, 2006. PubMed ID: 16674822. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(934-942) Integrase(219-227) DNA(4884..4910) |
Pol Epitope Map |
---|---|---|
Author Location | Integrase | |
Epitope |
KIQNFRVYY
|
Epitope Alignment
|
Epitope Name | KLY9 | |
Subtype | C | |
Species (MHC/HLA) | human(A*30:02) | |
Immunogen | HIV-1 infection | |
Country | South Africa | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Degranulation, CD107a and b cell surface mobilization, Intracellular cytokine staining, Proliferation, Tetramer binding | |
Keywords | rate of progression |
Day2007 Cheryl L. Day, Photini Kiepiela, Alasdair J. Leslie, Mary van der Stok, Kriebashne Nair, Nasreen Ismail, Isobella Honeyborne, Hayley Crawford, Hoosen M. Coovadia, Philip J. R. Goulder, Bruce D. Walker, and Paul Klenerman. Proliferative Capacity of Epitope-Specific CD8 T-cell Responses Is Inversely Related to Viral Load in Chronic Human Immunodeficiency Virus Type 1 Infection. J. Virol., 81(1):434-438, Jan 2007. PubMed ID: 17050606. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(934-942) Integrase(219-227) DNA(4884..4910) |
Pol Epitope Map |
---|---|---|
Author Location | Integrase(219-227) | |
Epitope |
KIQNFRVYY
|
Epitope Alignment
|
Epitope Name | KIY9 | |
Species (MHC/HLA) | human(A*30:02) | |
Immunogen | HIV-1 infection | |
Country | South Africa | |
Experimental methods | Intracellular cytokine staining, Proliferation, Tetramer binding | |
Keywords |
Day2006 Cheryl L. Day, Daniel E. Kaufmann, Photini Kiepiela, Julia A. Brown, Eshia S. Moodley, Sharon Reddy, Elizabeth W. Mackey, Joseph D. Miller, Alasdair J. Leslie, Chantal DePierres, Zenele Mncube, Jaikumar Duraiswamy, Baogong Zhu, Quentin Eichbaum, Marcus Altfeld, E. John Wherry, Hoosen M. Coovadia, Philip J. R. Goulder, Paul Klenerman, Rafi Ahmed, Gordon J. Freeman, and Bruce D. Walker. PD-1 Expression on HIV-Specific T Cells Is Associated with T-Cell Exhaustion and Disease Progression. Nature, 443(7109):350-354, 21 Sep 2006. PubMed ID: 16921384. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(934-942) Integrase(219-227) DNA(4884..4910) |
Pol Epitope Map |
---|---|---|
Author Location | Pol(934-942) | |
Epitope |
KIQNFRVYY
|
Epitope Alignment
|
Epitope Name | KYY9 | |
Species (MHC/HLA) | human(A*32) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(934-942) Integrase(219-227) DNA(4884..4910) |
Pol Epitope Map |
---|---|---|
Author Location | Pol | |
Epitope |
KIQNFRVYY
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human | |
Immunogen | vaccine | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | vaccine-induced immune responses |
Vaccine type | adenovirus type 5 (Ad5), DNA prime with Ad5 boost |
---|---|
Vaccine strain | B clade IIIB, B clade JRFL, B clade CAM-1 |
Vaccine component | Gag, Nef, Pol |
Li2011a Fusheng Li, Adam C. Finnefrock, Sheri A. Dubey, Bette T. M. Korber, James Szinger, Suzanne Cole, M. Juliana McElrath, John W. Shiver, Danilo R. Casimiro, Lawrence Corey, and Steven G Self. Mapping HIV-1 Vaccine Induced T-Cell Responses: Bias Towards Less-Conserved Regions and Potential Impact on Vaccine Efficacy in the Step Study. PLoS One, 6(6):e20479, 2011. PubMed ID: 21695251. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(934-942) Integrase(219-227) DNA(4884..4910) |
Pol Epitope Map |
---|---|---|
Author Location | Pol | |
Epitope |
KIQNFRVYY
|
Epitope Alignment
|
Subtype | B, CRF01_AE, D | |
Species (MHC/HLA) | human | |
Immunogen | HIV-1 infection | |
Country | Sweden | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | subtype comparisons, computational epitope prediction, vaccine antigen design |
Perez2008 Carina L. Pérez, Mette V. Larsen, Rasmus Gustafsson, Melissa M. Norström, Ann Atlas, Douglas F. Nixon, Morten Nielsen, Ole Lund, and Annika C. Karlsson. Broadly Immunogenic HLA Class I Supertype-Restricted Elite CTL Epitopes Recognized in a Diverse Population Infected with Different HIV-1 Subtypes. J. Immunol., 180(7):5092-5100, 1 Apr 2008. PubMed ID: 18354235. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(934-942) Integrase(219-227) DNA(4884..4910) |
Pol Epitope Map |
---|---|---|
Author Location | ||
Epitope |
KIQNFRVYY
|
Epitope Alignment
|
Species (MHC/HLA) | human | |
Immunogen | HIV-1 infection, vaccine | |
Patient MHC/HLA | 203-157: A*30:01, A*30:02, B*42, B*44 | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | vaccine-induced immune responses, acute/early infection |
Vaccine type | canarypox prime with gp120 boost, polyepitope |
---|---|
Vaccine strain | B clade LAI, B clade MN |
Vaccine component | Gag, gp120, gp41, Nef, Pol, Protease |
Horton2006a Helen Horton, Colin Havenar-Daughton, Deborah Lee, Erin Moore, Jianhong Cao, John McNevin, Thomas Andrus, Haiying Zhu, Abbe Rubin, Tuofu Zhu, Connie Celum, and M. Juliana McElrath. Induction of Human Immunodeficiency Virus Type 1 (HIV-1)-Specific T-Cell Responses in HIV Vaccine Trial Participants Who Subsequently Acquire HIV-1 Infection. J. Virol., 80(19):9779-9788, Oct 2006. PubMed ID: 16973582. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(934-942) Integrase(219-227) DNA(4884..4910) |
Pol Epitope Map |
---|---|---|
Author Location | ||
Epitope |
KIQNFRVYY
|
Epitope Alignment
|
Species (MHC/HLA) | human | |
Immunogen | HIV-1 infection, vaccine | |
Patient MHC/HLA | 014A-005: A*25:01, A*30:02, B*07:02, B*18:01, C*07:02, C*12:03 | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | vaccine-induced immune responses, acute/early infection |
Vaccine type | canarypox prime with gp120 boost |
---|---|
Vaccine strain | B clade LAI, B clade MN |
Vaccine component | Gag-Pol, gp120, gp41 |
Horton2006a Helen Horton, Colin Havenar-Daughton, Deborah Lee, Erin Moore, Jianhong Cao, John McNevin, Thomas Andrus, Haiying Zhu, Abbe Rubin, Tuofu Zhu, Connie Celum, and M. Juliana McElrath. Induction of Human Immunodeficiency Virus Type 1 (HIV-1)-Specific T-Cell Responses in HIV Vaccine Trial Participants Who Subsequently Acquire HIV-1 Infection. J. Virol., 80(19):9779-9788, Oct 2006. PubMed ID: 16973582. Show all entries for this paper.