HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 19 matching records:

Displaying record number 58994

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HXB2 Location Pol(934-942)
Integrase(219-227)
DNA(4884..4910)
Pol Epitope Map
Author Location Pol
Epitope KIQNFRVYY Epitope Alignment
KIQNFRVYY epitope logo
Epitope Name Pol934
Subtype A
Species (MHC/HLA) human(A*01)
Immunogen HIV-1 infection, vaccine
Patient MHC/HLA P4: A*30:02, A*68:01, B*56:01, B*58:01
Country Guinea-Bissau
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords vaccine-induced immune responses, vaccine antigen design, therapeutic vaccine, chronic infection

Vaccine Details

Vaccine type peptide
Vaccine strain A clade
Adjuvant CAF01

Notes

References

Roman2013 Victor Raúl Gómez Román, Kristoffer Jarlov Jensen, Sanne Skov Jensen, Christian Leo-Hansen, Sanne Jespersen, David da Silva Té, Candida Medina Rodrigues, Christoph Mikkel Janitzek, Lasse Vinner, Terese Lea Katzenstein, Peter Andersen, Ingrid Kromann, Lars Vibe Andreasen, Ingrid Karlsson, and Anders Fomsgaard. Therapeutic Vaccination Using Cationic Liposome-Adjuvanted HIV Type 1 Peptides Representing HLA-Supertype-Restricted Subdominant T Cell Epitopes: Safety, Immunogenicity, and Feasibility in Guinea-Bissau. AIDS Res Hum Retroviruses, 29(11):1504-1512, Nov 2013. PubMed ID: 23634822. Show all entries for this paper.


Displaying record number 61946

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HXB2 Location Pol(934-942)
Integrase(219-227)
DNA(4884..4910)
Pol Epitope Map
Author Location Pol(934-)
Epitope KIQNFRVYY Epitope Alignment
KIQNFRVYY epitope logo
Epitope Name KY9
Subtype A3, B, C, CRF02_AG
Species (MHC/HLA) human(A*03:01, A*11:01, A*29:02, A*30:01, A*30:02, A*32:01, A*80:01)
Immunogen HIV-1 infection
Patient MHC/HLA 1213: A*30:01, A*30:02, B*07:02, B*58:01
Country Denmark, Guinea-Bissau
Experimental methods HLA binding, Intracellular cytokine staining, Tetramer binding
Keywords binding affinity, vaccine antigen design

Notes

References

Karlsson2012 Ingrid Karlsson, Henrik Kløverpris, Kristoffer Jarlov Jensen, Anette Stryhn, Søren Buus, Annika Karlsson, Lasse Vinner, Philip Goulder, and Anders Fomsgaard. Identification of Conserved Subdominant HIV Type 1 CD8+ T Cell Epitopes Restricted within Common HLA Supertypes for Therapeutic HIV Type 1 Vaccines. AIDS Res. Hum. Retroviruses, 28(11):1434-1443, Nov 2012. PubMed ID: 22747336. Show all entries for this paper.


Displaying record number 58406

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HXB2 Location Pol(934-942)
Integrase(219-227)
DNA(4884..4910)
Pol Epitope Map
Author Location Pol
Epitope KIQNFRVYY Epitope Alignment
KIQNFRVYY epitope logo
Epitope Name Pol934
Subtype B, CRF02_AG
Species (MHC/HLA) human(A1)
Immunogen HIV-1 infection
Country Cote D'Ivoire, Denmark, Ghana, Guinea-Bissau, Mali, Senegal
Experimental methods Intracellular cytokine staining, Pentamer labeling
Keywords vaccine antigen design

Notes

References

Perez2008 Carina L. Pérez, Mette V. Larsen, Rasmus Gustafsson, Melissa M. Norström, Ann Atlas, Douglas F. Nixon, Morten Nielsen, Ole Lund, and Annika C. Karlsson. Broadly Immunogenic HLA Class I Supertype-Restricted Elite CTL Epitopes Recognized in a Diverse Population Infected with Different HIV-1 Subtypes. J. Immunol., 180(7):5092-5100, 1 Apr 2008. PubMed ID: 18354235. Show all entries for this paper.

Vinner2011 Lasse Vinner, Birgitta Holmgren, Kristoffer J. Jensen, Joakim Esbjornsson, Marie Borggren, Julie L. Hentze, Ingrid Karlsson, Betina S. Andresen, Gregers J. Gram, Henrik Kloverpris, Peter Aaby, Zacarias José Da Silva, Eva-Maria Fenyö, and Anders Fomsgaard. Sequence Analysis of HIV-1 Isolates from Guinea-Bissau: Selection of Vaccine Epitopes Relevant in Both West African and European Countries. APMIS, 119(8):487-497, Aug 2011. PubMed ID: 21749448. Show all entries for this paper.


Displaying record number 59915

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HXB2 Location Pol(934-942)
Integrase(219-227)
DNA(4884..4910)
Pol Epitope Map
Author Location Pol(934-942)
Epitope KIQNFRVYY Epitope Alignment
KIQNFRVYY epitope logo
Epitope Name KYY9
Species (MHC/HLA) human(A*11)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope, chronic infection

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 58555

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HXB2 Location Pol(934-942)
Integrase(219-227)
DNA(4884..4910)
Pol Epitope Map
Author Location Integrase
Epitope KIQNFRVYY Epitope Alignment
KIQNFRVYY epitope logo
Epitope Name A30-KYY9
Subtype B
Species (MHC/HLA) human(A*30)
Immunogen HIV-1 infection
Country United States
Experimental methods  
Keywords review, rate of progression, acute/early infection

Notes

References

Streeck2010 Hendrik Streeck and Douglas F. Nixon. T Cell Immunity in Acute HIV-1 Infection. J. Infect. Dis., 202(Suppl 2):S302-8, 15 Oct 2010. PubMed ID: 20846037. Show all entries for this paper.


Displaying record number 59914

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HXB2 Location Pol(934-942)
Integrase(219-227)
DNA(4884..4910)
Pol Epitope Map
Author Location Pol(934-942)
Epitope KIQNFRVYY Epitope Alignment
KIQNFRVYY epitope logo
Epitope Name KYY9
Species (MHC/HLA) human(A*30)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope, chronic infection

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 55949

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HXB2 Location Pol(934-942)
Integrase(219-227)
DNA(4884..4910)
Pol Epitope Map
Author Location Integrase
Epitope KIQNFRVYY Epitope Alignment
KIQNFRVYY epitope logo
Epitope Name KY9(Integrase)
Subtype B
Species (MHC/HLA) human(A30)
Immunogen HIV-1 infection
Country China
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords chronic infection

Notes

References

Zhai2008 Song Zhai, Yan Zhuang, Yang Song, Shu Li, Dedong Huang, Wenzhen Kang, Xinhong Li, Qi Liao, Yanhou Liu, Zhongfang Zhao, Yichen Lu, and Yongtao Sun. HIV-1-Specific Cytotoxic T Lymphocyte (CTL) Responses Against Immunodominant Optimal Epitopes Slow the Progression of AIDS in China. Curr. HIV Res., 6(4):335-350, Jun 2008. PubMed ID: 18691032. Show all entries for this paper.


Displaying record number 53138

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HXB2 Location Pol(934-942)
Integrase(219-227)
DNA(4884..4910)
Pol Epitope Map
Author Location Integrase
Epitope KIQNFRVYY Epitope Alignment
KIQNFRVYY epitope logo
Epitope Name KY9
Species (MHC/HLA) human(A30)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining
Keywords epitope processing, supervised treatment interruptions (STI), immunodominance

Notes

References

Rodriguez2004 William R. Rodriguez, Marylyn M. Addo, Almas Rathod, Cecily A. Fitzpatrick, Xu G. Yu, Beth Perkins, Eric S. Rosenberg, Marcus Altfeld, and Bruce D. Walker. CD8+ T Lymphocyte Responses Target Functionally Important Regions of Protease and Integrase in HIV-1 Infected Subjects. J. Transl. Med., 2(1):15, 21 May 2004. PubMed ID: 15154967. Show all entries for this paper.


Displaying record number 1966

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HXB2 Location Pol(934-942)
Integrase(219-227)
DNA(4884..4910)
Pol Epitope Map
Author Location Integrase(219-227)
Epitope KIQNFRVYY Epitope Alignment
KIQNFRVYY epitope logo
Epitope Name Pol-KY9; IN-KY9
Subtype B
Species (MHC/HLA) human(A*30:02)
Immunogen HIV-1 infection
Patient MHC/HLA A*02:05, A*30:02, B*14:02, B*53:01, C*04:01, C*08:02; 00RCH28: A*02:05, A*30:02, B*14:02, B*53:01, C*04:01, C*08:02
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay
Keywords novel epitope

Notes

References

Sabbaj2003 Steffanie Sabbaj, Anju Bansal, G. Douglas Ritter, Christopher Perkins, Bradley H. Edwards, Ethan Gough, Jianming Tang, James J. Szinger, Bette Korber, Craig M. Wilson, Richard A. Kaslow, Mark J. Mulligan, and Paul A. Goepfert. Cross-Reactive CD8+ T Cell Epitopes Identified in US Adolescent Minorities. J. Acquir. Immune Defic. Syndr., 33(4):426-438, 1 Aug 2003. PubMed ID: 12869831. Show all entries for this paper.


Displaying record number 52539

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HXB2 Location Pol(934-942)
Integrase(219-227)
DNA(4884..4910)
Pol Epitope Map
Author Location Integrase(219-227)
Epitope KIQNFRVYY Epitope Alignment
KIQNFRVYY epitope logo
Species (MHC/HLA) human(A*30:02)
Immunogen HIV-1 infection
Experimental methods  
Keywords optimal epitope, A-list

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 53284

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HXB2 Location Pol(934-942)
Integrase(219-227)
DNA(4884..4910)
Pol Epitope Map
Author Location ( C consensus)
Epitope KIQNFRVYY Epitope Alignment
KIQNFRVYY epitope logo
Subtype C
Species (MHC/HLA) human(A*30:02)
Immunogen HIV-1 infection
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords characterizing CD8+ T cells

Notes

References

Kiepiela2004 Photini Kiepiela, Alasdair J. Leslie, Isobella Honeyborne, Danni Ramduth, Christina Thobakgale, Senica Chetty, Prinisha Rathnavalu, Corey Moore, Katja J. Pfafferott, Louise Hilton, Peter Zimbwa, Sarah Moore, Todd Allen, Christian Brander, Marylyn M. Addo, Marcus Altfeld, Ian James, Simon Mallal, Michael Bunce, Linda D. Barber, James Szinger, Cheryl Day, Paul Klenerman, James Mullins, Bette Korber, Hoosen M. Coovadia, Bruce D. Walker, and Philip J. R. Goulder. Dominant Influence of HLA-B in Mediating the Potential Co-Evolution of HIV and HLA. Nature, 432(7018):769-775, 9 Dec 2004. LA-UR 04-5920. PubMed ID: 15592417. Show all entries for this paper.


Displaying record number 54331

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HXB2 Location Pol(934-942)
Integrase(219-227)
DNA(4884..4910)
Pol Epitope Map
Author Location Integrase(219-227)
Epitope KIQNFRVYY Epitope Alignment
KIQNFRVYY epitope logo
Species (MHC/HLA) human(A*30:02)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, Cytokine production, HLA binding, Other
Keywords vaccine-induced immune responses, HLA cross-presentation, HLA associated polymorphism

Notes

References

Reche2006 Pedro A. Reche, Derin B. Keskin, Rebecca E. Hussey, Petronela Ancuta, Dana Gabuzda, and Ellis L. Reinherz. Elicitation from Virus-Naive Individuals of Cytotoxic T Lymphocytes Directed against Conserved HIV-1 Epitopes. Med. Immunol., 5:1, 2006. PubMed ID: 16674822. Show all entries for this paper.


Displaying record number 54605

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HXB2 Location Pol(934-942)
Integrase(219-227)
DNA(4884..4910)
Pol Epitope Map
Author Location Integrase
Epitope KIQNFRVYY Epitope Alignment
KIQNFRVYY epitope logo
Epitope Name KLY9
Subtype C
Species (MHC/HLA) human(A*30:02)
Immunogen HIV-1 infection
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ, Degranulation, CD107a and b cell surface mobilization, Intracellular cytokine staining, Proliferation, Tetramer binding
Keywords rate of progression

Notes

References

Day2007 Cheryl L. Day, Photini Kiepiela, Alasdair J. Leslie, Mary van der Stok, Kriebashne Nair, Nasreen Ismail, Isobella Honeyborne, Hayley Crawford, Hoosen M. Coovadia, Philip J. R. Goulder, Bruce D. Walker, and Paul Klenerman. Proliferative Capacity of Epitope-Specific CD8 T-cell Responses Is Inversely Related to Viral Load in Chronic Human Immunodeficiency Virus Type 1 Infection. J. Virol., 81(1):434-438, Jan 2007. PubMed ID: 17050606. Show all entries for this paper.


Displaying record number 55169

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HXB2 Location Pol(934-942)
Integrase(219-227)
DNA(4884..4910)
Pol Epitope Map
Author Location Integrase(219-227)
Epitope KIQNFRVYY Epitope Alignment
KIQNFRVYY epitope logo
Epitope Name KIY9
Species (MHC/HLA) human(A*30:02)
Immunogen HIV-1 infection
Country South Africa
Experimental methods Intracellular cytokine staining, Proliferation, Tetramer binding
Keywords  

Notes

References

Day2006 Cheryl L. Day, Daniel E. Kaufmann, Photini Kiepiela, Julia A. Brown, Eshia S. Moodley, Sharon Reddy, Elizabeth W. Mackey, Joseph D. Miller, Alasdair J. Leslie, Chantal DePierres, Zenele Mncube, Jaikumar Duraiswamy, Baogong Zhu, Quentin Eichbaum, Marcus Altfeld, E. John Wherry, Hoosen M. Coovadia, Philip J. R. Goulder, Paul Klenerman, Rafi Ahmed, Gordon J. Freeman, and Bruce D. Walker. PD-1 Expression on HIV-Specific T Cells Is Associated with T-Cell Exhaustion and Disease Progression. Nature, 443(7109):350-354, 21 Sep 2006. PubMed ID: 16921384. Show all entries for this paper.


Displaying record number 59913

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HXB2 Location Pol(934-942)
Integrase(219-227)
DNA(4884..4910)
Pol Epitope Map
Author Location Pol(934-942)
Epitope KIQNFRVYY Epitope Alignment
KIQNFRVYY epitope logo
Epitope Name KYY9
Species (MHC/HLA) human(A*32)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope, chronic infection

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 58068

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HXB2 Location Pol(934-942)
Integrase(219-227)
DNA(4884..4910)
Pol Epitope Map
Author Location Pol
Epitope KIQNFRVYY Epitope Alignment
KIQNFRVYY epitope logo
Subtype B
Species (MHC/HLA) human
Immunogen vaccine
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords vaccine-induced immune responses

Vaccine Details

Vaccine type adenovirus type 5 (Ad5), DNA prime with Ad5 boost
Vaccine strain B clade IIIB, B clade JRFL, B clade CAM-1
Vaccine component Gag, Nef, Pol

Notes

References

Li2011a Fusheng Li, Adam C. Finnefrock, Sheri A. Dubey, Bette T. M. Korber, James Szinger, Suzanne Cole, M. Juliana McElrath, John W. Shiver, Danilo R. Casimiro, Lawrence Corey, and Steven G Self. Mapping HIV-1 Vaccine Induced T-Cell Responses: Bias Towards Less-Conserved Regions and Potential Impact on Vaccine Efficacy in the Step Study. PLoS One, 6(6):e20479, 2011. PubMed ID: 21695251. Show all entries for this paper.


Displaying record number 55465

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HXB2 Location Pol(934-942)
Integrase(219-227)
DNA(4884..4910)
Pol Epitope Map
Author Location Pol
Epitope KIQNFRVYY Epitope Alignment
KIQNFRVYY epitope logo
Subtype B, CRF01_AE, D
Species (MHC/HLA) human
Immunogen HIV-1 infection
Country Sweden
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords subtype comparisons, computational epitope prediction, vaccine antigen design

Notes

References

Perez2008 Carina L. Pérez, Mette V. Larsen, Rasmus Gustafsson, Melissa M. Norström, Ann Atlas, Douglas F. Nixon, Morten Nielsen, Ole Lund, and Annika C. Karlsson. Broadly Immunogenic HLA Class I Supertype-Restricted Elite CTL Epitopes Recognized in a Diverse Population Infected with Different HIV-1 Subtypes. J. Immunol., 180(7):5092-5100, 1 Apr 2008. PubMed ID: 18354235. Show all entries for this paper.


Displaying record number 54954

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HXB2 Location Pol(934-942)
Integrase(219-227)
DNA(4884..4910)
Pol Epitope Map
Author Location  
Epitope KIQNFRVYY Epitope Alignment
KIQNFRVYY epitope logo
Species (MHC/HLA) human
Immunogen HIV-1 infection, vaccine
Patient MHC/HLA 203-157: A*30:01, A*30:02, B*42, B*44
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords vaccine-induced immune responses, acute/early infection

Vaccine Details

Vaccine type canarypox prime with gp120 boost, polyepitope
Vaccine strain B clade LAI, B clade MN
Vaccine component Gag, gp120, gp41, Nef, Pol, Protease

Notes

References

Horton2006a Helen Horton, Colin Havenar-Daughton, Deborah Lee, Erin Moore, Jianhong Cao, John McNevin, Thomas Andrus, Haiying Zhu, Abbe Rubin, Tuofu Zhu, Connie Celum, and M. Juliana McElrath. Induction of Human Immunodeficiency Virus Type 1 (HIV-1)-Specific T-Cell Responses in HIV Vaccine Trial Participants Who Subsequently Acquire HIV-1 Infection. J. Virol., 80(19):9779-9788, Oct 2006. PubMed ID: 16973582. Show all entries for this paper.


Displaying record number 54927

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HXB2 Location Pol(934-942)
Integrase(219-227)
DNA(4884..4910)
Pol Epitope Map
Author Location  
Epitope KIQNFRVYY Epitope Alignment
KIQNFRVYY epitope logo
Species (MHC/HLA) human
Immunogen HIV-1 infection, vaccine
Patient MHC/HLA 014A-005: A*25:01, A*30:02, B*07:02, B*18:01, C*07:02, C*12:03
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords vaccine-induced immune responses, acute/early infection

Vaccine Details

Vaccine type canarypox prime with gp120 boost
Vaccine strain B clade LAI, B clade MN
Vaccine component Gag-Pol, gp120, gp41

Notes

References

Horton2006a Helen Horton, Colin Havenar-Daughton, Deborah Lee, Erin Moore, Jianhong Cao, John McNevin, Thomas Andrus, Haiying Zhu, Abbe Rubin, Tuofu Zhu, Connie Celum, and M. Juliana McElrath. Induction of Human Immunodeficiency Virus Type 1 (HIV-1)-Specific T-Cell Responses in HIV Vaccine Trial Participants Who Subsequently Acquire HIV-1 Infection. J. Virol., 80(19):9779-9788, Oct 2006. PubMed ID: 16973582. Show all entries for this paper.


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