Search CTL/CD8+ T-Cell Epitope Database

Found 3 matching records:

Displaying record number 61764

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HXB2 Location	Pol(981-988) Integrase(266-273) DNA(5025..5048)	Pol Epitope Map
Author Location	Integrase(265-273)
Epitope	KIIRDYGK	Epitope Alignment
Epitope Name	KK8
Species (MHC/HLA)	human(B*08:01)
Immunogen
Experimental methods
Keywords	optimal epitope, A-list

Notes

• C. Brander notes this as a B*0801-restricted Int epitope (Borthwick2017).

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.

Displaying record number 61847

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HXB2 Location	Pol(981-988) Integrase(266-273) DNA(5025..5048)	Pol Epitope Map
Author Location
Epitope	KIIRDYGK	Epitope Alignment
Epitope Name	KK8
Species (MHC/HLA)	human(B*08:01)
Immunogen	HIV-1 infection, vaccine
Patient MHC/HLA	VID413: A*01:01, A*03:01, B*08:01, B*44:02, C*05:01, C*07:01, DQB1*02, DQB1*03:01, DRB1*03:01, DRB1*11:01, DRB3
Country	United Kingdom
Experimental methods	Intracellular cytokine staining, Other
Keywords	vaccine-induced immune responses, novel epitope

Notes

• Since CTL response in natural HIV-1 infections is mostly against variable but immunodominant epitopes, lymphocytes from 12 vaccine(HIVconsv)-exposed subjects of the HIV-CORE 002 study were used to determine and define 14 less variable but typically subdominant, optimal novel epitopes.
• Epitope KIIRDYGK (KK8) is within peptide VVPRRKAKIIRDYGK (HC176). KK8 is an HLA-B*0801-restricted novel epitope which is a candidate for the Los Alamos Immunology database A-list.

References

Borthwick2017 Nicola Borthwick, Zhansong Lin, Tomohiro Akahoshi, Anuska Llano, Sandra Silva-Arrieta, Tina Ahmed, Lucy Dorrell, Christian Brander, Hayato Murakoshi, Masafumi Takiguchi, and Tomáš Hanke. Novel, In-Natural-Infection Subdominant HIV-1 CD8+ T-Cell Epitopes Revealed in Human Recipients of Conserved-Region T-Cell Vaccines. PLoS One, 12(4):1-19, 2017. PubMed ID: 28448594. Show all entries for this paper.

Displaying record number 55251

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HXB2 Location	Pol(981-988) Integrase(266-273) DNA(5025..5048)	Pol Epitope Map
Author Location	Integrase(266-272)
Epitope	KIIRDYGK	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining, Other
Keywords	assay or method development, optimal epitope

Notes

• HLA-A11-restricted CTL epitopes in 2 male Han Chinese subjects (one ART naive and one receiving HAART) were determined. A novel epitope was discovered and 5 other putative epitopes confirmed using 425 overlapping peptides spanning the entire HIV-1 clade B proteome. By employing intracellular cytokine staining, the authors developed a new method of mapping optimal epitopes and defining their HLA restriction efficiently. In spite of its being the most common HLA type in China, A*11-restricted epitopes were recognized less frequently than other epitopes, and A*11-restricted responses formed a mean of only 13% of the responses against HIV.
• This epitope, KIIRDYGK, of unknown HLA restriction, was detected within overlapping peptides KVVPRRKAKIIRDYGKQM and KIIRDYGKQMAGDDCVA.

References

Wang2007 Shaoyang Wang, Yongtao Sun, Song Zhai, Yan Zhuang, Shuguang Zhao, Whenzhen Kang, Xinhong Li, Dedong Huang, Xu G. Yu, Bruce D. Walker, and Marcus A. Altfeld. Identification of HLA-A11-Restricted HIV-1-Specific Cytotoxic T-Lymphocyte Epitopes in China. Curr. HIV Res., 5(1):119-128, Jan 2007. PubMed ID: 17266563. Show all entries for this paper.