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Displaying record number 1630

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HXB2 Location	Pol(356-365) RT(201-210) DNA(3150..3179)	Pol Epitope Map
Author Location	Pol
Epitope	KIEELRQHLL	Epitope Alignment
Species (MHC/HLA)	human(B58)
Immunogen
Experimental methods
Keywords

Notes

• The program Epimatrix was used in conjunction with the program Conservatrix to identify conserved regions of HIV that might serve as epitopes.
• A subset of the potential epitopes was identified that could bind to the appropriate HLA-allele, and 15 predicted B7 superfamily (HLA B7, B8, and B58) epitopes could stimulate IFNγ production in an ELISPOT assay.
• KIEELRQHLL was newly identified as a HLA-B58 epitope in this study, it had been previously shown to be presented by HLA-A2 and Bw60.
• KIEELRQHLL did not bind detectably to B7.

References

DeGroot2001 A. S. De Groot, A. Bosma, N. Chinai, J. Frost, B. M. Jesdale, M. A. Gonzalez, W. Martin, and C. Saint-Aubin. From genome to vaccine: in silico predictions, ex vivo verification. Vaccine, 19(31):4385-95, 14 Aug 2001. PubMed ID: 11483263. Show all entries for this paper.