HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 13 matching records:

Displaying record number 59906

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HXB2 Location Gag(481-489)
p2p7p1p6(118-126)
DNA(2230..2256)
Gag Epitope Map
Author Location Gag(481-489)
Epitope KELYPLTSL Epitope Alignment
KELYPLTSL epitope logo
Epitope Name KSL9
Species (MHC/HLA) human(B*35:02, B*35:03, B*53:01)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope, chronic infection

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 53845

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HXB2 Location Gag(481-489)
p2p7p1p6(118-126)
DNA(2230..2256)
Gag Epitope Map
Author Location Gag p6(481-489)
Epitope KELYPLTSL Epitope Alignment
KELYPLTSL epitope logo
Show epitope variants
Epitope Name KL9
Species (MHC/HLA) human(B*40)
Immunogen HIV-1 infection
Patient MHC/HLA M-1005: A*02, A*32, B*07, B*40, C*03, C*07; P-1026: A*24, A*32, B*07, B*18, C*07
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords responses in children, mother-to-infant transmission, escape, acute/early infection, viral fitness and reversion

Notes

References

Sanchez-Merino2005 Victor Sanchez-Merino, Siwei Nie, and Katherine Luzuriaga. HIV-1-Specific CD8+ T Cell Responses and Viral Evolution in Women and Infants. J. Immunol., 175(10):6976-6986, 15 Nov 2005. PubMed ID: 16272358. Show all entries for this paper.


Displaying record number 53873

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HXB2 Location Gag(481-489)
p2p7p1p6(118-126)
DNA(2230..2256)
Gag Epitope Map
Author Location Gag(481-489)
Epitope KELYPLTSL Epitope Alignment
KELYPLTSL epitope logo
Show epitope variants
Subtype B
Species (MHC/HLA) human(B*40)
Immunogen HIV-1 infection
Patient MHC/HLA A*03, A*24, B*35, B*40
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords acute/early infection, variant cross-reactivity, superinfection

Notes

References

Yang2005 Otto O. Yang, Eric S. Daar, Beth D. Jamieson, Arumugam Balamurugan, Davey M. Smith, Jacqueline A. Pitt, Christos J. Petropoulos, Douglas D. Richman, Susan J. Little, and Andrew J. Leigh Brown. Human Immunodeficiency Virus Type 1 Clade B Superinfection: Evidence for Differential Immune Containment of Distinct Clade B Strains. J. Virol., 79(2):860-868, Jan 2005. PubMed ID: 15613314. Show all entries for this paper.


Displaying record number 59905

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HXB2 Location Gag(481-489)
p2p7p1p6(118-126)
DNA(2230..2256)
Gag Epitope Map
Author Location Gag(481-489)
Epitope KELYPLTSL Epitope Alignment
KELYPLTSL epitope logo
Epitope Name KSL9
Species (MHC/HLA) human(B*40)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope, chronic infection

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 56381

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HXB2 Location Gag(481-489)
p2p7p1p6(118-126)
DNA(2230..2256)
Gag Epitope Map
Author Location p2p7p1p6(481-489)
Epitope KELYPLTSL Epitope Alignment
KELYPLTSL epitope logo
Epitope Name KL9
Subtype B
Species (MHC/HLA) human(B*40)
Immunogen HIV-1 infection
Country Australia, Canada, Germany, United States
Experimental methods  
Keywords HLA associated polymorphism

Notes

References

Brumme2008 Zabrina L. Brumme, Chanson J. Brumme, Jonathan Carlson, Hendrik Streeck, Mina John, Quentin Eichbaum, Brian L Block, Brett Baker, Carl Kadie, Martin Markowitz, Heiko Jessen, Anthony D. Kelleher, Eric Rosenberg, John Kaldor, Yuko Yuki, Mary Carrington, Todd M. Allen, Simon Mallal, Marcus Altfeld, David Heckerman, and Bruce D. Walker. Marked Epitope- and Allele-Specific Differences in Rates of Mutation in Human Immunodeficiency Type 1 (HIV-1) Gag, Pol, and Nef Cytotoxic T-Lymphocyte Epitopes in Acute/Early HIV-1 Infection. J. Virol., 82(18):9216-9227, Sep 2008. PubMed ID: 18614631. Show all entries for this paper.


Displaying record number 54362

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HXB2 Location Gag(481-489)
p2p7p1p6(118-126)
DNA(2230..2256)
Gag Epitope Map
Author Location p15
Epitope KELYPLTSL Epitope Alignment
KELYPLTSL epitope logo
Epitope Name B40-KL9(p15)
Species (MHC/HLA) human(B40)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, immunodominance, early-expressed proteins

Notes

References

Altfeld2006 Marcus Altfeld, Elizabeth T. Kalife, Ying Qi, Hendrik Streeck, Mathias Lichterfeld, Mary N. Johnston, Nicole Burgett, Martha E. Swartz, Amy Yang, Galit Alter, Xu G. Yu, Angela Meier, Juergen K. Rockstroh, Todd M. Allen, Heiko Jessen, Eric S. Rosenberg, Mary Carrington, and Bruce D. Walker. HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8+ T Cell Response against HIV-1. PLoS Med., 3(10):e403, Oct 2006. PubMed ID: 17076553. Show all entries for this paper.


Displaying record number 1226

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HXB2 Location Gag(481-489)
p2p7p1p6(118-126)
DNA(2230..2256)
Gag Epitope Map
Author Location p2p7p1p6(118-126)
Epitope KELYPLTSL Epitope Alignment
KELYPLTSL epitope logo
Species (MHC/HLA) human(B*40:01)
Immunogen  
Experimental methods  
Keywords optimal epitope, A-list

Notes

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 54281

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HXB2 Location Gag(481-489)
p2p7p1p6(118-126)
DNA(2230..2256)
Gag Epitope Map
Author Location p6(2233-)
Epitope KELYPLTSL Epitope Alignment
KELYPLTSL epitope logo
Species (MHC/HLA) human(B*40:01)
Immunogen HIV-1 infection
Country Australia
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords escape, HLA associated polymorphism

Notes

References

Bhattacharya2007 Tanmoy Bhattacharya, Marcus Daniels, David Heckerman, Brian Foley, Nicole Frahm, Carl Kadie, Jonathan Carlson, Karina Yusim, Ben McMahon, Brian Gaschen, Simon Mallal, James I. Mullins, David C. Nickle, Joshua Herbeck, Christine Rousseau, Gerald H. Learn, Toshiyuki Miura, Christian Brander, Bruce Walker, and Bette Korber. Founder Effects in the Assessment of HIV Polymorphisms and HLA Allele Associations. Science, 315(5818):1583-1586, 16 Mar 2007. PubMed ID: 17363674. Show all entries for this paper.


Displaying record number 59908

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HXB2 Location Gag(481-489)
p2p7p1p6(118-126)
DNA(2230..2256)
Gag Epitope Map
Author Location Gag(481-489)
Epitope KELYPLTSL Epitope Alignment
KELYPLTSL epitope logo
Epitope Name KSL9
Species (MHC/HLA) human(B*55)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope, chronic infection

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 52266

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HXB2 Location Gag(481-489)
p2p7p1p6(118-126)
DNA(2230..2256)
Gag Epitope Map
Author Location p15(118-126 SF2)
Epitope KELYPLTSL Epitope Alignment
KELYPLTSL epitope logo
Epitope Name p15-24
Subtype B
Species (MHC/HLA) human(B60)
Immunogen HIV-1 infection
Experimental methods  
Keywords immunodominance, HLA cross-presentation

Notes

References

Yu2002a Xu G. Yu, Hong Shang, Marylyn M. Addo, Robert L. Eldridge, Mary N. Phillips, Margaret E. Feeney, Daryld Strick, Christian Brander, Philip J. R. Goulder, Eric S. Rosenberg, Bruce D. Walker, Marcus Altfeld, and HIV Study Collaboration. Important Contribution of p15 Gag-Specific Responses to the Total Gag-Specific CTL Responses. AIDS, 16(3):321-328, 15 Feb 2002. PubMed ID: 11834942. Show all entries for this paper.


Displaying record number 59907

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HXB2 Location Gag(481-489)
p2p7p1p6(118-126)
DNA(2230..2256)
Gag Epitope Map
Author Location Gag(481-489)
Epitope KELYPLTSL Epitope Alignment
KELYPLTSL epitope logo
Epitope Name KSL9
Species (MHC/HLA) human(C*16)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope, chronic infection

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 62833

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HXB2 Location Gag(481-489)
p2p7p1p6(118-126)
DNA(2230..2256)
Gag Epitope Map
Author Location p2p7p1p6(481-489)
Epitope KELYPLTSL Epitope Alignment
KELYPLTSL epitope logo
Subtype B
Species (MHC/HLA) human
Immunogen engineered
Experimental methods Other, Relative replication capacity assay
Keywords assay or method development, protective allele

Notes

References

Du2017 Yushen Du, Tian-Hao Zhang, Lei Dai, Xiaojuan Zheng, Aleksandr M. Gorin, John Oishi, Ting-Ting Wu, Janice M. Yoshizawa, Xinmin Li, Otto O. Yang, Otoniel Martinez-Maza, Roger Detels, and Ren Sun. Effects of Mutations on Replicative Fitness and Major Histocompatibility Complex Class I Binding Affinity Are Among the Determinants Underlying Cytotoxic-T-Lymphocyte Escape of HIV-1 Gag Epitopes. mBio, 8(6), 28 Nov 2017. PubMed ID: 29184023. Show all entries for this paper.


Displaying record number 56034

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HXB2 Location Gag(481-489)
p2p7p1p6(118-126)
DNA(2230..2256)
Gag Epitope Map
Author Location p2p7p1p6
Epitope KELYPLTSL Epitope Alignment
KELYPLTSL epitope logo
Show epitope variants
Epitope Name KL9(p2p7p1p6)
Subtype B
Species (MHC/HLA) human
Immunogen HIV-1 infection
Country China
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords variant cross-reactivity, chronic infection

Notes

References

Zhai2008 Song Zhai, Yan Zhuang, Yang Song, Shu Li, Dedong Huang, Wenzhen Kang, Xinhong Li, Qi Liao, Yanhou Liu, Zhongfang Zhao, Yichen Lu, and Yongtao Sun. HIV-1-Specific Cytotoxic T Lymphocyte (CTL) Responses Against Immunodominant Optimal Epitopes Slow the Progression of AIDS in China. Curr. HIV Res., 6(4):335-350, Jun 2008. PubMed ID: 18691032. Show all entries for this paper.


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