HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 7 matching records:

Displaying record number 58377

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HXB2 Location Gag(481-489)
p2p7p1p6(118-126)
DNA(2230..2256)
Gag Epitope Map
Author Location Gag(481-498)
Epitope KELYPLASL Epitope Alignment
KELYPLASL epitope logo
Subtype B
Species (MHC/HLA) human(A*02:01)
Immunogen HIV-1 infection
Patient MHC/HLA CH040: A*02:01, A*31:01, B*40:01, B*44:02, C*03:02, C*05:01
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining
Keywords dynamics, escape, acute/early infection, autologous responses, characterizing CD8+ T cells

Notes

References

Ferrari2011 Guido Ferrari, Bette Korber, Nilu Goonetilleke, Michael K. P. Liu, Emma L. Turnbull, Jesus F. Salazar-Gonzalez, Natalie Hawkins, Steve Self, Sydeaka Watson, Michael R. Betts, Cynthia Gay, Kara McGhee, Pierre Pellegrino, Ian Williams, Georgia D. Tomaras, Barton F. Haynes, Clive M. Gray, Persephone Borrow, Mario Roederer, Andrew J. McMichael, and Kent J. Weinhold. Relationship between Functional Profile of HIV-1 Specific CD8 T Cells and Epitope Variability with the Selection of Escape Mutants in Acute HIV-1 Infection. PLoS Pathog., 7(2):e1001273, 2011. PubMed ID: 21347345. Show all entries for this paper.


Displaying record number 60965

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HXB2 Location Gag(481-489)
p2p7p1p6(118-126)
DNA(2230..2256)
Gag Epitope Map
Author Location p6(33-41)
Epitope KELYPLASL Epitope Alignment
KELYPLASL epitope logo
Subtype B
Species (MHC/HLA) human(B*40)
Immunogen HIV-1 infection
Patient MHC/HLA 98621: A*02:01:01G, B*40:01:01G, B*44:02:01G, C*03:04:01G, C*05:01; 51729: A*24:02, A*24:02, B*35:05, B*40:01, C*03:04, C*04:01
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords acute/early infection

Notes

References

Kunwar2013 Pratima Kunwar, Natalie Hawkins, Warren L. Dinges, Yi Liu, Erin E. Gabriel, David A. Swan, Claire E. Stevens, Janine Maenza, Ann C. Collier, James I. Mullins, Tomer Hertz, Xuesong Yu, and Helen Horton. Superior Control of HIV-1 Replication by CD8+ T Cells Targeting Conserved Epitopes: Implications for HIV Vaccine Design. PLoS One, 8(5):e64405, 2013. PubMed ID: 23741326. Show all entries for this paper.


Displaying record number 57383

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HXB2 Location Gag(481-489)
p2p7p1p6(118-126)
DNA(2230..2256)
Gag Epitope Map
Author Location Gag(481-489)
Epitope KELYPLASL Epitope Alignment
KELYPLASL epitope logo
Epitope Name KL9
Subtype B
Species (MHC/HLA) human(B*40)
Immunogen in vitro stimulation or selection, HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Other
Keywords TCR usage, assay or method development, chronic infection

Notes

References

Balamurugan2010 Arumugam Balamurugan, Hwee L. Ng, and Otto O. Yang. Rapid T Cell Receptor Delineation Reveals Clonal Expansion Limitation of the Magnitude of the HIV-1-Specific CD8+ T Cell Response. J. Immunol., 185(10):5935-5942, 15 Nov 2010. PubMed ID: 20944001. Show all entries for this paper.


Displaying record number 62538

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HXB2 Location Gag(481-489)
p2p7p1p6(118-126)
DNA(2230..2256)
Gag Epitope Map
Author Location Gag(481-489)
Epitope KELYPLASL Epitope Alignment
KELYPLASL epitope logo
Epitope Name KL9-G
Subtype B
Species (MHC/HLA) human(B*40)
Immunogen HIV-1 infection
Patient MHC/HLA S00016: A*03, A*32, B*18, B*40, C*02, C*07
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Other
Keywords dynamics, chronic infection

Notes

References

Balamurugan2017 Arumugam Balamurugan, Deon Claiborne, Hwee L. Ng, and Otto O. Yang. HIV-1 Epitope Variability Is Associated with T Cell Receptor Repertoire Instability and Breadth. J. Virol., 91(16), 15 Aug 2017. PubMed ID: 28592539. Show all entries for this paper.


Displaying record number 61511

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HXB2 Location Gag(481-489)
p2p7p1p6(118-126)
DNA(2230..2256)
Gag Epitope Map
Author Location Gag(481-489)
Epitope KELYPLASL Epitope Alignment
KELYPLASL epitope logo
Epitope Name GagKL9
Subtype B
Species (MHC/HLA) human(B*40:02)
Immunogen HIV-1 infection
Country Japan
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining, Other
Keywords optimal epitope, chronic infection

Notes

References

Murakoshi2015 Hayato Murakoshi, Tomohiro Akahoshi, Madoka Koyanagi, Takayuki Chikata, Takuya Naruto, Rie Maruyama, Yoshiko Tamura, Naoki Ishizuka, Hiroyuki Gatanaga, Shinichi Oka, and Masafumi Takiguchi. Clinical Control of HIV-1 by Cytotoxic T Cells Specific for Multiple Conserved Epitopes. J. Virol., 89(10):5330-5339, May 2015. PubMed ID: 25741000. Show all entries for this paper.


Displaying record number 61054

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HXB2 Location Gag(481-489)
p2p7p1p6(118-126)
DNA(2230..2256)
Gag Epitope Map
Author Location p6(33-41)
Epitope KELYPLASL Epitope Alignment
KELYPLASL epitope logo
Subtype B
Species (MHC/HLA) human
Immunogen HIV-1 infection
Patient MHC/HLA CH040: A*02:01, A*31:01, B*40:01, B*44:02, C*03:02, C*05:01
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Other
Keywords computational epitope prediction, escape, acute/early infection, mutation acquisition

Notes

References

Barton2016 John P. Barton, Nilu Goonetilleke, Thomas C. Butler, Bruce D. Walker, Andrew J. McMichael, and Arup K. Chakraborty. Relative Rate and Location of Intra-Host HIV Evolution to Evade Cellular Immunity Are Predictable. Nat. Commun., 7:11660, 23 May 2016. PubMed ID: 27212475. Show all entries for this paper.


Displaying record number 58024

Download this epitope record as JSON.

HXB2 Location Gag(481-489)
p2p7p1p6(118-126)
DNA(2230..2256)
Gag Epitope Map
Author Location Gag
Epitope KELYPLASL Epitope Alignment
KELYPLASL epitope logo
Subtype B
Species (MHC/HLA) human
Immunogen vaccine
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords vaccine-induced immune responses

Vaccine Details

Vaccine type adenovirus type 5 (Ad5), DNA prime with Ad5 boost
Vaccine strain B clade IIIB, B clade JRFL, B clade CAM-1
Vaccine component Gag, Nef, Pol

Notes

References

Li2011a Fusheng Li, Adam C. Finnefrock, Sheri A. Dubey, Bette T. M. Korber, James Szinger, Suzanne Cole, M. Juliana McElrath, John W. Shiver, Danilo R. Casimiro, Lawrence Corey, and Steven G Self. Mapping HIV-1 Vaccine Induced T-Cell Responses: Bias Towards Less-Conserved Regions and Potential Impact on Vaccine Efficacy in the Step Study. PLoS One, 6(6):e20479, 2011. PubMed ID: 21695251. Show all entries for this paper.


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