HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 36 matching records:

Displaying record number 57559

HXB2 Location Nef(92-100)
DNA(9070..9096)
Nef Epitope Map
Author Location  
Epitope KEKGGLEGL Epitope Alignment
KEKGGLEGL epitope logo
Subtype B
Species (MHC/HLA) human(A11)
Immunogen HIV-1 infection
Country United Kingdom
Experimental methods CD8 T-cell Elispot - IFNγ, Tetramer binding
Keywords acute/early infection, assay or method development

Notes

References

Turnbull2009 Emma L. Turnbull, MaiLee Wong, Shuyi Wang, Xiping Wei, Nicola A. Jones, Karen E. Conrod, Diana Aldam, Jo Turner, Pierre Pellegrino, Brandon F. Keele, Ian Williams, George M. Shaw, and Persephone Borrow. Kinetics of Expansion of Epitope-Specific T Cell Responses During primary HIV-1 Infection. J. Immunol., 182(11):7131-7145, 1 Jun 2009. PubMed ID: 19454710. Show all entries for this paper.


Displaying record number 59904

HXB2 Location Nef(92-100)
DNA(9070..9096)
Nef Epitope Map
Author Location Nef(92-100)
Epitope KEKGGLEGL Epitope Alignment
KEKGGLEGL epitope logo
Epitope Name KL9
Species (MHC/HLA) human(B*3502, B*3503, B*5301)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 56035

HXB2 Location Nef(92-100)
DNA(9070..9096)
Nef Epitope Map
Author Location Nef
Epitope KEKGGLEGL Epitope Alignment
KEKGGLEGL epitope logo
Epitope Name KL9(Nef)
Subtype B
Species (MHC/HLA) human(B40)
Immunogen HIV-1 infection
Country China
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords  

Notes

References

Zhai2008 Song Zhai, Yan Zhuang, Yang Song, Shu Li, Dedong Huang, Wenzhen Kang, Xinhong Li, Qi Liao, Yanhou Liu, Zhongfang Zhao, Yichen Lu, and Yongtao Sun. HIV-1-Specific Cytotoxic T Lymphocyte (CTL) Responses Against Immunodominant Optimal Epitopes Slow the Progression of AIDS in China. Curr. HIV Res., 6(4):335-350, Jun 2008. PubMed ID: 18691032. Show all entries for this paper.


Displaying record number 55512

HXB2 Location Nef(92-100)
DNA(9070..9096)
Nef Epitope Map
Author Location Nef
Epitope KEKGGLEGL Epitope Alignment
KEKGGLEGL epitope logo
Epitope Name KL9
Subtype B
Species (MHC/HLA) human(B40)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Tetramer binding
Keywords characterizing CD8+ T cells

Notes

References

Streeck2008 Hendrik Streeck, Zabrina L. Brumme, Michael Anastario, Kristin W. Cohen, Jonathan S. Jolin, Angela Meier, Chanson J. Brumme, Eric S. Rosenberg, Galit Alter, Todd M. Allen, Bruce D. Walker, and Marcus Altfeld. Antigen Load and Viral Sequence Diversification Determine the Functional Profile of HIV-1-Specific CD8+ T Cells. PLoS Med, 5(5):e100, 6 May 2008. PubMed ID: 18462013. Show all entries for this paper.


Displaying record number 55088

HXB2 Location Nef(92-100)
DNA(9070..9096)
Nef Epitope Map
Author Location Nef
Epitope KEKGGLEGL Epitope Alignment
KEKGGLEGL epitope logo
Epitope Name KL-9
Species (MHC/HLA) human(B40)
Immunogen HIV-1 infection
Experimental methods  
Keywords escape, TCR usage, mutation acquisition

Notes

References

Yu2007 Xu G. Yu, Mathias Lichterfeld, Katie L. Williams, Javier Martinez-Picado, and Bruce D. Walker. Random T-Cell Receptor Recruitment in Human Immunodeficiency Virus Type 1 (HIV-1)-Specific CD8+ T Cells from Genetically Identical Twins Infected with the Same HIV-1 Strain. J Virol, 81(22):12666-12669, Nov 2007. PubMed ID: 17804503. Show all entries for this paper.


Displaying record number 54363

HXB2 Location Nef(92-100)
DNA(9070..9096)
Nef Epitope Map
Author Location Nef
Epitope KEKGGLEGL Epitope Alignment
KEKGGLEGL epitope logo
Epitope Name B40-KL9(Nef)
Species (MHC/HLA) human(B40)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, immunodominance, early-expressed proteins

Notes

References

Altfeld2006 Marcus Altfeld, Elizabeth T. Kalife, Ying Qi, Hendrik Streeck, Mathias Lichterfeld, Mary N. Johnston, Nicole Burgett, Martha E. Swartz, Amy Yang, Galit Alter, Xu G. Yu, Angela Meier, Juergen K. Rockstroh, Todd M. Allen, Heiko Jessen, Eric S. Rosenberg, Mary Carrington, and Bruce D. Walker. HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8+ T Cell Response against HIV-1. PLoS Med., 3(10):e403, Oct 2006. PubMed ID: 17076553. Show all entries for this paper.


Displaying record number 55204

HXB2 Location Nef(92-100)
DNA(9070..9096)
Nef Epitope Map
Author Location  
Epitope KEKGGLEGL Epitope Alignment
KEKGGLEGL epitope logo
Species (MHC/HLA) human(B40)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords supertype, HLA cross-presentation

Notes

References

Frahm2007b Nicole Frahm, Karina Yusim, Todd J. Suscovich, Sharon Adams, John Sidney, Peter Hraber, Hannah S. Hewitt, Caitlyn H. Linde, Daniel G. Kavanagh, Tonia Woodberry, Leah M. Henry, Kellie Faircloth, Jennifer Listgarten, Carl Kadie, Nebojsa Jojic, Kaori Sango, Nancy V. Brown, Eunice Pae, M. Tauheed Zaman, Florian Bihl, Ashok Khatri, Mina John, Simon Mallal, Francesco M. Marincola, Bruce D . Walker, Alessandro Sette, David Heckerman, Bette T. Korber, and Christian Brander. Extensive HLA Class I Allele Promiscuity among Viral CTL Epitopes. Eur. J. Immunol., 37(9):2419-2433, Sep 2007. PubMed ID: 17705138. Show all entries for this paper.


Displaying record number 59902

HXB2 Location Nef(92-100)
DNA(9070..9096)
Nef Epitope Map
Author Location Nef(92-100)
Epitope KEKGGLEGL Epitope Alignment
KEKGGLEGL epitope logo
Epitope Name KL9
Species (MHC/HLA) human(B*40)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 54578

HXB2 Location Nef(92-100)
DNA(9070..9096)
Nef Epitope Map
Author Location Nef(92-100)
Epitope KEKGGLEGL Epitope Alignment
KEKGGLEGL epitope logo
Show epitope variants
Epitope Name KL9
Subtype B
Species (MHC/HLA) human(B*40)
Immunogen HIV-1 infection
Country United States
Experimental methods Intracellular cytokine staining, Other
Keywords rate of progression, escape, mutation acquisition

Notes

References

Karlsson2007 Annika C. Karlsson, Astrid K. N. Iversen, Joan M. Chapman, Tulio de Oliviera, Gerald Spotts, Andrew J. McMichael, Miles P. Davenport, Frederick M. Hecht, and Douglas F. Nixon. Sequential Broadening of CTL Responses in Early HIV-1 Infection Is Associated with Viral Escape. PLoS ONE, 2:e225, 2007. PubMed ID: 17311088. Show all entries for this paper.


Displaying record number 58806

HXB2 Location Nef(92-100)
DNA(9070..9096)
Nef Epitope Map
Author Location Nef
Epitope KEKGGLEGL Epitope Alignment
KEKGGLEGL epitope logo
Show epitope variants
Epitope Name KL9
Subtype A, B, C, CRF01_AE, D, F, G, H
Species (MHC/HLA) human(B*40)
Immunogen HIV-1 infection
Country United Kingdom
Experimental methods CD8 T-cell Elispot - IFNγ, Degranulation, CD107a and b cell surface mobilization
Keywords subtype comparisons, epitope processing

Notes

References

Culshaw2012 Abigail Culshaw, Tao Dong, and Sarah Louise Rowland-Jones. A 2 Amino Acid Shift in Position Leads to a Substantial Difference in the Pattern of Processing of 2 HIV-1 Epitopes. J. Acquir. Immune Defic. Syndr., 59(4):335-339, 1 Apr 2012. PubMed ID: 22217677. Show all entries for this paper.


Displaying record number 58764

HXB2 Location Nef(92-100)
DNA(9070..9096)
Nef Epitope Map
Author Location Nef(92-100)
Epitope KEKGGLEGL Epitope Alignment
KEKGGLEGL epitope logo
Epitope Name Nef-KL9
Subtype B
Species (MHC/HLA) human(B*40)
Immunogen HIV-1 infection
Country Australia, Canada, United States
Experimental methods Chromium-release assay
Keywords class I down-regulation by Nef

Notes

References

Chen2012 Diana Y. Chen, Arumugam Balamurugan, Hwee L. Ng, William G. Cumberland, and Otto O. Yang. Epitope Targeting and Viral Inoculum Are Determinants of Nef-Mediated Immune Evasion of HIV-1 from Cytotoxic T Lymphocytes. Blood, 120(1):100-111, 5 Jul 2012. PubMed ID: 22613796. Show all entries for this paper.


Displaying record number 58548

HXB2 Location Nef(92-100)
DNA(9070..9096)
Nef Epitope Map
Author Location Nef
Epitope KEKGGLEGL Epitope Alignment
KEKGGLEGL epitope logo
Epitope Name B40-KL9
Subtype B
Species (MHC/HLA) human(B*40)
Immunogen HIV-1 infection
Country United States
Experimental methods  
Keywords review, rate of progression, acute/early infection

Notes

References

Streeck2010 Hendrik Streeck and Douglas F. Nixon. T Cell Immunity in Acute HIV-1 Infection. J. Infect. Dis., 202(Suppl 2):S302-8, 15 Oct 2010. PubMed ID: 20846037. Show all entries for this paper.


Displaying record number 57393

HXB2 Location Nef(92-100)
DNA(9070..9096)
Nef Epitope Map
Author Location Nef(92-100)
Epitope KEKGGLEGL Epitope Alignment
KEKGGLEGL epitope logo
Epitope Name KL9
Subtype B
Species (MHC/HLA) human(B*40)
Immunogen HIV-1 infection, in vitro stimulation or selection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Other
Keywords TCR usage, assay or method development

Notes

References

Balamurugan2010 Arumugam Balamurugan, Hwee L. Ng, and Otto O. Yang. Rapid T Cell Receptor Delineation Reveals Clonal Expansion Limitation of the Magnitude of the HIV-1-Specific CD8+ T Cell Response. J. Immunol., 185(10):5935-5942, 15 Nov 2010. PubMed ID: 20944001. Show all entries for this paper.


Displaying record number 56413

HXB2 Location Nef(92-100)
DNA(9070..9096)
Nef Epitope Map
Author Location Nef(92-100)
Epitope KEKGGLEGL Epitope Alignment
KEKGGLEGL epitope logo
Epitope Name KL9
Subtype B
Species (MHC/HLA) human(B*40)
Immunogen HIV-1 infection
Country Australia, Canada, Germany, United States
Experimental methods  
Keywords HLA associated polymorphism

Notes

References

Brumme2008 Zabrina L. Brumme, Chanson J. Brumme, Jonathan Carlson, Hendrik Streeck, Mina John, Quentin Eichbaum, Brian L Block, Brett Baker, Carl Kadie, Martin Markowitz, Heiko Jessen, Anthony D. Kelleher, Eric Rosenberg, John Kaldor, Yuko Yuki, Mary Carrington, Todd M. Allen, Simon Mallal, Marcus Altfeld, David Heckerman, and Bruce D. Walker. Marked Epitope- and Allele-Specific Differences in Rates of Mutation in Human Immunodeficiency Type 1 (HIV-1) Gag, Pol, and Nef Cytotoxic T-Lymphocyte Epitopes in Acute/Early HIV-1 Infection. J. Virol., 82(18):9216-9227, Sep 2008. PubMed ID: 18614631. Show all entries for this paper.


Displaying record number 55258

HXB2 Location Nef(92-100)
DNA(9070..9096)
Nef Epitope Map
Author Location Nef(92-100)
Epitope KEKGGLEGL Epitope Alignment
KEKGGLEGL epitope logo
Subtype B
Species (MHC/HLA) human(B*40)
Immunogen HIV-1 infection
Country China
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining, Other
Keywords assay or method development, optimal epitope

Notes

References

Wang2007 Shaoyang Wang, Yongtao Sun, Song Zhai, Yan Zhuang, Shuguang Zhao, Whenzhen Kang, Xinhong Li, Dedong Huang, Xu G. Yu, Bruce D. Walker, and Marcus A. Altfeld. Identification of HLA-A11-Restricted HIV-1-Specific Cytotoxic T-Lymphocyte Epitopes in China. Curr. HIV Res., 5(1):119-128, Jan 2007. PubMed ID: 17266563. Show all entries for this paper.


Displaying record number 60964

HXB2 Location Nef(92-100)
DNA(9070..9096)
Nef Epitope Map
Author Location Nef(92-100)
Epitope KEKGGLEGL Epitope Alignment
KEKGGLEGL epitope logo
Subtype B
Species (MHC/HLA) human(B*4001)
Immunogen HIV-1 infection
Patient MHC/HLA 98621: A*0201, A*0201, B*4001, B*4401, Cw*0304, Cw*0501; 51729: A*2401, A*2401, B*3505, B*4001, C*0304, C*0401
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords acute/early infection

Notes

References

Kunwar2013 Pratima Kunwar, Natalie Hawkins, Warren L. Dinges, Yi Liu, Erin E. Gabriel, David A. Swan, Claire E. Stevens, Janine Maenza, Ann C. Collier, James I. Mullins, Tomer Hertz, Xuesong Yu, and Helen Horton. Superior Control of HIV-1 Replication by CD8+ T Cells Targeting Conserved Epitopes: Implications for HIV Vaccine Design. PLoS One, 8(5):e64405, 2013. PubMed ID: 23741326. Show all entries for this paper.


Displaying record number 53786

HXB2 Location Nef(92-100)
DNA(9070..9096)
Nef Epitope Map
Author Location Nef
Epitope KEKGGLEGL Epitope Alignment
KEKGGLEGL epitope logo
Epitope Name KL9
Species (MHC/HLA) (B*4001)
Immunogen  
Experimental methods  
Keywords review, immunodominance, escape, acute/early infection, early-expressed proteins, kinetics, viral fitness and reversion

Notes

References

Lichterfeld2005 Mathias Lichterfeld, Xu G. Yu, Sylvie Le Gall, and Marcus Altfeld. Immunodominance of HIV-1-Specific CD8+ T-Cell Responses in Acute HIV-1 Infection: At the Crossroads of Viral and Host Genetics. Trends Immunol., 26(3):166-171, Mar 2005. PubMed ID: 15745859. Show all entries for this paper.


Displaying record number 55067

HXB2 Location Nef(92-100)
DNA(9070..9096)
Nef Epitope Map
Author Location Nef
Epitope KEKGGLEGL Epitope Alignment
KEKGGLEGL epitope logo
Epitope Name KL9
Species (MHC/HLA) human(B*4001)
Immunogen HIV-1 infection
Patient MHC/HLA A*0201, A*2402, B*4001, B*5001, Cw03, Cw4
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining
Keywords immunodominance, escape, variant cross-reactivity

Notes

References

Draenert2006 Rika Draenert, Todd M. Allen, Yang Liu, Terri Wrin, Colombe Chappey, Cori L. Verrill, Guillem Sirera, Robert L. Eldridge, Matthew P. Lahaie, Lidia Ruiz, Bonaventura Clotet, Christos J. Petropoulos, Bruce D. Walker, and Javier Martinez-Picado. Constraints on HIV-1 Evolution and Immunodominance Revealed in Monozygotic Adult Twins Infected with the Same Virus. J. Exp. Med., 203(3):529-539, 20 Mar 2006. PubMed ID: 16533886. Show all entries for this paper.


Displaying record number 57820

HXB2 Location Nef(92-100)
DNA(9070..9096)
Nef Epitope Map
Author Location Nef
Epitope KEKGGLEGL Epitope Alignment
KEKGGLEGL epitope logo
Subtype B
Species (MHC/HLA) human(B*4001)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords computational epitope prediction, HLA associated polymorphism

Notes

References

Almeida2011 Coral-Ann M. Almeida, Corine Bronke, Steven G. Roberts, Elizabeth McKinnon, Niamh M. Keane, Abha Chopra, Carl Kadie, Jonathan Carlson, David W. Haas, Sharon A. Riddler, Richard Haubrich, David Heckerman, Simon Mallal, and Mina John. Translation of HLA-HIV Associations to the Cellular Level: HIV Adapts to Inflate CD8 T Cell Responses against Nef and HLA-Adapted Variant Epitopes. J. Immunol., 187(5):2502-2513, 1 Sep 2011. PubMed ID: 21821798. Show all entries for this paper.


Displaying record number 58245

HXB2 Location Nef(92-100)
DNA(9070..9096)
Nef Epitope Map
Author Location Nef(99-100)
Epitope KEKGGLEGL Epitope Alignment
KEKGGLEGL epitope logo
Show epitope variants
Subtype B
Species (MHC/HLA) human(B*4001)
Immunogen HIV-1 infection
Patient MHC/HLA A*0201, B*4001, B*5501, Cw*09, Cw*10
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining
Keywords escape, acute/early infection, autologous responses, characterizing CD8+ T cells

Notes

References

Ferrari2011 Guido Ferrari, Bette Korber, Nilu Goonetilleke, Michael K. P. Liu, Emma L. Turnbull, Jesus F. Salazar-Gonzalez, Natalie Hawkins, Steve Self, Sydeaka Watson, Michael R. Betts, Cynthia Gay, Kara McGhee, Pierre Pellegrino, Ian Williams, Georgia D. Tomaras, Barton F. Haynes, Clive M. Gray, Persephone Borrow, Mario Roederer, Andrew J. McMichael, and Kent J. Weinhold. Relationship between Functional Profile of HIV-1 Specific CD8 T Cells and Epitope Variability with the Selection of Escape Mutants in Acute HIV-1 Infection. PLoS Pathog., 7(2):e1001273, 2011. PubMed ID: 21347345. Show all entries for this paper.


Displaying record number 1021

HXB2 Location Nef(92-100)
DNA(9070..9096)
Nef Epitope Map
Author Location ( LAI)
Epitope KEKGGLEGL Epitope Alignment
KEKGGLEGL epitope logo
Subtype B
Species (MHC/HLA) human(B*4001)
Immunogen  
Experimental methods  
Keywords optimal epitope

Notes

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 52572

HXB2 Location Nef(92-100)
DNA(9070..9096)
Nef Epitope Map
Author Location Nef(92-100)
Epitope KEKGGLEGL Epitope Alignment
KEKGGLEGL epitope logo
Species (MHC/HLA) human(B*4002)
Immunogen  
Experimental methods  
Keywords optimal epitope

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 1963

HXB2 Location Nef(92-100)
DNA(9070..9096)
Nef Epitope Map
Author Location Nef(92-100)
Epitope KEKGGLEGL Epitope Alignment
KEKGGLEGL epitope logo
Epitope Name Nef-KL9
Subtype B
Species (MHC/HLA) human(B*4002)
Immunogen HIV-1 infection
Patient MHC/HLA 01RCH59: A*0201, A*3201, B*4002, B*5301, Cw*0202, Cw*0401
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay
Keywords novel epitope

Notes

References

Sabbaj2003 Steffanie Sabbaj, Anju Bansal, G. Douglas Ritter, Christopher Perkins, Bradley H. Edwards, Ethan Gough, Jianming Tang, James J. Szinger, Bette Korber, Craig M. Wilson, Richard A. Kaslow, Mark J. Mulligan, and Paul A. Goepfert. Cross-Reactive CD8+ T Cell Epitopes Identified in US Adolescent Minorities. J. Acquir. Immune Defic. Syndr., 33(4):426-438, 1 Aug 2003. PubMed ID: 12869831. Show all entries for this paper.


Displaying record number 56483

HXB2 Location Nef(92-100)
DNA(9070..9096)
Nef Epitope Map
Author Location Nef
Epitope KEKGGLEGL Epitope Alignment
KEKGGLEGL epitope logo
Subtype C
Species (MHC/HLA) human(B*4403)
Immunogen HIV-1 infection
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords viral fitness and reversion, HLA associated polymorphism

Notes

References

Matthews2008 Philippa C. Matthews, Andrew Prendergast, Alasdair Leslie, Hayley Crawford, Rebecca Payne, Christine Rousseau, Morgane Rolland, Isobella Honeyborne, Jonathan Carlson, Carl Kadie, Christian Brander, Karen Bishop, Nonkululeko Mlotshwa, James I. Mullins, Hoosen Coovadia, Thumbi Ndung'u, Bruce D. Walker, David Heckerman, and Philip J. R. Goulder. Central Role of Reverting Mutations in HLA Associations with Human Immunodeficiency Virus Set Point. J. Virol., 82(17):8548-8559, Sep 2008. PubMed ID: 18596105. Show all entries for this paper.


Displaying record number 56604

HXB2 Location Nef(92-100)
DNA(9070..9096)
Nef Epitope Map
Author Location Nef(91-100)
Epitope KEKGGLEGL Epitope Alignment
KEKGGLEGL epitope logo
Epitope Name KL9
Subtype C
Species (MHC/HLA) human(B*4403)
Immunogen HIV-1 infection
Country South Africa, Zambia
Experimental methods  
Keywords viral fitness and reversion, HLA associated polymorphism

Notes

References

Goepfert2008 Paul A. Goepfert, Wendy Lumm, Paul Farmer, Philippa Matthews, Andrew Prendergast, Jonathan M. Carlson, Cynthia A. Derdeyn, Jianming Tang, Richard A. Kaslow, Anju Bansal, Karina Yusim, David Heckerman, Joseph Mulenga, Susan Allen, Philip J. R. Goulder, and Eric Hunter. Transmission of HIV-1 Gag Immune Escape Mutations Is Associated with Reduced Viral Load in Linked Recipients. J. Exp. Med., 205(5):1009-1017, 12 May 2008. PubMed ID: 18426987. Show all entries for this paper.


Displaying record number 59903

HXB2 Location Nef(92-100)
DNA(9070..9096)
Nef Epitope Map
Author Location Nef(92-100)
Epitope KEKGGLEGL Epitope Alignment
KEKGGLEGL epitope logo
Epitope Name KL9
Species (MHC/HLA) human(B*55)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 52745

HXB2 Location Nef(92-100)
DNA(9070..9096)
Nef Epitope Map
Author Location Nef
Epitope KEKGGLEGL Epitope Alignment
KEKGGLEGL epitope logo
Epitope Name KL9
Species (MHC/HLA) human(B60)
Immunogen HIV-1 infection
Patient MHC/HLA A2, A24, B38, B60, Cw12, Cw2
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords supervised treatment interruptions (STI), early treatment

Notes

References

Montefiori2003 David C. Montefiori, Marcus Altfeld, Paul K. Lee, Miroslawa Bilska, Jintao Zhou, Mary N. Johnston, Feng Gao, Bruce D. Walker, and Eric S. Rosenberg. Viremia Control Despite Escape from a Rapid and Potent Autologous Neutralizing Antibody Response after Therapy Cessation in an HIV-1-Infected Individual. J. Immunol., 170(7):3906-3914, Apr 2003. PubMed ID: 12646660. Show all entries for this paper.


Displaying record number 52516

HXB2 Location Nef(92-100)
DNA(9070..9096)
Nef Epitope Map
Author Location Nef(92-100 NL-43)
Epitope KEKGGLEGL Epitope Alignment
KEKGGLEGL epitope logo
Show epitope variants
Subtype B
Species (MHC/HLA) human(B60)
Immunogen HIV-1 infection
Experimental methods  
Keywords class I down-regulation by Nef, escape

Notes

References

Ali2003 Ayub Ali, Satish Pillai, Hwee Ng, Rachel Lubong, Douglas D. Richman, Beth D. Jamieson, Yan Ding, M. Juliana McElrath, John C. Guatelli, and Otto O. Yang. Broadly Increased Sensitivity to Cytotoxic T Lymphocytes Resulting from Nef Epitope Escape Mutations. J. Immunol., 171(8):3999-4005, Oct 2003. PubMed ID: 14530319. Show all entries for this paper.


Displaying record number 1528

HXB2 Location Nef(92-100)
DNA(9070..9096)
Nef Epitope Map
Author Location Nef(90-98 SF2)
Epitope KEKGGLEGL Epitope Alignment
KEKGGLEGL epitope logo
Species (MHC/HLA) human(B60)
Immunogen HIV-1 infection
Experimental methods  
Keywords HAART, ART, acute/early infection

Notes

References

Altfeld2001b M. Altfeld, E. S. Rosenberg, R. Shankarappa, J. S. Mukherjee, F. M. Hecht, R. L. Eldridge, M. M. Addo, S. H. Poon, M. N. Phillips, G. K. Robbins, P. E. Sax, S. Boswell, J. O. Kahn, C. Brander, P. J. Goulder, J. A. Levy, J. I. Mullins, and B. D. Walker. Cellular immune responses and viral diversity in individuals treated during acute and early HIV-1 infection. J. Exp. Med., 193(2):169-80, 15 Jan 2001. URL: http://www.jem.org/cgi/content/full/193/2/169. PubMed ID: 11148221. Show all entries for this paper.


Displaying record number 52110

HXB2 Location Nef(92-100)
DNA(9070..9096)
Nef Epitope Map
Author Location Nef
Epitope KEKGGLEGL Epitope Alignment
KEKGGLEGL epitope logo
Species (MHC/HLA) human(B60)
Immunogen HIV-1 infection
Experimental methods  
Keywords epitope processing

Notes

References

Cao2002 Huyen Cao, Deepak Agrawal, Nicholas Kushner, Neal Touzjian, Max Essex, and Yichen Lu. Delivery of exogenous protein antigens to major histocompatibility complex class I pathway in cytosol. J. Infect. Dis., 185(2):244-251, 15 Jan 2002. PubMed ID: 11807699. Show all entries for this paper.


Displaying record number 53154

HXB2 Location Nef(92-100)
DNA(9070..9096)
Nef Epitope Map
Author Location Nef(92-100)
Epitope KEKGGLEGL Epitope Alignment
KEKGGLEGL epitope logo
Epitope Name Nef KL9
Subtype B
Species (MHC/HLA) human(B60)
Immunogen HIV-1 infection
Experimental methods Chromium-release assay, Flow cytometric T-cell cytokine assay
Keywords binding affinity, TCR usage, characterizing CD8+ T cells

Notes

References

Yang2003a Otto O. Yang, Phuong T. Nguyen Sarkis, Alicja Trocha, Spyros A. Kalams, R. Paul Johnson, and Bruce D. Walker. Impacts of Avidity and Specificity on the Antiviral Efficiency of HIV-1-Specific CTL. J. Immunol., 171(7):3718-3724, 1 Oct 2003. PubMed ID: 14500671. Show all entries for this paper.


Displaying record number 52790

HXB2 Location Nef(92-100)
DNA(9070..9096)
Nef Epitope Map
Author Location Nef(92-100 NL43)
Epitope KEKGGLEGL Epitope Alignment
KEKGGLEGL epitope logo
Show epitope variants
Epitope Name KL9
Subtype B
Species (MHC/HLA) human(B60)
Immunogen HIV-1 infection
Experimental methods CTL suppression of replication, Chromium-release assay
Keywords escape

Notes

References

Yang2003 Otto O Yang, Phuong Thi Nguyen Sarkis, Ayub Ali, Jason D Harlow, Christian Brander, Spyros A Kalams, and Bruce D Walker. Determinant of HIV-1 Mutational Escape from Cytotoxic T Lymphocytes. J. Exp. Med., 197(10):1365-1375, May 2003. PubMed ID: 12743169. Show all entries for this paper.


Displaying record number 1839

HXB2 Location Nef(92-100)
DNA(9070..9096)
Nef Epitope Map
Author Location Nef( SF2)
Epitope KEKGGLEGL Epitope Alignment
KEKGGLEGL epitope logo
Species (MHC/HLA) human(B60)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Altfeld2000 M. A. Altfeld, A. Trocha, R. L. Eldridge, E. S. Rosenberg, M. N. Phillips, M. M. Addo, R. P. Sekaly, S. A. Kalams, S. A. Burchett, K. McIntosh, B. D. Walker, and P. J. Goulder. Identification of dominant optimal HLA-B60- and HLA-B61-restricted cytotoxic T-lymphocyte (CTL) epitopes: rapid characterization of CTL responses by enzyme-linked immunospot assay. J. Virol., 74:8541, 2000. PubMed ID: 10954555. Show all entries for this paper.


Displaying record number 53380

HXB2 Location Nef(92-100)
DNA(9070..9096)
Nef Epitope Map
Author Location ( B consensus)
Epitope KEKGGLEGL Epitope Alignment
KEKGGLEGL epitope logo
Epitope Name KL10
Subtype B
Species (MHC/HLA) human(B60)
Immunogen HIV-1 infection
Patient MHC/HLA A3, B14, B60, Cw3, Cw7
Experimental methods Chromium-release assay, Cytokine production, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining
Keywords assay or method development, memory cells, characterizing CD8+ T cells

Notes

References

Lichterfeld2004b Mathias Lichterfeld, Xu G. Yu, Michael T. Waring, Stanley K. Mui, Mary N. Johnston, Daniel Cohen, Marylyn M. Addo, John Zaunders, Galit Alter, Eunice Pae, Daryld Strick, Todd M. Allen, Eric S. Rosenberg, Bruce D. Walker, and Marcus Altfeld. HIV-1-Specific Cytotoxicity Is Preferentially Mediated by a Subset of CD8+ T Cells Producing both Interferon-gamma and Tumor Necrosis Factor-alpha. Blood, 104(2):487-394, 15 Jul 2004. PubMed ID: 15059848. Show all entries for this paper.


Displaying record number 1813

HXB2 Location Nef(92-100)
DNA(9070..9096)
Nef Epitope Map
Author Location Nef(92-100)
Epitope KEKGGLEGL Epitope Alignment
KEKGGLEGL epitope logo
Species (MHC/HLA) human(B*60, B*61)
Immunogen HIV-1 infection
Experimental methods  
Keywords immunodominance

Notes

References

Day2001 C. L. Day, A. K. Shea, M. A. Altfeld, D. P. Olson, S. P. Buchbinder, F. M. Hecht, E. S. Rosenberg, B. D. Walker, and S. A. Kalams. Relative dominance of epitope-specific cytotoxic T-lymphocyte responses in human immunodeficiency virus type 1-infected persons with shared HLA alleles. J. Virol., 75(14):6279-91, Jul 2001. URL: http://jvi.asm.org/cgi/content/full/75/14/6279. PubMed ID: 11413294. Show all entries for this paper.


Displaying record number 57501

HXB2 Location Nef(92-100)
DNA(9070..9096)
Nef Epitope Map
Author Location Nef
Epitope KEKGGLEGL Epitope Alignment
KEKGGLEGL epitope logo
Show epitope variants
Subtype B
Species (MHC/HLA) human
Immunogen HIV-1 infection
Country Australia
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords assay or method development, HLA associated polymorphism

Notes

References

Almeida2010 Coral-Ann M. Almeida, Steven G. Roberts, Rebecca Laird, Elizabeth McKinnon, Imran Ahmad, Niamh M. Keane, Abha Chopra, Carl Kadie, David Heckerman, Simon Mallal, and Mina John. Exploiting Knowledge of Immune Selection in HIV-1 to Detect HIV-Specific CD8 T-Cell Responses. Vaccine, 28(37):6052-6057, 23 Aug 2010. PubMed ID: 20619380. Show all entries for this paper.


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