HIV molecular immunology database
Found 37 matching records:
Download this epitope record as JSON.
HXB2 Location | Nef(92-100) DNA(9070..9096) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(92-100) | |
Epitope |
KEKGGLEGL
|
Epitope Alignment
|
Epitope Name | KL9 | |
Species (MHC/HLA) | human(B*35:02, B*35:03, B*53:01) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(92-100) DNA(9070..9096) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(92-100) | |
Epitope |
KEKGGLEGL
|
Epitope Alignment
|
Epitope Name | KL9-N | |
Subtype | B | |
Species (MHC/HLA) | human(B*40) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | S00016: A*03, A*32, B*18, B*40, C*02, C*07 | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Other | |
Keywords | dynamics, chronic infection |
Balamurugan2017 Arumugam Balamurugan, Deon Claiborne, Hwee L. Ng, and Otto O. Yang. HIV-1 Epitope Variability Is Associated with T Cell Receptor Repertoire Instability and Breadth. J. Virol., 91(16), 15 Aug 2017. PubMed ID: 28592539. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(92-100) DNA(9070..9096) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(92-100) | |
Epitope |
KEKGGLEGL
|
Epitope Alignment
|
Show epitope variants | ||
Epitope Name | KL9 | |
Subtype | B | |
Species (MHC/HLA) | human(B*40) | |
Immunogen | HIV-1 infection | |
Country | United States | |
Experimental methods | Intracellular cytokine staining, Other | |
Keywords | rate of progression, escape, mutation acquisition |
Karlsson2007 Annika C. Karlsson, Astrid K. N. Iversen, Joan M. Chapman, Tulio de Oliviera, Gerald Spotts, Andrew J. McMichael, Miles P. Davenport, Frederick M. Hecht, and Douglas F. Nixon. Sequential Broadening of CTL Responses in Early HIV-1 Infection Is Associated with Viral Escape. PLoS ONE, 2:e225, 2007. PubMed ID: 17311088. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(92-100) DNA(9070..9096) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(92-100) | |
Epitope |
KEKGGLEGL
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(B*40) | |
Immunogen | HIV-1 infection | |
Country | China | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining, Other | |
Keywords | assay or method development, optimal epitope |
Wang2007 Shaoyang Wang, Yongtao Sun, Song Zhai, Yan Zhuang, Shuguang Zhao, Whenzhen Kang, Xinhong Li, Dedong Huang, Xu G. Yu, Bruce D. Walker, and Marcus A. Altfeld. Identification of HLA-A11-Restricted HIV-1-Specific Cytotoxic T-Lymphocyte Epitopes in China. Curr. HIV Res., 5(1):119-128, Jan 2007. PubMed ID: 17266563. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(92-100) DNA(9070..9096) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(92-100) | |
Epitope |
KEKGGLEGL
|
Epitope Alignment
|
Epitope Name | KL9 | |
Subtype | B | |
Species (MHC/HLA) | human(B*40) | |
Immunogen | HIV-1 infection | |
Country | Australia, Canada, Germany, United States | |
Experimental methods | ||
Keywords | HLA associated polymorphism |
Brumme2008 Zabrina L. Brumme, Chanson J. Brumme, Jonathan Carlson, Hendrik Streeck, Mina John, Quentin Eichbaum, Brian L Block, Brett Baker, Carl Kadie, Martin Markowitz, Heiko Jessen, Anthony D. Kelleher, Eric Rosenberg, John Kaldor, Yuko Yuki, Mary Carrington, Todd M. Allen, Simon Mallal, Marcus Altfeld, David Heckerman, and Bruce D. Walker. Marked Epitope- and Allele-Specific Differences in Rates of Mutation in Human Immunodeficiency Type 1 (HIV-1) Gag, Pol, and Nef Cytotoxic T-Lymphocyte Epitopes in Acute/Early HIV-1 Infection. J. Virol., 82(18):9216-9227, Sep 2008. PubMed ID: 18614631. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(92-100) DNA(9070..9096) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(92-100) | |
Epitope |
KEKGGLEGL
|
Epitope Alignment
|
Epitope Name | KL9 | |
Subtype | B | |
Species (MHC/HLA) | human(B*40) | |
Immunogen | in vitro stimulation or selection, HIV-1 infection | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Other | |
Keywords | TCR usage, assay or method development, chronic infection |
Balamurugan2010 Arumugam Balamurugan, Hwee L. Ng, and Otto O. Yang. Rapid T Cell Receptor Delineation Reveals Clonal Expansion Limitation of the Magnitude of the HIV-1-Specific CD8+ T Cell Response. J. Immunol., 185(10):5935-5942, 15 Nov 2010. PubMed ID: 20944001. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(92-100) DNA(9070..9096) |
Nef Epitope Map |
---|---|---|
Author Location | ||
Epitope |
KEKGGLEGL
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(B*40) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | MM50: A*02, A*03, B*13, B*40, C*03, C*06 | |
Country | United Kingdom | |
Experimental methods | Tetramer binding | |
Keywords | dynamics, acute/early infection, assay or method development |
Turnbull2009 Emma L. Turnbull, MaiLee Wong, Shuyi Wang, Xiping Wei, Nicola A. Jones, Karen E. Conrod, Diana Aldam, Jo Turner, Pierre Pellegrino, Brandon F. Keele, Ian Williams, George M. Shaw, and Persephone Borrow. Kinetics of Expansion of Epitope-Specific T Cell Responses During primary HIV-1 Infection. J. Immunol., 182(11):7131-7145, 1 Jun 2009. PubMed ID: 19454710. Show all entries for this paper.
Yang2019 Yiding Yang, and Vitaly V. Ganusov. Defining Kinetic Properties of HIV-Specific CD8(+) T-Cell Responses in Acute Infection. Microorganisms, 7(3):microorganisms7030069 doi, Mar 2019. PubMed ID: 30836625 Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(92-100) DNA(9070..9096) |
Nef Epitope Map |
---|---|---|
Author Location | Nef | |
Epitope |
KEKGGLEGL
|
Epitope Alignment
|
Epitope Name | B40-KL9 | |
Subtype | B | |
Species (MHC/HLA) | human(B*40) | |
Immunogen | HIV-1 infection | |
Country | United States | |
Experimental methods | ||
Keywords | review, rate of progression, acute/early infection |
Streeck2010 Hendrik Streeck and Douglas F. Nixon. T Cell Immunity in Acute HIV-1 Infection. J. Infect. Dis., 202(Suppl 2):S302-8, 15 Oct 2010. PubMed ID: 20846037. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(92-100) DNA(9070..9096) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(92-100) | |
Epitope |
KEKGGLEGL
|
Epitope Alignment
|
Epitope Name | Nef-KL9 | |
Subtype | B | |
Species (MHC/HLA) | human(B*40) | |
Immunogen | HIV-1 infection | |
Country | Australia, Canada, United States | |
Experimental methods | Chromium-release assay | |
Keywords | class I down-regulation by Nef |
Chen2012 Diana Y. Chen, Arumugam Balamurugan, Hwee L. Ng, William G. Cumberland, and Otto O. Yang. Epitope Targeting and Viral Inoculum Are Determinants of Nef-Mediated Immune Evasion of HIV-1 from Cytotoxic T Lymphocytes. Blood, 120(1):100-111, 5 Jul 2012. PubMed ID: 22613796. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(92-100) DNA(9070..9096) |
Nef Epitope Map |
---|---|---|
Author Location | Nef | |
Epitope |
KEKGGLEGL
|
Epitope Alignment
|
Show epitope variants | ||
Epitope Name | KL9 | |
Subtype | A, B, C, CRF01_AE, D, F, G, H | |
Species (MHC/HLA) | human(B*40) | |
Immunogen | HIV-1 infection | |
Country | United Kingdom | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Degranulation, CD107a and b cell surface mobilization | |
Keywords | subtype comparisons, epitope processing |
Culshaw2012 Abigail Culshaw, Tao Dong, and Sarah Louise Rowland-Jones. A 2 Amino Acid Shift in Position Leads to a Substantial Difference in the Pattern of Processing of 2 HIV-1 Epitopes. J. Acquir. Immune Defic. Syndr., 59(4):335-339, 1 Apr 2012. PubMed ID: 22217677. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(92-100) DNA(9070..9096) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(92-100) | |
Epitope |
KEKGGLEGL
|
Epitope Alignment
|
Epitope Name | KL9 | |
Species (MHC/HLA) | human(B*40) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(92-100) DNA(9070..9096) |
Nef Epitope Map |
---|---|---|
Author Location | Nef | |
Epitope |
KEKGGLEGL
|
Epitope Alignment
|
Epitope Name | KL-9 | |
Species (MHC/HLA) | human(B40) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | escape, TCR usage, mutation acquisition |
Yu2007 Xu G. Yu, Mathias Lichterfeld, Katie L. Williams, Javier Martinez-Picado, and Bruce D. Walker. Random T-Cell Receptor Recruitment in Human Immunodeficiency Virus Type 1 (HIV-1)-Specific CD8+ T Cells from Genetically Identical Twins Infected with the Same HIV-1 Strain. J Virol, 81(22):12666-12669, Nov 2007. PubMed ID: 17804503. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(92-100) DNA(9070..9096) |
Nef Epitope Map |
---|---|---|
Author Location | ||
Epitope |
KEKGGLEGL
|
Epitope Alignment
|
Species (MHC/HLA) | human(B40) | |
Immunogen | HIV-1 infection | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | supertype, HLA cross-presentation |
Frahm2007b Nicole Frahm, Karina Yusim, Todd J. Suscovich, Sharon Adams, John Sidney, Peter Hraber, Hannah S. Hewitt, Caitlyn H. Linde, Daniel G. Kavanagh, Tonia Woodberry, Leah M. Henry, Kellie Faircloth, Jennifer Listgarten, Carl Kadie, Nebojsa Jojic, Kaori Sango, Nancy V. Brown, Eunice Pae, M. Tauheed Zaman, Florian Bihl, Ashok Khatri, Mina John, Simon Mallal, Francesco M. Marincola, Bruce D . Walker, Alessandro Sette, David Heckerman, Bette T. Korber, and Christian Brander. Extensive HLA Class I Allele Promiscuity among Viral CTL Epitopes. Eur. J. Immunol., 37(9):2419-2433, Sep 2007. PubMed ID: 17705138. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(92-100) DNA(9070..9096) |
Nef Epitope Map |
---|---|---|
Author Location | Nef | |
Epitope |
KEKGGLEGL
|
Epitope Alignment
|
Epitope Name | KL9 | |
Subtype | B | |
Species (MHC/HLA) | human(B40) | |
Immunogen | HIV-1 infection | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Tetramer binding | |
Keywords | dynamics, characterizing CD8+ T cells, chronic infection |
Streeck2008 Hendrik Streeck, Zabrina L. Brumme, Michael Anastario, Kristin W. Cohen, Jonathan S. Jolin, Angela Meier, Chanson J. Brumme, Eric S. Rosenberg, Galit Alter, Todd M. Allen, Bruce D. Walker, and Marcus Altfeld. Antigen Load and Viral Sequence Diversification Determine the Functional Profile of HIV-1-Specific CD8+ T Cells. PLoS Med, 5(5):e100, 6 May 2008. PubMed ID: 18462013. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(92-100) DNA(9070..9096) |
Nef Epitope Map |
---|---|---|
Author Location | Nef | |
Epitope |
KEKGGLEGL
|
Epitope Alignment
|
Epitope Name | B40-KL9(Nef) | |
Species (MHC/HLA) | human(B40) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | rate of progression, immunodominance, early-expressed proteins |
Altfeld2006 Marcus Altfeld, Elizabeth T. Kalife, Ying Qi, Hendrik Streeck, Mathias Lichterfeld, Mary N. Johnston, Nicole Burgett, Martha E. Swartz, Amy Yang, Galit Alter, Xu G. Yu, Angela Meier, Juergen K. Rockstroh, Todd M. Allen, Heiko Jessen, Eric S. Rosenberg, Mary Carrington, and Bruce D. Walker. HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8+ T Cell Response against HIV-1. PLoS Med., 3(10):e403, Oct 2006. PubMed ID: 17076553. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(92-100) DNA(9070..9096) |
Nef Epitope Map |
---|---|---|
Author Location | Nef | |
Epitope |
KEKGGLEGL
|
Epitope Alignment
|
Epitope Name | KL9(Nef) | |
Subtype | B | |
Species (MHC/HLA) | human(B40) | |
Immunogen | HIV-1 infection | |
Country | China | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | chronic infection |
Zhai2008 Song Zhai, Yan Zhuang, Yang Song, Shu Li, Dedong Huang, Wenzhen Kang, Xinhong Li, Qi Liao, Yanhou Liu, Zhongfang Zhao, Yichen Lu, and Yongtao Sun. HIV-1-Specific Cytotoxic T Lymphocyte (CTL) Responses Against Immunodominant Optimal Epitopes Slow the Progression of AIDS in China. Curr. HIV Res., 6(4):335-350, Jun 2008. PubMed ID: 18691032. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(92-100) DNA(9070..9096) |
Nef Epitope Map |
---|---|---|
Author Location | Nef | |
Epitope |
KEKGGLEGL
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(B*40:01) | |
Immunogen | HIV-1 infection | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | computational epitope prediction, HLA associated polymorphism |
Almeida2011 Coral-Ann M. Almeida, Corine Bronke, Steven G. Roberts, Elizabeth McKinnon, Niamh M. Keane, Abha Chopra, Carl Kadie, Jonathan Carlson, David W. Haas, Sharon A. Riddler, Richard Haubrich, David Heckerman, Simon Mallal, and Mina John. Translation of HLA-HIV Associations to the Cellular Level: HIV Adapts to Inflate CD8 T Cell Responses against Nef and HLA-Adapted Variant Epitopes. J. Immunol., 187(5):2502-2513, 1 Sep 2011. PubMed ID: 21821798. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(92-100) DNA(9070..9096) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(99-100) | |
Epitope |
KEKGGLEGL
|
Epitope Alignment
|
Show epitope variants | ||
Subtype | B | |
Species (MHC/HLA) | human(B*40:01) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | MM43: A*02, A*02:01, B*40:01, B*55:01, C*03, C*03 | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining | |
Keywords | dynamics, escape, acute/early infection, autologous responses, characterizing CD8+ T cells |
Ferrari2011 Guido Ferrari, Bette Korber, Nilu Goonetilleke, Michael K. P. Liu, Emma L. Turnbull, Jesus F. Salazar-Gonzalez, Natalie Hawkins, Steve Self, Sydeaka Watson, Michael R. Betts, Cynthia Gay, Kara McGhee, Pierre Pellegrino, Ian Williams, Georgia D. Tomaras, Barton F. Haynes, Clive M. Gray, Persephone Borrow, Mario Roederer, Andrew J. McMichael, and Kent J. Weinhold. Relationship between Functional Profile of HIV-1 Specific CD8 T Cells and Epitope Variability with the Selection of Escape Mutants in Acute HIV-1 Infection. PLoS Pathog., 7(2):e1001273, 2011. PubMed ID: 21347345. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(92-100) DNA(9070..9096) |
Nef Epitope Map |
---|---|---|
Author Location | Nef | |
Epitope |
KEKGGLEGL
|
Epitope Alignment
|
Epitope Name | KL9 | |
Species (MHC/HLA) | human(B*40:01) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | A*02:01, A*24:02, B*40:01, B*50:01, C*03, Cw4 | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining | |
Keywords | immunodominance, escape, variant cross-reactivity |
Draenert2006 Rika Draenert, Todd M. Allen, Yang Liu, Terri Wrin, Colombe Chappey, Cori L. Verrill, Guillem Sirera, Robert L. Eldridge, Matthew P. Lahaie, Lidia Ruiz, Bonaventura Clotet, Christos J. Petropoulos, Bruce D. Walker, and Javier Martinez-Picado. Constraints on HIV-1 Evolution and Immunodominance Revealed in Monozygotic Adult Twins Infected with the Same Virus. J. Exp. Med., 203(3):529-539, 20 Mar 2006. PubMed ID: 16533886. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(92-100) DNA(9070..9096) |
Nef Epitope Map |
---|---|---|
Author Location | Nef | |
Epitope |
KEKGGLEGL
|
Epitope Alignment
|
Epitope Name | KL9 | |
Species (MHC/HLA) | (B*40:01) | |
Immunogen | ||
Experimental methods | ||
Keywords | review, immunodominance, escape, acute/early infection, early-expressed proteins, kinetics, viral fitness and reversion |
Lichterfeld2005 Mathias Lichterfeld, Xu G. Yu, Sylvie Le Gall, and Marcus Altfeld. Immunodominance of HIV-1-Specific CD8+ T-Cell Responses in Acute HIV-1 Infection: At the Crossroads of Viral and Host Genetics. Trends Immunol., 26(3):166-171, Mar 2005. PubMed ID: 15745859. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(92-100) DNA(9070..9096) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(92-100) | |
Epitope |
KEKGGLEGL
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(B*40:01) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | 98621: A*02:01:01G, B*40:01:01G, B*44:02:01G, C*03:04:01G, C*05:01; 51729: A*24:02, A*24:02, B*35:05, B*40:01, C*03:04, C*04:01 | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | acute/early infection |
Kunwar2013 Pratima Kunwar, Natalie Hawkins, Warren L. Dinges, Yi Liu, Erin E. Gabriel, David A. Swan, Claire E. Stevens, Janine Maenza, Ann C. Collier, James I. Mullins, Tomer Hertz, Xuesong Yu, and Helen Horton. Superior Control of HIV-1 Replication by CD8+ T Cells Targeting Conserved Epitopes: Implications for HIV Vaccine Design. PLoS One, 8(5):e64405, 2013. PubMed ID: 23741326. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(92-100) DNA(9070..9096) |
Nef Epitope Map |
---|---|---|
Author Location | ( LAI) | |
Epitope |
KEKGGLEGL
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(B*40:01) | |
Immunogen | ||
Experimental methods | ||
Keywords | optimal epitope, A-list |
Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(92-100) DNA(9070..9096) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(92-100) | |
Epitope |
KEKGGLEGL
|
Epitope Alignment
|
Epitope Name | Nef-KL9 | |
Subtype | B | |
Species (MHC/HLA) | human(B*40:02) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | 01RCH59: A*02:01, A*32:01, B*40:02, B*53:01, C*02:02, C*04:01 | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Chromium-release assay | |
Keywords | novel epitope |
Sabbaj2003 Steffanie Sabbaj, Anju Bansal, G. Douglas Ritter, Christopher Perkins, Bradley H. Edwards, Ethan Gough, Jianming Tang, James J. Szinger, Bette Korber, Craig M. Wilson, Richard A. Kaslow, Mark J. Mulligan, and Paul A. Goepfert. Cross-Reactive CD8+ T Cell Epitopes Identified in US Adolescent Minorities. J. Acquir. Immune Defic. Syndr., 33(4):426-438, 1 Aug 2003. PubMed ID: 12869831. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(92-100) DNA(9070..9096) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(92-100) | |
Epitope |
KEKGGLEGL
|
Epitope Alignment
|
Species (MHC/HLA) | human(B*40:02) | |
Immunogen | ||
Experimental methods | ||
Keywords | optimal epitope, A-list |
Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(92-100) DNA(9070..9096) |
Nef Epitope Map |
---|---|---|
Author Location | Nef | |
Epitope |
KEKGGLEGL
|
Epitope Alignment
|
Subtype | C | |
Species (MHC/HLA) | human(B*44:03) | |
Immunogen | HIV-1 infection | |
Country | South Africa | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | viral fitness and reversion, HLA associated polymorphism |
Matthews2008 Philippa C. Matthews, Andrew Prendergast, Alasdair Leslie, Hayley Crawford, Rebecca Payne, Christine Rousseau, Morgane Rolland, Isobella Honeyborne, Jonathan Carlson, Carl Kadie, Christian Brander, Karen Bishop, Nonkululeko Mlotshwa, James I. Mullins, Hoosen Coovadia, Thumbi Ndung'u, Bruce D. Walker, David Heckerman, and Philip J. R. Goulder. Central Role of Reverting Mutations in HLA Associations with Human Immunodeficiency Virus Set Point. J. Virol., 82(17):8548-8559, Sep 2008. PubMed ID: 18596105. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(92-100) DNA(9070..9096) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(91-100) | |
Epitope |
KEKGGLEGL
|
Epitope Alignment
|
Epitope Name | KL9 | |
Subtype | C | |
Species (MHC/HLA) | human(B*44:03) | |
Immunogen | HIV-1 infection | |
Country | South Africa, Zambia | |
Experimental methods | ||
Keywords | viral fitness and reversion, HLA associated polymorphism |
Goepfert2008 Paul A. Goepfert, Wendy Lumm, Paul Farmer, Philippa Matthews, Andrew Prendergast, Jonathan M. Carlson, Cynthia A. Derdeyn, Jianming Tang, Richard A. Kaslow, Anju Bansal, Karina Yusim, David Heckerman, Joseph Mulenga, Susan Allen, Philip J. R. Goulder, and Eric Hunter. Transmission of HIV-1 Gag Immune Escape Mutations Is Associated with Reduced Viral Load in Linked Recipients. J. Exp. Med., 205(5):1009-1017, 12 May 2008. PubMed ID: 18426987. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(92-100) DNA(9070..9096) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(92-100) | |
Epitope |
KEKGGLEGL
|
Epitope Alignment
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Epitope Name | KL9 | |
Species (MHC/HLA) | human(B*55) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
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HXB2 Location | Nef(92-100) DNA(9070..9096) |
Nef Epitope Map |
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Author Location | Nef(92-100) | |
Epitope |
KEKGGLEGL
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Epitope Alignment
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Species (MHC/HLA) | human(B*60, B*61) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords |
Day2001 C. L. Day, A. K. Shea, M. A. Altfeld, D. P. Olson, S. P. Buchbinder, F. M. Hecht, E. S. Rosenberg, B. D. Walker, and S. A. Kalams. Relative dominance of epitope-specific cytotoxic T-lymphocyte responses in human immunodeficiency virus type 1-infected persons with shared HLA alleles. J. Virol., 75(14):6279-91, Jul 2001. URL: http://jvi.asm.org/cgi/content/full/75/14/6279. PubMed ID: 11413294. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(92-100) DNA(9070..9096) |
Nef Epitope Map |
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Author Location | Nef(92-100) | |
Epitope |
KEKGGLEGL
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Epitope Alignment
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Epitope Name | Nef KL9 | |
Subtype | B | |
Species (MHC/HLA) | human(B60) | |
Immunogen | HIV-1 infection | |
Experimental methods | Chromium-release assay, Flow cytometric T-cell cytokine assay | |
Keywords | binding affinity, TCR usage, characterizing CD8+ T cells |
Yang2003a Otto O. Yang, Phuong T. Nguyen Sarkis, Alicja Trocha, Spyros A. Kalams, R. Paul Johnson, and Bruce D. Walker. Impacts of Avidity and Specificity on the Antiviral Efficiency of HIV-1-Specific CTL. J. Immunol., 171(7):3718-3724, 1 Oct 2003. PubMed ID: 14500671. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(92-100) DNA(9070..9096) |
Nef Epitope Map |
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Author Location | Nef(90-98 SF2) | |
Epitope |
KEKGGLEGL
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Epitope Alignment
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Species (MHC/HLA) | human(B60) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | HAART, ART, acute/early infection |
Altfeld2001b M. Altfeld, E. S. Rosenberg, R. Shankarappa, J. S. Mukherjee, F. M. Hecht, R. L. Eldridge, M. M. Addo, S. H. Poon, M. N. Phillips, G. K. Robbins, P. E. Sax, S. Boswell, J. O. Kahn, C. Brander, P. J. Goulder, J. A. Levy, J. I. Mullins, and B. D. Walker. Cellular immune responses and viral diversity in individuals treated during acute and early HIV-1 infection. J. Exp. Med., 193(2):169-80, 15 Jan 2001. URL: http://www.jem.org/cgi/content/full/193/2/169. PubMed ID: 11148221. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(92-100) DNA(9070..9096) |
Nef Epitope Map |
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Author Location | Nef( SF2) | |
Epitope |
KEKGGLEGL
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Epitope Alignment
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Species (MHC/HLA) | human(B60) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords |
Altfeld2000 M. A. Altfeld, A. Trocha, R. L. Eldridge, E. S. Rosenberg, M. N. Phillips, M. M. Addo, R. P. Sekaly, S. A. Kalams, S. A. Burchett, K. McIntosh, B. D. Walker, and P. J. Goulder. Identification of dominant optimal HLA-B60- and HLA-B61-restricted cytotoxic T-lymphocyte (CTL) epitopes: rapid characterization of CTL responses by enzyme-linked immunospot assay. J. Virol., 74:8541, 2000. PubMed ID: 10954555. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(92-100) DNA(9070..9096) |
Nef Epitope Map |
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Author Location | Nef | |
Epitope |
KEKGGLEGL
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Epitope Alignment
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Species (MHC/HLA) | human(B60) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | epitope processing |
Cao2002 Huyen Cao, Deepak Agrawal, Nicholas Kushner, Neal Touzjian, Max Essex, and Yichen Lu. Delivery of exogenous protein antigens to major histocompatibility complex class I pathway in cytosol. J. Infect. Dis., 185(2):244-251, 15 Jan 2002. PubMed ID: 11807699. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(92-100) DNA(9070..9096) |
Nef Epitope Map |
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Author Location | Nef(92-100 NL-43) | |
Epitope |
KEKGGLEGL
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Epitope Alignment
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Show epitope variants | ||
Subtype | B | |
Species (MHC/HLA) | human(B60) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | class I down-regulation by Nef, escape |
Ali2003 Ayub Ali, Satish Pillai, Hwee Ng, Rachel Lubong, Douglas D. Richman, Beth D. Jamieson, Yan Ding, M. Juliana McElrath, John C. Guatelli, and Otto O. Yang. Broadly Increased Sensitivity to Cytotoxic T Lymphocytes Resulting from Nef Epitope Escape Mutations. J. Immunol., 171(8):3999-4005, Oct 2003. PubMed ID: 14530319. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(92-100) DNA(9070..9096) |
Nef Epitope Map |
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Author Location | ( B consensus) | |
Epitope |
KEKGGLEGL
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Epitope Alignment
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Epitope Name | KL10 | |
Subtype | B | |
Species (MHC/HLA) | human(B60) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | A3, B14, B60, Cw3, Cw7 | |
Experimental methods | Chromium-release assay, Cytokine production, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining | |
Keywords | assay or method development, memory cells, characterizing CD8+ T cells |
Lichterfeld2004b Mathias Lichterfeld, Xu G. Yu, Michael T. Waring, Stanley K. Mui, Mary N. Johnston, Daniel Cohen, Marylyn M. Addo, John Zaunders, Galit Alter, Eunice Pae, Daryld Strick, Todd M. Allen, Eric S. Rosenberg, Bruce D. Walker, and Marcus Altfeld. HIV-1-Specific Cytotoxicity Is Preferentially Mediated by a Subset of CD8+ T Cells Producing both Interferon-gamma and Tumor Necrosis Factor-alpha. Blood, 104(2):487-394, 15 Jul 2004. PubMed ID: 15059848. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(92-100) DNA(9070..9096) |
Nef Epitope Map |
---|---|---|
Author Location | Nef | |
Epitope |
KEKGGLEGL
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Epitope Alignment
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Epitope Name | KL9 | |
Species (MHC/HLA) | human(B60) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | A2, A24, B38, B60, C*12, Cw2 | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | supervised treatment interruptions (STI), early treatment |
Montefiori2003 David C. Montefiori, Marcus Altfeld, Paul K. Lee, Miroslawa Bilska, Jintao Zhou, Mary N. Johnston, Feng Gao, Bruce D. Walker, and Eric S. Rosenberg. Viremia Control Despite Escape from a Rapid and Potent Autologous Neutralizing Antibody Response after Therapy Cessation in an HIV-1-Infected Individual. J. Immunol., 170(7):3906-3914, Apr 2003. PubMed ID: 12646660. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(92-100) DNA(9070..9096) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(92-100 NL43) | |
Epitope |
KEKGGLEGL
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Epitope Alignment
|
Show epitope variants | ||
Epitope Name | KL9 | |
Subtype | B | |
Species (MHC/HLA) | human(B60) | |
Immunogen | HIV-1 infection | |
Experimental methods | CTL suppression of replication, Chromium-release assay | |
Keywords | escape |
Yang2003 Otto O Yang, Phuong Thi Nguyen Sarkis, Ayub Ali, Jason D Harlow, Christian Brander, Spyros A Kalams, and Bruce D Walker. Determinant of HIV-1 Mutational Escape from Cytotoxic T Lymphocytes. J. Exp. Med., 197(10):1365-1375, May 2003. PubMed ID: 12743169. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(92-100) DNA(9070..9096) |
Nef Epitope Map |
---|---|---|
Author Location | Nef | |
Epitope |
KEKGGLEGL
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Epitope Alignment
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Show epitope variants | ||
Subtype | B | |
Species (MHC/HLA) | human | |
Immunogen | HIV-1 infection | |
Country | Australia | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | assay or method development, HLA associated polymorphism, chronic infection |
Almeida2010 Coral-Ann M. Almeida, Steven G. Roberts, Rebecca Laird, Elizabeth McKinnon, Imran Ahmad, Niamh M. Keane, Abha Chopra, Carl Kadie, David Heckerman, Simon Mallal, and Mina John. Exploiting Knowledge of Immune Selection in HIV-1 to Detect HIV-Specific CD8 T-Cell Responses. Vaccine, 28(37):6052-6057, 23 Aug 2010. PubMed ID: 20619380. Show all entries for this paper.