Search CTL/CD8+ T-Cell Epitope Database

Found 8 matching records:

Displaying record number 59899

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HXB2 Location	gp160(59-69) gp120(59-69) DNA(6399..6431)	gp160 Epitope Map
Author Location	Env(59-69)
Epitope	`KAYETEVHNVW`	Epitope Alignment
Epitope Name	KW11
Species (MHC/HLA)	human(A*23)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords	rate of progression, optimal epitope, chronic infection

Notes

Correlation between HLA class I and spontaneous control of HIV-1 was significant for 7-8 epitopes when 341 chronic, HIV-infected subjects, divided into controllers and non-controllers, were tested for EliSpot responses to 257 optimally defined epitopes. 21 epitopes were associated with viral progression. Protective epitopes tend to cluster in regions of critical stability for the protein, therefore constraining escape.
KAYETEVHNVW had a significantly positive association with HLA A*23; it was recognized by 2/11 A*23-positive subjects and 2/167 A*23-negative subjects.
KAYETEVHNVW was significantly nonprotective, associated with HIV chronic disease progression when restricted by HLA-A*23 in a cohort of 245 controllers and 96 progressors.

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.

Displaying record number 59901

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HXB2 Location	gp160(59-69) gp120(59-69) DNA(6399..6431)	gp160 Epitope Map
Author Location	Env(59-69)
Epitope	`KAYETEVHNVW`	Epitope Alignment
Epitope Name	KW11
Species (MHC/HLA)	human(A*34)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords	rate of progression, optimal epitope, chronic infection

Notes

Correlation between HLA class I and spontaneous control of HIV-1 was significant for 7-8 epitopes when 341 chronic, HIV-infected subjects, divided into controllers and non-controllers, were tested for EliSpot responses to 257 optimally defined epitopes. 21 epitopes were associated with viral progression. Protective epitopes tend to cluster in regions of critical stability for the protein, therefore constraining escape.
KAYETEVHNVW had a significantly positive association with HLA A*34; it was recognized by 1/6 A*34-positive subjects and 0/159 A*34-negative subjects.
KAYETEVHNVW was significantly nonprotective, associated with HIV chronic disease progression when restricted by HLA-A*34 in a cohort of 245 controllers and 96 progressors.

References

Displaying record number 59898

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HXB2 Location	gp160(59-69) gp120(59-69) DNA(6399..6431)	gp160 Epitope Map
Author Location	Env(59-69)
Epitope	`KAYETEVHNVW`	Epitope Alignment
Epitope Name	KW11
Species (MHC/HLA)	human(A*36)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords	rate of progression, optimal epitope, chronic infection

Notes

Correlation between HLA class I and spontaneous control of HIV-1 was significant for 7-8 epitopes when 341 chronic, HIV-infected subjects, divided into controllers and non-controllers, were tested for EliSpot responses to 257 optimally defined epitopes. 21 epitopes were associated with viral progression. Protective epitopes tend to cluster in regions of critical stability for the protein, therefore constraining escape.
KAYETEVHNVW had a significantly positive association with HLA A*36; it was recognized by 2/6 A*36-positive subjects and 4/178 A*36-negative subjects.
KAYETEVHNVW was significantly nonprotective, associated with HIV chronic disease progression when restricted by HLA-A*36 in a cohort of 245 controllers and 96 progressors.

References

Displaying record number 59900

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HXB2 Location	gp160(59-69) gp120(59-69) DNA(6399..6431)	gp160 Epitope Map
Author Location	Env(59-69)
Epitope	`KAYETEVHNVW`	Epitope Alignment
Epitope Name	KW11
Species (MHC/HLA)	human(B*37)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords	rate of progression, optimal epitope, chronic infection

Notes

Correlation between HLA class I and spontaneous control of HIV-1 was significant for 7-8 epitopes when 341 chronic, HIV-infected subjects, divided into controllers and non-controllers, were tested for EliSpot responses to 257 optimally defined epitopes. 21 epitopes were associated with viral progression. Protective epitopes tend to cluster in regions of critical stability for the protein, therefore constraining escape.
KAYETEVHNVW had a significantly positive association with HLA B*37; it was recognized by 1/2 B*37-positive subjects and 1/165 B*37-negative subjects.
KAYETEVHNVW was significantly nonprotective, associated with HIV chronic disease progression when restricted by HLA-B*37 in a cohort of 245 controllers and 96 progressors.

References

Displaying record number 59897

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HXB2 Location	gp160(59-69) gp120(59-69) DNA(6399..6431)	gp160 Epitope Map
Author Location	Env(59-69)
Epitope	`KAYETEVHNVW`	Epitope Alignment
Epitope Name	KW11
Species (MHC/HLA)	human(B*44)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords	rate of progression, optimal epitope, chronic infection

Notes

Correlation between HLA class I and spontaneous control of HIV-1 was significant for 7-8 epitopes when 341 chronic, HIV-infected subjects, divided into controllers and non-controllers, were tested for EliSpot responses to 257 optimally defined epitopes. 21 epitopes were associated with viral progression. Protective epitopes tend to cluster in regions of critical stability for the protein, therefore constraining escape.
KAYETEVHNVW had a significantly positive association with HLA B*44; it was recognized by 7/53 B*44-positive subjects and 6/184 B*44-negative subjects.
KAYETEVHNVW was significantly nonprotective, associated with HIV chronic disease progression when restricted by HLA-B*44 in a cohort of 245 controllers and 96 progressors.

References

Displaying record number 59896

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HXB2 Location	gp160(59-69) gp120(59-69) DNA(6399..6431)	gp160 Epitope Map
Author Location	Env(59-69)
Epitope	`KAYETEVHNVW`	Epitope Alignment
Epitope Name	KW11
Species (MHC/HLA)	human(B*57)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords	rate of progression, optimal epitope, chronic infection

Notes

Correlation between HLA class I and spontaneous control of HIV-1 was significant for 7-8 epitopes when 341 chronic, HIV-infected subjects, divided into controllers and non-controllers, were tested for EliSpot responses to 257 optimally defined epitopes. 21 epitopes were associated with viral progression. Protective epitopes tend to cluster in regions of critical stability for the protein, therefore constraining escape.
KAYETEVHNVW had a significantly positive association with HLA B*57; it was recognized by 26/104 B*57-positive subjects and 13/237 B*57-negative subjects.
KAYETEVHNVW was significantly nonprotective, associated with HIV chronic disease progression when restricted by HLA-B*57 in a cohort of 245 controllers and 96 progressors.

References

Displaying record number 54106

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HXB2 Location	gp160(59-69) gp120(59-69) DNA(6399..6431)	gp160 Epitope Map
Author Location
Epitope	`KAYETEVHNVW`	Epitope Alignment
Epitope Name	KW11
Species (MHC/HLA)	human(B*58)
Immunogen
Experimental methods
Keywords	optimal epitope, A-list

Notes

C. Brander notes this is a B*58 epitope.

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.

Displaying record number 54057

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HXB2 Location	gp160(59-69) gp120(59-69) DNA(6399..6431)	gp160 Epitope Map
Author Location	( C consensus)
Epitope	`KAYETEVHNVW`	Epitope Alignment
Subtype	C
Species (MHC/HLA)	human(B*58:01)
Immunogen	HIV-1 infection
Country	South Africa
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	rate of progression, optimal epitope

Notes

A comprehensive analysis of 160 class I T cell responses in 578 individuals from KwaZulu-Natal, South Africa was performed. Gag-specific responses were associated with lowering viremia, while Env, accessory and regulatory protein-specific responses were associated with higher viremia.
KAYETEVHNVW is an optimal epitope.

References

Kiepiela2007 Photini Kiepiela, Kholiswa Ngumbela, Christina Thobakgale, Dhanwanthie Ramduth, Isobella Honeyborne, Eshia Moodley, Shabashini Reddy, Chantal de Pierres, Zenele Mncube, Nompumelelo Mkhwanazi, Karen Bishop, Mary van der Stok, Kriebashnie Nair, Nasreen Khan, Hayley Crawford, Rebecca Payne, Alasdair Leslie, Julia Prado, Andrew Prendergast, John Frater, Noel McCarthy, Christian Brander, Gerald H. Learn, David Nickle, Christine Rousseau, Hoosen Coovadia, James I. Mullins, David Heckerman, Bruce D. Walker, and Philip Goulder. CD8+ T-Cell Responses to Different HIV Proteins Have Discordant Associations with Viral Load. Nat. Med., 13(1):46-53, Jan 2007. PubMed ID: 17173051. Show all entries for this paper.