Search CTL/CD8+ T-Cell Epitope Database

Found 2 matching records:

Displaying record number 1273

Download this epitope record as JSON.

HXB2 Location	Rev(14-23) DNA(6009..6038)	Rev Epitope Map
Author Location	Rev(14-23 BRU)
Epitope	KAVRIKLFLY	Epitope Alignment
Species (MHC/HLA)	human(B*57:01)
Immunogen	HIV-1 infection
Experimental methods
Keywords	HLA cross-presentation

Notes

• Rev and Tat are expressed early in the virus life cycle and thus may be important targets for CTL against HIV early in infection and for vaccines -- therefore CTL responses against Tat and Rev were screened using overlapping peptides.
• 11/57 (19.3%) HIV-1+ individuals recognized at least 1 Tat peptide, and 21/57 (37%) responded to at least 1 Rev peptide.
• This epitope was also recognized by another individual in whom it was restricted by HLA*B5801, an allele closely related to HLA*B5701, suggesting cross-presentation by the two HLA alleles.

References

Addo2001 Marylyn M. Addo, Marcus Altfeld, Eric S. Rosenberg, Robert L. Eldridge, Mary N. Philips, Kathleen Habeeb, Ashok Khatri, Christian Brander, Gregory K. Robbins, Gail P. Mazzara, Philip J. R. Goulder, and Bruce D. Walker. The HIV-1 Regulatory Proteins Tat and Rev are Freqently Targeted by cytotoxic T Lymphocytes (CTL) Derived from HIV Infected Individuals. Proc. Natl. Acad. Sci. U.S.A., 98(4):1781-1786, 13 Feb 2001. PubMed ID: 11172028. Show all entries for this paper.

Displaying record number 1272

Download this epitope record as JSON.

HXB2 Location	Rev(14-23) DNA(6009..6038)	Rev Epitope Map
Author Location	Rev(14-23 BRU)
Epitope	KAVRIKLFLY	Epitope Alignment
Species (MHC/HLA)	human(B*58:01)
Immunogen	HIV-1 infection
Experimental methods
Keywords	HLA cross-presentation

Notes

• Rev and Tat are expressed early in the virus life cycle and thus may be important targets for CTL against HIV early in infection and for vaccines -- therefore CTL responses against Tat and Rev were screened using overlapping peptides.
• 11/57 (19.3%) HIV-1+ individuals recognized at least 1 Tat peptide, and 21/57 (37%) responded to at least 1 Rev peptide.
• This epitope was also recognized by another individual in whom it was restricted by HLA*B5701, an allele closely related to HLA*B5801, suggesting cross-presentation by the two HLA alleles.

References

Addo2001 Marylyn M. Addo, Marcus Altfeld, Eric S. Rosenberg, Robert L. Eldridge, Mary N. Philips, Kathleen Habeeb, Ashok Khatri, Christian Brander, Gregory K. Robbins, Gail P. Mazzara, Philip J. R. Goulder, and Bruce D. Walker. The HIV-1 Regulatory Proteins Tat and Rev are Freqently Targeted by cytotoxic T Lymphocytes (CTL) Derived from HIV Infected Individuals. Proc. Natl. Acad. Sci. U.S.A., 98(4):1781-1786, 13 Feb 2001. PubMed ID: 11172028. Show all entries for this paper.